484
Views
50
CrossRef citations to date
0
Altmetric
Research Article

Epstein–Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1

, &
Pages 1586-1591 | Received 24 Nov 2011, Accepted 16 Jan 2012, Published online: 01 Mar 2012

References

  • Weiss LM, Movahed LA, Warnke RA, . Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. N Engl J Med 1989;320:502–506.
  • Kwon JM, Park YH, Kang JH, . The effect of Epstein-Barr virus status on clinical outcome in Hodgkin's lymphoma. Ann Hematol 2006;85:463–468.
  • Fahraeus R, Fu HL, Ernberg I, . Expression of Epstein-Barr virus-encoded proteins in nasopharyngeal carcinoma. Int J Cancer 1988;42:329–338.
  • Shibata D, Weiss LM. Epstein-Barr virus-associated gastric adenocarcinoma. Am J Pathol 1992;140:769–774.
  • Murray PG, Young LS, Rowe M, . Immunohistochemical demonstration of the Epstein-Barr virus-encoded latent membrane protein in paraffin sections of Hodgkin's disease. J Pathol 1992;166:1–5.
  • Peng M, Lundgren E. Transient expression of the Epstein-Barr virus LMP1 gene in human primary B cells induces cellular activation and DNA synthesis. Oncogene 1992;7:1775–1782.
  • Gires O, Zimber-Strobl U, Gonnella R, . Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J 1997;16:6131–6140.
  • Huen DS, Henderson SA, Croom-Carter D, . The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene 1995;10:549–560.
  • Mcfarland EDC, Izumi KM, Mosialos G. Epstein-Barr virus transformation: involvement of latent membrane protein 1-mediated activation of NFkB. Oncogene 1999;19:6959–6964.
  • Park S, Lee J, Ko YH, . The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma. Blood 2007;110:972–978.
  • Kim JH, Kim WS, Park C, . Egr-1, a new downstream molecule of Epstein-Barr virus latent membrane protein 1. FEBS Lett 2007;581:623–628.
  • Kim JH, Kim WS, Park C. SNARK, a novel downstream molecule of EBV latent membrane protein 1, is associated with resistance to cancer cell death. Leuk Lymphoma 2008;49:1392–1398.
  • Bonavida B. Rituximab-induced inhibition of antiapoptotic cell survival pathways: implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions. Oncogene 2007;26:3629–3636.
  • Stolz C, Hess G, Hähnel PS, . Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis. Blood 2008;112:3312–3321.
  • Suzuki E, Umezawa K, Bonavida B. Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis. Oncogene 2007;26:6184–6193.
  • Jazirehi AR, Vega MI, Bonavida B. Development of rituximab-resistant lymphoma clones with altered cell signaling and cross-resistance to chemotherapy. Cancer Res 2007;67:1270–1281.
  • Olejniczak SH, Hernandez-Ilizaliturri FJ, Clements JL, . Acquired resistance to rituxiamb resulting from decreased Bax and Bak expression. Clin Cancer Res 2008;14:1550–1560.
  • Pavan A, Spina M, Canzonieri V, . Recent prognostic factors in duffuse large B-cell lymphoma indicate NF-kappaB pathway as a target for new therapeutic strategies. Leuk Lymphoma 2008;49:2048–2058.
  • Tao YG, Tan YN, Liu YP, . Epstein-Barr virus latent membrane protein 1 modulates epidermal growth factor receptor promoter activity in a nuclear factor kappa B-dependent manner. Cell Signal 2004;16:781–790.
  • Yamanaka Y, Tagawa H, Takahashi N, . Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia. Blood 2009;114:3265–3275.
  • Kluiver J, Haralambieva E, de Jong D, . Lack of BIC and microRNA miR-155 expression in primary cases of Burkitt lymphoma. Genes Chromosomes Cancer 2006;45:147–153.
  • Kluiver J, Poppema S, de Jong D, . BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol 2005;207:243–249.
  • Inomata M, Tagawa H, Guo YM, . MicroRNA-17 - 92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes. Blood 2007;113:396–402.
  • Linnstaedt SD, Gottwein E, Skalsky RL, . Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J Virol 2010;84:11670–11678.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.