CD5 Negative IGM Rheumatoid Factor B Cells in B-Chronic Lymphocytic Leukemia and Benign Mixed Cryoglobulinemia

References

• Carson D. A., Chen P. P., Fox R. I., Kipps T. J., Jirik F., Goldfien R. D., Silverman G., Radoux V., Fong S. Rheumatoid factors and immune networks. Annual Revue of Immunology 1987; 5: 109–126
   PubMed Web of Science ®Google Scholar
• Carson D. A., Chen P. P., Kipps T. J. New roles for rheumatoid factor. Journal of Clinical Investigation 1991; 87: 379–383
   PubMed Web of Science ®Google Scholar
• Casali P., Notkins A. L. CD5+ B lymphocytes, polyreactive antibodies and the human B-cell repertoire. Immunology Today 1989; 10: 364–368
   PubMedGoogle Scholar
• Waikenburg H. A., Ball J., Burch T. A., Bennett P. H., Lawrence J. S. Rheumatoid factors in a rural population. Annals of Rheumatologic Diseases 1966; 25: 497–502
   PubMed Web of Science ®Google Scholar
• Metzger H. Myeloma proteins and antibodies. American Journal of Medicine 1969; 47: 837–844
   PubMed Web of Science ®Google Scholar
• Kipps T. J., Tomhave E., Pratt L. F., Duffy S., Chen P. P., Carson D. A. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences USA 1989; 86: 5913–5919
   PubMed Web of Science ®Google Scholar
• Kipps T. J., Fong S., Tomhave E., Chen P. P., Goldfien R. D., Carson D. A. High frequency expression of a conserved kappa light chain variable region gene in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences USA 1987; 84: 2916–2920
   PubMed Web of Science ®Google Scholar
• Kipps T. J., Tomhave E., Chen P. P., Carson D. A. Autoantibody-associated K light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Journal of Experimental Medicine 1988; 167: 840–852
   PubMed Web of Science ®Google Scholar
• Shtoeger Z. W., Wakai M., Tse D., Vinciguerra V. P., Allen S. L., Budman D. R., Lichtman S. T., Schulman P., Weiselberg L. R., Chiorazzi N. Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia. Journal of Experimental Medicine 1989; 169: 255–268
   PubMed Web of Science ®Google Scholar
• Borche L., Lim A., Binet J. L., Dighiero G. Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies. Blood 1990; 76: 562–569
   PubMed Web of Science ®Google Scholar
• Pasquali J. L., Waltzinger C., Kuntz J. L., Knapp A. M., Levallois H. The majority of peripheral blood monoclonal IgM rheumatoid factor secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. Blood 1991; 77: 1761–1765
   PubMed Web of Science ®Google Scholar
• Pascual V., Capra J. D. Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Advances in Immunology 1991; 49: 1–74
   PubMed Web of Science ®Google Scholar
• Lorenz W., Straubinger B., Zachau H. G. Physical map of the human immunoglobulin K locus and its implications for the mechanisms of VK-JK rearrangement. Nucleic Acids Research 1987; 15: 9667–9677
   PubMed Web of Science ®Google Scholar
• Vasicek T. J., Leder P. Structure and expression of the human immunoglobulin genes. Journal of Experimental Medicine 1990; 172: 6509–620
   Web of Science ®Google Scholar
• Tonegawa S. Somatic generation of antibodies diversity. Nature 1983; 302: 575–581
   PubMed Web of Science ®Google Scholar
• Andrews D. W., Capra J. D. Amino acid sequence of the variable regions of light chains from two idiotypically cross-reactive human IgM anti-y globulins of the Wa group. Biochemistry 1981; 20: 5816–5822
   PubMed Web of Science ®Google Scholar
• Kunkel H. G., Agnello V., Joslin F. G., Winchester R. J., Capra J. D. Cross-idiotypic specificity among monoclonal IgM proteins with anti-gamma globulin activity. Journal of Experimental Medicine 1973; 137: 331–342
   PubMed Web of Science ®Google Scholar
• Andrews D. W., Capra J. D. Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: Suggestion that the J segments are involved in the structural correlate of the idiotype. Proceedings of the National Academy of Sciences USA 1981; 78: 3799–3803
   PubMed Web of Science ®Google Scholar
• Chen P. P., Albrandt K., Orida N. K., Radoux V., Chen E. W., Schrantz R., Liu F. T., Carson D. A. Genetic basis for the cross reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies. Proceedings of the National Academy of Sciences USA 1986; 83: 8318–8322
   PubMed Web of Science ®Google Scholar
• Newkirk M. M., Gram H., Heinrich G. F., Ostberg L., Capra J. D., Wasserman R. L. Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-Cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family. Journal of Clinical Investigation 1988; 81: 1511–1518
   PubMed Web of Science ®Google Scholar
• Silverman G., Schrohenloher R. E., Accavitti M. A., Koopman W. J., Carson D. A. Structural characterization of the second major cross reactive idiotype group of human rheumatoid factors. Arthritis and Rheumatism 1990; 33: 1347–1360
