Nuclear phosphoinositides and their roles in cell biology and disease

References

• Ablain J, de The H. 2011. Revisiting the differentiation paradigm in acute promyelocytic leukemia. Blood 117:5795–5802.
   PubMed Web of Science ®Google Scholar
• Aguissa-Touré AH, Wong RP, Li G. 2011. The ING family tumor suppressors: From structure to function. Cell Mol Life Sci 68:45–54.
   Google Scholar
• Ahn JY, Liu X, Cheng D, Peng J, Chan PK, Wade PA, Ye K. 2005. Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Mol Cell 18:435–445.
   PubMed Web of Science ®Google Scholar
• Ahn JY, Rong R, Liu X, Ye K. 2004. PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus. EMBO J 23:3995–4006.
   PubMedGoogle Scholar
• Aisiku O, Dowal L, Scarlata S. 2011. Protein kinase C phosphorylation of PLCß1 regulates its cellular localization. Arch Biochem Biophys 509:186–190.
   Google Scholar
• Aisiku OR, Runnels LW, Scarlata S. 2010. Identification of a novel binding partner of phospholipase cß1: Translin-associated factor X. PLoS ONE 5:e15001.
   Google Scholar
• Ali H, Nakano T, Saino-Saito S, Hozumi Y, Katagiri Y, Kamii H, Sato S, Kayama T, Kondo H, Goto K. 2004. Selective translocation of diacylglycerol kinase zeta in hippocampal neurons under transient forebrain ischemia. Neurosci Lett 372:190–195.
   Google Scholar
• Alonso MT, García-Sancho J. 2011. Nuclear Ca(2+) signalling. Cell Calcium 49:280–289.
   Google Scholar
• Avazeri N, Courtot AM, Pesty A, Duquenne C, Lefèvre B. 2000. Cytoplasmic and nuclear phospholipase C-β 1 relocation: Role in resumption of meiosis in the mouse oocyte. Mol Biol Cell 11:4369–4380.
   PubMedGoogle Scholar
• Balla T, Szentpetery Z, Kim YJ. 2009. Phosphoinositide signaling: New tools and insights. Physiology 24:231–244.
   PubMedGoogle Scholar
• Banfic H, Visnjic D, Mise N, Balakrishnan S, Deplano S, Korchev YE, Domin J. 2009. Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus. Biochem J 422:53–60.
   PubMed Web of Science ®Google Scholar
• Banfic H, Zizak M, Divecha N, Irvine RF. 1993. Nuclear diacylglycerol is increased during cell proliferation in vivo. Biochem J 290:633–636.
   Google Scholar
• Bejar R, Levine R, Ebert BL. 2011. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol 29:504–515.
   PubMed Web of Science ®Google Scholar
• Bernardi R, Pandolfi PP. 2007. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol 8:1006–1016.
   PubMed Web of Science ®Google Scholar
• Bertagnolo V, Marchisio M, Capitani S, Neri LM. 1997. Intranuclear translocation of phospholipase C β2 during HL-60 myeloid differentiation. Biochem Biophys Res Commun 235:831–837.
   PubMed Web of Science ®Google Scholar
• Bertagnolo V, Marchisio M, Volinia S, Caramelli E, Capitani S. 1998. Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-γ1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells. FEBS Lett 441:480–484.
   PubMedGoogle Scholar
• Bezin S, Fossier P, Cancela JM. 2008. Nucleoplasmic reticulum is not essential in nuclear calcium signalling mediated by cyclic ADPribose in primary neurons. Pflugers Arch 456:581–586.
   Google Scholar
• Birbach A, Verkuyl JM, Matus A. 2006. Reversible, activity-dependent targeting of profilin to neuronal nuclei. Exp Cell Res 312:2279–2287.
   Google Scholar
• Bootman MD, Fearnley C, Smyrnias I, MacDonald F, Roderick HL. 2009. An update on nuclear calcium signalling. J Cell Sci 122:2337–2350.
   PubMedGoogle Scholar
• Borden KL. 2008. Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: Can we fit the pieces together using an RNA regulon? Biochim Biophys Acta 1783:2145–2154.
   PubMed Web of Science ®Google Scholar
• Boronenkov IV, Loijens JC, Umeda M, Anderson RA. 1998. Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol Biol Cell 9:3547–3560.
   PubMed Web of Science ®Google Scholar
• Brantley MA Jr, Harbour JW. 2000. Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region. Cancer Res 60:4320–4323.
   Google Scholar
• Bultsma Y, Keune WJ, Divecha N. 2010. PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα. Biochem J 430:223–235.
   PubMedGoogle Scholar
• Bunce MW, Boronenkov IV, Anderson RA. 2008. Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. J Biol Chem 283:8678–8686.
   PubMed Web of Science ®Google Scholar
• Cai J, Abramovici H, Gee SH, Topham MK. 2009. Diacylglycerol kinases as sources of phosphatidic acid. Biochim Biophys Acta 1791:942–948.
   PubMed Web of Science ®Google Scholar
• Castano E, Philimonenko VV, Kahle M, Fukalová J, Kalendová A, Yildirim S, Dzijak R, Dingová-Krásna H, Hozák P. 2010. Actin complexes in the cell nucleus: New stones in an old field. Histochem Cell Biol 133:607–626.
   Google Scholar
• Chang SC, Majerus PW. 2006. Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. Biochem Biophys Res Commun 339:209–216.
   Google Scholar
• Chawla S, Hardingham GE, Quinn DR, Bading H. 1998. CBP: A signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science 281:1505–1509.
   PubMedGoogle Scholar
• Chen M, Elder RT, Yu M, O’Gorman MG, Selig L, Benarous R, Yamamoto A, Zhao Y. 1999. Mutational analysis of Vpr-induced G2 arrest, nuclear localization, and cell death in fission yeast. J Virol 73:3236–3245.
   Google Scholar
• Chen MZ, Zhu X, Sun HQ, Mao YS, Wei Y, Yamamoto M, Yin HL. 2009. Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase β in a Syk-dependent manner. J Biol Chem 284:23743–23753.
   PubMed Web of Science ®Google Scholar
• Chinnam M, Goodrich DW. 2011. RB1, development, and cancer. Curr Top Dev Biol 94:129–169.
