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Review Article

A Review of the Specifications and Toxicity of Synthetic Food Colors Permitted in Canada

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Pages 81-133 | Published online: 26 Sep 2008

References

  • Adams J. B., Butler R. A rapid method for detecting erythrosine in canned red fruits. Analyst 1976; 101: 140
  • Aizawa H. Interaction of food colors with protein. II. Binding of some azo and isoxanthene dyes with bovine albumin. Shokuhin Eiseigaku Zasshi 1967; 8: 40
  • Aizawa H. Interaction of food colors with protein. V. Metachromasy of Isoxanthene dyes by protein. Shokuhin Eiseigaku Zasshi 1967; 8: 387
  • Aizawa H. Interaction of food colors with protein. VII. Binding capacity and free energy of binding on azo color by protein. Eiyo To Shokuryo 1969; 22: 231
  • Albrecht R., Manchon P. Métabolisme et toxicité des colorants azoiques. Ann. Nutr. Aliment. 1973; 27: 1
  • Alfredson B. V., Stieflel J. R., Thorp F., Jr., Boten W. D., Gray M. L. Toxicity studies on alkyldimethylbenzylammonium chloride in rats and dogs. J. Am. Pharm. Assoc. Sci. Ed. 1951; 40: 263
  • Allan R. J., Roxon J. J. Metabolism by intestinal bacteria: the effect of bile salts on tartrazine azo reduction. Xenobiotica 1974; 4: 637
  • Allman G. A. Contemporary aspects of foodstuffs colourings. Food Manuf. 1967; 40: 22
  • Ames B. N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 1975; 31: 347
  • Andersen C. J., Keiding N. R., Nielsen A. B. False elevation of serum protein-bound iodine caused by red colored drugs or foods. Scand. J. Clin. Lab. Invest. 1964; 16: 249
  • Anderson J. R. A., Lock L. C., Martin E. C. The separation of permissible food dyes by two-dimensional chromatography and electrophoresis on paper. Aust. J. Appl. Sci. 1957; 8: 112
  • Andrianova M. M. Carcinogenous properties of red food pigments — Amaranth, SX Purple, and 4R Purple. Vopr. Pitan. 1970; 29: 61
  • Anon. Color Certification. Temporary listing for certification of Citrus Red No. 2 for coloring mature oranges. Fed. Regist. 1959; 24: 2945
  • Anon. Color certification. Republication and recodification of regulations. Fed. Regist. 1959; 24: 3851
  • Anon. Color additives. Diluents in color additive mixtures; final order listing for food and drug use. Fed. Regist. 1964; 29: 13893
  • Anon. Color additives, listing of color additives for food use exempt from certification. Fed. Regist. 1966; 31: 1063
  • Anon. Color additives. FD&C Yellow No. 5; listing for food and drug use subject to certification. Fed. Regist. 1966; 31: 3008
  • Anon. Color additives: miscellaneous amendments. Fed. Regist. 1968; 33: 8812
  • Anon. Color additives. FD and C Blue No. 1. Fed. Regist. 1969; 34: 7445
  • Anon. Identifying artificial color on oranges. Chemistry 1970; 43: 29
  • Anon. Color additives. Official Methods of Analysis of the Association of Official Analytical Chemists, W. Horwitz. Association of Official Analytical Chemists, Washington, D.C. 1975; 629
  • Aoyama K., Miyazawa F., Hatta S., Otake S., Urabe M., Sakai Y., Fujita A. Hygienic studies on food dyes. I. Frequency of illegal usage of rhodamine, auramine and malachite green in food, and their effect on the digestive enzymes. Eisei Shikenjo Hokoku 1957; 75: 237
  • Arnold D. W., Kennedy G. L., Jr., Keplinger M. L., Calandra J. C. Failure of FD&C Red No. 2 to produce dominant lethal effects in the mouse. Food Cosmet. Toxicol. 1976; 14: 163
  • Atack F. W. The Canadian food color regulations. Can. Chem. Metall. 1934; 18: 137
  • Baigusheva M. M. Carcinogenic properties of the amaranth paste. Vopr. Pitan. 1968; 27: 46
  • Bailey J. E., Calvey R. J. Spectral compilation of dyes, intermediates and other reaction products structurally related to FD&C Yellow No. 6. J. Assoc. Off. Anal. Chem. 1975; 58: 1087
  • Bailey J. E., Cox E. A. Chromatographic analysis of 4,4′-(diazoamino)-dibenzenesulfonic acid in FD&C Yellow No. 6, J. Assoc. Off. Anal. Chem. 1975; 58: 609
  • Bandelin F. J., Tuschhoff J. V. Paper chromatography of some certified dyes. J. Am. Pharm. Assoc. 1960; 49: 302
  • Banerjee S. K., Mathew T. V., Mitra S. N. Quantitative estimation of added coal-tar dyes in foods by polyamide adsorption and paper chromatography. Res. Ind. 1969; 14: 87
  • Banerjee S. K., Mathew T. V., Mukherjee A. K., Mitra S. N. Comparative studies on the effect of preservatives and chemicals on food colors in coloured foodstuffs. Res. Ind. 1970; 15: 18
  • Barrett J. F., Ryan A. J. Thin-layer chromatography of some food colours on silica gel. Nature (London) 1963; 199: 372
  • Barrett J. F., Pitt P. A., Ryan A. J., Wright S. E. The metabolism of 2-phenylazo-1-na-phthol-4-and-5-sulphonic acids in the rat. Biochem. Pharmacol. 1965; 14: 873
  • Barrett J. F., Pitt P. A., Ryan A. J., Wright S. E. The demethylation of methyl orange and m-methyl orangein vivo and. in vitro, Biochem. Pharmacol. 1966; 15: 675
  • Barry B. W., Russell G. F. J. Interaction of Amaranth with some alkyltrimethylammonium salts: a coacervation phenomenon. J. Pharm. Sci. 1972; 61: 502
  • Begue W. J., Bard R. C., Koehne G. W. Microbial inhibition by erythrosin. J. Dent. Res. 1966; 45: 1464
  • Bell S. Thin layer chromatographic separation and spectrodensitometric determination of higher and lower sulfonated subsidiary dyes in FD&C Yellow No. 6. J. Assoc. Off. Anal. Chem. 1975; 58: 717
  • Bernstein R., Haugen H. F., Frey H. Thyroid function during erythrosine ingestion in doses encountered in therapy with conventional antibiotics. Scand. J. Clin. Lab. Invest. 1975; 35: 49
  • Bertagni P., Hirom P. C., Millburn P., Osiyemi F. O., Smith R. L., Turbert H. B., Williams R. T. Sex and species differences in the biliary excretion of tartrazine and lissamine fast yellow in the rat, guinea-pig, and rabbit. The influence of sex hormones on tartrazine excretion in the rat. J. Pharm. Pharmacol. 1972; 24: 620
  • Boffey P. M. Color additives: botched experiment leads to banning of Red dye No. 2. Science 1976; 191: 450
  • Bonser G. M., Clayson D. B., Jull J. W. The induction of tumours of the subcutaneous tissues, liver and intestine in the mouse by certain dyestuffs and their intermediates. Br. J. Cancer 1956; 10: 653
  • Bonser G. M., Clayson D. B. A sulphonamide derivative which induces urinary tract epithelial hyperplasia and carcinomas of the bladder epithelium in the mouse. Br. J. Urol. 1964; 36: 26
  • Bora S. S., Radichevich I., Werner S. C. Artifactual elevation of PBI from an iodinated dye used to stain medicinal capsules pink. J. Clin. Endocrinol. 1969; 29: 1269
  • Bowie W. C., Wallace W. C., Lindstrom H. V. Some clinical manifestations of erythrosine in rats. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1966; 25: 556
  • Brain K. R., Jones B. E., Turner T. D. Application of densitometry to the qualitative and quantitative evaluation of pharmaceutical colourants. J. Chromatogr. 1975; 109: 383
  • Bray H. G., Clowes R. C., Thorpe W. V. The metabolism of azobenzene andp-hydroxyazobenzene in the rabbit. Biochem. J. 1957; 49: 65
  • Brodie B. B., Hogben C. A. M. Some physicochemical factors in drug action. J. Pharm. Pharmacol. 1957; 9: 345
  • Burnett C. M., Agersborg H. P. K., Jr., Borzelleca J. F., Eagle E., Ebert A. G., Pierce E. C., Kirschman J. C., Scala R. A. Teratogenic studies with certified colors in rats and rabbits. Toxicol. Appl. Pharmacol. 1974; 29: 121
