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Original Article

Molecular Cloning and Sequence Analysis of the 5′-Flanking Region of the Sprague-Dawley Rat Thrombomodulin Gene

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Pages 55-60 | Received 16 May 1998, Published online: 11 Jul 2009

References

  • Appleton M. A., Attanoos R. L., Jasani B. Thrombomodulin as a marker of vascular and lymphatic tumours. Histopathology 1996; 29: 153–157
  • Archipoff G., Beretz A., Freyssinet J, Klein-Soyer C., Brisson C., Cazenave J. Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumor necrosis factor, thrombin or phorbol ester. Biochem. J. 1991; 273: 679–684
  • Boehme M. J., Autschbach F., Zuna I., Scherbaum W. A., Stange E., Raeth U., Sieg A., Stremmel W. Elevated serum levels and reduced immunohistochemical expression of thrombomodulin in active ulcerative colitis. Gastroenterology 1997; 113: 107–117
  • Conway E. M., Boffa M. C., Nowakowski B., Steiner-Mosonyi M. An ultrasrructural study of thrombomodulin endocytosis: internalization occurs via clathrin-coated and non-coated pits. J. Cell Physiol. 1992; 151: 604–612
  • Dittman W. A., Kumada T., Sadler E., Majerus P. W. The structure and function of mouse thrombomodulin. J. Biol. Chem. 1988; 263: 15815–15922
  • Dittman W. A., Nelson S.C, Greer P. K., Horton E. T., Palomba M. L., McCachren S. Characterization of thrombomodulin expression in response to retinoic acid and identification of a retinoic acid response element in the human thrombomodulin gene. J.Biol. Chem. 1994; 269: 16925–16932
  • Esmon C. T. The regulation of natural anticoagulant pathways. Science 1987; 235: 1348–1352
  • Faisst S., Meyer S. Complication of vertebrate-encoded transcription factors. Nucleic Acids Res. 1992; 20: 3–26
  • Healy A. M., Rayburn H. B., Rosenberg R. D., Weiler H. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc. Natl. Acad. Sci. USA 1995; 92: 850–654
  • Moore K. L., Andreoli S. P., Esmon N. L., Esmon C. T., Bang N. U. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J. Clin. Invest. 1987; 79: 124–130
  • Niforas P., Sanderson G. M., Bird C. H., Bird P. Characterization of the mouse thrombomodulin gene and functional analysis of the 5′ flanking region in F9 teratocarcinoma cells. Biochim. Biophys. Acta 1993; 1173: 179–188
  • Ogawa S., Gerlach H., Esposito C., Pasagian-Macaulay A., Brett J., Stern D. Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium: increased monolayer permeability and induction of procoagulant properties. J. Clin. Invest. 1990; 85: 1090–1098
  • Richter K. K., Fink L. M., Hughes B. M., Sung C., Hauer-Jensen M. Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy?. Radiother. Oncol. 1997; 44: 65–71
  • Roesler W. J., Vandenbark G. R., Hanson R. W. Cyclic AMP and the induction of eukaryotic gene transcription. J. Biol. Chem. 1988; 263: 9063–9066
  • Ruiz M., Bugge T. H., Hirschmann P., Stunnenberg H. G. Functional characterization of a natural retinoic acid responsive element. EMBO J. 1991; 10: 3829–3838
  • Vehar G. A., Davie E. W. Preparation and properties of bovine factor VIII (antihemophilic factor). Biochemistry 1980; 19: 401–409
  • Wang I., Richter K. K., Sung C., Hauer-Jensen M. Association of chronic endothelial dysfunction with sustained transforming growth factor-β (TGF-β) overexpression and progression of experimental radiation enteropathy. (Abstract). Radiation Research Society 1997; 45: 194
  • Weiler-Guettler H., Yu K., Soff G., Gudas L., Rosenberg R. D. Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embroyonal carcinoma cells. Proc. Natl. Acad. Sci. USA 1992; 89: 2155–2159
  • Wen D., Dittman W. A., Ye R. D., Deaven L. L., Majerus P., Sadler J. E. Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry 1987; 26: 4350–4357
  • Yu K., Morioka H., Fritze L., Beeler D. L., Jackman R. W., Rosenberg R. D. Transcriptional regulation of the thrombomodulin gene. J. Biol. Chem. 1992; 267: 23237–23247

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