Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells

References

• Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 2004;4:45–60.
   PubMed Web of Science ®Google Scholar
• Gendler SJ, Spicer AP, Lalani EN, et al. Structure and biology of a carcinoma-associated mucin, MUC1. Am Rev Respir Dis 1991;144:S42–S47.
   PubMed Web of Science ®Google Scholar
• Baldus SE, Engelmann K, Hanisch FG. MUC1 and the MUCs: a family of human mucins with impact in cancer biology. Crit Rev Clin Lab Sci 2004;41:189–231.
   PubMed Web of Science ®Google Scholar
• Spicer AP, Rowse GJ, Lidner TK, Gendler SJ. Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem 1995;270:30093–30101.
   PubMed Web of Science ®Google Scholar
• Li Y, Liu D, Chen D, Kharbanda S, Kufe D. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 2003;22:6107–6110.
   PubMed Web of Science ®Google Scholar
• Rakha EA, Boyce RW, Abd El-Rehim D, et al. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol 2005;18:1295–1304.
   PubMed Web of Science ®Google Scholar
• Yonezawa S, Goto M, Yamada N, Higashi M, Nomoto M. Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior. Proteomics 2008;8:3329–3341.
   PubMed Web of Science ®Google Scholar
• Brayman M, Thathiah A, Carson DD. MUC1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol 2004;2:4.
   PubMedGoogle Scholar
• Carraway KL 3rd, Funes M, Workman HC, Sweeney C. Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways. Curr Top Dev Biol 2007;78:1–22.
   PubMed Web of Science ®Google Scholar
• Sloane JP, Hughes F, Ormerod MG. An assessment of the value of epithelial membrane antigen and other epithelial markers in solving diagnostic problems in tumour histopathology. Histochem J 1983;15:645–654.
   PubMedGoogle Scholar
• Delsol G, Gatter KC, Stein H, et al. Human lymphoid cells express epithelial membrane antigen. Implications for diagnosis of human neoplasms. Lancet 1984;2:1124–1129.
   PubMed Web of Science ®Google Scholar
• Takahashi T, Makiguchi Y, Hinoda Y, et al. Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient. J Immunol 1994;153:2102–2109.
   PubMed Web of Science ®Google Scholar
• Treon SP, Raje N, Anderson KC. Immunotherapeutic strategies for the treatment of plasma cell malignancies. Semin Oncol 2000;27:598–613.
   PubMed Web of Science ®Google Scholar
• Singh R, Bandyopadhyay D. MUC1: a target molecule for cancer therapy. Cancer Biol Ther 2007;6:481–486.
   PubMed Web of Science ®Google Scholar
• Yamada Y, Tomonaga M, Fukuda H, et al. A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol 2001;113:375–382.
   PubMed Web of Science ®Google Scholar
• Tsukasaki K, Hermine O, Bazarbachi A, et al. Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol 2009;27:453–459.
   PubMed Web of Science ®Google Scholar
• Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984–87). Br J Haematol 1991;79:428–437.
   PubMed Web of Science ®Google Scholar
• Karube K, Ohshima K, Tsuchiya T, et al. Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol 2004;126:81–84.
   PubMed Web of Science ®Google Scholar
• Kohno T, Yamada Y, Akamatsu N, et al. Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells. Cancer Sci 2005;96:527–533.
   PubMed Web of Science ®Google Scholar
• Abe M, Uchihashi K, Kazuto T, et al. Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells. Eur J Haematol 2008;81:209–217.
   PubMed Web of Science ®Google Scholar
• Uchiyama T. Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu Rev Immunol 1997;15:15–37.
   PubMed Web of Science ®Google Scholar
• Dewan MZ, Terashima K, Taruishi M, et al. Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB. J Virol 2003;77:5286–5294.
   PubMed Web of Science ®Google Scholar
• Uchiyama T, Ishikawa T, Imura A. Cell adhesion molecules in HTLV-I infection. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13(Suppl. 1):S114–S118.