   PubMed Web of Science ®Google Scholar
• Goni F., Chen P. P., Pons-Estel B., Carson D. A., Frangione B. Sequence similarities and cross- idiotypic specificity of L chains among human monoclonal IgM-K with anti-gamma globulin activity. Journal of Immunology 1985; 135: 4073–4079
   PubMed Web of Science ®Google Scholar
• Pasquali J. L., Urliacher A., Stork D. A highly conserved determinant on human rheumatoid factor idiotypes defined by a mouse monoclonal antibody. European Journal of Immunology 1983; 13: 197–201
   PubMed Web of Science ®Google Scholar
• Schroeder H. W., Jr, Hillson J. L., Perlmutter R. M. Early restriction of the human antibody repertoire. Science 1987; 238: 791–793
   PubMed Web of Science ®Google Scholar
• Kipps T. J., Robbins B. A., Carson D. A. Uniform high frequency expression of autoantibody associated cross-reactive-idiotypes in the primary follicles of human fetal spleen. Journal of Experimental Medicine 1990; 171: 189–196
   PubMed Web of Science ®Google Scholar
• Harris E. D., Jr. Rheumatoid arthritis. Pathophysiology and implications for therapy. New England Journal of Medicine 1990; 322: 1277–1289
   PubMed Web of Science ®Google Scholar
• Blaison G., Kuntz J. L., Pasquali J. L. Molecular analysis of VkIII variable regions of polyclonal rheumatoid factors during rheumatoid arthritis. European Journal of Immunology 1991; 21: 1221–1227
   PubMed Web of Science ®Google Scholar
• Pascual V., Randen I., Thompson K., Sould M., Forre C., Natvig J. B., Capra J. D. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from EBV transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis: further evidence that some autoantibodies are unmutated copies of germline genes. Journal of Clinical Investigation 1990; 86: 1320–1328
   PubMed Web of Science ®Google Scholar
• Martin T., Knapp A. M., Muller S., Pasquali J. L. Polyclonal human rheumatoid factors cross-reacting with histone H3: Characterization of an idiotype on the H3 binding site. Journal of Clinical Immunology 1990; 10: 211–219
   PubMed Web of Science ®Google Scholar
• Pasquali J. L., Azerad G., Martin T., Muller S. The double reactivity of a human monoclonal rheumatoid factor to IgG and histone is related to distinct binding sites. European Journal of Immunology 1988; 18: 1127–1130
   PubMed Web of Science ®Google Scholar
• Hirohata S., Tetsufumi I., Miyamoto T. Frequency analysis of human peripheral blood B cells producing IgM-rheumatoid factors. Journal of Immunology 1990; 145: 1681–1686
   PubMed Web of Science ®Google Scholar
• Roosnek E., Lanzavecchia A. Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells. Journal of Experimental Medicine 1991; 173: 487–489
   PubMed Web of Science ®Google Scholar
• Pratt L. F., Rassenti L., Larrick J., Robbins B., Banks P. M., Kipps T. J. Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermuta-tion. Journal of Immunology 1988; 143: 699–705
   Web of Science ®Google Scholar
• Kipps T. J., Robbins B. A., Kuster P., Carson D. A. Autoantibody associated cross-reactive idiotypes expressed at high frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of follicular center cell origin. Blood 1988; 72: 422–432
   PubMed Web of Science ®Google Scholar
• Fong S., Gilbertson T. A., Hueniken R. J., Singhal S. K., Vaughan J. H., Carson D. A. IgM rheumatoid factor autoantibody and immunoglobulin producing precursor cells in the bone marrow of humans. Cellular Immunology 1985; 95: 157–172
   PubMed Web of Science ®Google Scholar
• Kipps T. J. The CD5 B cell. Advances in Immunology 1989; 47: 117–185
   PubMed Web of Science ®Google Scholar
• San Miguel J. F., Caballero M. D., Gonzales M., Zola H., Lopez Borrasca A. L. Immunological phenotype of neoplasms involving the B cell in the last step of differentiation. British Journal of Haematology 1986; 62: 75–83
   PubMed Web of Science ®Google Scholar
• Spier C. M., Grogan T. M., Fielder K., Richter L., Rangel C. Immunophenotypes in “well differentiated” lympho-proliferative disorders, with emphasis on small lymphocytic lymphoma. Human Pathology 1986; 17: 1126–1136
   PubMed Web of Science ®Google Scholar
• Herzenberg L. A., Stall A. M., Lalor P. A., Sidman C., Moore W. A., Parks D. R. The LY-1 B cell lineage. Immunological Reviews 1986; 93: 81–102
   PubMed Web of Science ®Google Scholar
• Hayakawa K., Hardy R. R., Herzenberg L. A. Progenitors for Ly-1 B cells are distinct from progenitors from other B cells. Journal of Experimental Medicine 1985; 161: 1554–1566
   PubMed Web of Science ®Google Scholar
• Kipps T. J., Duffy S. F. Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes. Journal of Clinical Investigation 1991; 87, (In Press)
   Web of Science ®Google Scholar
