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Original Article

The Role of FAS-Mediated Apoptosis in Chronic Myelogenous Leukemia

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Pages 283-297 | Received 10 Sep 1999, Published online: 01 Jul 2009

References

  • Heisterkamp N., Stam K., Groffen J., De Klein A., Grosveld G. Structural organization of the ber gene and its role in the Ph1 translocation. Nature 1985; 315: 758–761
  • Shtiveiman E., Lifshitz B., Gale R. P., Roe B. A., Canaani E. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. Cell 1986; 47: 277–284
  • Clark S. S., McLaughin J., Timmonis M, Pendergast A. M., Bin-Neriah Y., Dow L., Rovera G., Smith S. D., Witte O. N. Expression of a distinctive BCR-ABL oncogene in Phi-positive acute lymphocytic leukemia (ALL). Science 1988; 238: 775–778
  • Pane F., Frigeri F., Sindona M., Luciano L., Ferrara F., Cimino R., Meloni G., Saglio G., Salvatore F., Rotoli B. Neutrophilic-chronic myeloid leukemia: A distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction). Blood 1996; 88: 2410, 1996
  • Li S., Ilaria R. L., Jr, Million R. P., Daley G. Q., Van Elten R. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J. Exp. Med. 1999; 189: 1399–1412
  • Lugo T. G., Pendergast A. M., Muller A. J., Witte O. N. Tyrosine kinase and transformation poteney of bcr-abl oncogene products. Science 1990; 250: 559–562
  • Heisterkamp N., Jenster G., Ten Hoeve J., Zovich D., Pat-Tengale P. K., Groffen J. Acute leukemia in bcr/abl transgenic mice. Nature 1990; 344: 251–253
  • Daley G. Q. Animal models of BCR/ABL-induced leukemias. Leuk. Lymphoma 1993; 11: 57–60, Suppl. 1
  • Daley G. Q., Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P2l0bcr/abl protein. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 9312–9316
  • Gishizky M. L., Witte O. Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro. Science 1992; 256: 836–839
  • Sawers C. L. Chronic myeloid leukemia. N. Engl. J. Med. 1999; 340: 1330–1340
  • Pendergast A. M., Quilliam L. A., Cripe L. D., Bassing C. H., Dai Z., Li N., Batzer A., Rabun K. M., Dcr C. J., Schlessinger J., Gishizky M. L. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 1993; 75: 175–185
  • Lowenstein E. J., Daly R. J., Batzer A. G., Margolis W. L., Lammers R., Ullrich A., Skolnik E. Y., Bar-Sagi D., Schlessinger J. The SH2 and SH3 domain-containing protein Grb2 links receptor tyrosine kinase to Ras signaling. Cell 1992; 70: 431–432
  • Tauchi T., Boswell H. S., Leibowitz D., Broxmeyer H. E. Coupling between p210bcr-abl and She and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to Ras activation pathway. J. Exp. Med. 1994; 179: 167–175
  • Sattler M., Salgia R. Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells. Leukemia 1998; 12: 637–644
  • Kolibaba K. S., Bhat A., Heaney C., Oda T., Druker B J. CRKL binding to BCR-ABL and BCR-ABL transformation. Leuk. Lymphoma 1999; 33: 119–126
  • Carpino N., Wisniewski D., Strife A., Marshak D., Kobayashi R., Stillman B., Clarkson B. p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous progenitor cells. Cell 1997; 88: 197–204
  • Matsuguchi T., Inhorn R. C., Carlesso N., Xu C, Druker B., Griffin J. D. Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. EMBO J. 1995; 14: 257–265
  • Bhat A., Kolibaba K., Oda T., Ohno-Jones S., Heaney C., Druker B. J. Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells. J. Biol. Chem. 1997; 272: 16170–16175
  • Afar D. E., Han L., McLaughlin J., Wong S., Dhaka A., Parmar K., Rosenberg N., Witte O. N., Colicelli J. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Immunity 1997; 6: 773–782
  • Salgia R., Brunkhorst B., Pisick E., Li J. L., Lo S. H., Chen L. B., Griffin J. D. Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. Oncogene 1995; 11: 1149–1155