   PubMed Web of Science ®Google Scholar
• Cho YS, Chennathukuzhi VM, Handel MA, Eppig J, Hecht NB. 2004. The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells. J Biol Chem 279:31514–31523.
   Google Scholar
• Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E. 2008. Phosphoinositide 3-kinase p110β activity: Key role in metabolism and mammary gland cancer but not development. Sci Signal 1:ra3.
   PubMed Web of Science ®Google Scholar
• Ciruela A, Hinchliffe KA, Divecha N, Irvine RF. 2000. Nuclear targeting of the β isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its α-helix 7. Biochem J 346 Pt 3:587–591.
   Google Scholar
• Clarke JH, Letcher AJ, D’santos CS, Halstead JR, Irvine RF, Divecha N. 2001. Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells. Biochem J 357:905–910.
   PubMed Web of Science ®Google Scholar
• Cocco L, Faenza I, Fiume R, Maria Billi A, Gilmour RS, Manzoli FA. 2006. Phosphoinositide-specific phospholipase C (PI-PLC) β1 and nuclear lipid-dependent signaling. Biochim Biophys Acta 1761:509–521.
   Google Scholar
• Cocco L, Gilmour RS, Ognibene A, Letcher AJ, Manzoli FA, Irvine RF. 1987. Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J 248:765–770.
   PubMed Web of Science ®Google Scholar
• Cocco L, Martelli AM, Gilmour RS, Ognibene A, Manzoli FA, Irvine RF. 1988. Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor I. Biochem Biophys Res Commun 154:1266–1272.
   PubMedGoogle Scholar
• Cocco L, Martelli AM, Gilmour RS, Ognibene A, Manzoli FA, Irvine RF. 1989. Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor I. Biochem Biophys Res Commun 159:720–725.
   PubMedGoogle Scholar
• Colombo E, Alcalay M, Pelicci PG. 2011. Nucleophosmin and its complex network: A possible therapeutic target in hematological diseases. Oncogene 30:2595–2609.
   PubMed Web of Science ®Google Scholar
• Cooney MA, Malcuit C, Cheon B, Holland MK, Fissore RA, D’Cruz NT. 2010. Species-specific differences in the activity and nuclear localization of murine and bovine phospholipase C zeta 1. Biol Reprod 83:92–101.
   PubMed Web of Science ®Google Scholar
• Costa C, Hirsch E. 2010. More than just kinases: The scaffolding function of PI3K. Curr Top Microbiol Immunol 346:171–181.
   Google Scholar
• Cremer T, Küpper K, Dietzel S, Fakan S. 2004. Higher order chromatin architecture in the cell nucleus: On the way from structure to function. Biol Cell 96:555–567.
   PubMed Web of Science ®Google Scholar
• D’Angelo G, Vicinanza M, Di Campli A, De Matteis MA. 2008. The multiple roles of PtdIns(4)P− not just the precursor of PtdIns(4,5)P2. J Cell Sci 121:1955–1963.
   PubMed Web of Science ®Google Scholar
• de Graaf P, Klapisz EE, Schulz TK, Cremers AF, Verkleij AJ, van Bergen en Henegouwen PM. 2002. Nuclear localization of phosphatidylinositol 4-kinase β. J Cell Sci 115:1769–1775.
   PubMed Web of Science ®Google Scholar
• De Santa F, Albini S, Mezzaroma E, Baron L, Felsani A, Caruso M. 2007. pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation. Mol Cell Biol 27:7248–7265.
   PubMedGoogle Scholar
• Déléris P, Bacqueville D, Gayral S, Carrez L, Salles JP, Perret B, Breton-Douillon M. 2003. SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles. J Biol Chem 278:38884–38891.
   PubMed Web of Science ®Google Scholar
• Didichenko SA, Thelen M. 2001. Phosphatidylinositol 3-kinase c2α contains a nuclear localization sequence and associates with nuclear speckles. J Biol Chem 276:48135–48142.
   PubMed Web of Science ®Google Scholar
• Divecha N. 2010. Methods to assess changes in the pattern of nuclear phosphoinositides. Methods Mol Biol 645:165–177.
   Google Scholar
• Divecha N, Banfic H, Irvine RF. 1991. The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. EMBO J 10:3207–3214.
   PubMed Web of Science ®Google Scholar
• Divecha N, Rhee SG, Letcher AJ, Irvine RF. 1993. Phosphoinositide signalling enzymes in rat liver nuclei: Phosphoinositidase C isoform β 1 is specifically, but not predominantly, located in the nucleus. Biochem J 289:617–620.
   PubMed Web of Science ®Google Scholar
• Divecha N, Roefs M, Los A, Halstead J, Bannister A, D’Santos C. 2002. Type I PIPkinases interact with and are regulated by the retinoblastoma susceptibility gene product-pRB. Curr Biol 12:582–587.
   Google Scholar
• Doucet CM, Hetzer MW. 2010. Nuclear pore biogenesis into an intact nuclear envelope. Chromosoma 119:469–477.
   Google Scholar
• Driscoll B, T’Ang A, Hu YH, Yan CL, Fu Y, Luo Y, Wu KJ, Wen S, Shi XH, Barsky L, Weinberg K, Murphree AL, Fung YK. 1999. Discovery of a regulatory motif that controls the exposure of specific upstream cyclin-dependent kinase sites that determine both conformation and growth suppressing activity of pRb. J Biol Chem 274:9463–9471.
   Google Scholar
• Dundr M, Misteli T. 2010. Biogenesis of nuclear bodies. Cold Spring Harb Perspect Biol 2:a000711.
   PubMed Web of Science ®Google Scholar
• Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. 2003. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol 5:440–446.
   PubMed Web of Science ®Google Scholar
• Evangelisti C, Astolfi A, Gaboardi GC, Tazzari P, Pession A, Goto K, Martelli AM. 2009. TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest. Cell Signal 21:801–809.
   Google Scholar
• Evangelisti C, Bortul R, Falà F, Tabellini G, Goto K, Martelli AM. 2007. Nuclear diacylglycerol kinases: Emerging downstream regulators in cell signaling networks. Histol Histopathol 22:573–579.