   PubMedGoogle Scholar
• Hasegawa H, Nomura T, Kishimoto K, Yanagisawa K, Fujita S. SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily, associates preferentially with alpha 5 beta 1 integrin and regulates adhesion of human T cell leukemia virus type 1-infected T cells to fibronectin. J Immunol 1998;161:3087–3095.
   PubMed Web of Science ®Google Scholar
• Sasaki H, Nishikata I, Shiraga T, et al. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood 2005;105:1204–1213.
   PubMed Web of Science ®Google Scholar
• Hasegawa H, Yamada Y, Harasawa H, et al. Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand. Br J Haematol 2005;128:253–265.
   PubMed Web of Science ®Google Scholar
• Yamada Y, Ohmoto Y, Hata T, et al. Features of the cytokines secreted by adult T cell leukemia (ATL) cells. Leuk Lymphoma 1996;21:443–447.
   PubMed Web of Science ®Google Scholar
• Yamada Y, Sugawara K, Hata T, et al. Interleukin-15 (IL-15) can replace the IL-2 signal in IL-2-dependent adult T-cell leukemia (ATL) cell lines: expression of IL-15 receptor alpha on ATL cells. Blood 1998;91:4265–4272.
   PubMed Web of Science ®Google Scholar
• Maeda T, Yamada Y, Moriuchi R, et al. Fas gene mutation in the progression of adult T cell leukemia. J Exp Med 1999;189:1063–1071.
   PubMed Web of Science ®Google Scholar
• Hasegawa H, Yamada Y, Komiyama K, et al. Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells. Blood 2006;107:679–688.
   PubMed Web of Science ®Google Scholar
• Hasegawa H, Yamada Y, Iha H, et al. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells. Leukemia 2009;23:2090–2101.
   PubMed Web of Science ®Google Scholar
• de Cremoux P, Extra JM, Denis MG, et al. Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction. Clin Cancer Res 2000;6:3117–3122.
   PubMed Web of Science ®Google Scholar
• Utsunomiya T, Yonezawa S, Sakamoto H, et al. Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res 1998;4:2605–2614.
   PubMed Web of Science ®Google Scholar
• Price MR, Rye PD, Petrakou E, et al. Summary report on the ISOBM TD-4 Workshop: analysis of 56 monoclonal antibodies against the MUC1 mucin. San Diego, Calif., November 17-23, 1996. Tumour Biol 1998;19(Suppl. 1):1–20.
   PubMed Web of Science ®Google Scholar
• Fattorossi A, Battaglia A, Malinconico P, et al. Constitutive and inducible expression of the epithelial antigen MUC1 (CD227) in human T cells. Exp Cell Res 2002;280:107–118.
   PubMed Web of Science ®Google Scholar
• Rahn JJ, Dabbagh L, Pasdar M, Hugh JC. The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature. Cancer 2001;91:1973–1982.
   PubMed Web of Science ®Google Scholar
• Sagara M, Yonezawa S, Nagata K, et al. Expression of mucin 1 (MUC1) in esophageal squamous-cell carcinoma: its relationship with prognosis. Int J Cancer 1999;84:251–257.
   PubMed Web of Science ®Google Scholar
• Baldus SE, Hanisch FG, Kotlarek GM, et al. Coexpression of MUC1 mucin peptide core and the Thomsen-Friedenreich antigen in colorectal neoplasms. Cancer 1998;82:1019–1027.
   PubMed Web of Science ®Google Scholar
• Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Coexpression of MUC1 glycoprotein with multiple angiogenic factors in non-small cell lung cancer suggests coactivation of angiogenic and migration pathways. Clin Cancer Res 2000;6:1917–1921.
   PubMed Web of Science ®Google Scholar
• Tsutsumida H, Goto M, Kitajima S, Kubota I, Hirotsu Y, Yonezawa S. Combined status of MUC1 mucin and surfactant apoprotein A expression can predict the outcome of patients with small-size lung adenocarcinoma. Histopathology 2004;44:147–155.
