Novel Insights into the Mechanism of t(14;18)(q32;q21) Translocation in Follicular Lymphoma

References

• Rabbitts T. H. Chromosomal translocations in human cancer. Nature 1994; 372: 143–149
   PubMed Web of Science ®Google Scholar
• Harris N. L., Jaffe E. S., Stein H., Banks P. M., Chan J. K., Cleary M. L., Delsol G., De Wolf-Peeters C., Falini B., Gatter K.C. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361–1392
   PubMed Web of Science ®Google Scholar
• Tsujimoto Y., Finger L. R., Yunis J., Nowell P. C., Croce C.M. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 1984; 226: 1097–1099
   PubMed Web of Science ®Google Scholar
• Bakhshi A., Jensen J. P., Goldman P., Wright J. J., McBride O. W., Epstein A. L., Korsmeyer S.J. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985; 41: 899–906
   PubMed Web of Science ®Google Scholar
• Tsujimoto Y., Gorham J., Cossman J., Jaffe E., Croce C.M. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 1985; 229: 1390–1393
   PubMed Web of Science ®Google Scholar
• Cleary M. L., Sklar J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc. Natl. Acad. Sci. U.S.A. 1985; 82: 7439–7443
   PubMed Web of Science ®Google Scholar
• Seto M., Jaeger U., Hockett R. D., Graninger W., Bennett S., Goldman P., Korsmeyer S.J. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J. 1988; 7: 123–131
   PubMed Web of Science ®Google Scholar
• McDonnell T. J., Deane N., Platt F. M., Nunez G., Jaeger U., McKearn J. P., Korsmeyer S.J. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989; 57: 79–88
   PubMed Web of Science ®Google Scholar
• Bakhshi A., Wright J. J., Graninger W., Seto M., Owens J., Cossman J., Jensen J. P., Goldman P., Korsmeyer S.J. Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc. Natl. Acad. Sci. U.S.A. 1987; 84: 2396–2400
   PubMed Web of Science ®Google Scholar
• Tsujimoto Y., Louie E., Bashir M. M., Croce CM. The reciprocal partners of both the t(14;18) and the t(11;14) translocations involved in B-cell neoplasms are rearranged by the same mechanism. Oncogene 1988; 2: 347–351
   PubMed Web of Science ®Google Scholar
• Cotter F., Price C., Zucca E., Young B.D. Direct sequence analysis of the 14q+ and 18q-chromosome junctions in follicular lymphoma. Blood 1990; 76: 131–135
   PubMed Web of Science ®Google Scholar
• Wyatt R. T., Rudders R. A., Zelenetz A., Delellis R. A., Krontiris T.G. BCL2 oncogene translocation is mediated by a chi-like consensus. J. Exp. Med. 1992; 175: 1575–1588
   PubMed Web of Science ®Google Scholar
• Meijerink J. P., Raemaekers J. M., Mensink E.J. New type of t(14;18) in a non-Hodgkin's lymphoma provides insight in molecular events in early B-cell differentiation. Br. J. Haematol. 1995; 91: 630–639
   PubMed Web of Science ®Google Scholar
• Stamatopoulos K., Kosmas C., Belessi C., Papadaki T., Afendaki S., Anagnostou D., Loukopoulos D. t(14;18) chromosomal translocation in follicular lymphoma: an event occurring with almost equal frequency both at the D to J(H) and at later stages in the rearrangement process of the immunoglobulin heavy chain gene locus. Br. J. Haematol. 1997; 99: 866–872
   PubMed Web of Science ®Google Scholar
• Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996; 381: 751–758
   PubMed Web of Science ®Google Scholar
• Gellert M. Recent advances in understanding V(D)J recombination. Adv. Immunol. 1997; 64: 39–64:39–64
   PubMed Web of Science ®Google Scholar
• Crescenzi M., Seto M., Herzig G. P., Weiss P. D., Griffith R. C., Korsmeyer S.J. Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 4869–4873
   PubMed Web of Science ®Google Scholar
• Gauwerky C. E., Haluska F. G., Tsujimoto Y., Nowell P. C., Croce C.M. Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 8548–8552
   PubMed Web of Science ®Google Scholar
• Jaeger U., Boecskoer S., Le T., Mitterbauer G., Bolz I., Chott A., Kneba M., Mannhalter C., Nadel B. Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation. Blood 2000; 95: 3520–3529
   PubMed Web of Science ®Google Scholar
• Cleary M. L., Galili N., Sklar J. Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. J. Exp. Med. 1986; 164: 315–320
   PubMed Web of Science ®Google Scholar
• Buchonnet G., Lenain P., Ruminy P., Lepretre S., Stamatoullas A., Parmentier F., Jardin F., Duval C., Tilly H., Bastard C. Characterisation of BCL2-JH rearrangements in follicular lymphoma: PCR detection of 3′BCL2 breakpoints and evidence of a new cluster. Leukemia 2000; 14: 1563–1569
   PubMed Web of Science ®Google Scholar
• Lewis S. M., Agard E., Suh S., Czyzyk L. Cryptic signals and the fidelity of V(D)J joining. Mol. Cell Biol. 1997; 17: 3125–3136
   PubMed Web of Science ®Google Scholar
• Vaandrager J. W., Schuuring E., Philippo K., Kluin P.M. V(D)J recombinase-mediated transposition of the BCL2 gene to the 1GH locus in follicular lymphoma. Blood 2000; 96: 1947–1952
   PubMed Web of Science ®Google Scholar
• Corbett S. J., Tomlinson I. M., Sonnhammer E. L., Buck D., Winter G. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination. J. Mol. Biol. 1997; 270: 587–597
   PubMed Web of Science ®Google Scholar
• Fugmann S. D., Lee A. I., Shockett RE., Villey I. J., Schatz D.G. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 2000; 18: 495–527