   PubMed Web of Science ®Google Scholar
• Evangelisti C, Gaboardi GC, Billi AM, Ognibene A, Goto K, Tazzari PL, McCubrey JA, Martelli AM. 2010. Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta. Cell Cycle 9:384–388.
   PubMed Web of Science ®Google Scholar
• Evangelisti C, Riccio M, Faenza I, Zini N, Hozumi Y, Goto K, Cocco L, Martelli AM. 2006. Subnuclear localization and differentiation-dependent increased expression of DGK-zeta in C2C12 mouse myoblasts. J Cell Physiol 209:370–378.
   PubMedGoogle Scholar
• Evangelisti C, Tazzari PL, Riccio M, Fiume R, Hozumi Y, Falà F, Goto K, Manzoli L, Cocco L, Martelli AM. 2007. Nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts. FASEB J 21:3297–3307.
   PubMed Web of Science ®Google Scholar
• Faenza I, Bavelloni A, Fiume R, Santi P, Martelli AM, Maria Billi A, Lo Vasco VR, Manzoli L, Cocco L. 2004. Expression of phospholipase C β family isoenzymes in C2C12 myoblasts during terminal differentiation. J Cell Physiol 200:291–296.
   PubMedGoogle Scholar
• Faenza I, Ramazzotti G, Bavelloni A, Fiume R, Gaboardi GC, Follo MY, Gilmour RS, Martelli AM, Ravid K, Cocco L. 2007. Inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter. Endocrinology 148:1108–1117.
   PubMed Web of Science ®Google Scholar
• Fakan S, van Driel R. 2007. The perichromatin region: A functional compartment in the nucleus that determines large-scale chromatin folding. Semin Cell Dev Biol 18:676–681.
   PubMed Web of Science ®Google Scholar
• Farrants AK. 2008. Chromatin remodelling and actin organisation. FEBS Lett 582:2041–2050.
   Google Scholar
• Ferguson BJ, Dovey CL, Lilley K, Wyllie AH, Rich T. 2007. Nuclear phospholipase C γ: Punctate distribution and association with the promyelocytic leukemia protein. J Proteome Res 6:2027–2032.
   Google Scholar
• Fiume R, Ramazzotti G, Teti G, Chiarini F, Faenza I, Mazzotti G, Billi AM, Cocco L. 2009. Involvement of nuclear PLCβ1 in lamin B1 phosphorylation and G2/M cell cycle progression. FASEB J 23:957–966.
   Google Scholar
• Follo MY, Bosi C, Finelli C, Fiume R, Faenza I, Ramazzotti G, Gaboardi GC, Manzoli L, Cocco L. 2006. Real-time PCR as a tool for quantitative analysis of PI-PLCβ1 gene expression in myelodysplastic syndrome. Int J Mol Med 18:267–271.
   PubMed Web of Science ®Google Scholar
• Follo MY, Finelli C, Clissa C, Mongiorgi S, Bosi C, Martinelli G, Baccarani M, Manzoli L, Martelli AM, Cocco L. 2009. Phosphoinositide-phospholipase C β1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia. J Clin Oncol 27:782–790.
   PubMed Web of Science ®Google Scholar
• Fricker M, Hollinshead M, White N, Vaux D. 1997. Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol 136:531–544.
   PubMed Web of Science ®Google Scholar
• Fukami K, Inanobe S, Kanemaru K, Nakamura Y. 2010. Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog Lipid Res 49:429–437.
   PubMed Web of Science ®Google Scholar
• Gabev E, Kasianowicz J, Abbott T, McLaughlin S. 1989. Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2). Biochim Biophys Acta 979:105–112.
   PubMed Web of Science ®Google Scholar
• García KD, Shah T, García J. 2004. Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice. Am J Physiol, Cell Physiol 287:C1048–C1057.
   Google Scholar
• Gayral S, Déléris P, Laulagnier K, Laffargue M, Salles JP, Perret B, Record M, Breton-Douillon M. 2006. Selective activation of nuclear phospholipase D-1 by g protein-coupled receptor agonists in vascular smooth muscle cells. Circ Res 99:132–139.
   Google Scholar
• Giacinti C, Giordano A. 2006. RB and cell cycle progression. Oncogene 25:5220–5227.
   PubMed Web of Science ®Google Scholar
• Goh AM, Coffill CR, Lane DP. 2011. The role of mutant p53 in human cancer. J Pathol 223:116–126.
   PubMed Web of Science ®Google Scholar
• Gonzales ML, Mellman DL, Anderson RA. 2008. CKIα is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. J Biol Chem 283:12665–12673.
   Google Scholar
• Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. 2003. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 114:99–111.
   PubMed Web of Science ®Google Scholar
• Gu T, Zhang Z, Wang J, Guo J, Shen WH, Yin Y. 2011. CREB is a novel nuclear target of PTEN phosphatase. Cancer Res 71:2821–2825.
   PubMed Web of Science ®Google Scholar
• Haase A, Nordmann C, Sedehizade F, Borrmann C, Reiser G. 2008. RanBPM, a novel interaction partner of the brain-specific protein p42IP4/centaurin α-1. J Neurochem 105:2237–2248.
   Google Scholar
• Halstead JR, van Rheenen J, Snel MH, Meeuws S, Mohammed S, D’Santos CS, Heck AJ, Jalink K, Divecha N. 2006. A role for PtdIns(4,5)P2 and PIP5Kα in regulating stress-induced apoptosis. Curr Biol 16:1850–1856.
   Google Scholar
• Hamilton MJ, Ho VW, Kuroda E, Ruschmann J, Antignano F, Lam V, Krystal G. 2011. Role of SHIP in cancer. Exp Hematol 39:2–13.
   Google Scholar
• Handwerger KE, Gall JG. 2006. Subnuclear organelles: New insights into form and function. Trends Cell Biol 16:19–26.
   PubMed Web of Science ®Google Scholar
• Heck JN, Mellman DL, Ling K, Sun Y, Wagoner MP, Schill NJ, Anderson RA. 2007. A conspicuous connection: Structure defines function for the phosphatidylinositol-phosphate kinase family. Crit Rev Biochem Mol Biol 42:15–39.