   PubMed Web of Science ®Google Scholar
• Ligtenberg MJ, Buijs F, Vos HL, Hilkens J. Suppression of cellular aggregation by high levels of episialin. Cancer Res 1992;52:2318–2324.
   PubMed Web of Science ®Google Scholar
• Ren J, Agata N, Chen D, et al. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell 2004;5:163–175.
   PubMed Web of Science ®Google Scholar
• Treon SP, Mollick JA, Urashima M, et al. Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood 1999;93:1287–1298.
   PubMed Web of Science ®Google Scholar
• Dyomin VG, Palanisamy N, Lloyd KO, et al. MUC1 is activated in a B-cell lymphoma by the t(1;14)(q21;q32;translocation and is rearranged and amplified in B-cell lymphoma subsets. Blood 2000;95:2666–2671.
   PubMed Web of Science ®Google Scholar
• Delsol G, Al Saati T, Gatter KC, et al. Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis. Am J Pathol 1988;130:59–70.
   PubMed Web of Science ®Google Scholar
• Brossart P, Schneider A, Dill P, et al. The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes. Cancer Res 2001;61:6846–6850.
   PubMed Web of Science ®Google Scholar
• Brugger W, Buhring HJ, Grunebach F, et al. Expression of MUC-1 epitopes on normal bone marrow: implications for the detection of micrometastatic tumor cells. J Clin Oncol 1999;17:1535–1544.
   PubMed Web of Science ®Google Scholar
• Dent GA, Civalier CJ, Brecher ME, Bentley SA. MUC1 expression in hematopoietic tissues. Am J Clin Pathol 1999;111:741–747.
   PubMed Web of Science ®Google Scholar
• Rughetti A, Biffoni M, Pierelli L, et al. Regulated expression of MUC1 epithelial antigen in erythropoiesis. Br J Haematol 2003;120:344–352.
   PubMed Web of Science ®Google Scholar
• Correa I, Plunkett T, Vlad A, et al. Form and pattern of MUC1 expression on T cells activated in vivo or in vitro suggests a function in T-cell migration. Immunology 2003;108:32–41.
   PubMed Web of Science ®Google Scholar
• Osaka A, Yanagihara K, Yamada Y, et al. Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications. Tohoku J Exp Med 2009;218:99–105.
   PubMed Web of Science ®Google Scholar
• Theodoropoulos G, Carraway KL. Molecular signaling in the regulation of mucins. J Cell Biochem 2007;102:1103–1116.
   Web of Science ®Google Scholar
• Kam JL, Regimbald LH, Hilgers JH, et al. MUC1 synthetic peptide inhibition of intercellular adhesion molecule-1 and MUC1 binding requires six tandem repeats. Cancer Res 1998;58:5577–5581.
   PubMed Web of Science ®Google Scholar
• McDermott KM, Crocker PR, Harris A, et al. Overexpression of MUC1 reconfigures the binding properties of tumor cells. Int J Cancer 2001;94:783–791.
   PubMed Web of Science ®Google Scholar
• Galiegue-Zouitina S, Delestre L, Dupont C, Troussard, Shelley CS. Underexpression of RhoH in hairy cell leukemia. Cancer Res 2008;68:4531–4540.
   PubMed Web of Science ®Google Scholar
• Li Y, Kuwahara H, Ren J, Wen G, Kufe D. The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J Biol Chem 2001;276:6061–6064.
   PubMed Web of Science ®Google Scholar
• Kufe D. Oncogenic function of the MUC1 receptor subunit in gene regulation. Oncogene 2010;29:5663–5666.
   PubMed Web of Science ®Google Scholar
• Bafna S, Kaur S, Batra SK. Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene 2010;29:2893–2904.
   PubMed Web of Science ®Google Scholar
• Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 2005;7:167–178.
   PubMed Web of Science ®Google Scholar
• Smyth MJ, Takeda K, Hayakawa Y, Peschon JJ, van den Brink MR, Yagita H. Nature's TRAIL–on a path to cancer immunotherapy. Immunity 2003;18:1–6.
   PubMed Web of Science ®Google Scholar