  • Mandanas R. A., Leibowitz D. S., Gharehbaghi K., Tauchi T., Burgess G. S., Miyazawa K., Jayaram H. N., Boswell H. S. Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells. Blood 1993; 82: 1838–1847
  • Skorski T., Wlodarski P., Daheron L., Salomoni P., Nieborowska-Skorska M., Majewski M., Wasik M., Calabretta B. BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. Proc. Natl. Acad. Set. USA 1998; 95: 11858–11862
  • Salomoni P., Wasik M. A., Riedel R. F., Reiss K, Choi J. K., Skorski T., Calabretta B. Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. J. Exp. Med. 1998; 187: 1995–2007
  • Shi C. S., Tuscano J. M., Witte O. N., Kehrl J. H. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. Blood 1999; 93: 1338–1345
  • Raitano A. B., Halpern J. R., Hambuch T. M., Sawyers C. L. The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc. Natl. Acad. Sci. USA 1995; 92: 11746–11750
  • Calabretta B., Skorski T. BCR/ABL regulation of PI-3 kinase activity. Leuk. Lymphoma 1996; 23: 473–476
  • Skorski T., Bellacosa A., Nieborowska-Skorska M., Majewski M., Martinez R., Choi J. K., Trotta R., Wlodarski P., Perrotti D., Chan T O., Wasik M. A., Tsichlis P. N., Calabretta B. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 1997; 16: 6151–6161
  • Amarante-Mendes G. P., McGahon A. J., Nishioka W. K., Afar D. E., Witte O. N., Green D. R. Bcl-2 independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with up-regulation of Bcl-xL. Oncogene 1998; 16: 1383–1390
  • Deininger M. W., Goldman J. M. Chronic myeloid leukemia. Curr. Opin. Hematol. 1998; 5: 302–308
  • Majewski M., Nieborowska-Skorska M., Salomoni P., Slupianek A., Reiss K., Trotta R., Calabretta B., Skorski T. Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt. Cancer Res. 1999; 59: 2815–2819
  • Sawyers C. L., Callahan W., Witte O. N. Dominant negative MYC blocks transformation by ABL oncogenes. Cell 1992; 70: 901–910
  • Reuther J. Y., Reuther G. W., Cortez D., Pendergast A. M., Baldwin A. S., Jr. A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes Dev. 1998; 12: 968–81
  • Carlesso N., Frank D. A., Griffin J. D. Tyrosyl phosporilation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med. 1996; 183: 247–254
  • Nieborowska-Skorska M., Wasik M. A., Slupianek A., Salomoni P., Kitamura T., Calabretta B., Skorski T. Signal transducer and activator of transcription (STAT) 5 activation by BCR/ABL is dependent on intact Sre homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J. Exp. Med. 1999; 189: 1229–1242
  • Skorski T., Nieborowska-Skorska M., Barletta C., Malaguarnera L., Szczylik C, Chen T. S., Lange B., Calabretta B. Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligonucleotides combined with mafosfamide. J. Clin. Invest. 1993; 92: 194–202
  • De Fabritiis P., Petti M. C., Montefusco E., De Propris M. S., Sala R., Bellucci R., Mancini M., Lisci A., Bonetto R, Geiser T., Calabretta B., Mandelli F. BCR-ABL antisense oligodeoxynucleotide in vitro purging and autologous bone marrow transplantation for patients with chronic myelogenous leukemia in advanced phase. Blood 1998; 91: 3156–3162
  • Carlo-Stella C., Dotti G., Mangoni L., Regazzi E., Garau D., Rizzo M. T., Savoldo B., Rizzoli V. Selection of myeloid progenitors lacking BCR-ABL mRNA in chronic myelogenous leukemia patients after in vitro treatment with the tyrosine kinase inhibitor genistein. Blood 1996; 88: 3091–1996
  • Druker B. J., Tamura S., Buchdunger E., Ohno S., Segal G. M., Fanning S., Zimmermann J., Lydon N. B. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 1996; 2: 561–566
  • Deininger M. W., Goldman J. M., Lydon N., Melo J. V. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood 1997; 90: 3691–3698