• Hayakawa K., Hardy R. R., Honda M., Herzenberg L. A., Steinberg A. D. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proceedings of the National Academy of Sciences USA 1984; 81: 2494–2498
   PubMed Web of Science ®Google Scholar
• Casali P., Burastero S. E., Nakamura M., Inghirami G., Notkins A. L. Human lymphocytes making rheumatoid factor belong to Leu-1 B cell subset. Science 1987; 236: 77–81
   PubMed Web of Science ®Google Scholar
• Dighiero G., Lymberi P., Holmberg D., Lundquist I., Coutinho A., Avrameas S. High frequency of natural autoantibodies in normal newborn mice. Journal of Immunology 1985; 134: 765–771
   PubMed Web of Science ®Google Scholar
• Stall A. M., Farinas M. C., Tarlinton D. M., Lalor P. A., Herzenberg L. A., Strober S. Ly-1 B-cell clones similar to human chronic lymphocytic leukemia routinely develop in older normal mice and young autoimmune Zealand black-related animals. Proceedings of the National Academy of Sciences USA 1988; 85: 7312–7318
   PubMed Web of Science ®Google Scholar
• Lanier B. L., Warner N. L., Ledbetter J. A., Herzenberg L. A. Expression, of Ly-1 antigen on certain murine B cell lymphomas. Journal of Experimental Medicine 1981; 153: 998–1003
   PubMed Web of Science ®Google Scholar
• Davidsohn A., Manheimer-Lory A., Aranow C., Peterson C., Hannigan N., Diamond B. Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosous-related idiotypes. Journal of Clinical Investigation 1990; 85: 1401–1409
   PubMed Web of Science ®Google Scholar
• Van Es J. H., Gmelig Meyling F. H. J., Van de Akker W. R. M., Aanstoot H., Derksen R. H. W.M., Logtenberg T. Somatic mutations in the variable regions of a human IgG anti-double- standed DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosous. Journal of Experimental Medicine 1991; 173: 461–470
   PubMed Web of Science ®Google Scholar
• Sherr D. H., Dorf M. E., Gibson M., Sidman C. L. Ly-1 B helper cells in autoimmune “viable motheaten” mice. Journal of Immunology 1987; 139: 1811–1817
   PubMed Web of Science ®Google Scholar
• Van de Velde H., Von Hoegen I., Luo W., Parnes J., Thielemans K. The B-cell surface protein CD72/Ly-2b is the ligand for CDS. Nature 1991; 351: 662–665
   PubMed Web of Science ®Google Scholar
• Newkirk M. M., Mageed R. A., Jefferis R., Chen P. P., Capra J. D. Complete aminoacid sequences of variable regions of two human IgM rheumatoid factors BOR and KAS of the Wa idiotypic family reveal restricted use of heavy and light chain variable and joining region gene segments. Journal of Immunology 1987; 166: 550–564
   Google Scholar
• Pons-Estel B., Goni F., Solomon A., Frangione B. Sequences similarities among kIIIb chains of monoclonal human IgMk autoantibodies. Journal of Experimental Medicine 1984; 160: 893–904
   PubMed Web of Science ®Google Scholar
• Berek C., Milstein C. The dynamic nature of the antibody repertoire. Immunological Reviews 1988; 105: 5–26
   PubMed Web of Science ®Google Scholar
• Perl A., Wang N., Williams J. M., Hunt M. J., Rosenfield S. I., Condemi J. J., Packman C. H., Abraham G. N. Aberrant immunoglobulin and c myc gene rearrangements in patients with non malignant monoclonal cryoglobulinemia. Journal of Immunology 1987; 139: 3512–3519
   PubMed Web of Science ®Google Scholar
• Sanz I., Casali P., Thomas J. W., Notkins A. L., Capra J. D. Nucleotide sequences of eight human natural autoantibodies VH regions reveals apparent restricted use of VH families. Journal of Immunology 1989; 142: 4054–4061
   PubMed Web of Science ®Google Scholar
• Dighiero G., Hart S., Lim A., Borche L., Levy R., Miller R. A. Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomas. Blood 1991; 78: 581–585
   PubMed Web of Science ®Google Scholar
• Gorevic P. D., Kassab H. J., Levo Y., Kohn R., Meltzer M., Prose P., Franklin E. C. Mixed cryoglobulinemia: clinical aspects and long term follow-up of 40 patients. American Journal of Medicine 1980; 69: 287–308
   PubMed Web of Science ®Google Scholar
• Pasquali J. L., Martin T., Knapp A. M., Levallois H., Farradji A. Monoclonal rheumatoid factor secreting cells in a patient with mixed cryoglobulinemia. Homogeneity and stability of the idiotypic production and in vitro idiotypic supression. Journal of Immunology 1989; 143: 1826–1831
   PubMed Web of Science ®Google Scholar
• Gu H., Förster I., Rajewsky K. Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenic timing of Ly-1 B cell and B-CLL progenitor generation. European Journal of Molecular Biology 1990; 9: 2133–2140
   PubMed Web of Science ®Google Scholar
• Caligaris-Cappio F., Riva M., Tesio L., Schena M., Gaidano G., Bergui L. Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features. Blood 1989; 73: 259–1263
   Google Scholar