  • Butterworth K. R., Gaunt I. F., Grasso P., Gangolli S. D. Acute and short-term toxicity studies on erythrosine BS in rodents. Food Cosmet. Toxicol. 1976; 14: 525
  • Butterworth K. R., Gaunt I. F., Grasso P., Gangolli S. D. Short-term toxicity of erythrosine BS in pigs. Food Cosmet. Toxicol. 1976; 14: 533
  • Calvery H. O. Coal-tar colors. Their use in foods, drugs and cosmetics. Am. J. Pharm. 1942; 114: 324
  • Canning J. H. Tar products — their past and future. J. Gas Light., Water Supply Sanit. Improv. 1916; 134: 455
  • Castille A. Rapport sur les “methodes de recherche et de dosage de colorants”. Acta Unio Int. Contra Cancrum 1957; 13: 93
  • Ceresa G. Sull'identificazione della natura dei coloranti sintetici impiegati nell'industria alimentare. Ann. Sper. Agrar. 1959; 13: 545
  • Chafee F. H., Settipane G. A. Asthma caused by FD&C approved dyes. J. Allergy 1967; 40: 65
  • Chang B. L., Haney W. G., Jr., Nuessle N. O. Sterilization of selected colorants by cobalt-60. J. Pharm. Sci. 1974; 63: 758
  • Chemical Abstracts, 9th Collective Index 1972–1976; Vol. 76–85
  • Chiang Hung-Cheh. Polyamide-silica gel thin-layer chromatography of red food dyes. J. Chromatogr. 1969; 40: 189
  • Childs J. J., Nakajima C., Clayson D. B. The metabolism of 1-phenylazo-2-naphthol in the rat with reference to the action of the intestinal flora. Biochem. Pharmacol. 1967; 16: 1555
  • Cohon M. S. Tartrazine revisited. Drug Intell. Clin. Pharm. 1975; 9: 198
  • Collins T. F. X., McLaughlin J., Gray G. C. Teratology studies on food colourings. I. Embryotoxicity of Amaranth (FD&C Red # 2) in rats. Food Cosmet. Toxicol. 1972; 10: 619
  • Collins T. F. X., Keeler H. V., Black T. N., Ruggles D. I., Gray G. C. Long-term effects of dietary amaranth in rats. I. Effects on reproduction. Toxicology 1975; 3: 115
  • Collins T. F. X., Black T. N., Ruggles D. I., Gray G. C. Long-term effects of dietary amaranth in rats. II. Effects on fetal development. Toxicology 1975; 3: 129
  • Collins T. F. X., Black T. N., Ruggles D. I., Gray G. C. Teratological evaluation of FD&C Red No. 2 — A collaborative government-industry study. II. FDA's study. J. Toxicol. Environ. Health 1976; 1: 857
  • Collins T. F. X., Ruggles D. I., Holson J. F., Jr., Schumacher H., Gaylor D. W., Kennedy G. L., Jr. Teratologic evaluation of FD&C Red No. 2 — A collaborative government-industry study. I. Introduction, experimental materials, and procedures. J. Toxicol. Environ. Health 1976; 1: 851
  • Collins T. F. X., Long E. L. Effects of chronic oral administration of erythrosine in the mongolian gerbil. Food Cosmet. Toxicol. 1976; 14: 233
  • Committee, British Food Manufacturing Industries Research Association. The extraction and identification of permitted food colouring matters with special reference to the changes undergone during processing and subsequent storage. Analyst 1963; 88: 864
  • Comptroller General of United States. Report Need to Establish the Safety of Color Additive FD&C Red No. 2. Food and Drug Administration 1975
  • Cooke A. C. Separation and identification of food colours, N.Z. J. Sci. 1959; 2: 260
  • Coste M. F., Verain A., Gattefosse M. A propos de la technologie des matiěres colorantes. Labo Pharma Probl. Tech. 1969; 180: 49
  • Criddle W. J., Moody G. J., Thomas J. D. R. Use of thin films for electrophoresis of coal tar food colours. Nature, (London) 1964; 202: 1327
  • Criddle W. J., Moody G. J., Thomas J. D. R. Thin-film electrophoresis. I. Electrophoretic behaviour of coal-tar food colours on paper and thin films. J. Chromatogr. 1964; 16: 350
  • Dacre J. C. Chronic toxicity and carcinogenicity studies on citrus Red No. 2. Proc. Univ. Otago Med. Sch. 1965; 43: 31
  • Dacre J. C. Carcinogenic compounds on edible meat in New Zealand. N.Z. Med. J. 1971; 73: 74
  • Damiani C. Identificazione con cromatografia su carta di coloranti idro-solubili impiegati negli alimenti mediante un mezzo fluente a bas di piridina. Ind. Aliment., (Pinerolo, Italy) 1965; 4: 41
  • Daniel J. W. The excretion and metabolism of edible food colors. Toxicol. Appl. Pharmacol. 1962; 4: 572
  • Daniel J. W. Enzymic reduction of azo food colorings. Food Cosmet. Toxicol. 1967; 5: 533
  • Danowski T. S., Greenman J. H. Rise in serum precipitable or protein-bound iodine following massive doses of inorganic iodide. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1949; 8: 31
  • Davidek J., Davidkova E. The use of polyamide in analyses of water soluble food dyes. IV. Thin layer chromatographic separation of water soluble food dyes. J. Chromatogr. 1967; 26: 529
  • Davis K. J., Fitzhugh O. G., Nelson A. A. Chronic rat and dog toxicity studies on tartrazine. Toxicol. Appl. Pharmacol. 1964; 6: 621
  • Davis K. J., Nelson A. A., Zwickey R. E., Hansen W. H., Fitzhugh O. G. Chronic toxicity of ponceau SX to rats, mice, and dogs. Toxicol. Appl. Pharmacol. 1966; 8: 306
  • Del Bianco F. M., Trabacchi G. Metodo per I'estrazione dei coloranti nei prodotti alimentari, Rass. Chim. 1961; 13: 17
  • Dellinger H. S. Aplicacion de la cromatografia a la investigacion de colorantes en alimentos, bebidas y productos farmaceuticos. An. Bromatol. 1960; 12: 9
  • Deshusses J., Desbaumes P. Identification des colorants des rouges a lévres par chromatographie sur couche mince. Mitt. Geb. Lebensmittelunters. Hyg. 1966; 57: 373
  • Despopoulos A., Branagan R. Renal and hepatic transport of food dyes. J. Pharmacol. Exp. Ther. 1968; 163: 222
  • Dickes G. J. The separation of synthetic water-soluble colouring matters by thin layer chromatography. J. Assoc. Public Anal. 1965; 3: 49
  • Dickinson D., Raven T. W. Stability of erythrosine in artificially coloured canned cherries. J. Sci. Food Agric. 1962; 13: 650
  • Dieckhues B. Untersuchungen zur reduktiven Spaltung der Azofarbstoffe durch Bakterian. Zen tralbl. Bakteriol. Parasitenk. Infektionskr. 1960; 180: 244, Abstr. 1
  • Dixon E. J., Groffman D. M. The determination of unsulphonated primary aromatic amines in water-soluble food dyes and other food additives. Analyst 1975; 100: 476
  • Dobrecky J., De Carnevale Bonino R. C. D. Separacion por cromatografia en papel de los colorantes permitidos por la comunidad economica europea. Rev. Asoc. Bioquim. Argent. 1967; 32: 139
  • Dobrecky J., De Carnevale Bonino R. C. D. Separacion cromatografia de colorantes permitidos para alimentos en nuestro pais. Rev. Asoc. Bioquim. Argent. 1967; 32(12)168–169
  • Dobrecky J., De Carnevale Bonino R. C. D. Separacion por cromatografia en papel de los colorantes permitidos para alimentos, drogas y cosměticos en los EE.UU. Rev. Asoc. Bioquim. Argent. 1967; 32: 16
  • Doeglas H. M. G. Reactions to aspirin and food additives in patients with chronic urticaria including the physical urticarias. Br. J. Dermatol. 1975; 93: 135
  • Dolinsky M. Report on subsidiary dyes in FD&C colors. Lower sulfonated dyes in FD&C Yellow No. 5. J. Assoc. Off. Agri. Chem. 1951; 34: 411
  • Dolinsky M. Report on lower sulfonated dyes in FD&C Blue No. 1. J. Assoc. Off. Agri. Chem. 1953; 36: 798
  • Dolinsky M., Jones J. H. Studies on coal-tar colors. IX. D&C Yellow No. 7, D&C Orange No. 5, D&C Red No. 21, tetrachlorofluorescein, D&C Red No. 27, and FD&C Red No. 3. J. Assoc. Off. Agric. Chem. 1951; 34: 114
  • Dolinsky M. Report on subsidiary dyes in FD&C colors. Lower sulfonated dye in FD&C Blue No. 1. J. Assoc. Off. Agric. Chem. 1955; 38: 359
  • Dolinsky M. Report on subsidiary dyes in FD&C colors. I. Higher sulfonated dyes in FD&C Yellow No. 6. J. Assoc. Off. Agric. Chem. 1954; 37: 805