   PubMed Web of Science ®Google Scholar
• Hirsch E, Braccini L, Ciraolo E, Morello F, Perino A. 2009. Twice upon a time: PI3K’s secret double life exposed. Trends Biochem Sci 34:244–248.
   PubMed Web of Science ®Google Scholar
• HOKIN MR, HOKIN LE. 1953. Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. J Biol Chem 203:967–977.
   PubMed Web of Science ®Google Scholar
• Hozumi Y, Ito T, Nakano T, Nakagawa T, Aoyagi M, Kondo H, Goto K. 2003. Nuclear localization of diacylglycerol kinase zeta in neurons. Eur J Neurosci 18:1448–1457.
   PubMedGoogle Scholar
• Hu Y, Liu Z, Ye K. 2005. Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings. Proc Natl Acad Sci USA 102:16853–16858.
   Google Scholar
• Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD. 2007. Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: Chemistry, biology, and molecular modeling. J Am Chem Soc 129:6498–6506.
   Google Scholar
• Islas S, Vega J, Ponce L, González-Mariscal L. 2002. Nuclear localization of the tight junction protein ZO-2 in epithelial cells. Exp Cell Res 274:138–148.
   PubMedGoogle Scholar
• Ito T, Hozumi Y, Sakane F, Saino-Saito S, Kanoh H, Aoyagi M, Kondo H, Goto K. 2004. Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain. J Biol Chem 279:23317–23326.
   PubMedGoogle Scholar
• Jang YH, Min do S. 2011. Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C(α) and extracellular signal-regulated kinase signaling pathways. J Biol Chem 286:4680–4689.
   Google Scholar
• Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ. 2008. Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis. Nature 454:776–779.
   PubMed Web of Science ®Google Scholar
• Jones DR, Bultsma Y, Keune WJ, Halstead JR, Elouarrat D, Mohammed S, Heck AJ, D’Santos CS, Divecha N. 2006. Nuclear PtdIns5P as a transducer of stress signaling: An in vivo role for PIP4Kβ. Mol Cell 23:685–695.
   PubMed Web of Science ®Google Scholar
• Kakuk A, Friedländer E, Vereb G Jr, Kása A, Balla A, Balla T, Heilmeyer LM Jr, Gergely P, Vereb G. 2006. Nucleolar localization of phosphatidylinositol 4-kinase PI4K230 in various mammalian cells. Cytometry A 69:1174–1183.
   PubMedGoogle Scholar
• Keune W, Bultsma Y, Sommer L, Jones D, Divecha N. 2011. Phosphoinositide signalling in the nucleus. Adv Enzyme Regul 51:91–99.
   Google Scholar
• Kim CG, Park D, Rhee SG. 1996. The role of carboxyl-terminal basic amino acids in Gqα-dependent activation, particulate association, and nuclear localization of phospholipase C-β1. J Biol Chem 271:21187–21192.
   PubMed Web of Science ®Google Scholar
• Kind J, van Steensel B. 2010. Genome-nuclear lamina interactions and gene regulation. Curr Opin Cell Biol 22:320–325.
   PubMed Web of Science ®Google Scholar
• Kouchi Z, Fujiwara Y, Yamaguchi H, Nakamura Y, Fukami K. 2011. Phosphatidylinositol 5-phosphate 4-kinase type II β is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells. Biochem Biophys Res Commun 408:523–529.
   PubMed Web of Science ®Google Scholar
• Krieghoff-Henning E, Hofmann TG. 2008. Role of nuclear bodies in apoptosis signalling. Biochim Biophys Acta 1783:2185–2194.
   PubMed Web of Science ®Google Scholar
• Kumar A, Fernandez-Capetillo O, Fernadez-Capetillo O, Carrera AC. 2010. Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair. Proc Natl Acad Sci USA 107:7491–7496.
   PubMed Web of Science ®Google Scholar
• Kumar A, Redondo-Muñoz J, Perez-García V, Cortes I, Chagoyen M, Carrera AC. 2011. Nuclear but not cytosolic phosphoinositide 3-kinase β has an essential function in cell survival. Mol Cell Biol 31:2122–2133.
   PubMed Web of Science ®Google Scholar
• Kuroda K, Ito M, Shikano T, Awaji T, Yoda A, Takeuchi H, Kinoshita K, Miyazaki S. 2006. The role of X/Y linker region and N-terminal EF-hand domain in nuclear translocation and Ca2+ oscillation-inducing activities of phospholipase Czeta, a mammalian egg-activating factor. J Biol Chem 281:27794–27805.
   Google Scholar
• Kwiatkowska K. 2010. One lipid, multiple functions: How various pools of PI(4,5)P(2) are created in the plasma membrane. Cell Mol Life Sci 67:3927–3946.
   Google Scholar
• Kwon IS, Lee KH, Choi JW, Ahn JY. 2010. PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus. BMB Rep 43:127–132.
   Google Scholar
• Laishram RS, Anderson RA. 2010. The poly A polymerase Star-PAP controls 3′-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. EMBO J 29:4132–4145.
   PubMed Web of Science ®Google Scholar
• Lallemand-Breitenbach V, de Thé H. 2010. PML nuclear bodies. Cold Spring Harb Perspect Biol 2:a000661.
   Google Scholar
• Larman MG, Saunders CM, Carroll J, Lai FA, Swann K. 2004. Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta. J Cell Sci 117:2513–2521.
   PubMed Web of Science ®Google Scholar
• Lewis AE, Sommer L, Arntzen MO, Strahm Y, Morrice NA, Divecha N, D’Santos CS. 2011. Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction. Mol Cell Proteomics. in press, doi: 10.1074/mcp.M110.003376
   Google Scholar
• Li C, Ao J, Fu J, Lee DF, Xu J, Lonard D, O’Malley BW. 2011. Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene, in press. doi:10.1038/onc.2011.151.
   Google Scholar
• Lindsay Y, McCoull D, Davidson L, Leslie NR, Fairservice A, Gray A, Lucocq J, Downes CP. 2006. Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci 119:5160–5168.
