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Research Article

Review of The Toxicology of Styrene

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Pages 227-249 | Published online: 26 Sep 2008

References

  • The Merck Index, 10th ed., M. Windholz. Merck & Co., Rahway, NJ 1983; 8732
  • USITC. Synthetic Organic Chemicals, U.S. Production and Sales, 1985. September, 1986; 333, USITC Publ. No. 1892
  • Am. Ind. Hyg. Assoc. J. 1968; 29: 526, Hygienic guide series
  • Registry of Toxic Effects of Chemical Substances, R. J. Lewis, Sr., R. L. Tatken. U.S. Department of Health and Human Services, Cincinnati, OH 1980; Vol. 2
  • Onashi Y., Nakai Y., Ikeoka H., Koshimo H., Esaki Y., Horiguchi S., Teramoto K. Electron microscopic study of the respiratory toxicity of styrene. Osaka City Med. J. 1985; 31: 11
  • Spencer H. C., Irish D. D., Adams E. M., Rowe V. K. The response of laboratory animals to monomeric styrene. J. Ind. Hyg. Toxicol 1942; 24: 295
  • Ohashi Y., Nakai Y., Ikeoka H., Koshimo H., Nakata J., Esaki Y. Degeneration and regeneration of respiratory mucosa of rats after exposure to styrene. J. Appl. Toxicol. 1986; 10: 405
  • Alarie Y. Sensory irritation of the upper airways by airborne chemicals. Toxicol. Appl. Pharmacol 1973; 24: 279
  • Wolf M. A., Rowe V. K., McCollister D. D., Hollingsworth R. L., Oyen F. Toxicological studies of certain alkylated benzenes and benzene. AMA Arch. Ind. Health 1956; 14: 387
  • Carpenter C. P., Shaffer C. B., Weil C. S., Smyth H. F. Studies on the inhalation of 1:3-butadiene; with a comparison of its narcotic effect with benzol, toluol, and styrene, and a note on the elimination of styrene by the human. J. Ind. Hyg. Toxicol 1944; 26: 69
  • Stewart R. D., Dodd H. C., Baretta E. D., Schaffer A. W. Human exposure to styrene vapor. Arch. Environ. Health 1968; 16: 656
  • Chmielewski J., Renke W. Clinical and experimental studies on the pathogenesis of toxic effects of styrene. Bull. Inst. Mar. Trap. Med. Gdynia 1975; 299
  • Criteria for Recommended Standard … Occupational Exposure to Styrene. National Institute for Occupational Safety and Health, Cincinnati, OH, Rep. No. 83–119 Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, available from NTIS, Springfield, VA, PB84–148295
  • Huff J. E. Styrene, styrene oxide, polystyrene, and β-nitrostyrene/styrene carcinogenicity in rodents. Industrial Hazards of Plastic and Synthetic Elastomers. Alan R. Liss, New York 1984; Vol. 141: 227
  • Dow, Two year chronic inhalation toxicity and carcinogenicity study on monomeric styrene in rats, in Final Report. Chemical Manufacturers Association sponsored study. 1978
  • Ponomarkov V., Tomatis L. Effects of long-term oral administration of styrene to mice and rats. Scand. J. Work Environ. Health 1978; 4: 127
  • Bioassay of Styrene for Possible Carcinogenicity. National Cancer Institute, National Institutes of Health, U.S. Department of Health, Education and Welfare. 1979, Rep. No. 79–1741
  • van Duuren B. L., Nelson N., Orris L., Palmes E. D., Schmitt F. L. Carcinogenicity of epoxides, lactones, and peroxy compounds. J. Natl. Cancer Inst. 1963; 31: 41
  • Weil C. S., Condra N., Haun C., Striegel J. A. Experimental Carcinogenicity and acute toxicity of representative epoxides. Am. Ind. Hyg. Assoc. J. 1963; 24: 305
  • Kotin P., Falk H. L. Organic peroxides, hydrogen peroxide, epoxides, and neoplasia. Radial. Res. Suppl. 1963; 3: 193
  • Maltoni C., Failla G., Kassapidis G. First experimental demonstration of the carcinogenic effects of styrene oxide. Med. Lav. 1979; 5: 358
  • Maltoni C. Early results of the experimental assessments of the carcinogenic effects of one epoxy solvent: styrene oxide. Occupational Health Hazards of Solvents, A. Englund, K. Ringen, M. A. Mehlman. Princeton Scientific Publishers, Princeton, NJ 1982; Vol. 2: 97
  • Murray F. J., John J. A., Balmer M. F., Schwetz B. A. Teratologic evaluation of styrene given to rats and rabbits by inhalation or by gavage. Toxicology 1978; 11: 335