  • Dolinsky M. Report on subsidiary dyes in FD&C colors. II. Subsidiary dyes in FD&C Red No. 2. J. Assoc. Off. Agric. Chem. 1954; 37: 808
  • Drake J. J. P. Food Colors — harmless aesthetics or epicurean luxuries. Toxicology 1975; 5: 3
  • Draper R. E. Separation and determination of FD&C Red No. 4 and FD&C Red No. 40 in maraschino cherries by column chromatography. J. Assoc. Off. Anal. Chem. 1973; 56: 703
  • Draper R. E. Effect of FD&C Red No. 3 (erythrosine) on the determination of FD&C azo color additives. J. Assoc. Off. Anal. Chem. 1975; 58: 614
  • Edelstein S. M. Dyes and dyeing in the Confederacy. Am. Dyest. Rep. 1962; 51: 35
  • European Economic Community. Report of the Scientific Committee for Food. First Series, Luxembourg 1975
  • Eisenbrand J. Acceleration of the bleaching of azo dyes by ascorbic acid in an aqueous solution by the addition of hydrogen peroxide,Dtsch. Lebensm. Rundsch., 69, 167, 1973;. Chem. Abstr. 1973; 79: 17018r
  • Eisenbrand J., Klauck A. Die Reduktion von künstlichen Lebensmittelfarbstoffen durch garende Hefen. Arzneim. Forsch. 1955; 5: 13
  • Elson L. A., Warren F. L. The metabolism of azo compounds. 1. Azobenzene. Biochem. J. 1944; 38: 217
  • Epley H. C., Hall A. G. An experimental study of the stability of certain factors of vitamin B complex toward various food, drug, and cosmetic colors. Am. J. Pharm. 1947; 119: 309
  • Ershoff B. H., Thurston E. W. Effects of diet on amaranth (FD&C red No. 2) toxicity in the rat. J. Nutr. 1974; 104: 937
  • Ershoff B. H. Protective effects of cholestyramine in rats fed a low-fibre diet containing toxic doses of sodium cyclamate or amaranth. Proc. Soc. Exp. Biol. Med. 1976; 152: 253
  • Evans W. H., Macnab J. A., Wardleworth D. F. Infra-red identification of synthetic food colours. J. Sci. Food Agric. 1970; 21: 207
  • FAO/WHO Expert Committee on Food Additives. Specifications for the Identity and Purity of Food Additives and their Toxicological Evaluation: Food colors and Some Antimicrobials and Antioxidants. Report Ser. No. 38, Tech. Rep. No. 309, World Health Organization. 1965
  • FAO/WHO Expert Committee on Food Additives. Specifications for Identity and Purity and Toxicological Evaluation of Food Colours. FAO Nutrition Meetings Report Ser. No. 38B, WHO/Food. 1966; 66: 25
  • FAO/WHO Expert Committee on Food Additives. Specifications for the Identity and Purity of Food Additives and their Toxicological Evaluation: Some Food Colours, Emulsifiers, Stabilizers, Anticaking Agents, and Certain Other Substances. FAO Nutrition Meetings Report Ser. No. 46, WHO Tech. Rep. Ser. No. 445, 1970
  • FAO/WHO. Evaluation of Mercury, Lead, Cadmium and Food Additives Amaranth, Diethylpyro-carbonate and Octyl Gallate. FAO Nutrition Meetings Rep. Ser. No. 51A, 1972; 60–66
  • FAO/WHO Expert Committee on Food Additives. Evaluation of certain food additives. FAO Nutrition Meeting Rep. Ser. No. 54; WHO Tech. Rep. Ser. No. 557, 1974
  • FAO/WHO. Joint Expert Committee on Food Additives. 21st Rep., Geneva, April 18–27, 1977
  • Feingold B. F. Recognition of food additives as a cause of symptoms of allergy. Ann. Allergy 1968; 26: 309
  • Feingold B. F. Why Your Child is Hyperactive. Random House, New York 1975
  • Finnegan J. K., Larson P. S., Smith R. B., Jr., Haag J., Reid J. D., Dreyfus M. L. Pharmacologic observations on two quaternary germicides. J. Pharmacol. Exp. Ther. 1953; 109: 422
  • Foltz A. K., Yeransian J. A., Sloman K. G. Food, Rev. Anal. Chem. 1977; 49: 194R
  • Food and Drugs Act and Regulations, with Amendments to August 25, 1976., Division 6, Table III. Queen's Printer, OttawaCanada 1977
  • Food Standards Committee. Report on the Review of the Colouring Matter in Food, Regulations, 1957. Her Majesty's Stationery Office. 1964
  • Fore H., Walker R., Golberg L. Studies on Brown FK. II. Degradative changes undergone. in vitro and in vivo, Food Cosmet. Toxicol. 1967; 5: 459
  • Freeman K. A., Jones J. H., Graichen C. Studies on coal-tar colors. VIII. FD&C Yellow No. 5. Assoc. Off. Agric. Chem. 1950; 33: 937
  • Fuller A. T. Isp-aminobenzenesulphonamide the active agent in prontosil therapy. Lancet 1937; 1: 194
  • Furia T. E., Bellanca N. Development of new, nonabsorbable polymeric antioxidants for use in foods. J. Am. Oil Chem. Soc. 1976; 53: 132
  • Furia T. E. Nonabsorbable polymeric food colors. Food Technol. 1977; 31: 34
  • Galea V., Preda N., Popa L., Sendrea D. Cercetari asupra toxicitatii colorantului alimentar amarant. Igiena 1971; 20: 331
  • Gales V., Preda N., Popa L., Sendrea D., Simu G. Recherches toxicologiques sur le colorant amaranthe. Eur. J. Toxicol. 1972; 5: 167
  • Gangolli S. D., Grasso P., Golberg L. Physical factors determining the early local tissue reactions produced by food colourings and other compounds injected subcutaneously. Food Cosmet. Toxicol. 1967; 5: 601
  • Gangolli S. D., Grasso P., Golberg L., Hooson J. Protein binding by food colourings in relation to the production of subcutaneous sarcoma. Food Cosmet. Toxicol. 1972; 10: 449
  • Gaunt I. F., Farmer M., Grasso P., Gangolli S. D. Acute (rat and mouse) and short-term (rat) toxicity studies on Sunset Yellow F.C.F. Food Cosmet. Toxicol. 1967; 5: 747
  • Gaunt I. F., Kiss I. S., Grasso P., Gangolli S. D. Short-term toxicity study on Sunset Yellow F.C.F. in the miniature pig. Food Cosmet. Toxicol. 1969; 7: 9
  • Gaunt I. F., Kiss I. S., Grasso P., Gangolli S. D. Short-term toxicity study on Indigo Carmine in the pig. Food Cosmet. Toxicol. 1969; 7: 17
  • Gaunt I. F., Carpanini F. M. B., Kiss I. S., Grasso P. Short-term toxicity of yellow 2G in rats. Food Cosmet. Toxicol. 1971; 9: 343
  • Gaunt I. F., Mason P. L., Grasso P., Kiss I. S. Long-term toxicity of Sunset Yellow F.C.F. in mice. Food Cosmet. Toxicol. 1974; 12: 1
  • Gill J. P. Foodstuff colours. The present international position. Chem. Prod. 1962; 25: 56
  • Gillette J. R. Biochemistry of drug oxidation and reduction by enzymes in hepatic endoplasmic reticulum. Adv. Pharmacol. 1967; 4: 219
  • Golberg L. The toxicology of artificial colouring materials. J. Soc. Cosmet. Chem. 1967; 18: 421
  • Gomberg M., Tabern D. L. The composition of erythrosin. J. Ind. Eng. Chem. 1922; 14: 1115
  • Graham R. C. B., Allmark M. G. Screening of some food colors for estrogenic activity. Toxicol. Appl. Pharmacol. 1959; 1: 144
  • Graham R. J. T., Nya A. E. The partition chromatography of food dyes on polycarbonatecoated foils. J. Chromatogr. 1969; 43: 547
  • Graichen C., Heine K. S., Jr. Studies on coal-tar colors. XVI. FD&C Red No. 4. J. Assoc. Off. Agric. Chem. 1954; 37: 905
  • Graichen C., Sclar R. N., Ettelstein N., Freeman K. A. Isolation and separation of coal-tar colors in foods. J. Assoc. Off. Agric. Chem. 1955; 38: 792
  • Graichen C., Molitor J. C. Determination of certifiable FD&C color additives in foods and drugs. J. Assoc. Off. Agric. Chem. 1963; 46: 1022
  • Graichen C. Quantitative determination of FD&C colors in foods. J. Assoc. Off. Agric. Chem. 1975; 58: 278
  • Grasso P., Golberg L. Early changes at the site of repeated subcutaneous injection of food colourings. Food Cosmet. Toxicol. 1966; 4: 269
  • Grasso P., Golberg L. Subcutaneous sarcoma as an index of carcinogenic potency. Food Cosmet. Toxicol. 1966; 4: 297
  • Grasso P., Gaunt I. F., Hall D. E., Golberg L., Batstone E. Studies on Brown FK. III. Administration of high doses to rats and mice. Food Cosmet. Toxicol. 1968; 6: 13
