Expression levels of Lyn, Syk, PLCγ2 and ERK in patients with chronic lymphocytic leukemia, and higher levels of Lyn are associated with a shorter treatment-free survival

References

• Caligaris-Cappio F, Hamblin TJ. B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol 1999;17:399–408.
   PubMed Web of Science ®Google Scholar
• Gentile M, Mauro FR, Guarini A, et al. New developments in the diagnosis, prognosis and treatment of chronic lymphocytic leukemia. Curr Opin Oncol 2005;17:597–604.
   PubMed Web of Science ®Google Scholar
• Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848–1854.
   PubMed Web of Science ®Google Scholar
• Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001;194:1639–1647.
   PubMed Web of Science ®Google Scholar
• Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003;348:1764–1775.
   PubMed Web of Science ®Google Scholar
• Orchard JA, Ibbotson RE, Davis Z, et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 2004;363: 105–111.
   PubMed Web of Science ®Google Scholar
• Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004;351:893–901.
   PubMed Web of Science ®Google Scholar
• Rodriguez A, Villuendas R, Yanez L, et al. Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: clinical correlation. Leukemia 2007;21:1984–1991.
   PubMed Web of Science ®Google Scholar
• Dal Porto JM, Gauld SB, Merrell KT, et al. B cell antigen receptor signaling 101. Mol Immunol 2004;41:599–613.
   PubMed Web of Science ®Google Scholar
• Kong GH, Bu JY, Kurosaki T, et al. Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase. Immunity 1995;2:485–492.
   PubMed Web of Science ®Google Scholar
• Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996;87:4990–4997.
   PubMed Web of Science ®Google Scholar
• Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981;48:198–206.
   PubMed Web of Science ®Google Scholar
• Xu W, Li JY, Wu YJ, et al. CD38 as a prognostic factor in Chinese patients with chronic lymphocytic leukaemia. Leuk Res 2009;33: 237–243.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhang Y, Zheng W, et al. Distinctive IgVH gene segments usage and mutation status in Chinese patients with chronic lymphocytic leukemia. Leuk Res 2008;32:1491–1498.
   PubMed Web of Science ®Google Scholar
• Qiu HX, Xu W, Cao XS, et al. Cytogenetic characterisation in Chinese patients with chronic lymphocytic leukemia: a prospective, multicenter study on 143 cases analysed with interphase fluorescence in situ hybridisation. Leuk Lymphoma 2008;49:1887–1892.
   PubMed Web of Science ®Google Scholar
• Xu W, Cao X, Miao KR, et al. Serum thymidine kinase 1 concentration in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors. Int J Hematol 2009;90:205–211.
   PubMed Web of Science ®Google Scholar
• Wang YH, Zou ZJ, Liu L, et al. Quantification of ZAP-70 mRNA by real-time PCR is a prognostic factor in chronic lymphocytic leukemia. J Cancer Res Clin Oncol 2012;138:1011–1017.
   PubMed Web of Science ®Google Scholar
• Keshvara LM, Isaacson CC, Yankee TM, et al. Syk- and Lyn- dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol 1998;161:5276–5283.
   PubMed Web of Science ®Google Scholar
• Campbell KS. Signal transduction from the B cell antigen-receptor. Curr Opin Immunol 1999;11:256–264.
   PubMed Web of Science ®Google Scholar
• Chen L, Widhopf G, Huynh L, et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002;100:4609–4614.
   PubMed Web of Science ®Google Scholar
• Chen L, Apgar J, Huynh L, et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 2005;105: 2036–2041.
   PubMed Web of Science ®Google Scholar
• Gobessi S, Laurenti L, Longo PG, et al. ZAP-70 enhances B- cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. Blood 2007;109:2032–2039.
   PubMed Web of Science ®Google Scholar
• Chen L, Huynh L, Apgar J, et al. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 2008;111:2685–2692.
   PubMed Web of Science ®Google Scholar
• Magnac C, Porcher R, Davi F, et al. Predictive value of serum thymidine kinase level for Ig-V mutational status in B-CLL. Leukemia 2003;17:133–137.
   PubMed Web of Science ®Google Scholar
• Kheirallah S, Caron P, Gross E, et al. Rituximab inhibits B-cell receptor signaling. Blood 2010;115:985–994.
   PubMed Web of Science ®Google Scholar
• Contri A, Brunati AM, Trentin L, et al. Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest 2005;115:369–378.
   PubMed Web of Science ®Google Scholar
• Young RM, Hardy IR, Clarke RL, et al. Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target. Blood 2009;113:2508–2516.
   PubMed Web of Science ®Google Scholar
• Hussein K, von Neuhoff N, Büsche G, et al. Opposite expression pattern of Src kinase Lyn in acute and chronic haematological malignancies. Ann Hematol 2009;88:1059–1067.
   PubMed Web of Science ®Google Scholar