Monoclonal B-cell lymphocytosis: a reappraisal of its clinical implications

References

• Cheson BD, Bennett JM, Rai KR, . Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group. Am J Hematol 1988;29:152–163.
   PubMed Web of Science ®Google Scholar
• Cheson BD, Bennett JM, Grever M, . National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996;87:4990–4997.
   PubMed Web of Science ®Google Scholar
• Montserrat E, Viñolas N, Reverter JC, . Natural history of chronic lymphocytic leukemia: on the progression and prognosis of early clinical stages. Nouv Rev Fr Hematol 1988;30:359–361.
   PubMedGoogle Scholar
• French Cooperative Group on Chronic Lymphocytic Leukaemia. Natural history of stage A chronic lymphocytic leukaemia in untreated patients. Br J Haematol 1990;76:45–57.
   Web of Science ®Google Scholar
• Molica S. Survival and disease progression studies in early chronic lymphocytic leukemia. Blood 1991;78:895–899.
   PubMed Web of Science ®Google Scholar
• Ghia P, Prato G, Scielzo C, . Monoclonal CD5 + and CD5− B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 2004;103:2337–2342.
   PubMed Web of Science ®Google Scholar
• Rawstron A, Green M, Kuzmicki A, . Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 2002;100:635–639.
   PubMed Web of Science ®Google Scholar
• Marti GE, Rawstron AC, Ghia P, . Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 2005;130:325–332.
   PubMed Web of Science ®Google Scholar
• Dagklis A, Fazi C, Sala C, . The immunoglobulin gene repertoire of population CLL-like MBL is different from CLL: diagnostic implications for clinical monitoring. Blood 2009;114:26–32.
   PubMed Web of Science ®Google Scholar
• Nieto WG, Almeida J, Romero A, . Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood 2009;114:33–37.
   PubMed Web of Science ®Google Scholar
• Scarfò L, Dagklis A, Scielzo C, . CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it? Semin Cancer Biol 2010;20:384–390.
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Shanafelt T, Lanasa MC, . Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL). Cytometry B Clin Cytom 2010;78(Suppl. 1):S19–S23.
   PubMed Web of Science ®Google Scholar
• Rawstron AC, Bennett FL, O'Connor SJ, . Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med 2008;359:575–583.
   PubMed Web of Science ®Google Scholar
• Shanafelt TD, Kay NE, Jenkins G, . B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome. Blood 2009;113: 4188–4196.
   PubMed Web of Science ®Google Scholar
• Shanafelt TD, Kay NE, Rabe KG, . Natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol 2009;27:3959–3963.
   PubMed Web of Science ®Google Scholar
• Rossi D, Sozzi E, Puma A, . The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol 2009;146:64–75.
   PubMed Web of Science ®Google Scholar
• Molica S, Mauro FR, Giannarelli D, . Differentiating chronic lymphocytic leukemia from monoclonal B-lymphocytosis according to clinical outcome: on behalf of the GIMEMA chronic lymphoproliferative diseases working group. Haematologica 2011;96: 277–283.
   PubMed Web of Science ®Google Scholar
• Marti GE, Faguet GB, Stewart C, . Evolution of leukemic heterogeneity of human B-CLL lymphocytes between and within patients. Curr Top Microbiol Immunol 1992;182:303–311.
   PubMedGoogle Scholar
• Marti GE, Faguet G, Bertin P, . CD20 and CD5 expression in B-chronic lymphocytic leukemia (B-CLL). Ann NY Acad Sci 1992;651: 480–483.
   PubMed Web of Science ®Google Scholar
• Batata A, Shen B. Chronic lymphocytic leukemia with low lymphocyte count. Cancer 1993;71:2732–2738.
   PubMed Web of Science ®Google Scholar
• Byrd JC. Clonal lymphocytosis of unknown significance (CLUS): what clues will CLUS yield? Blood 2002;100(Suppl. 1): Abstract 2777.