   PubMed Web of Science ®Google Scholar
• Liu N, Fukami K, Yu H, Takenawa T. 1996. A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. J Biol Chem 271:355–360.
   PubMed Web of Science ®Google Scholar
• Liu Y, Bankaitis VA. 2010. Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res 49:201–217.
   PubMed Web of Science ®Google Scholar
• Los AP, de Widt J, Topham MK, van Blitterswijk WJ, Divecha N. 2007. Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein. Biochim Biophys Acta 1773:352–357.
   Google Scholar
• Los AP, Vinke FP, de Widt J, Topham MK, van Blitterswijk WJ, Divecha N. 2006. The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. J Biol Chem 281:858–866.
   PubMedGoogle Scholar
• Lu F, Dai DL, Martinka M, Ho V, Li G. 2006. Nuclear ING2 expression is reduced in human cutaneous melanomas. Br J Cancer 95:80–86.
   Google Scholar
• Lui PP, Kong SK, Kwok TT, Lee CY. 1998. The nucleus of HeLa cell contains tubular structures for Ca2+ signalling. Biochem Biophys Res Commun 247:88–93.
   Google Scholar
• Lukinovic-Skudar V, Donlagic L, Banfíc H, Visnjic D. 2005. Nuclear phospholipase C-β1b activation during G2/M and late G1 phase in nocodazole-synchronized HL-60 cells. Biochim Biophys Acta 1733:148–156.
   Google Scholar
• Lukinovic-Skudar V, Matkovic K, Banfic H, Visnjic D. 2007. Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G(1) phase of the cell cycle. Biochim Biophys Acta 1771:514–521.
   Google Scholar
• Luo B, Prescott SM, Topham MK. 2004. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Iα by a novel mechanism. Cell Signal 16:891–897.
   Google Scholar
• Majerus PW, York JD. 2009. Phosphoinositide phosphatases and disease. J Lipid Res 50 Suppl:S249–S254.
   Google Scholar
• Malhas A, Goulbourne C, Vaux DJ. 2011. The nucleoplasmic reticulum: Form and function. Trends Cell Biol 21:362–373.
   PubMedGoogle Scholar
• Malviya AN, Rogue P, Vincendon G. 1990. Stereospecific inositol 1,4,5-[32P]trisphosphate binding to isolated rat liver nuclei: Evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus. Proc Natl Acad Sci USA 87:9270–9274.
   PubMed Web of Science ®Google Scholar
• Malyavantham KS, Bhattacharya S, Alonso WD, Acharya R, Berezney R. 2008. Spatio-temporal dynamics of replication and transcription sites in the mammalian cell nucleus. Chromosoma 117:553–567.
   Google Scholar
• Marius P, Guerra MT, Nathanson MH, Ehrlich BE, Leite MF. 2006. Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell Calcium 39:65–73.
   PubMed Web of Science ®Google Scholar
• Marqués M, Kumar A, Poveda AM, Zuluaga S, Hernández C, Jackson S, Pasero P, Carrera AC. 2009. Specific function of phosphoinositide 3-kinase β in the control of DNA replication. Proc Natl Acad Sci USA 106:7525–7530.
   PubMed Web of Science ®Google Scholar
• Martelli AM, Evangelisti C, Chiarini F, McCubrey JA. 2010. The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients. Oncotarget 1:89–103.
   PubMed Web of Science ®Google Scholar
• Martelli AM, Falcieri E, Zweyer M, Bortul R, Tabellini G, Cappellini A, Cocco L, Manzoli L. 2002. The controversial nuclear matrix: A balanced point of view. Histol Histopathol 17:1193–1205.
   Google Scholar
• Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L, Cocco L. 1992. Nuclear localization and signalling activity of phosphoinositidase C β in Swiss 3T3 cells. Nature 358:242–245.
   PubMed Web of Science ®Google Scholar
• Martelli AM, Manzoli L, Cocco L. 2004. Nuclear inositides: Facts and perspectives. Pharmacol Ther 101:47–64.
   PubMed Web of Science ®Google Scholar
• Mazzotti G, Zini N, Rizzi E, Rizzoli R, Galanzi A, Ognibene A, Santi S, Matteucci A, Martelli AM, Maraldi NM. 1995. Immunocytochemical detection of phosphatidylinositol 4,5-bisphosphate localization sites within the nucleus. J Histochem Cytochem 43:181–191.
   PubMed Web of Science ®Google Scholar
• McCrea HJ, De Camilli P. 2009. Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda) 24:8–16.
   PubMedGoogle Scholar
• Meerschaert K, Tun MP, Remue E, De Ganck A, Boucherie C, Vanloo B, Degeest G, Vandekerckhove J, Zimmermann P, Bhardwaj N, Lu H, Cho W, Gettemans J. 2009. The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain. Cell Mol Life Sci 66:3951–3966.
   Google Scholar
• Mellman DL, Anderson RA. 2009. A novel gene expression pathway regulated by nuclear phosphoinositides. Adv Enzyme Regul 49:11–28.
   Google Scholar
• Mellman DL, Gonzales ML, Song C, Barlow CA, Wang P, Kendziorski C, Anderson RA. 2008. A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature 451:1013–1017.
   PubMed Web of Science ®Google Scholar
• Mérida I, Avila-Flores A, Merino E. 2008. Diacylglycerol kinases: At the hub of cell signalling. Biochem J 409:1–18.
   PubMed Web of Science ®Google Scholar
• Metjian A, Roll RL, Ma AD, Abrams CS. 1999. Agonists cause nuclear translocation of phosphatidylinositol 3-kinase γ. A Gβγ-dependent pathway that requires the p110γ amino terminus. J Biol Chem 274:27943–27947.
   PubMedGoogle Scholar
• Mongelard F, Bouvet P. 2007. Nucleolin: A multiFACeTed protein. Trends Cell Biol 17:80–86.
   PubMed Web of Science ®Google Scholar
• Monserrate JP, York JD. 2010. Inositol phosphate synthesis and the nuclear processes they affect. Curr Opin Cell Biol 22:365–373.
   Google Scholar
• Morrison AJ, Shen X. 2009. Chromatin remodelling beyond transcription: The INO80 and SWR1 complexes. Nat Rev Mol Cell Biol 10:373–384.