  • Grasso P., Muir A. R., Golberg L., Batstone E. Studies on Brown FK. IV. Cytopathic effects of Brown FK on cardiac and skeletal muscle in the rat. Food Cosmet. Toxicol. 1968; 6: 13
  • Grasso P., Lansdown A. B. G., Kiss I. S., Gaunt I. F., Gangolli S. D. Nodular hyperplasia in the rat liver, following prolonged feeding of Ponceau MX. Food Cosmet. Toxicol. 1969; 7: 425
  • Green M. Sublingual provocative testing for foods and FD&C dyes. Ann. Allergy 1974; 33: 274
  • Gregson R. H. S., Hirom P. C., Millburn P., Smith R. L., Turbert H. B., Williams R. T. The biliary excretion of tartrazine. Sex differences in the rat and species differences in the rat, guinea-pig and rabbit. J. Pharm. Pharmacol. 1972; 24: 20
  • Griffiths M. H. E. Systematic identification of food dyes using paper chromatographic techniques. J. Food Technol. 1966; 1: 63
  • Gross E. Über die Erzeugung von Sarkomen durch die besonders gereinigten Triphenylmethanfarbs-toffe Lichtgrun SF und Patentblau AE bei der wiederholten subcutanen Injektion an der Ratte. Z. Krebsforsch. 1961; 64: 287
  • Haas S. Contamination of protein-bound iodine by pink gelatin capsules colored with erythrosine. Ann. Intern. Med. 1970; 72: 549
  • Hajratwala B. R. Influence of sunscreening agents or color stability of tablets coated with certified dyes. II. FD&C Blue No. 1. J. Pharm. Sci. 1974; 63: 1927
  • Hall D. E., Lee F. S., Fairweather F. A. Acute (mouse and rat) and short-term (rat) toxicity studies on Ponceau MX. Food Cosmet. Toxicol. 1966; 4: 375
  • Hall J. R. Certified colors for foods. Food Ind. 1936; 8: 24
  • Hansen W. H., Fitzhugh O. G., Nelson A. A., Davis K. J. Chronic toxicity of two food colors, Brilliant Blue FCF and indigotine. Toxicol. Appl. Pharmacol. 1966; 8: 29
  • Hansen W. H., Long E. L., Davis K. J., Nelson A. A., Fitzhugh O. G. Chronic toxicity of three food colourings: Guinea Green B, Light Green SF Yellowish, and Fast Green F.C.F. in rats, dogs and mice. Food Cosmet. Toxicol. 1966; 4: 389
  • Hansen W. H., Zwickey R. E., Brouwer J. B., Fitzhugh O. G. Long-term toxicity studies of erythrosine. I. Effects in rats and dogs. Food Cosmet. Toxicol. 1973; 11: 527
  • Hansen W. H., Davis K. J., Graham S. L., Perry C. H., Jacobson K. H. Long-term toxicity studies of erythrosine. II. Effects on haematology and thyroxine and protein-bound iodine in rats. Food Cosmet. Toxicol. 1973; 11: 535
  • Harrow L. S., Jones J. H. The decomposition of azo colors in acid solution. J. Assoc. Off. Agric. Chem. 1954; 37: 1012
  • Hashimoto Y., Shimizu S. Paper chromatographic separation of intermediate products of food colors. J. Pharm. Soc. Jpn. 1953; 73: 767
  • Health and Welfare, Canada, News Release February 2, 1976
  • Hernandez P. H., Gillette J. R., Mazel P. Studies on the mechanism of action of mammalian hepatic azoreductase. I. Azoreductase activity of reduced nicotinamide adenine dinucleotide phos-phate-cytochrome c reductase. Biochem. Pharmacol. 1967; 16: 1859
  • Hess S. M., Fitzhugh O. G. Metabolism of coal-tar colors. II. Bile studies. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1954; 13: 365
  • Hess S. M., Fitzhugh O. G. Absorption and excretion of certain triphenylmethane colors in rats and dogs. J. Pharmacol. Exp. Ther. 1955; 114: 38
  • Hesselbach M. L., O'Gara R. W. Fast Green and Light Green-induced tumors: induction, morphology, and effect on host. J. Natl. Cancer Inst. 1960; 24: 769
  • Hirom P. C., Millburn P., Osiyemi F. O., Smith R. L., Turbert H. B., Williams R. T. The effect of testosterone on the biliary excretion of tartrazine in female rats. Biochem. J. 1972; 127: 25
  • Hirom P. C., Millburn P., Smith R. L., Williams R. T. Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions. Biochem. J. 1972; 129: 1071
  • Hobin N. K. Turbidimetric determination of soluble sulfates in water-soluble color additives. J. Assoc. Off. Anal. Chem. 1970; 53: 242
  • Holson J. F., Jr., Schumacher H. J., Gaylor D. W., Gaines T. B. Teratological evaluation of FD&C Red No. 2 — a collaborative government— industry study. IV. NCTR's study. J. Toxicol. Environ. Health. 1976; 1: 867
  • Holson J. F., Jr., Gaylor D. W., Schumacher H. J., Collins T. F. X., Ruggles D. I., Keplinger M. L., Kennedy G. L., Jr. Teratological evaluation of FD&C Red No. 2 — a collaborative. government—industry study. V. Combined findings and discussion, J. Toxicol. Environ. Health 1976; 1: 875
  • Honkawa T. Two-wavelength spectrophotometric determination of food color mixtures with the function generator. Anal. Lett. 1975; 8: 901
  • Honohan T., Enderlin F. E., Ryerson B. A. Absorption, metabolism and excretion of the azo food dyes, amaranth, sunset yellow and tartrazine after oral administration to rats. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1976; 35: 328
  • Hoodless R. A., Pitman K. G., Stewart T. E., Thomson J., Arnold J. E. Separation and identification of food colours. I. Identification of synthetic water soluble food colours using thinlayer chromatography. J. Chromatogr. 1971; 54: 393
  • Hooson J., Gaunt I. F., Kiss I. S., Grasso P., Butterworth K. R. Long-term toxicity of indigo carmine in mice. Food Cosmet. Toxicol. 1975; 13: 167
  • Hosen H. The relationship of FD&C dyes and respiratory allergy. J. Asthma Res. 1972; 10: 131
  • Iga T., Awazu S., Hanano M., Nogami H. Pharmacokinetic studies of biliary excretion. 1. Comparison of the excretion behavior in azo dyes and indigo carmine. Chem. Pharm. Bull. 1970; 18: 2431
  • Iga T., Awazu S., Nogami H. Pharmacokinetic study of biliary excretion. II. Comparison of excretion behavior in triphenylmethane dyes. Chem. Pharm. Bull. 1971; 19: 273
  • Iga T., Awazu S., Nogami H. Pharmacokinetic study of biliary excretion. III. Comparison of excretion behavior in xanthene dyes, fluorescein, and bromsulphthalein. Chem. Pharm. Bull. 1971; 19: 297
  • Iga T., Awazu S., Hanano M., Nogami H. Pharmacokinetic studies of biliary excretion. IV. The relationship between the biliary excretion behavior and the elimination from plasma of azo dyes and triphenylmethane dyes in rat. Chem. Pharm. Bull. 1971; 19: 2609
  • Iida H., Endo M. Precipitation of direct dyes and acid dyes by iron salts. Kogyo Kagaku Zasshi 1967; 70: 403
  • Ikeda M., Uesugi T. Studies on the biliary excretion mechanism of drugs. 1. Biliary excretion of azo dyes in the rat. Biochem. Pharmacol. 1973; 22: 2743
  • Inada K., Miyazawa F. Photodynamic action of food dye on bacteria. Shokuhin Eiseigaku Zasshi 1969; 10: 344
  • International Agency for Research on Cancer. Monographs, Some Aromatic Azo Compounds, International Agency for Research on Cancer. Lyon 1975; 8: 105
  • Ito T., Ikezawa H., Tejima S. Food additives and digestive enzyme. III. Food dyes and tryptic activity. J. Hyg. Chem. 1970; 16: 134
  • Jablonski C. F. Report on coloring matters in foods. J. Assoc. Off. Agric. Chem. 1929; 12: 354
  • Jablonski C. F. Report on coloring matters in foods. J. Assoc. Off. Agric. Chem. 1930; 13: 412
  • Jablonski C. F. Report on coloring matters in food. J. Assoc. Off. Agric. Chem. 1932; 15: 362
  • Jablonski C. F. Report on coloring matters in foods. J. Assoc. Off. Agric. Chemists 1951; 34: 232
  • Jacobs M. B. Food and flavor color. Am. Perfum. Aromat. 1957; 70: 67
  • Johnson H. M., Peeler J. T., Smith B. G. Tartrazine: quantitative passive hemagglutination studies on a foodborne allergen of small molecular weight. Immunochemistry 1971; 8: 281