  • Kankaanpää J. T. J., Elovaara E., Hemminki K., Vainio H. The effect of maternally inhaled styrene on embryonal and foetal development in mice and Chinese hamsters. Acta Pharmacol. Toxicol. 1980; 47: 127
  • Bellies R. P., Butala J. H., Stack C. R., Makris S. Chronic toxicity and three-generation reproduction study of styrene monomer in the drinking water of rats. Fundam. Appl. Toxicol. 1985; 5: 855
  • Sikov M. R., Cannon W. C., Carr D. B., Miller R. A., Niemeier R. W., Hardin B. D. Reproductive toxicology of inhaled styrene oxide in rats and rabbits. J. Appl. Toxicol. 1986; 6: 155
  • Srivastava S. P., Das M., Mushtaq M., Chandra S. V., Seth P. K. Hepatic effects of orally administered styrene in rats. J. Appl. Toxicol. 1982; 2: 219
  • Vainio H., Norppa H., Hemminki K., Sorsa M. Metabolism and genotoxicity of styrene. Adv. Exp. Med. Biol 1981; 136A: 257
  • Norppa H., Vainio H. Genetic toxicity of styrene and some of its derivatives. Scand. J. Work Environ. Health 1983; 9: 108
  • Vainio H., Norppa H., Hemminki K., Sorsa M. Metabolism and genotoxicity of styrene. Biological Reactive Intermediates-LL: Chemical Mechanisms and Biological Effects, A Pan, R. Snyder, D. V. Parke, J. Kocisis, D. J. Jollow, G. G. Gibson, C. M. Witmer. Plenum Press, New York 1982; 257
  • Vainio H., Norppa H., Belevedere G. Metabolism and mutagenicity of styrene oxide. Prog. Clin. Biol. Res. 1984; 141: 215
  • Milvy P., Garro A. Mutagenic activity of styrene oxide (1,2-epoxyethylbenzene), a presumed styrene metabolite. Mutat. Res. 1976; 40: 15
  • Watabe T., Hiratsuka A., Aizawa T., Sawahata T., Ozawa N., Isobe M., Takabatake E. Studies on metabolism and toxicity of styrene. IV. 1-Vinylbenzene 3,4-oxide, a potent mutagen formed as a possible intermediate in the metabolismin vivo of styrene to 4-vinylphenol. Mutat. Res. 1982; 93: 45
  • Stoltz D. R., Withey J. R. Mutagenicity testing of styrene and styrene epoxide in Salmonella typhimurium. Bull. Environ. Contam. Toxicol. 1977; 17: 739
  • deMeester C., Poncelet F., Roberfroid M., Rondelet J., Mercier M. Mutagenic activity of styrene and styrene oxide. A preliminary study. Arch. Int. Physiol. Biochim. 1977; 85: 398
  • deMeester C., Poncelet F., Roberfroid M., Rondelet J., Mercier M. Mutagenicity of styrene and styrene oxide. Mutat. Res. 1977; 56: 147
  • Watabe T., Isobe M., Sawahata T., Yoshikawa K., Yamada S., Takabatake E. Metabolism and mutagenicity of styrene. Scand. J. Work Environ. Health 1978; 4: 142
  • Busk L. Mutagenic effects of styrene and styrene oxide. Mutat. Res. 1979; 67: 201
  • Bauer C., Leporini C., Bronzetti G., Corsi C., Nieri R., Tonarelli S. The problem of negative results for styrene in thein vitro mutagenesis test with metabolic activation (microsomal assay)—behaviour of epoxide of epoxide hydrolase in the incubation mixtures. Boll. Soc. Ital. Biol. Sper. 1980; 56: 2200
  • deMeester C., Duverger-van Bogaert M., Lambotte-Vandepaer M., Mercier M., Poncelet F. Mutagenicity of styrene in theSalmonella typhimurium test system. Mutat. Res. 1981; 90: 443
  • Norppa H., Elovaara E., Husgafvel-Pursiainen K., Sorsa M., Vainio H. Effects of styrene oxide on chromosome aberrations, sister chromatid exchange and hepatic drug biotransformation in Chinese hamsters in vivo. Chem. Biol. Interact. 1979; 26: 305
  • Norppa H., Sorsa M., Pfäffli R., Vainio H. Styrene and styrene oxide induce SCEs and are metabolized in human lymphocyte cultures. Carcinogenesis 1980; 1: 357
  • Hansteen I. L., Jelmert O., Torgrimsen T., Forsund B. Low human exposure to styrene in relation to chromosome breaks, gaps and sister chromatid exchanges. Hereditas 1984; 100: 87
  • Nordenson I., Beckman L. Chromosomal aberrations in lymphocytes of workers exposed to low levels of styrene. Hum. Hered. 1984; 34: 178
  • Leibman K. C. Metabolism and toxicity of styrene. Environ. Health Perspect. 1975; 11: 115