   PubMed Web of Science ®Google Scholar
• Mortier E, Wuytens G, Leenaerts I, Hannes F, Heung MY, Degeest G, David G, Zimmermann P. 2005. Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. EMBO J 24:2556–2565.
   PubMed Web of Science ®Google Scholar
• Myers KR, Casanova JE. 2008. Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends Cell Biol 18:184–192.
   PubMedGoogle Scholar
• Nakano T, Hozumi Y, Ali H, Saino-Saito S, Kamii H, Sato S, Kayama T, Watanabe M, Kondo H, Goto K. 2006. Diacylglycerol kinase zeta is involved in the process of cerebral infarction. Eur J Neurosci 23:1427–1435.
   Google Scholar
• Nalaskowski MM, Deschermeier C, Fanick W, Mayr GW. 2002. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. Biochem J 366:549–556.
   Google Scholar
• Neri LM, Billi AM, Manzoli L, Rubbini S, Gilmour RS, Cocco L, Martelli AM. 1994. Selective nuclear translocation of protein kinase C α in Swiss 3T3 cells treated with IGF-I, PDGF and EGF. FEBS Lett 347:63–68.
   PubMedGoogle Scholar
• Neri LM, Martelli AM, Borgatti P, Colamussi ML, Marchisio M, Capitani S. 1999. Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 cells. FASEB J 13:2299–2310.
   PubMedGoogle Scholar
• Obrdlik A, Louvet E, Kukalev A, Naschekin D, Kiseleva E, Fahrenkrog B, Percipalle P. 2010. Nuclear myosin 1 is in complex with mature rRNA transcripts and associates with the nuclear pore basket. FASEB J 24:146–157.
   Google Scholar
• Okada M, Fujii M, Yamaga M, Sugimoto H, Sadano H, Osumi T, Kamata H, Hirata H, Yagisawa H. 2002. Carboxyl-terminal basic amino acids in the X domain are essential for the nuclear import of phospholipase C delta1. Genes Cells 7:985–996.
   Google Scholar
• Okada M, Jang SW, Ye K. 2008. Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY. Proc Natl Acad Sci USA 105:8649–8654.
   PubMed Web of Science ®Google Scholar
• Okada M, Taguchi K, Maekawa S, Fukami K, Yagisawa H. 2010. Calcium fluxes cause nuclear shrinkage and the translocation of phospholipase C-delta1 into the nucleus. Neurosci Lett 472:188–193.
   Google Scholar
• Okuwaki M. 2008. The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein. J Biochem 143:441–448.
   PubMed Web of Science ®Google Scholar
• Ondrias K, Lencesova L, Sirova M, Labudova M, Pastorekova S, Kopacek J, Krizanova O. 2011. Apoptosis induced clustering of IP(3) R1 in nuclei of nondifferentiated PC12 cells. J Cell Physiol, in press.doi:10.1002/jcp.22665.
   Google Scholar
• Osborne SL, Thomas CL, Gschmeissner S, Schiavo G. 2001. Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. J Cell Sci 114:2501–2511.
   PubMed Web of Science ®Google Scholar
• Peña PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG. 2006. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature 442:100–103.
   PubMed Web of Science ®Google Scholar
• Philimonenko VV, Janácek J, Harata M, Hozák P. 2010. Transcription-dependent rearrangements of actin and nuclear myosin I in the nucleolus. Histochem Cell Biol 134:243–249.
   Google Scholar
• Piazzi M, Bavelloni A, Faenza I, Blalock W, Urbani A, D’Aguanno S, Fiume R, Ramazzotti G, Maraldi NM, Cocco L. 2010. eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser5³ is a novel substrate for protein kinase C ßI. Mol Cell Proteomics 9:2719–2728.
   Google Scholar
• Pusl T, Wu JJ, Zimmerman TL, Zhang L, Ehrlich BE, Berchtold MW, Hoek JB, Karpen SJ, Nathanson MH, Bennett AM. 2002. Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium. J Biol Chem 277:27517–27527.
   PubMedGoogle Scholar
• Raben DM, Tu-Sekine B. 2008. Nuclear diacylglycerol kinases: Regulation and roles. Front Biosci 13:590–597.
   Google Scholar
• Raghu P, Manifava M, Coadwell J, Ktistakis NT. 2009. Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors). Biochim Biophys Acta 1791:889–897.
   Google Scholar
• Ramazzotti G, Faenza I, Gaboardi GC, Piazzi M, Bavelloni A, Fiume R, Manzoli L, Martelli AM, Cocco L. 2008. Catalytic activity of nuclear PLC-β(1) is required for its signalling function during C2C12 differentiation. Cell Signal 20:2013–2021.
   Google Scholar
• Rando OJ, Zhao K, Janmey P, Crabtree GR. 2002. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex. Proc Natl Acad Sci USA 99:2824–2829.
   PubMed Web of Science ®Google Scholar
• Reiser G, Bernstein HG. 2004. Altered expression of protein p42IP4/centaurin-α 1 in Alzheimer’s disease brains and possible interaction of p42IP4 with nucleolin. Neuroreport 15:147–148.
   Google Scholar
• Resnick AC, Saiardi A. 2008. Inositol polyphosphate multikinase: Metabolic architect of nuclear inositides. Front Biosci 13:856–866.
   Google Scholar
• Resnick AC, Snowman AM, Kang BN, Hurt KJ, Snyder SH, Saiardi A. 2005. Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Proc Natl Acad Sci USA 102:12783–12788.
   PubMed Web of Science ®Google Scholar
• Richardson JP, Wang M, Clarke JH, Patel KJ, Irvine RF. 2007. Genomic tagging of endogenous type IIβ phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation. Cell Signal 19:1309–1314.
   PubMed Web of Science ®Google Scholar
• Rizzolio F, Esposito L, Muresu D, Fratamico R, Jaraha R, Caprioli GV, Giordano A. 2010. RB gene family: Genome-wide ChIP approaches could open undiscovered roads. J Cell Biochem 109:839–843.
   Google Scholar
• Roberts HF, Clarke JH, Letcher AJ, Irvine RF, Hinchliffe KA. 2005. Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines. FEBS Lett 579:2868–2872.