  • Johnson H. M., Smith B. G., Kauffman P. E. Tartrazine: solid-phase radioimmunoassay studies of an azo dye implicated in allergic reactions (azo dyes and allergy). Proc. Soc. Exp. Biol. Med. 1975; 150: 278
  • Johnson R. K. Uncombined intermediates in FD&C blue No. 1. J. Assoc. Off. Anal. Chem. 1967; 50: 526
  • Jones J. H., Harrow L. S., Heine K. S., Jr. Studies on coal-tar colors. XX. FD&C Blue No. 2. J. Assoc. Off. Agric. Chem. 1955; 38: 949
  • Jones J. H., Dolinksy M., Harrow L. S., Heine K. S., Jr., Staves M. C. Studies on the triphenylmethane colors derived from ethylbenzylaniline sulfonic acid. J. Assoc. Off. Agric. Chem. 1955; 38: 977
  • Jones R., Ryan A. J., Wright S. E. The metabolism and excretion of tartrazine in the rat, rabbit, and man. Food Cosmet. Toxicol. 1964; 2: 447
  • Jones A. V., Thomas J. D. R. The influence of certain metal ions on the visible spectra of food dyes. J. Food Technol. 1968; 3: 1
  • Jones R., Ryan A. J., Wright S. E. The metabolism of some fat-soluble phenylazopyrazolones in the rat. Food Cosmet. Toxicol. 1966; 4: 411
  • Juhlin L., Michaelsson G., Zetterstrom O. Urticaria and asthma induced by food and drug additives in patients with aspirin hypersensitivity. J. Allergy Clin. Immunol. 1972; 50: 92
  • Juhlin L., Michaelsson G. Urtikaria utlost av konserveringsmedel och fargtillsatser i livsmedel och lakemedel. äkartidningen 1973; 70: 1411
  • Kada T., Tutikawa K., Sadaie Y. In vitro and host mediated “rec-assay” procedures for screening chemical mutagens, and phloxine, a mutagenic red dye detected. Mutat. Res. 1972; 16: 165
  • Kamikura M. Thin layer chromatography of synthetic dyes. IV. Separation and identification of water-soluble dyes (1). On the developing solvent and condition of activation of silica gel. Shokuhin Eiseigaku Zasshi 1966; 7: 338
  • Kamin H., Masters B. S. S., Gibson Q. H., Williams C. H., Jr. Microsomal TPNH-cytochrome creductase. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1965; 24: 1164
  • Kamm J. J., Gillette J. R. Mechanism of stimulation of mammalian nitroreductase by flavins. Life Sci. 1963; 2: 254
  • Kempton R. T., Bott P. A., Richards A. N. The glomerular elimination of indigo carmine in rabbits. Am. J. Anat. 1937; 61: 505
  • Kennedy W. F., Jr., Wirjoatmadja K., Akamatsu T. J., Bonica J. J. Cardiovascular and respiratory effects of Indigo Carmine. J. Urol. 1968; 100: 775
  • Keplinger M. L., Wright P. L., Plank J. B., Calandra J. C. Teratologic studies with F.D.&C. Red No. 2 in rats and rabbits. Toxicol. Appl. Pharmacol. 1974; 28: 209
  • Keplinger M. L., Kinoshita F. K., Smith S. H., Kennedy G. L., Jr. Teratological evaluation of F.D.&C. Red No. 2 — a collaborative government—industry study. III. I.B.T.'s study. J. Toxicol. Environ. Health 1976; 1: 863
  • Khanna S. K., Singh G. B. Toxicity of commonly used food colours: a review. J. Sci. Ind. Res. 1975; 34: 631
  • Khanna S. K., Singh G. B., Hasan M. Z. Metal contaminants in various food colours. J. Sci. Food Agric. 1976; 27: 170
  • Khera K. S., Przybylski W., McKinley W. P. Implantation and embryonic survival in rats treated with amaranth during gestation. Food Cosmet. Toxicol. 1974; 12: 507
  • Khera K. S., Roberts G., Trivett G., Terry G., Whalen C. A teratogenicity study with amaranth in cats. Toxicol. Appl. Pharmacol. 1976; 38: 389
  • Kitson J. A., Strachan C. C. Metallic discoloration of candied fruits. Food Technol. 1955; 9: 582
  • Klevansky H., Kingsley H. J. Fixed drug eruptions caused by dyes. S. Afr. Med. J. 1964; 38: 216
  • Knowles M. E., Gilbert J., McWeeny D. J. Stability of red food colors in the presence of nitrite in canned pork luncheon meat. J. Sci. Food Agric. 1974; 25: 1239
  • Koch L. Systematic group separation of mixtures of FD&C, D&C and Ext. D&C colors by use of immiscible solvents. J. Assoc. Off. Agric. Chem. 1943; 26: 245
  • Koch L. Some legal, chemical, and physical aspects of permitted color additives. Am. Perfum. Cosmet. 1967; 82: 35
  • Kretlow W. H. What to know about food colors. Food Ind. 1940; 12: 38
  • Kuramoto R., Lachman L., Cooper J. A study of the effect of certain pharmaceutical materials on color stability. J, Am. Pharm. Assoc. 1958; 47: 175
  • Lacy W. W., Ugaz C., Newman E. V. The use of indigo carmine for dye dilution curves. Cir. Res. 1955; 3: 570
  • Larson K. S. A teratologic study with the dyes amaranth and Ponceau 4R in mice. Toxicology 1975; 4: 75
  • Leegwater D. C., De Groot A. P., Van Kalmthout-Kuyper M. The aetiology of caecal enlargement in the rat. Food Cosmet. Toxicol. 1974; 12: 687
  • Lethco E. J., Webb J. M. The fate of FD&C Blue No. 2 in rats. J. Pharmacol. Exp. Ther. 1964; 154: 384
  • Lindstrom H. V., Hansen W. H. The metabolism of FD&C Red #1. III. The Fate of 2,5-para-xylidine in rats and the relation between toxicity and metabolism of xylidine isomers. Fed. Proc., Fed. Am. Soc. Exp. Biol. 1962; 21: 450
  • Lindstrom H. V., Wallace W. C., Hansen W. H., Nelson A. A., Fitzhugh O. G. The metabolism of FD&C Red #1. IV. The metabolism and toxicity of pseudocumidine and mesidine in rats. Fed. Proc., Fed. Am. Soc. Exp. Biol. 1963; 22: 188
  • Link W. B. Intermediates in food, drug, and cosmetic colors. J. Assoc. Off. Agric. Chem. 1961; 44: 43
  • Link W. B. Studies on coal-tar colors. XXVI. FD&C Red No. 2. J. Assoc. Off. Agric. Chem. 1961; 44: 53
  • Lockey S. D. Allergic reactions due to FD&C Yellow No 5 tartrazine, and aniline dye used as a coloring and identifying agent in various steroids. Ann. Allergy 1959; 17: 719
  • Lockey S. D. Sensitizing properties of food additives and other commercial products. Ann. Allergy 1972; 30: 638
  • Lockey S. D. Drug reactions and sublingual testing with certified food colors. Ann. Allergy 1973; 31: 423
  • Lolua A. M., Poutilova I. N., Chernenko L. E. Contamination of some food products. Ind. Chim. Belge 1967; 32: 818
  • Lu F. C., Lavallee A. The acute toxicity of some synthetic colours used in drugs and foods. Can. Pharm. J. 1964; 97: 530
  • Luck H., Rickerl E. Lebensmittelzusatzstoffe und mutagene Wirkung. VI. Mitteilung. Prufung der in Westdeutschland zugelassenen und ursprunglich vorgeschlagenen.2 Lebensmittelfarbstoffe auf mutagene Wirkung an Escherichia coli. Z. Lebensm. Unters. Forsch. 1960; 112: 157
  • Luck H., Wallnnöfer P., Bach H. Lebensmittelzusatzstoffe und mutagene Wirkung. VII. Mitteilung. Prüfung einiger Xanthen-Farbstoffe auf mutagene Wirkung an Escherichia coli. Pathol. Microbiol. 1963; 26: 206
  • Lück H. Untersuchungen über Veränderungen von Lebensmittelfarbstoffen. Z. Lebensm. Unter. Forsch. 1965; 126: 193
  • Luckey T. D. Germfree Life and Gnotobiology. Academic Press, New York 1963
  • Malkus Z., Szokolay A. Hygeinické problémy potravinarskych barviv. Cesk. Hyg. 1965; 10: 163
  • Manchon P. Problémes biologiques poses par l'emploi dans l'alimentation des colorants azoiques. Biol. Med. 1965; 54: 160
  • Manchon P H., Gradnauer S., Lowy R. Etudes sur l'activitè azoréductasique des surnageants d'homogènat de foie de rat. I. Influence de divers effecteurs. Food Cosmet. Toxicol. 1964; 2: 349
  • Manchon P H., Lowy R. Action du methylorange sur l'activitè respiratoire de prèparations de foie de rat. Food Cosmet. Toxicol. 1965; 3: 775
  • Manchon P., Lowy R., Gradnauer S. Action de mèthylorange sur la consommation d'oxygène de diverses prèparations de foie de rat. C. R. Soc. Biol. 1962; 156: 1615
  • Mannell W. A., Grice H. C., Lu F. C., Allmark M. G. Chronic toxicity studies on food colours. IV. Observations on the toxicity of tartrazine, amaranth, and Sunset yellow in rats. J. Pharm. Pharmacol. 1958; 10: 625