   Google Scholar
• Wang C, Amato D, Rabah R, . Differentiation of monoclonal B lymphocytosis of undetermined significance (MLUS) and chronic lymphocytic leukemia (CLL) with weak CD5 expression from CD5(-) CLL. Leuk Res 2002;26:1125–1129.
   PubMed Web of Science ®Google Scholar
• Hallek M, Cheson BD, Catovsky D, .; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer Institute-Working Group (NCI-WG) 1996 guidelines. Blood 2008;111:5446–5456.
   PubMed Web of Science ®Google Scholar
• Hanson CA, Kurtin PJ, Dogan A. The proposed diagnostic criteria change for chronic lymphocytic leukemia: unintended consequences? Blood 2009;113:6495–6496.
   PubMed Web of Science ®Google Scholar
• Molica S, Gentile M, Mauro FR, . An increased number of individuals with clinically recognized monoclonal B-cell lymphocytosis (MBL) characterizes a recent database of chronic lymphocytic leukemia (CLL) Rai stage 0. Acta Haematol 2012;127:149–151.
   PubMed Web of Science ®Google Scholar
• Shanafelt TD, Ghia P, Lanasa MC, . Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia 2010;24:512–520.
   PubMed Web of Science ®Google Scholar
• Lanasa MC, Allgood SD, Slager SL, . Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL. Leukemia 2011;25:1459–1466.
   PubMed Web of Science ®Google Scholar
• Gibson SE, Swerdlow SH, Ferry JA, . Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis. Haematologica 2011;96:1144–1152.
   PubMed Web of Science ®Google Scholar
• Ghia P. Another piece of the puzzle: is there a “nodal” monoclonal B-cell lymphocytosis? Haematologica 2011;96:1144–1152.
   PubMed Web of Science ®Google Scholar
• Molica S, Reverter JC, Alberti A, . Timing of diagnosis and lymphocyte accumulation patterns in chronic lymphocytic leukemia: analysis of their clinical significance. Eur J Haematol 1990;44: 277–281.
   PubMed Web of Science ®Google Scholar
• Landgren O, Albitar M, Ma W, . B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med 2009;360:659–667.
   PubMed Web of Science ®Google Scholar
• Molica S, Fabris S, Cutrona G, . Differentiation on biological basis of monoclonal B-cell lymphocytosis (MBL) from chronic lymphocytic leukemia (CLL): results of a prospective GISL (Gruppo Italiano Studio Linfomi) trial. Blood 2010;116(Suppl. 1): Abstract 1360.
   Google Scholar
• Matos DM, Ismael SJ, Scrideli CA, . Monoclonal B-cell lymphocytosis in first-degree chronic lymphocytic leukaemia. Br J Haematol 2009;147:339–346.
   PubMed Web of Science ®Google Scholar
• Fazi C, Scarfò L, Pecciarini L, . General population low-count CLL-like MBL persists over time without clinical progression, though carrying the same cytogenetic abnormalities of CLL. Blood 2011;118:6618–6625.
   PubMed Web of Science ®Google Scholar
• Molica S. Quality of life in chronic lymphocytic leukemia: a neglected issue. Leuk Lymphoma 2005;46:1709–1714.
   PubMed Web of Science ®Google Scholar
• Levin TT, Li Y, Riskind J, . Depression, anxiety and quality of life in a chronic lymphocytic leukemia cohort. Gen Hosp Psychiatry 2007;29:251–256.
   PubMed Web of Science ®Google Scholar
• Rabe K, Cerhan JR, Hanson CA, . Infectious complications among individuals with monoclonal B-cell lymphocytosis (MBL): a prospective case-control study of newly diagnosed patients. Blood 2011;118(Suppl. 1): Abstract 3903.
   Google Scholar
• Rawstron AC, Yuille MR, Fuller J, . Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood 2002;100:2289–2290.
   PubMed Web of Science ®Google Scholar
• Del Giudice I, Mauro FR, De Propris MS, . Identification of monoclonal B-cell lymphocytosis among sibling transplant donors for chronic lymphocytic leukemia patients. Blood 2009;114:2848–2849.
   PubMed Web of Science ®Google Scholar