NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFκB and JNK

References

• Melnick A, Licht JD. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 1999;93:3167–3215.
   PubMed Web of Science ®Google Scholar
• Chen Z, Brand NJ, Chen A, et al. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 1993;12:1161–1167.
   PubMed Web of Science ®Google Scholar
• Redner RL, Rush EA, Faas S, et al. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood 1996;87:882–886.
   PubMed Web of Science ®Google Scholar
• Wells RA, Catzavelos C, Kamel-Reid S. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Nat Genet 1997;17:109–113.
   PubMed Web of Science ®Google Scholar
• Arnould C, Philippe C, Bourdon V, et al. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. Hum Mol Genet 1999;8:1741–1749.
   PubMed Web of Science ®Google Scholar
• Catalano A, Dawson MA, Somana K, et al. The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. Blood 2007;110:4073–4076.
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Tsuzuki S, Tsuzuki M, et al. BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia. Blood 2010;116:4274–4283.
   PubMed Web of Science ®Google Scholar
• Kondo T, Mori A, Darmanin S, et al. The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia. Haematologica 2008;93:1414–1416.
   PubMed Web of Science ®Google Scholar
• Won D, Shin SY, Park CJ, et al. OBFC2A/RARA: a novel fusion gene in variant acute promyelocytic leukemia. Blood 2013;121:1432–1435.
   PubMed Web of Science ®Google Scholar
• Chen Y, Li S, Zhou C, et al. TBLR1 fuses to retinoid acid receptor alpha in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia. Blood 2014;124:936–945.
   PubMed Web of Science ®Google Scholar
• Redner RL, Corey SJ, Rush EA. Differentiation of t(5;17) variant acute promyelocytic leukemic blasts by all-trans retinoic acid. Leukemia 1997;11:1014–1016.
   PubMed Web of Science ®Google Scholar
• Du C, Redner RL, Cooke MP, et al. Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes. Blood 1999; 94:793–802.
   PubMed Web of Science ®Google Scholar
• Rego EM, Ruggero D, Tribioli C, et al. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene 2006;25:1974–1979.
   PubMed Web of Science ®Google Scholar
• Rush EA, Schlesinger KW, Watkins SC, et al. The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML. Leuk Res 2006;30:979–986.
   PubMed Web of Science ®Google Scholar
• Redner RL, Chen JD, Rush EA, et al. The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties. Blood 2000;95: 2683–2690.
   PubMed Web of Science ®Google Scholar
• Chattopadhyay A, Hood BL, Conrads TP, et al. Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD. Mol Cancer Res 2014;12:1283–1291.
   PubMed Web of Science ®Google Scholar
• Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ 2003;10:45–65.
   PubMed Web of Science ®Google Scholar
• Rush EA, Pollock SL, Abecassis I, et al. Interaction with RXR is necessary for NPM-RAR-induced myeloid differentiation blockade. Leuk Res 2013;37:1704–1710.
   PubMed Web of Science ®Google Scholar
• Wajant H, Scheurich P. TNFR1-induced activation of the classical NF-kappaB pathway. FEBS J 2011;278:862–876.
   PubMed Web of Science ®Google Scholar
• Delhalle S, Deregowski V, Benoit V, et al. NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis. Oncogene 2002;21:3917–3924.
   PubMed Web of Science ®Google Scholar
• Dhar SK, Lynn BC, Daosukho C, et al. Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene. J Biol Chem 2004;279:28209–28219.
   PubMed Web of Science ®Google Scholar
• Kretzschmar M, Meisterernst M, Scheidereit C, et al. Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitro. Genes Dev 1992;6:761–774.
   PubMed Web of Science ®Google Scholar
• Bender LM, Morgan MJ, Thomas LR, et al. The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ 2005;12:473–481.
   PubMed Web of Science ®Google Scholar
• Morgan M, Thorburn J, Pandolfi PP, et al. Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. J Cell Biol 2002;157:975–984.
   PubMed Web of Science ®Google Scholar
• Gilmore TD. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 2006;25:6680–6684.
   PubMed Web of Science ®Google Scholar
• Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009;9: 537–549.
   PubMed Web of Science ®Google Scholar
• Hartman AD, Wilson-Weekes A, Suvannasankha A, et al. Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation. Exp Hematol 2006;34:1360–1376.
   PubMed Web of Science ®Google Scholar
• Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003;114:181–190.
   PubMed Web of Science ®Google Scholar
• Kieser A. Pursuing different “TRADDes”: TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1. Biol Chem 2008;389:1261–1271.
   PubMed Web of Science ®Google Scholar
• Schneider F, Neugebauer J, Griese J, et al. The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity. PLoS Biol 2008;6:e8.
   PubMed Web of Science ®Google Scholar
• Chio II, Sasaki M, Ghazarian D, et al. TRADD contributes to tumour suppression by regulating ULF-dependent p19(Arf) ubiquitylation. Nat Cell Biol 2012;14:625–633.
   PubMed Web of Science ®Google Scholar