  • Danishefsky I., Willhite M. The metabolism of styrene in the rat. J. Biol. Chem. 1954; 211: 549
  • Shugaev B. B., Yaroslavl B. Concentrations of hydrocarbons in tissues as a measure of toxicity. Arch. Environ. Health 1969; 18: 878
  • Bakke O. M., Scheline R. R. Hydroxylation of aromatic hydrocarbons in the rat. Toxicol. Appl. Pharmacol. 1970; 16: 691
  • Ohtsuji H., Ikeda M. The metabolism of styrene in the rat and the stimulatory effect of phenobarbital. Toxicol. Appl. Pharmacol. 1971; 18: 321
  • Withey J. R. Quantitative analysis of styrene monomer in polystyrene and foods including some preliminary studies of the uptake and pharmacodynamics of the monomer in rats. Environ. Health Perspect. 1976; 17: 125
  • van Rees H. The partition coefficients of styrene between blood and air and between oil and blood. Int. Arch. Arbeitsmed. 1974; 33: 39
  • Withey J. R., Collins P. G. Pharmacokinetics and distribution of styrene monomer in rats after intravenous administration. J. Toxicol. Environ. Health 1977; 3: 1011
  • Withey J. R., Collins P. G. The distribution and pharmacokinetics of styrene monomer in rats by the pulmonary route. J. Environ. Pathol. Toxicol. 1979; 2: 1329
  • Pantarotto C., Fanelli R., Bidoli F., Morazzoni P., Salmona M., Szczawinska K. Arene oxides in styrene metabolism, a new perspective in styrene toxicity?. Scand. J. Work Environ. Health 1978; 4: 67
  • Delbressine L. P. C., Ketelaars H. C. J., Seutter-Berlage F., Smeets F. L. M. Phenaceturic acid, a new urinary metabolite of styrene in the rat. Xenobiotica 1980; 10: 337
  • Carlsson A. Distribution and elimination of14C-styrene in rat. Scand. J. Work Environ. Health 1981; 7: 45
  • Engstrom J., Bjurstrom R., Astrand I., Ovrum P. Uptake, distribution and elimination of styrene in man. Scand. J. Work Environ. Health 1978; 4: 315
  • Lof A., Gullstrand E., Nordqvist M. B. Tissue distribution of styrene, styrene glycol and more polar styrene metabolites in the mouse. Scand. J. Work Environ. Health 1983; 9: 419
  • Lof A., Gullstrand E., Lundgren E., Nordqvist M. B. Occurrence of styrene-7,8-oxide and styrene glycol in mouse after the administration of styrene. Scand. J. Work Environ. Health 1984; 10: 179
  • Fiserova-Bergerova V., Teisinger J. Pulmonary styrene vapor retention. Ind. Med. Surg. 1965; 34: 620
  • Bardodej Z., Bardodejova E. Biotransformation of ethyl benzene, styrene, and alpha-methylstyrene in man. Am. Ind. Hyg. Assoc. J. 1970; 31: 206
  • Ohtsuji H., Ikeda M. A rapid colorimetric method for the determination of phenylglyoxylic and mandelic acids. Br. J. Ind. Med. 1970; 27: 150
  • Ikeda M., Imamura T., Hayashi M., Tabuchi T., Hara I. Evaluation of hippuric, phenyiglyoxylic and mandelic acids in urine as indices of styrene exposure. Int. Arch. Arbeitsmed. 1974; 32: 93
  • Engstrom K., Harkonen H., Kalliokoski P., Rantanen J. Urinary mandelic acid concentration after occupational exposure to styrene and its use as a biological exposure test. Scand. J. Work Environ. Health 1976; 2: 21
  • Wolff M. S., Daunt S. M., Lorimer W. V., Selikoff I. J. Styrene and related hydrocarbons in subcutaneous fat from polymerization workers. J. Toxicol. Environ. Health 1977; 2: 997
  • Wilson H. K., Cocker J., Purnell C. J., Brown R. H., Gompertz D. The time course of mandelic and phenylglyoxylic acid excretion in workers exposed to styrene under model conditions. Br. J. Ind. Med. 1979; 36: 235
  • Guillemin M., Bauer D. Human exposure to styrene. III. Elimination kinetics of urinary mandelic and phenylglyoxylic acids after single experimental exposure. Int. Arch. Occup. Environ. Health 1979; 44: 249
  • Pfäffli P., Hesso A., Vainio H., Hyvönen M. 4-Vinylphenol excretion suggestive of arene oxide formation in workers occupationally exposed to styrene. Toxicol. Appl. Pharmacol 1981; 60: 85
  • Wigaeus E., Lof A., Bjurstrom R., Nordqvist M. B. Exposure to styrene, uptake, distribution, metabolism and elimination in man. Scand. J. Work Environ. Health 1983; 9: 479