  • Mannell W. A., Grice H. C., Allmark M. G. Chronic toxicity studies on food colours. V. Observations on the toxicity of Brilliant Blue FCF, Guinea Green B, and Benzyl Violet 4B in rats. J. Pharm. Pharmacol. 1961; 14: 378
  • Mannell W. A., Grice H. C. Chronic toxicity of Brilliant Blue FCF, Blue VRS, and Green S in rats. J. Pharm. Pharmacol. 1964; 16: 56
  • Mannell W. A. Further investigations on production of liver tumors in rats by Ponceau 3R. Food Cosmet. Toxicol. 1964; 2: 169
  • Marignan R., Boucard M., Gelis C. Influence possible de l'érythrosine sur le métabolisme thyroidien. Trav. Soc. Pharm. Montpellier 1964; 24: 127
  • Marmion D. M., White R. G., Cashion F. W., Whitcomb B. 6–6′- oxybis(2-naphthalenesulfonic acid) in Shaeffer's salt. J. Assoc. Off. Anal. Chem. 1971; 54: 137
  • Marmion D. M. 6,6′-Oxybis(2-naphthalenesulfonic acid) in FD&C Yellow No. 6. J. Assoc. Off. Anal. Chem. 1971; 54: 141
  • Marmion D. M. Determination of 4,4′-(diazoamino)-dibenzenesulfonic acid in FD&C Yellow No. 6. J. Assoc. Off. Anal. Chem. 1975; 58: 719
  • Mason R. P., Holtzman J. L. Free radical metabolites of amaranth (FD&C Red No. 2) and related azo dyes, Fed. Proc. Fed. Am. Soc. Exp. Biol. 1976; 35: 1422
  • McCormick R. D. Allura red — new food color offers greater brilliance and stability. Food Prod. Dev. 1971; 5: 26
  • McKeown G. G., Thomson J. L. The polarographic reduction of amaranth. Can. J. Chem. 1954; 32: 1025
  • McKeown G. G. The separation of amaranth and tartrazine. J. Assoc. Off. Agric. Chem. 1954; 37: 527
  • Melo M. S. Corantes organicos artificiais em géneros alimenticios. Rev. Inst. Adolfo Lutz 1943; 3: 183
  • Meuron G. L'état actuel de la question des colorants pour denrées alimentaires. Mitt. Lebensm. Hyg. 1955; 46: 97
  • Michaëlsson G., Juhlin L. Urticaria induced by preservatives and dye additives in food and drug. Br. J. Dermatol. 1973; 88: 525
  • Miller J. A., Miller E. C., Baumann C. A. On the methylation and demethylation of certain carcinogenic azo dyes in the rat. Cancer Res. 1945; 5: 162
  • Miller E. C., Plescia A. M., Miller J. A., Heidelberger C. The metabolism of methylated aminoazo dyes. 1. The demethylation of 3-methyl -4-dimethyl-C14-aminoazobenzene. in vivo, J. Biol. Chem. 1952; 196: 863
  • Mitra S. N., Mathew T. V., Gupta P. K. A note on paper chromatography of food colours. J. Inst. Chem. (Calcutta) 1968; 40: 177
  • Moten L. Quantitative determination of chromium in triphenylmethane color additives by atomic absorption spectroscopy. J. Assoc. Off. Anal. Chem. 1970; 53: 916
  • Mottier M., Potterat M. De l'extraction des colorants pour denrées alimentaires avec la quinoleine et de leur identification par chromatographic sur plaque d'alumine. Anal. Chim. Acta 1955; 13: 46
  • Mueller G. C., Miller J. A. The metabolism of 4-dimethylaminoazobenzene by rat liver homogenates. J. Biol. Chem. 1948; 176: 535
  • Mueller G. C., Miller J. A. The metabolism of methylated aminoazo dyes. II. Oxidative demethylation by rat liver homogenates. J. Biol. Chem. 1953; 202: 579
  • Nagy F., Sohar J. Beitrag zur oszillopolarographischen analytik der lebensmittelfarbstoffe. Chem. Zvesti 1962; 16: 389
  • National Academy of Sciences - National Research Council. Food Colors, Library of Congress Catalog 1971, Card No. 70–176233
  • Nelson A. A., Hagan E. C. Production of fibrosarcomas in rats at site of subcutaneous injection of various food dyes. Fed. Proc., Fed. Am. Soc. Exp. Biol. 1953; 12: 397
  • Netto I. Une méthode chromatographique de partage sur papier pour l'analyse de colorants alimentaires. Ann. Falsif. Fraudes 1957; 50: 166
  • Niitsu K. Studies on the metabolism and carcinogenicity of azo dyes used for food colors and direct dyestuffs. I. Studies on the metabolism of food colors, Orange II and Sunset Yellow FCF. Tokyo Jikeikai Ika Daigaku Zasshi 1973; 88: 460
  • Nolting E., Kohn O. Ber. Dtschn. Chem. Ges. 1960; 43: 805, 19, 138, 1886; quoted by Wenninger, J. A., Jones, J. H., and Dolinsky, M., Studies on coal-tar colors. XXIV: Red No. 4,J. Assoc. Agric. Chem.
  • Noonan J. Color additives in food. Handbook of Food Additives, T. E. Furia. CRC Press, Cleveland 1973; 587
  • Norton G. The preparation of tartrazine. Z. Farben Ind. 1928; 20: 8
  • Nursten H. E., Williams G. The stability of coal-tar food colours permitted in the UK. Chem. Ind., (London) 1969; 50: 1798
  • Oettel H., Frohberg H., Nothdurft H., Wilhelm G. Die Prufung einiger synthetischer Farbstoffe auf ihre Eignung zur Lebensmittelfärbung. Arch. Toxikol. 1965; 21: 9
  • Oravisto K. J. Investigations into the excretion mechanism of Indigo Carmine in normal human kidney. Ann. Chir. Gynaecol. Fenn. 1957; 46: 79, Suppl. 2
  • O'Reilly W. J., Coates P. E., McMahon K. A., Ting E., Priestly B. G. Pharmacokinetic models for the biliary excretion of amaranth in the rat. Life Sci. 1972; 2: 197
  • Parekh N., Popa G., Galaske R., Galaske W., Steinhausen M. Renal test dyes. 1. Physical and chemical properties of some dyes suitable for renal passage time measurements. Pfluegers Arch. 1973; 343: 1
  • Parihar D. B., Sharma S. P., Tewari K. C. Thin-layer chromatographic study ofp-toluene-sulphonates of some amines. J. Chromatogr. 1966; 24: 443
  • Parke D. V. The Biochemistry of Foreign Compounds. International Series of Monographs in Pure and Applied Biology, Biochemistry Division. Pergamon Press, Oxford 1976; Vol. 5: 76
  • Parrish J. R. Chromatography of food dyes on Sephadex. J. Chromatogr. 1968; 33: 542
  • Payne J. V. Benign red pigmentation of stool resulting from food coloring in a new breakfast cereal (The Franken Berry Stool). Pediatrics 1972; 49: 293
  • Peacock W. H. The Application Properties of the Certified “Coal Tar” Colors, Calco Tech. Bull. No. 715. American Cyanamide, Bound Brook, N.J. 1945
  • Pellerin F., Gautier J. A., Conrard A. M. Identification dans les préparations pharmaceutiques des colorants organiques de synthése autorisés. Ann. Pharm. Fr. 1964; 22: 621
  • Penner M. H. Thin-layer chromatography of certified coal-tar color additives. J. Pharm. Sci. 1968; 57: 2132
  • Perry A. R., Woolley D. G. The identification of some water-soluble food colours for thin layer chromatography. J. Assoc. Public Anal. 1969; 7: 94
  • Pierce E. C., Agersborg H. P. K., Jr., Borzelleca J. F., Burnett C. M., Eagle E., Ebert A. G., Kirschman J. C., Scala R. A. Multi-generation reproduction studies with certified colors in rats. Toxicol. Appl. Pharmacol. 1974; 29: 121
  • Pla-Delfina J. M. A systematic method for identification of food, drug, and cosmetic azo dyes. J. Soc. Cosmet. Chem. 1962; 13: 214
  • Preda N., Dancea S., Simu G H. Moditicari histologice provocate de administrarea experimentala de Amarant. Igiena 1973; 22: 235
  • Priestly B. G., O'Reilly W. J. Protein binding and the excretion of some azo dyes in rat bile. J. Pharm. Pharmacol. 1966; 18: 41
  • Pritchard A. B., Holmes P. A., Kirschman J. C. The fate of FD&C Red No. 2 and its metabolite, naphthionic acid, after different routes of administration in the rat. Toxicol. Appl. Pharmacol. 1976; 35: 1
  • Przybylski W., Smyth R. B., McKeown G. G. Determination of coal-tar colors on oranges. J. Assoc. Off. Agric. Chem. 1960; 43: 274
  • Radomski J. L., Deichmann Wm. B. Cathartic action and metabolism of certain coal tar food dyes. J. Pharmacol. Exp. Ther. 1956; 118: 322