  • Le Coutre P., Mologni L., Cleris L., Marchesi E., Buchdunger E., Giardini R., Formelli F., Gambacorti-Passerini C. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J. Natl. Cancer Inst. 1999; 91: 163–168
  • Sawyers C. L., McLaughlin J., Witte O. N. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr/Abl oncogene. J. Exp. Med. 1995; 181: 307–313
  • Skorski T., Kanakaraj P., Nieborowska-Skorska M., Ratajczak M. Z., Wen S. C., Zon G., Gewirtz A. M., Perussia B., Calabretta B. Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood 1995; 86: 726–736
  • Dickens M, Rogers J. S., Cavanagh J., Raitano A., Xia Z., Halpem J. R., Greenberg M. E., Sawyers C. L., Davis R. J. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 1997; 277: 693–696
  • Afar D. E.H., Goga A., McLaughlin J., Witte O. N., Sawyers C. L. Differential complementation of Bcr/Abl point mutants with c-Myc. Science 1994; 264: 424–426
  • Skorski T., Kanakaraj P., Ku D. H., Nieborowska-Skorska M., Canaani E., Zon G., Perussia B., Calabretta B. Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth. J. Exp. Med. 1994; 179: 1855–1865
  • Cortez D., Stoica G., Pierce J. H., Pendergast A. M. The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. Oncogene 1996; 13: 2589–2594
  • Selleri C., Maciejewski J. P., Sato T., Young N. S. Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood 1996; 87: 4149–4157
  • Wickremasinghe R. G., Hoffbrand A. V. Biochemical and genetic control of apoptosis: relevance to normal hematopoiesis and hematological malignancies. Blood 1999; 93: 3587–3600
  • Hannun Y. A. Apoptosis and the dilemma of cancer chemotherapy. Blood 1997; 89: 1845–1853
  • Friesen C., Herr I., Krammer P. H., Debatin K-M. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 1996; 2: 574–577
  • Reed J. C. Mechanisms of apoptosis avoidance in cancer. Curr. Opin. Oncol. 1999; 11: 68–75
  • Landowski T. H., Gleason-Guzman M. C., Dalton W. S. Selection for drug resistance results in resistance to Fas-mediated apoptosis. Blood 1997; 89: 1854–1861
  • McGahon A., Bissonnette R., Schmitt M., Cotter K. M., Green D. R., Cotter T. G. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. Blood 1994; 83: 1179–1187
  • Bedi A., Zehnbauer B. A., Barber J. P., Sharkis S. J., Jones R. J. Inhibition of apoptosis by BCR-ABL in cbronic myelogenous leukemia. Blood 1994; 83: 2038–2044
  • Bedi A., Berber J. P., Bedi G. C., El-Deiry W. S., Sidransky D., Vala M. S., Akhtar A. J., Hilton J., Jones R. J. BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents. Blood 1995; 86: 1148–1158
  • McGahon A., Nishioka W. K., Martin S. J., Mahboubi A., Cotter T. G., Green D. R. Regulation of the Fas apoptotic cell death pathway by Abl. J. Biol. Chem. 1995; 270: 22625–22631
  • Cotter T G. BCR-ABL: an anti-apoptosis gene in chronic myelogenous leukemia. Leuk. Lymphoma 1995; 18: 231–236
  • Yuan Z-M., Huang Y., Whang Y., Sawyers C., Weichselbaum R., Kharbanda S., Kufe D. Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 1996; 382: 272–274
  • McGahon A., Brown D. G., Martin S. J., Amarante-Mendes G. P., Cotter T. G., Cohen G. M., Green D. R. Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: Characterization of apoptotic death. Cell Death and Different. 1997; 4: 95–104
  • Selleri C., Sato T., Del Vecchio L., Luciano L., Barrett A. J., Rotoli B., Young N. S., Maciejewski J. P. Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. Blood 1997; 89: 957–964
  • Selleri C., Maciejewski J. P., Pane F., Luciano L., Raiola A. M., Mostarda I., Salvatore F., Rotoli B. Fas-mediated modulation of BCR/ABL in chronic myelogenous leukemia results in differential effects on apoptosis. Blood 1998; 92: 981–989
  • Amos T. A., Lewis J. L., Grand F. H., Gooding R. P., Goldman J. M., Gordon M. Y. Apoptosis in chronic myeloid leukemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids. Br. J. Haematol. 1995; 91: 387–393