  • Wieczorek H., Piotrowski J. K. Evaluation of low exposure to styrene. Int. Arch. Occup. Environ. Health 1985; 57: 57
  • Lof A., Lundgren E., Nordqvist M. B. Kinetics of styrene in workers from a plastics industry after controlled exposure: a comparison with subjects not previously exposed. Br. J. Ind. Med. 1986; 43: 537
  • Parkki M. G., Marniemi J., Vainio H. Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo. Toxicol. Appl. Pharmacol 1976; 38: 59
  • Sandell J., Parkki M. G., Marniemi J., Aitio A. Effect of inhalation and cutaneous exposure to styrene on drug metabolizing enzymes in the rat. Res. Commun. Chem. Pathol. Pharmacol. 1978; 19: 109
  • Elovaara E., Vainio H., Pfäffli P., Collan Y. Effects of intermittent styrene inhalation, ethanol intake and their combination on drug biotransformation in rat liver and kidneys. Med. Biol. 1979; 57: 321
  • Vainio H., Elovaara E. The interaction of styrene oxide with hepatic cytochrome P-450in vitro and effects of styrene oxide inhalation on xenobiotic biotransformation in mouse liver and kidney. Biochem. Pharmacol. 1979; 28: 2001
  • Das M., Dixit R., Mushtaq M., Srivastava S. P., Seth P. K. Effect of styrene on hepatic mixed function oxidases, glutathione content and glutathione-S-transferase activity in rats. Drug Chem. Toxicol. 1981; 4: 219
  • Delbressine L. P. C., Van Bladeren P. J., Smeets F. L. M., Seutter-Berlage F. Stereoselective oxidation of styrene to styrene oxide in rats as measured by mercapturic acid excretion. Xenobiotica 1981; 11: 589
  • Seutter-Berlage F., Delbressine L. P., Smeets F. L., Ketelaars H. C. Identification of three sulphur-containing urinary metabolites of styrene in the rat. Xenobiotica 1978; 8: 413
  • Ramsey J. C., Young J. D. Pharmacokinetics of inhaled styrene in rats and humans. Scand. J. Work Environ. Health 1978; 4: 84
  • Droz P. O., Guillemin M. P. Human styrene exposure. V. Development of a model for biological monitoring. Int. Arch. Occup. Environ. Health 1983; 53: 19
  • Andersen M., Ramsey J. A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans. Developments in the Science and Practice of Toxicology, A. W. Hayes, R. C. Schnell, T. S. Miya. Elsevier, Amsterdam 1983; 415
  • Ramsey J. C., Andersen M. E. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 1984; 73: 159
  • Andersen M. E., Gargas M. L., Ramsey J. C. Inhalation pharmacokinetics: evaluating systemic extraction, totalin vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood. Inhaled air concentration ratios. Toxicol. Appl. Pharmacol. 1984; 73: 176
  • van Anda J., Smith B. R., Fouts J. R., Bend J. R. Concentration-dependent metabolism and toxicity of [14C] styrene oxide in the isolated perfused rat liver. J. Pharmacol. Exp. Ther. 1979; 211: 207
  • Legraverend C., Elovaara E., Zitting A., Heinonen T., Uusvuori R. DNA binding of [14C]styrene in isolated rat hepatocytes. Chem. Biol. Interact. 1984; 51: 91
  • Nordqvist M. B., Löf A., Osterman-Golkar S., Walles S. A. S. Covalent binding of styrene and styrene-7,8-oxide to plasma proteins, hemoglobin and DNA in the mouse. Chem. Biol. Interact. 1985; 55: 63
  • Neumann H. G. Analysis of hemoglobin as a dose monitor for alkylating and arylating agents. Arch. Toxicol. 1984; 56: 1
  • Osterman-Golkar S., Ehrenberg L., Segerbäck D., Hallström I. Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat. Res. 1976; 34: 1
  • Farmer P. B., Bailey E., Gorf S. M., Törnqvist M., Osterman-Golkar S., Kautiainen A., Lewis-Enright D. P. Monitoring human exposure to ethylene oxide by the determination of haemoglobin adducts using gas chromatography-mass spectrometry. Carcinogenesis 1986; 7: 637
  • Törnqvist M., Mowrer J., Jensen S., Enrenberg L. Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method. Anal. Biochem. 1986; 154: 255
  • Hemminki K. Covalent binding of styrene oxide to amino acids, human serum proteins and hemoglobin. Prog. Clin. Biol. Res. 1986; 207: 159

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