  • Radomski J. L. The absorption, fate and excretion of citrus Red #2 (2,5-dimethoxyphenyl-azo-2-naphthol) and Ext. F&C Red #14 (1-xylylazo-2-naphthol). J. Pharmacol. Exp. Ther. 1961; 134: 100
  • Radomski J. L., Mellinger T. J. The absorption, fate, and excretion in rats of the water-soluble azo dyes, FD&C Red No. 2, FD&C Red No. 4, and FD&C Yellow No. 6. J. Pharmacol. Exp. Ther. 1962; 136: 259
  • Radomski J. L. Toxicology of food colors, J. Ann. Rev. Pharmacol. 1974; 14: 127
  • Raff A. M. Measurement of a color gamut obtained from FD&C colorants. J. Pharm. Sci. 1964; 53: 380
  • Rofe P. Azo dyes and Heinz bodies. Br. J. Ind. Med. 1957; 14: 275
  • Ross K. D. Reduction of the azo food dyes FD&C Red 2 (amaranth) and FD&C Red 40 by thermally degraded d-fructose and d-glucose. J. Agric. Food Chem. 1975; 23: 475
  • Roxon J. J., Ryan A. J., Wright S. E. Reduction of tartrazine by a Proteus species isolated from rats. Food Cosmet. Toxicol. 1966; 4: 419
  • Roxon J. J., Ryan A. J., Wright S. E. Reduction of water-soluble azo dyes by intestinal bacteria. Food Cosmet. Toxicol. 1967; 5: 367
  • Roxon J. J., Ryan A. J., Welling P. G., Wright S. F. Origin of urinary sulfanilic acid from tartrazine. Food Cosmet. Toxicol. 1967; 5: 447
  • Rubenchik B. L., Bykorez A. I. Biochemical and morphological changes in the liver of rats in cancerogenesis induced by N-dimethylaminoazobenol and amarant injections. Vopr. Onkol. 1963; 9: 68
  • Rubenchik B. L. Changes in riboflavin content in the course of experimentally induced carcinogenesis in rats. Vopr. Pitan. 1963; 22: 72
  • Ruiz S. L. Extraction et identification des colorants synthétiques incorporés aux aliments. Ann. Falsif. Fraudes 1956; 49: 315
  • Ryan A. J. Paper chromatographic techniques with particular reference to food dyes. Aust. Paint J. 1961; 6: 12
  • Ryan A. J., Wright S. E. The excretion of some azo dyes in rat bile. J. Pharm. Pharmacol. 1961; 13: 492
  • Ryan A. J., Roxon J. J., Sivayavirojana A. Bacterial azo reduction: a metabolic reaction in mammals. Nature (London) 1968; 219: 854
  • Ryan A. J., Welling P. G., Wright S. E. Further studies on the metabolism of tartrazine and related compounds in the intact rat. Food Cosmet. Toxicol. 1969; 7: 287
  • Ryan A. J. Factors involved in the metabolism of xenobiotics in mammals. Aust. J. Pharm. Sci. 1972; 1: 30
  • Sadini V. Recenti applicazioni della tecnica cromatografica alla ricerca della colorazione negli alimenti. Rass. Chim. 1960; 12: 13
  • Sadini V. Cromatografia di partizione su carta di coloranti per uso alimentare. Rass. Chim. 1960; 12: 23
  • Sadini V. Cromatografia di partizione su carta di coloranti per uso alimentare. Rass. Chim. 1960; 12: 27
  • Salant W., Bengis R. Physiological and pharmacological studies on coal tar colors. 1. Experiments with fat-soluble dyes. J. Biol. Chem. 1916; 27: 403
  • Sakagami Y., Takeshita R., Mizushima H., Iwamura Y. Application of DEAE-Sephadex to the separation of several acids from foods. Koshu Eiseiin Kenkyu Hokoku 1966; 15: 13
  • Salo T., Salminen K. Ober die Identifizierung der in Finnland zugelassenen synthetischen Lebensmittel-Farbstoffe. Suom. Kemistil. 1962; 35B: 146
  • Samter M., Beers R. F., Jr. Intolerance to aspirin, clinical studies and considerations of its pathogenesis. Ann. Intern. Med. 1968; 68: 975
  • Sansone R. The manufacture of tartrazine. Color Trade J. 1923; 13: 50
  • Satyanarayana Rao T. S., Sastry L. V. L., Siddappa G. S. Separation of synthetic food colours by chromatography and electrophoresis. Indian J. Technol. 1965; 3: 332
  • Saxena K. M., Chapman E. M., Pryles C. V. Minimal dosage of iodide required to suppress uptake of iodine-131 by normal thyroid. Science 1962; 138: 340
  • Scheline R. R., Longberg B. The absorption, metabolism and excretion of the sulphonated azo dye, Acid Yellow, by rats. Acta Pharmacol. Toxicol. 1965; 23: 1
  • Scheline R. R., Nygaard R. T., Longberg B. Enzymatic reduction of the azo dye, acid yellow, by extracts ofStreptococcus faecalis isolated from rat intestine. Food Cosmet. Toxicol. 1970; 8: 55
  • Schifferli J., Schramm A. T. Report on acetates, carbonates, halides, and sulphates in certified coal-tar colors, sodium acetate in FD&C Blue No. 1. J. Assoc. Off. Agric. Chem. 1949; 32: 614
  • Schrenzel M., Hess H. Suppositoires colorés avec des pigments. Pharm. Acta Helv. 1970; 45: 486
  • Schumacher R. J. Organic compounds in FD&C Blue No. 1. J. Assoc. Off. Agric. Chemists 1965; 48: 819
  • Schweppe H. Synthetic colouring materials. Thin Layer Chromatography, E. Stahl. Springer-Verlag, New York 1969; 612
  • Sclar R. N., Freeman K. A. Chromatographic procedures for the separation of water-soluble acid dye mixtures. J. Assoc. Off. Agric. Chemists 1955; 38: 796
  • Scott M. W., Goudie A. J., Huetteman A. J. Accelerated color loss of certified dyes in the presence of nonionic surfactants. J. Am. Pharm. Assoc. 1960; 49: 467
  • Society of Dyers and Colourists. Colour Index, Vol. 4 and 5, 3rd ed. Bradford, UK 1971
  • Seiler N. Identification and quantitation of amines by thin-layer chromatography. J. Chromatogr. 1971; 63: 97
  • Settipane G. A., Pudupakkam R. K. Aspirin intolerance. III. Subtypes, familial occurrence, and cross-reactivity with tartrazine. J. Allergy Clin. Immunol. 1975; 56: 215
  • Sharratt M., Farzer A. C., Paranjoti I. S. Biological effects of citrus Red #2 in the mouse. Food Cosmet. Toxicol. 1966; 4: 493
  • Shtenberg A. I., Gavrilenko E. V. Influence of the food dye-amaranth on the reproductive function and development of progeny in tests on albino rats. Vopr. Pitan. 1970; 29: 66
  • Shtenberg A. I., Gavrilenko E. V. Gonadotoxic and embryotoxic action of the food dye amaranth. Vopr. Pitan. 1972; 31: 28
  • Silman H. Food colours. Food Manuf. 1936; 11: 202
  • Singh M. Stability of color additives: FD&C Red No. 2 in baked goods. J. Assoc. Off. Anal. Chem. 1970; 53: 23
  • Singh M. Determination of 5, 7′-disulfo-3, 3′-dioxo-2′2′-biindoline, disodium salt, and 5-sulfo-3,3-dioxo2′2′-biindoline, sodium salt, in FD&C blue No. 2. J. Assoc. Off. Anal. Chem. 1970; 53: 250
  • Singh M., Graichen C. Determination of FD&C Red No. 3 (erythrosine) in rat blood serum. J. Assoc. Off. Anal. Chem. 1973; 56: 1458
  • Singh M. Determination of uncombined intermediates in FD&C Yellow No. 6 by high pressure liquid chromatography. J. Assoc. Offic. Anal. Chem. 1974; 57: 358
  • Singh M. High pressure liquid chromatographic determination of uncombined intermediates and subsidiary colors in FD&C Blue No. 2. J. Assoc. Off. Anal. Chem. 1975; 58: 48
  • Sisley P., Porscher C. Du sort des matières colorantes dans l'organisme animal. C.R. Seanc. Acad. Sci. 1911; 152: 1062
  • Sjöström L. B., Kensler C. J. Flavors and colors. Proc. Int. Symp. Food Protection 1962; 3: 50
  • Sloman K. G., Foltz A. K., Yeransian J. A. Food. Rev. Anal. Chem. 1975; 47: 56R
  • Smith J. N., Williams R. T. Studies in detoxication. A note on the glucuronides of benzeneazophenol and benzeneazoresorcinol. Biochem. J. 1951; 48: 546
  • Sobotka T. J., Brodie R. E., Spaid S. A. Tartrazine and the developing nervous system of rats. J. Toxicol. Environ. Health 1977; 2: 1211
  • Stanley R. L., Kirk P. L. Systematic identification of artificial food colors permitted in the United States. J. Agric. Food Chem. 1963; 11: 492
  • Stein C. Studies on coal-tar colors, FD&C Yellow No. 6 and C.I. No. 26. J. Assoc. Off. Agric. Chem. 1949; 32: 672
  • Stein C. Subsidiary colors in FD&C Blue No. 1. J. Assoc. Off. Anal. Chem. 1969; 52: 34