  • Albrecht T., Schwab R., Henkes M., Peshel C., Huber C., Aulitzky W. E. Primary immature myloid cells from CML patients are not resistant to induction of apoptosis by DNA damage and growth factor withdrawal. Br. J. Haematol 1996; 95: 501–507
  • The Italian Cooperative Study Group on Chronic Myeloid Leukemia. Interferon alfa-2s compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N. Engl. J. Med. 1994; 30: 820–825
  • Chronic Myeloid Leukemia Trialists' Collaborative Group. Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials. J. Natl. Cancer Inst. 1997; 89: 1616–1620
  • Geissler D., Gastl G., Aulitzky W., Tilg H., Gaggl S., Konwalinka G., Huber C. Recombinant inter-feron-alpha-2c in chronic myelogenous leukaemia: relationship of sensitivity of committed haematopoietic precursor cells in vitro (BFU-E, CFU-GM, CFU-Meg) and clinical response. Leuk. Res. 1990; 14: 629–636
  • Cornelissen J. J., Ploemacher R. E., Wognum B. W., Borsboom A., Kluin-Nelemans H. C., Hagemeijer A., Lowenberg B. An in vitro model for cytogenetic conversion in CML. Interferon-alpha preferentially inhibits the outgrowth of malignant stem cells preserved in long-term culture. J. Clin. Invest. 1998; 102: 976–983
  • Gordon M. Y., Marley S. B., Lewis J. L., Davidson R. J., Nguyen D. X., Grand F. H., Amos T. A., Goldman J. M. Treatment with interferon-alpha preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM. J. Clin. Invest. 1998; 102: 710–715
  • Bhatia R., McCarthy J. B., Verfaillie C. M. Interferon-alpha restores normal beta 1 integrin-mediated inhibition of hematopoietic progenitor proliferation by the marrow microenvironment in chronic myelogenous leukemia. Blood 1996; 87: 3883–3891
  • Bhatia R., Verfaillie C. M. The effect of interferon-alpha on beta-1 integrin mediated adhesion and growth regulation in chronic myelogenous leukemia. Leuk. Lym-phoma 1998; 28: 241–254
  • Aman J. M., Keller U., Derigs G., Mohammadzadeh M., Huber C., Peschel C. Regulation of cytokine expression by interpheron alpha in human bone marrow stroma cells: inhibition of hematopoietic growth factors and induction of IL-1 receptor antagonist. Blood 1994; 84: 4142–4150
  • Bathia R., McGlave P., Verfaillie C M. Treatment of marrow stroma with interferon-α restores normal β1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors. Role of MIP-1α. J. Clin. Invest. 1995; 96: 931–939
  • Wang C, Al-Omar H. M., Radvanyi L., Banerjee A., Bouman D., Squire J., Messner H. A. Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-alpha. Exp. Hematol. 1999; 27: 1176–1184
  • Nagata S. Apoptosis by death factor. Cell 1997; 88: 355–365
  • Chaudhuri A. R., Jeor S., St, Maciejewski J. P. Apoptosis induced by human cytomegalovirus infection can be enhanced by cytokines to limit the spread of virus. Exp. Hematol 1999; 27: 1194–1203
  • Maciejewski J. P., Selleri C., Anderson S., Young N. S. Fas antigen expression on CD34+human bone marrow cells is induced by interferon-γ and tumor necrosis factor-α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 1995; 85: 3183–3190
  • Nagafuji K., Shibuya T, Harada M., Mizuno S., Takenaka K., Miyamoto T, Okamura T., Gondo H., Niho Y. Functional expression of Fas antigen (CD95) on hematopoietic progenitor cells. Blood 1995; 86: 883–889
  • Sato T., Selleri C., Anderson S., Young N. S., Maciejewski J P. Expression and modulation of cellular receptors for interferon-gamma, tumour necrosis factor, and Fas on human bone marrow CD34+ cells. Br. J. Haematol 1997; 97: 356–365
  • Sato T., Selleri C., Young N. S., Maciejewski J. Hematopoietic inhibition by interferon-γ is partially mediated through interferon regulatory factor-1. Blood 1995; 86: 3373–3380