   PubMed Web of Science ®Google Scholar
• Tycko B., Reynolds T.C, Smith S. D., Sklar J. Consistent breakage between consensus recombinase heptamers of chromosome 9 DNA in a recurrent chromosomal translocation of human T cell leukemia. J. Exp. Med. 1989; 169: 369–377
   PubMed Web of Science ®Google Scholar
• Marculescu R., Le T., Boecskoer S., Mitterbauer G., Chott A., Mannhalter C., Jaeger U., Nadel B. Alternative end-joining in Follicular Lymphomas't(14;18). manuscript in preparation
   Google Scholar
• Lewis S., Gifford A., Baltimore D. DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes. Science 1985; 228: 677–685
   PubMed Web of Science ®Google Scholar
• Lieber M. R., Hesse J. E., Mizuuchi K., Gellert M. Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 8588–8592
   PubMed Web of Science ®Google Scholar
• Tycko B., Coyle H., Sklar J. Chimeric gamma-delta signal joints. Implications for the mechanism and regulation of T cell receptor gene rearrangement. J. Immunol. 1991; 147: 705–713
   PubMed Web of Science ®Google Scholar
• Garcia I. S., Kaneko Y., Gonzalez-Sarmiento R., Campbell K., White L., Boehm T., Rabbitts T.H. A study of chromosome 11p13 translocations involving TCR beta and TCR delta in human T cell leukaemia. Oncogene 1991; 6: 577–582
   PubMed Web of Science ®Google Scholar
• Zhu C., Bogue M. A., Lim D. S., Hasty P., Roth D.B. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 1996; 86: 379–389
   PubMedGoogle Scholar
• Dominguez O., Ruiz J. F., Lain D.L., Garcia-Diaz M., Gonzalez M. A., Kirchhoff T., Martinez A., Bernad A., Blanco L. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. EMBO J. 2000; 19: 1731–1742
   PubMed Web of Science ®Google Scholar
• Storb U. Progress in understanding the mechanism and consequences of somatic hypermutation. Immunol. Rev. 1998; 162: 5–11:5–11
   PubMed Web of Science ®Google Scholar
• Wilson P. C., de Bouteiller O., Liu Y. J., Potter K., Banchereau J., Capra J. D., Pascual V. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J. Exp. Med. 1998; 187: 59–70
   PubMed Web of Science ®Google Scholar
• Goossens T., Klein U., Kuppers R. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. U.S.A. 1998; 95: 2463–2468
   PubMed Web of Science ®Google Scholar
• Sale J. E., Neuberger M.S. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 1998; 9: 859–869
   Google Scholar
• Yamada M., Wasserman R., Reichard B. A., Shane S., Caton A. J., Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J. Exp. Med. 1991; 173: 395–407
   PubMed Web of Science ®Google Scholar
• Milili M., Schiff C., Fougereau M., Tonnelle C. The VDJ repertoire expressed in human preB cells reflects the selection of bona fide heavy chains. Eur. J. Immunol. 1996; 26: 63–69
   PubMed Web of Science ®Google Scholar
• Reth M. G., Alt F.W. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature 1984; 312: 418–423
   PubMed Web of Science ®Google Scholar
• Gu H., Kitamura D., Rajewsky K. DH reading frame bias: evolutionary selection, antigen selection or both? Evolutionary selection. Immunol. Today 1991; 12: 420–421
   PubMedGoogle Scholar
• Loffert D., Ehlich A., Muller W., Rajewsky K. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity 1996; 4: 133–144
   PubMed Web of Science ®Google Scholar
• Schatz D. G. Developing B-cell theories. Nature 1999; 400: 614–5, 617
   Web of Science ®Google Scholar
• Nagaoka H., Yu W., Nussenzweig M.C. Regulation of RAG expression in developing lymphocytes. Curr. Opin. Immunol. 2000; 12: 187–190
   PubMed Web of Science ®Google Scholar
• Nemazee D. Receptor selection in B and T lymphocytes. Annu. Rev. Immunol. 2000; 18: 19–51
   PubMed Web of Science ®Google Scholar
• Taki S., Schwenk F., Rajewsky K. Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus. Eur. J. Immunol. 1995; 25: 1888–1896
   PubMed Web of Science ®Google Scholar
• Papavasiliou F., Casellas R., Suh H., Qin X. F., Besmer E., Pelanda R., Nemazee D., Rajewsky K., Nussenzweig M.C. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science 1997; 278: 298–301
   PubMed Web of Science ®Google Scholar
• Hikida M., Mori M., Takai T., Tomochika K., Hamatani K., Ohmori H. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 1996; 274: 2092–2094
   PubMed Web of Science ®Google Scholar
• Han S., Zheng B., Schatz D. G., Spanopoulou E., Kelsoe G. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science 1996; 274: 2094–2097
   PubMed Web of Science ®Google Scholar
• Meffre E., Papavasiliou F., Cohen P., de Bouteiller O., Bell D., Karasuyama H., Schiff C., Banchereau J., Liu Y. J., Nussenzweig M.C. Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J. Exp. Med. 1998; 188: 765–772
   PubMed Web of Science ®Google Scholar
• Han S., Dillon S. R., Zheng B., Shimoda M., Schlissel M. S., Kelsoe G. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 1997; 278: 301–305
   PubMed Web of Science ®Google Scholar
• Yu W., Nagaoka H., Jankovic M., Misulovin Z., Suh H., Rolink A., Melchers F., Meffre E., Nussenzweig M.C. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 1999; 400: 682–687
   PubMed Web of Science ®Google Scholar