  • Stein C. TLC and spectrophotometric determination of 1[4-(2,5-dimethoxyphenylazo]-2,5-dimethoxyphenylazo]-2-naphthol and 1, 1′-(2,2′,5,5′-tetramethoxy-4,4′-biphenylenebisazo)-di-2-naphthol in Citrus Red No. 2. J. Assoc. Off. Anal. Chem. 1970; 53: 26
  • Stein C. Subsidiary colors in FD&C Green No. 3. J. Assoc. Off. Anal. Chem. 1970; 53: 677
  • Stoltz D. R. Unpublished results
  • Suzuki M., Nakamura E., Nagase Y. Analytical studies for dyes by using infrared spectrum. I. Studies on yellow dyes for food, Auramine and Butter Yellow. Yakugaku Zasshi 1959; 79: 1116
  • Suzuki M., Nakamura E., Nagase Y. Analytical studies for dyes by using infrared spectrum. II. Studies on green dyes for food and malachite green. Yakugaku Zasshi 1959; 79: 1209
  • Suzuki M., Nakamura E., Nagase Y. Analytical studies on dyes by infrared spectrum. III. On the red dyes for foods and Rhodamine B. Yakugaku Zasshi 1960; 80: 916
  • Sysoev A. B., Zhurkov V. S. A study of the mutagenic activity of synthetic food dyes, — sun yellow sunset FCF and its analogous compound — sun yellow K. Gig. Sanit. 1974; 9: 26
  • Takada K., Ueda M., Ohno M., Muranishi S. Biopharmaceutical study of the hepato-biliary transport of drugs. II. Roles of the liver cytoplasmic Y and Z binding proteins and T binder on the hepato-biliary transport of organic anionic compounds. Chem. Pharm. Bull. 1974; 22: 1477
  • Takada K., Narumiya O., Muranishi S. Biopharmaceutical study of the heapto-biliary transport of drugs. III. Binding characteristics of bromphenol blue and Amaranth to the liver cytoplasmic y and z binding properties. in vitro, Chem. Pharm. Bull. 1975; 23: 729
  • Takashima T., Rikimaru S., Mitani I., Ando A. Experimental studies on the distribution to the organs following intravenous injection of131I-erythrosin B. Nippon Igaku Hoshasen Gakkai Zasshi 1969; 29: 1025
  • Taveira M., Alves Filho J. E. Quimica bromatologica das essencias e corantes de origem biologica e sintéticos. Rev. Soc. Bras. Quim. 1933; 4: 291
  • Terashima T., Matsukura A., Sasakura H., Uemura T. Effect of Gamma irradiation on the food dyes. I. Eisei Shikenjo Hokoku 1959; 77: 163
  • Terashima T. Studies on high-voltage paper-electrophoretic analysis of water-soluble coal-tar dyes. I. On the migration distance of dyes. Shokuhin Eiseigaku Zasshi 1961; 2: 44
  • Tilden D. H. Report on Paper chromatography of coal tar colors. J. Assoc. Off. Agric. Chem. 1954; 37: 812
  • Tréfouël J., Tréfouël J., Nitti F., Bovet D. Activité dup-aminophénylsulfamide sur les infections streptococciques. Experimentales de la souris et du lapin. C.R. Soc. Biol. 1935; 120: 756
  • Truhaut R. Sur l'action cancérigène de certaines matierès colorantes. Importance en hygiene alimentaire, en thérapeutique et en hygiène gènérale. Ann. Pharm. Fr. 1955; 13: 36
  • Truhaut R., Ferrando R. Influence de l'administration, par voie orale, de différentes doses de deux colorants azoiques, l'Amarante et le Jaune Soleil FCF, sur la mise en réserve de la vitamine A dans le foie du Rat. C.R. Acad. Sci. 1975; 281: 459
  • Turner T. D., Jones B. E. The identification of blue triphenylmethane food dyes by thin-layer chromatography. J. Pharm. Pharmacol. 1971; 23: 806
  • Verma M. R., Dass R. Food and color. J. Sci. Ind. Res. 1956; 15A: 425
  • Verma M. R., Das R. J. Identification of certifiable food colours: Part I — Determination of Rf values of single food colours. J. Sci. Ind. Res. 1956; 15C: 186
  • Viejo J. P. Etude théorique de la chromatographie au moyen de solutions d'électrolytes. J. Pharm. Belg. 1965; 20: 343
  • Villanua L., Carballido A., Garcia Olmedo R., Valdehita M. T. Los colorantes artificiales de interes bromatologico(*). VI. Caracteristicas, propiedades, espectrofotometria y cromatografia circular sobre papel de hidrosolubles prohibidos. An. Bromatol. 1961; 13: 59
  • Villanua L., Carballido A., Garcia Olmedo R., Valdehita M. T. Los colorantes artificiales de interes bromatologico. VII. Marcha sistematica para la identificacion de colorantes hidrosolubles. An. Bromatol. 1961; 13: 263
  • Villanua L., Carballido H., Muniz S. Los colorantes artificiales de interes bromatologico. XI. Espectrofotometria en la zona ultravioleta de algunos hidrosolubles. An. Bromatol. 1968; 20: 113
  • Vos B. J., Radomski J. L., Fuyat H. N. Catharctic actions of FD&C Orange #1 and other coal-tar food dyes. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1953; 12: 376
  • Vought R. L., Brown F. A., Wolff J. Erythrosine: an adventitious source of iodine. J. Clin. Endocrinol. 1972; 34: 747
  • Walker R. The Metabolism of Azo Compounds: a review of the literature. Food Cosmet. Toxicol. 1970; 8: 659
  • Wang K. T. Polyamide layer chromatography of some synthetic food. colors, Nature (London) 1967; 213: 212
  • Waterman N., Lignac G. O. E. The influence of the feeding of a number of food colours on the occurrence of tumours in mice. Acta Physiol. Pharmacol. Neerl. 1958; 7: 35
  • Weast C. A. Dyeing Maraschino cherries with erythrosine. Fruit Prod. J. Am. Vinegar Ind. 1941; 20: 332
  • Webb J. M., Fonda M., Brouwer E. A. Metabolism and excretion patterns of fluorescein and certain halogenated fluorescein dyes in rats. J. Pharmacol. Exp. Thera. 1962; 137: 141
  • Weiss H. Richtlinien der EWG über Lebensmittelfarbstoffe. Dtsch Lebensm. Rundsch. 1962; 58: 324
  • Welham R. D. The early history of the synthetic dye industry. I. The chemical history. J. Soc. Dyers Colour. 1963; 79: 98
  • Wenninger J. A., Jones J. H., Dolinsky M. Studies on coal-tar colors, XXIV: FD&C Red No. 4. J. Assoc. Offic. Agric. Chem. 1960; 43: 805
  • Westoo G. On the metabolism of tartrazine in the rat. Acta Chem. Scand. 1965; 19: 1309
  • Willheim R., Ivy A. C. A preliminary study concerning the possibility of dietary carcinogenesis. Gastroenterology 1953; 23: 1
  • Williams R. T. Detoxication Mechanisms, 2nd eds. Chapman and Hall, London 1959; 499
  • Williams R. T., Millburn P., Smith R. L. The influence of enterohepatic circulation on toxicity of drugs. Ann. N. Y. Acad. Sci. 1965; 123: 110
  • Wittmer D. P., Nuessle N. O., Haney W. G., Jr. Simultaneous analysis of tartrazine and its intermediates by reversed phase liquid chromatography. Anal. Chem. 1975; 47: 1422
  • Yamaguchi J., Imazeki K., Kaneyuki K. The effect of additive on sucrose crystallization from supersaturated sucrose aqueous solution. Takamine Kenkyusho Nempo 1959; 11: 75
  • Yamamoto S., Ito Y., Noda S. Toxicity test of food additives by the disturbance of the life cycles ofChlorella and Saccharomyces cerevisiae var Sake. I. Toxicity tests for food pigments, (1). Shokuhin Eiseiqaku Zasshi 1967; 8: 396
  • Yang M. G., Manoharan K., Young A. K. Influence and degradation of dietary cellulose in cecum of rats. J. Nutr. 1969; 97: 260
  • Yanuka Y., Shalon Y., Weissenberg E., Nir-Grosfeld I. A paper-chromatographic method for the identification of food dyes. Analyst 1962; 87: 791
  • Yasuda K. Thin-layer chromatography of aromatic amines on cadmium sulphate-impregnated silica-gel thin-layers. J. Chromatogr. 1971; 60: 144
  • Zuckerman S. Colors for food, drugs and cosmetics. Kirk-Othmer Encycl. Chem. Technol., 2nd ed. 1964; 5: 857
  • Zuckerman S. Status report, U.S. certified colors (color additives). Am. Perfum. Cosmet. 1965; 80: 69
  • Zweig G. A demonstration of continous “electrochromatography” and “electrophoresis”. J. Chromatogr. 1959; 2: 202

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