References
- De Keersmaecker K, Marynen P, Cools J. Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia. Haematologica 2005;90:1116–1127.
- Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004;350:1535–1548.
- Graux C, Cools J, Michaux L, . Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 2006;20:1496–1510.
- Marks P, Rifkind RA, Richon VM, . Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 2001;1:194–202.
- Yang XJ, Seto E. HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene 2007;26:5310–5318.
- Glozak MA, Sengupta N, Zhang X, . Acetylation and deacetylation of non-histone proteins. Gene 2005;363:15–23.
- Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol 2009;27:5459–5468.
- Di Marcotullio L, Canettieri G, Infante P, . Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer. Biochim Biophys Acta 2011;1815:241–252.
- Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 2010;5:253–295.
- Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr Med Chem 2001;8:1505–1511.
- Kelly WK, O'Connor OA, Marks PA. Histone deacetylase inhibitors: from target to clinical trials. Expert Opin Investig Drugs 2002;11:1695–1713.
- Botrugno OA, Santoro F, Minucci S. Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer. Cancer Lett 2009;280:134–144.
- Prince HM, Bishton MJ, Harrison SJ. Clinical studies of histone deacetylase inhibitors. Clin Cancer Res 2009;15:3958–3969.
- Tsapis M, Lieb M, Manzo F, . HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway. Int J Biochem Cell Biol 2007;39:1500–1509.
- Scuto A, Kirschbaum M, Kowolik C, . The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood 2008;111:5093–5100.
- Sung ES, Kim A, Park JS, . Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells. Apoptosis 2010;15:1256–1269.
- Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, . Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma 2011;52:1544–1555.
- Walston T, Tuskey C, Edgar L, . Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell 2004;7:831–841.
- Nemeth MJ, Bodine DM. Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways. Cell Res 2007;17:746–758.
- Staal FJ, Clevers HC. WNT signalling and haematopoiesis: a WNT-WNT situation. Nat Rev Immunol 2005;5:21–30.
- Ying Y, Tao Q. Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics 2009;4:307–312.
- Tamai K, Semenov M, Kato Y, . LDL-receptor-related proteins in Wnt signal transduction. Nature 2000;407:530–535.
- Pinson KI, Brennan J, Monkley S, . An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 2000;407:535–538.
- Wehrli M, Dougan ST, Caldwell K, . arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 2000;407:527–530.
- Morin PJ, Sparks AB, Korinek V, . Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787–1790.
- Miyaki M, Iijima T, Kimura J, . Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. Cancer Res 1999;59: 4506–4509.
- Wang L, Heidt DG, Lee CJ, . Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Cancer Cell 2009;15:207–219.
- Zeng G, Germinaro M, Micsenyi A, . Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia 2006;8:279–289.
- Bordonaro M, Lazarova DL, Sartorelli AC. The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors. Exp Cell Res 2007;313:1652–1666.
- Lazarova DL, Bordonaro M, Carbone R, . Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate. Int J Cancer 2004;110:523–531.
- Kumagai T, Wakimoto N, Yin D, . Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells. Int J Cancer 2007;121:656–665.
- Chung EJ, Hwang SG, Nguyen P, . Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood 2002;100:982–990.
- Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, . Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia. Leuk Lymphoma 2009;50:2061–2070.
- Griffiths EA, Gore SD, Hooker C, . Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation. Leuk Lymphoma 2010;51:1711–1719.
- Young FM, Phungtamdet W, Sanderson BJ. Modification of MTT assay conditions to examine the cytotoxic effects of amitraz on the human lymphoblastoid cell line, WIL2NS. Toxicol In Vitro 2005;19:1051–1059.
- Teng Y, Wang X, Wang Y, . Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. Biochem Biophys Res Commun 2010;392:373–379.
- Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res 2007;5:981–989.
- Buchwald M, Kramer OH, Heinzel T. HDACi–targets beyond chromatin. Cancer Lett 2009;280:160–167.
- Valencia A, Roman-Gomez J, Cervera J, . Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia 2009;23:1658–1666.
- Romagnolo B, Berrebi D, Saadi-Keddoucci S, . Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin. Cancer Res 1999;59:3875–3879.
- Zeilstra J, Joosten SP, Wensveen FM, . WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer. Biochem Biophys Res Commun 2011;406:1–6.
- Ahmed Y, Hayashi S, Levine A, . Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. Cell 1998;93:1171–1182.
- Kim K, Pang KM, Evans M, . Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell 2000;11:3509–3523.
- Albuquerque C, Breukel C, van der Luijt R, . The “just-right” signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum Mol Genet 2002;11:1549–1560.
- Gaspar C, Fodde R. APC dosage effects in tumorigenesis and stem cell differentiation. Int J Dev Biol 2004;48:377–386.
- Hasegawa S, Sato T, Akazawa H, . Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc Natl Acad Sci USA 2002;99:297–302.
- Wong MH, Huelsken J, Birchmeier W, . Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling. J Biol Chem 2002;277:15843–15850.
- Olmeda D, Castel S, Vilaro S, . Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell 2003;14:2844–2860.
- , Niculescu AB 3rdChen X, Smeets M, . Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998;18:629–643.
- Chou CW, Wu MS, Huang WC, . HDAC inhibition decreases the expression of EGFR in colorectal cancer cells. PLoS One 2011;6:e18087.
- Zacharias N, Sailhamer EA, Li Y, . Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells. Resuscitation 2011;82:105–109.
- Emonds E, Fitzner B, Jaster R. Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells. World J Gastroenterol 2010;16:1970–1978.
- Wang XH, Meng XW, Sun X, . Wnt/beta-catenin signaling regulates MAPK and Akt1 expression and growth of hepatocellular carcinoma cells. Neoplasma 2011;58:239–244.
- Heo JS, Lee JC. β-Catenin mediates cyclic strain-stimulated cardiomyogenesis in mouse embryonic stem cells through ROS-dependent and integrin-mediated PI3K/Akt pathways. J Cell Biochem 2011;112:1880–1889.
- Cajanek L, Adlerz L, Bryja V, . WNT unrelated activities in commercially available preparations of recombinant WNT3a. J Cell Biochem 2010;111:1077–1079.