53
Views
23
CrossRef citations to date
0
Altmetric
Original Article

Telomere Dynamics and Genetic Instability in Disease Progression of Chronic Myeloid Leukemia

, , , , , , & show all
Pages 49-56 | Received 10 Mar 2000, Published online: 01 Jul 2009

References

  • Kantarjian H. M., Deisseroth A., Kurzrock R., Estrov Z., Talpaz M. Chronic myelogenous leukemia: A concise update. Blood 1993; 82: 691–703
  • Leber B., Bacchetti S. Telomeres and telomerase in normal and malignant haematologic cells. Leuk. Lymphoma 1996; 24: 1–9
  • De Lange T. Telomere dynamics and genome instability in human cancer, A. Telomeres, EH Blackburn, CW Greider. Cold Spring Harbor Lab Press, New York 1995; 265–293
  • Hahn W. C., Counter CM., Lundberg A. S., Beijersbergen R. L., Brooks M. W., Weinberg R. A. Creation of human tumour cells with defined genetic elements. Nature 1999; 400: 464–468
  • Faded S., Talpaz M., Estrov Z., Kantarjian H. M. Chronic myelogenous leukemia: biology and therapy. Ann. Intern. Med. 1999; 131: 207–19
  • Mashal R., Shtalrid M., Talpaz M. Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia. Blood 1990; 75: 180–189
  • Alimena G., De Cuia M.R., Diverio D., Gastaldi R., Nanni M. The karyotype of blastic crisis. Cancer Genet. Cytogenet. 1987; 26: 39–50
  • Harley C. B., Futcher A. B., Greider CW. Telomeres shorten during aging of human fibroblasts. Nature 1990; 345: 458–460
  • Hastie N. D., Dempster M., Dunlop M. G., Thompson A. M., Green D. K., Allshire R. C. Telomere reduction in human colorectal carcinoma and with aging. Nature 1990; 346: 866–868
  • Lindsey J., Megill N. I., Lindsey L. A., Green D. K., Cooke H. J. In vivo loss of telomeric repeats with age in humans. Mutat. Res. 1991; 256: 45–48
  • Vaziri H., Dragowska W., Allsopp R.C, Thomas T. E., Harley C. B., Lansdorp P. M. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA 1994; 91: 9857–9860
  • Iwama H., Ohyashiki K., Ohyashiki J. H. Telomere length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Human Genet. 1998; 102: 397–402
  • Iwama H., Ohyashiki K., Ohyashiki J. H. The relationship between telomere length and therapy-related cytogenetic responses in chronic myeloid leukemia. Cancer 1997; 79: 1552–1560
  • Boultwood J., Fidler C., Shepherd P. Telomere length shortening is associated with disease evolution in chronic myelogenous leukemia. Am. J. Hematol. 1999; 61: 5–9
  • Ohyashiki K., Ohyashiki J. H., Iwama H. Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression. Leukemia 1997; 11: 190–195
  • Ohyashiki J. H., Ohyashiki K., Shay J.W. A non-radioactive, fluorescence-based telomeric repeat amplification protocol to detect and quantitate telomerase activity. Trends Genet. 1996; 12: 395–396
  • Counter CM., Gupta J., Harley C. B., Leber B., Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995; 85: 2315–2320
  • Hiyama K., Hirai Y., Koizumi S. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 1995; 155: 3711–3715
  • Tatematsu K., Nakayama J., Danbara M. A novel quantitative “stretch PCR assay”, that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias. Oncogene 1996; 13: 2265–74
  • Chiu C. P., Dragowska W., Kim N. W. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cell 1996; 14: 239–248
  • Ohyashiki J. H., Ohyashiki K., Aizawa S. Replication errors in hematologic neoplasias: Genomic instability in progression of disease is different among different types of leukemia. Clin. Cancer Res. 1996; 2: 1583–1589
  • Wada C., Shionoya S., Fujino Y. Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia. Blood 1994; 83: 3449–3456
  • Mori N., Takeuchi S., Tasaka S. Absence of microsatellite instability during the progression of chronic myelocytic leukemia. Leukemia 1997; 11: 151–152
  • Silly H., Chase A., Mills K. I. No evidence for microsatellite instability or consistent loss of heterozygosity at selected loci in chronic myeloid leukaemia blast crisis. Leukemia 1994; 8: 1923–1928
  • Hayashi S., Iwama H., Yahata N., Ando K., Ohyashiki J. H., Ohyashiki K. Subsequential alterations of telomeric DNA length correlate with cytogenetic response in chronic myeloid leukemia treated with interferon alpha. Hematology 1999; 4: 1–10
  • Sakabe H., Yahata N., Kimura T. Human cord blood-derived primitive progenitors are enriched in CD34+c-kit- cells: correlation between long-term culture-initiating cells and telomerase expression. Leukemia 1998; 12: 728–34
  • Bryan T. M., Englezou A., Gupta J., Bacchetti S., Reddel R. R. telomere elongation in immortal human cells without detectable telomerase activity. The EMBO J. 1995; 14: 4240–4248
  • Greaves M. Is telomerase activity in cancer due to selection of stem cells and differentiation arrest?. Trend Genet. 1996; 12: 127–128
  • Shay J. W., Wright W.E. The reactivation of telomerase activity in cancer progression. Trend Genet. 1996; 12, 129- 131

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.