   PubMed Web of Science ®Google Scholar
• Rodrigues MA, Gomes DA, Andrade VA, Leite MF, Nathanson MH. 2008. Insulin induces calcium signals in the nucleus of rat hepatocytes. Hepatology 48:1621–1631.
   Google Scholar
• Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, Lam W, Cheng YC, Bennett AM, Nathanson MH. 2007. Nucleoplasmic calcium is required for cell proliferation. J Biol Chem 282:17061–17068.
   PubMedGoogle Scholar
• Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ. 2010. PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol 11:103–112.
   PubMed Web of Science ®Google Scholar
• Saino-Saito S, Hozumi Y, Goto K. 2011. Excitotoxicity by kainate-induced seizure causes diacylglycerol kinase ζ to shuttle from the nucleus to the cytoplasm in hippocampal neurons. Neurosci Lett 494:185–189.
   Google Scholar
• Salisbury E, Sakai K, Schoser B, Huichalaf C, Schneider-Gold C, Nguyen H, Wang GL, Albrecht JH, Timchenko LT. 2008. Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1. Exp Cell Res 314:2266–2278.
   PubMed Web of Science ®Google Scholar
• Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A. 2009. Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res 48:307–343.
   PubMed Web of Science ®Google Scholar
• Sbrissa D, Ikonomov OC, Deeb R, Shisheva A. 2002. Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells. J Biol Chem 277:47276–47284.
   PubMed Web of Science ®Google Scholar
• Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MG, Leonhardt H, Sedat JW. 2008. Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science 320:1332–1336.
   PubMed Web of Science ®Google Scholar
• Schill NJ, Anderson RA. 2009. Two novel phosphatidylinositol-4-phosphate 5-kinase type Iγ splice variants expressed in human cells display distinctive cellular targeting. Biochem J 422:473–482.
   PubMed Web of Science ®Google Scholar
• Semba S, Satake S, Matsushita M, Yokozaki H. 2009. Phosphatase activity of nuclear PTEN is required for CDX2-mediated intestinal differentiation of gastric carcinoma. Cancer Lett 274:143–150.
   Google Scholar
• Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y. 2007. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128:157–170.
   PubMed Web of Science ®Google Scholar
• Shen X, Ranallo R, Choi E, Wu C. 2003. Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12:147–155.
   PubMed Web of Science ®Google Scholar
• Shen X, Xiao H, Ranallo R, Wu WH, Wu C. 2003. Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Science 299:112–114.
   PubMed Web of Science ®Google Scholar
• Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O. 2006. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442:96–99.
   PubMed Web of Science ®Google Scholar
• Sindic A, Aleksandrova A, Fields AP, Volinia S, Banfic H. 2001. Presence and activation of nuclear phosphoinositide 3-kinase C2β during compensatory liver growth. J Biol Chem 276:17754–17761.
   PubMed Web of Science ®Google Scholar
• Skare P, Kreivi JP, Bergström A, Karlsson R. 2003. Profilin I colocalizes with speckles and Cajal bodies: A possible role in pre-mRNA splicing. Exp Cell Res 286:12–21.
   PubMed Web of Science ®Google Scholar
• Smith CD, Wells WW. 1983. Phosphorylation of rat liver nuclear envelopes. II. Characterization of in vitro lipid phosphorylation. J Biol Chem 258:9368–9373.
   PubMed Web of Science ®Google Scholar
• Sone Y, Ito M, Shirakawa H, Shikano T, Takeuchi H, Kinoshita K, Miyazaki S. 2005. Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic development. Biochem Biophys Res Commun 330:690–694.
   Google Scholar
• Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M, Pandolfi PP. 2011. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144:187–199.
   PubMed Web of Science ®Google Scholar
• Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP. 2008. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature 455:813–817.
   PubMed Web of Science ®Google Scholar
• Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA. 2007. The centaurin γ-1 GTPase-like domain functions as an NTPase. Biochem J 401:679–688.
   Google Scholar
• Stallings JD, Tall EG, Pentyala S, Rebecchi MJ. 2005. Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate. J Biol Chem 280:22060–22069.
   PubMed Web of Science ®Google Scholar
• Stiles BL. 2009. Phosphatase and tensin homologue deleted on chromosome 10: Extending its PTENtacles. Int J Biochem Cell Biol 41:757–761.
   PubMed Web of Science ®Google Scholar
• Stracker TH, Petrini JH. 2011. The MRE11 complex: Starting from the ends. Nat Rev Mol Cell Biol 12:90–103.
   PubMed Web of Science ®Google Scholar
• Sun B, Murray NR, Fields AP. 1997. A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition. J Biol Chem 272:26313–26317.
   PubMedGoogle Scholar
• Szivak I, Lamb N, Heilmeyer LM. 2006. Subcellular localization and structural function of endogenous phosphorylated phosphatidylinositol 4-kinase (PI4K92). J Biol Chem 281:16740–16749.
   PubMed Web of Science ®Google Scholar
• Tabellini G, Bortul R, Santi S, Riccio M, Baldini G, Cappellini A, Billi AM, Berezney R, Ruggeri A, Cocco L, Martelli AM. 2003. Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus. Exp Cell Res 287:143–154.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Imajoh-Ohmi S, Sawada T, Shirai R, Hashimoto Y, Iwasaki S, Kaibuchi K, Kanaho Y, Shirai T, Terada Y, Kimura K, Nagata S, Fukui Y. 1997. A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains. Eur J Biochem 245:512–519.
   PubMedGoogle Scholar
• Tavalai N, Stamminger T. 2008. New insights into the role of the subnuclear structure ND10 for viral infection. Biochim Biophys Acta 1783:2207–2221.
   PubMedGoogle Scholar
• Topham MK, Bunting M, Zimmerman GA, McIntyre TM, Blackshear PJ, Prescott SM. 1998. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. Nature 394:697–700.
   PubMed Web of Science ®Google Scholar
• Topham MK, Epand RM. 2009. Mammalian diacylglycerol kinases: Molecular interactions and biological functions of selected isoforms. Biochim Biophys Acta 1790:416–424.