  • Peter M. E., Krammer P. H. Mechanisms of CD95(APO-1/Fas)-mediated apoptosis. Curr. Opin. Immunol. 1998; 10: 545–551
  • Brenner B., Ferlinz K., Grassmé H., Weller K., Koppenhoefer U., Dichgans J., Sandhoff K., Lang F., Gulbins E. FAS/CD95/APO-1 activates the acidic sphingomyelinase via caspases. Cell Death Different. 1998; 5: 29–37
  • Selleri C., Sato T., Raiola A. M., Rotoli B., Young N. S., Maciejewski J. P. Induction of nitric oxide synthase is involved in the mechanism of Fas-mediated apoptosis in haemopoietic cells. Br. J. Haematol 1997; 99: 481–489
  • Miyamura K., Iijima N., Itou T., Tanimoto M., Saito H. Functional expression of Fas receptor on the progenitor cells of chronic myelogenous leukemia: induction by interferon-α, γ and ubemix. Blood 1996; 88: 232, (A). (suppl 1)
  • Rizzoli V., Savoldo B., Regazzi E., Garau D., Sammarelli G., Mangoni L., Carlo Stella C. Chronic myelogenous leukemia CD34+ marrow cells lacking CD95 expression are enriched for BCR/ABL negative primitive and committed progenitors. Bone Marr. Transplant. 1997; 19: 30, (A) (suppl. 1)
  • Pigeonnier-Lagarde V., Maguer-Satta V., Chachine H., Taupin F., Belloc J. L., Reiffers J., Mahon F. X. Expression of Fas antigen (CD95) on peripheral blood CD34+ chronic myeloid leukemia cells. Blood, 90: 281b, (A)
  • Yotnda P., Firat H., Garcia-Pons F., Garcia Z., Gourru G., Vernant J. P., Lemonnier F. A., Leblond V., Langlade-Demoyen P. Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia. J. Clin. Invest. 1998; 101: 2290–2296
  • Osman Y., Takahashi M., Zheng Z., Koike T., Toba K., Liu A., Furukawa T., Aoki S., Aizawa Y. Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients. Leukemia 1999; 13: 166–174
  • Smit W. M., Rijnbeek M., Van Bergen C. A., Fibbe W. E., Willemze R., Falkenburg J. H. T cells recognizing leukemic CD34(+) progenitor cells mediate the antileukemic effect of donor lymphocyte infusions for relapsed chronic myeloid leukemia after allogeneic stem cell transplantation. Proc. Natl. Acad. Sci. USA 1998; 95: 10152–10157
  • Nagata S. Fas ligand and immune evasion. Nat. Med. 1996; 2: 1306–1307
  • Walker P. R., Saas P., Dietrich P-Y. Tumor expression of Fas ligand (CD95L) and the consequences. Curr. Opin. Immunol 1998; 10: 564–572
  • Roger R., Issaad C., Pallardy M., Leglise M. C., Turhan A. G., Bertoglio J., Breard J. BCR-ABL does not prevent apoptotic cell death induced by human natural killer or lymphokine-activated killer cells. Blood 1996; 87: 1113–1122
  • Suda T, Hashimoto H., Tanaka M., Ochi T, Nagata S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J. Exp. Med. 1997; 186: 2045–2050
  • Tanaka M., Itai T, Adachi M., Nagata S. Downregulation of Fas ligand by shedding. Nat. Med. 1998; 4: 31–36
  • Amarante-Mendes G. P., Kim C. N., Liu L., Huang Y., Perkins C. L., Green D. R., Bhalla K. Bcr-Abl Exerts Its Antiapoptotic Effect Against Diverse Apoptotic Stimuli Through Blockage of Mitochondrial Release of Cytochrome C and Activation of Caspase-3. Blood 1998; 91: 1700–1705
  • Carlo Stella C., Regazzi E., Sammarelli G., Colla S., Garau D., Gazit A., Savoldo B., Cilloni D., Tabilio A., Levitzki A., Rizzoli V. Effects of the tyrosine kinase inhibitor AG957 and an Anti-Fas receptor antibody on CD34(+) chronic myelogenous leukemia progenitor cells. Blood 1999; 93: 3973–3982
  • Pane F, Mostarda I., Selleri C., Salzano R., Raiola A. M., Luciano L., Saglio G., Rotoli B., Salvatore F. Bcr/Abl mRNA and the 210bcr/abl protein are downmodulated by interferon-alpha in chronic myeloid leulemia patients. Blood 1999; 94: 2200–2207
  • Albitar H., Kantarijan T, Manshouri S., O'Brien S., Andreeff S., Kornblau S., Beran M, Keating M., Talpaz M. Expression of BCL-2 and FAS in chronic myelogenous leukemia (CML). Blood 1997; 88: 275b, (A). (suppl 1)

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