   PubMedGoogle Scholar
• Traweger A, Fuchs R, Krizbai IA, Weiger TM, Bauer HC, Bauer H. 2003. The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B. J Biol Chem 278:2692–2700.
   PubMedGoogle Scholar
• van den Bout I, Divecha N. 2009. PIP5K-driven PtdIns(4,5)P2 synthesis: Regulation and cellular functions. J Cell Sci 122:3837–3850.
   PubMed Web of Science ®Google Scholar
• Vanhaesebroeck B, Ali K, Bilancio A, Geering B, Foukas LC. 2005. Signalling by PI3K isoforms: Insights from gene-targeted mice. Trends Biochem Sci 30:194–204.
   PubMed Web of Science ®Google Scholar
• Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B. 2010. The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol 11:329–341.
   PubMed Web of Science ®Google Scholar
• Vann LR, Wooding FB, Irvine RF, Divecha N. 1997. Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei. Biochem J 327 (Pt 2):569–576.
   Google Scholar
• Visa N, Percipalle P. 2010. Nuclear functions of actin. Cold Spring Harb Perspect Biol 2:a000620.
   PubMed Web of Science ®Google Scholar
• Visnjic D, Banfic H. 2007. Nuclear phospholipid signaling: Phosphatidylinositol-specific phospholipase C and phosphoinositide 3-kinase. Pflugers Arch 455:19–30.
   PubMed Web of Science ®Google Scholar
• Visnjic D, Crljen V, Curic J, Batinic D, Volinia S, Banfic H. 2002. The activation of nuclear phosphoinositide 3-kinase C2β in all-trans-retinoic acid-differentiated HL-60 cells. FEBS Lett 529:268–274.
   PubMed Web of Science ®Google Scholar
• Visnjic D, Curic J, Crljen V, Batinic D, Volinia S, Banfic H. 2003. Nuclear phosphoinositide 3-kinase C2β activation during G2/M phase of the cell cycle in HL-60 cells. Biochim Biophys Acta 1631:61–71.
   PubMedGoogle Scholar
• Wang M, Bond NJ, Letcher AJ, Richardson JP, Lilley KS, Irvine RF, Clarke JH. 2010. Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIα and IIβ and a partial nuclear localization of the IIα isoform. Biochem J 430:215–221.
   PubMedGoogle Scholar
• Watt SA, Kular G, Fleming IN, Downes CP, Lucocq JM. 2002. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J 363:657–666.
   PubMed Web of Science ®Google Scholar
• Wenzel DM, Stoll KE, Klevit RE. 2010. E2s: Structurally economical and functionally replete. Biochem J 433:31–42.
   Google Scholar
• Xu A, Suh PG, Marmy-Conus N, Pearson RB, Seok OY, Cocco L, Gilmour RS. 2001. Phosphorylation of nuclear phospholipase C β1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I. Mol Cell Biol 21:2981–2990.
   PubMed Web of Science ®Google Scholar
• Xu A, Wang Y, Xu LY, Gilmour RS. 2001. Protein kinase C α -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C β1 in Swiss 3T3 cells. J Biol Chem 276:14980–14986.
   Google Scholar
• Yagisawa H, Okada M, Naito Y, Sasaki K, Yamaga M, Fujii M. 2006. Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-delta with the cell cycle. Biochim Biophys Acta 1761:522–534.
   Google Scholar
• Yamaga M, Fujii M, Kamata H, Hirata H, Yagisawa H. 1999. Phospholipase C-delta1 contains a functional nuclear export signal sequence. J Biol Chem 274:28537–28541.
   Google Scholar
• Ye J, Zhao J, Hoffmann-Rohrer U, Grummt I. 2008. Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription. Genes Dev 22:322–330.
   PubMed Web of Science ®Google Scholar
• Ye K. 2006. PIKE GTPase-mediated nuclear signalings promote cell survival. Biochim Biophys Acta 1761:570–576.
   Google Scholar
• Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH. 2002. Phospholipase C γ 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature 415:541–544.
   PubMedGoogle Scholar
• Ye K, Ahn JY. 2008. Nuclear phosphoinositide signaling. Front Biosci 13:540–548.
   PubMed Web of Science ®Google Scholar
• Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH. 2000. Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell 103:919–930.
   PubMed Web of Science ®Google Scholar
• Yoo Y, Wu X, Guan JL. 2007. A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. J Biol Chem 282:7616–7623.
   PubMedGoogle Scholar
• Yu H, Fukami K, Watanabe Y, Ozaki C, Takenawa T. 1998. Phosphatidylinositol 4,5-bisphosphate reverses the inhibition of RNA transcription caused by histone H1. Eur J Biochem 251:281–287.
   Google Scholar
• Zhang HK, Pan K, Wang H, Weng DS, Song HF, Zhou J, Huang W, Li JJ, Chen MS, Xia JC. 2008. Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma. Cancer Lett 261:183–192.
   Google Scholar
• Zhang S, Yu D. 2010. PI(3)king apart PTEN’s role in cancer. Clin Cancer Res 16:4325–4330.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Du G. 2009. Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases. Biochim Biophys Acta 1791:850–855.
   PubMed Web of Science ®Google Scholar
• Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR. 1998. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95:625–636.
   PubMed Web of Science ®Google Scholar
• Zhao R, Bodnar MS, Spector DL. 2009. Nuclear neighborhoods and gene expression. Curr Opin Genet Dev 19:172–179.
   PubMed Web of Science ®Google Scholar
• Zhong Z, Wilson KL, Dahl KN. 2010. Beyond lamins other structural components of the nucleoskeleton. Methods Cell Biol 98:97–119.
   Google Scholar
• Zimmermann P. 2006. The prevalence and significance of PDZ domain-phosphoinositide interactions. Biochim Biophys Acta 1761:947–956.
   PubMed Web of Science ®Google Scholar
• Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW. 2007. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci USA 104:16834–16839.
   PubMed Web of Science ®Google Scholar
• Zuchero JB, Coutts AS, Quinlan ME, Thangue NB, Mullins RD. 2009. p53-cofactor JMY is a multifunctional actin nucleation factor. Nat Cell Biol 11:451–459.
   PubMed Web of Science ®Google Scholar