Acute Megakaryoblastic Leukemia in Children and Adolescents: A Retrospective Analysis of 24 Cases

References

• Von Boros J., Korényi A. Über einen fall von akuter megakaryoblastenleukämie, zugleich einige bemerkun-gen zum problem des akuten leukämie. Z. Klin. Med. 1931; 118: 681–718
   Google Scholar
• Bennett J. M., Catovsky D., Daniel M.-T., Flandrin G., Galton D. A., Gralnick H. R., Sultan C. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7): a report of the French-American-British Cooperative Group. Ann. Intern. Med. 1985; 103: 460–462
   PubMed Web of Science ®Google Scholar
• Chan B. W. B., Flemans R. J., Zbinden G. Acute leukemia with megakaryocytic predominance. Cancer. 1971; 28: 1343–1349
   PubMed Web of Science ®Google Scholar
• Den Ottolander G. J., Velde J., Brederoo P., Geraedts J. P. M., Slee P. H. T., Willemze R., Zwaan F. E., Haak H. L., Muller H. P., Bieger R. Megakaryoblas-tic leukaemia (acute myelofibrosis): a report of three cases. Br. J. Haematol. 1979; 42: 9–20
   PubMed Web of Science ®Google Scholar
• Bevan D., Rose M., Greaves M. Leukaemia of platelet precursors: diverse features in four cases. Br. J. Haematol. 1982; 51: 147–164
   PubMed Web of Science ®Google Scholar
• Huang M.-J., Li C. Y., Nichols W. L., Young J.-H., Katzmann I. A. Acute leukemia with megakaryocytic differentiation: a study of 12 cases identified immunocyto-chemically. Blood 1984; 64: 427–439
   PubMed Web of Science ®Google Scholar
• San Miguel J. F., Gonzalea M., Canizo M. C., Ojeda E., Orfao A., Caballero M. D., Moro M. J., Fisac P., Borrasca A. L. Leukemias with megakaryoblastic involvement: clinical, hematologiC., and immunologic characteristics. Blood 1988; 72: 402–407
   PubMed Web of Science ®Google Scholar
• Ruiz-Arguelles G. J., Marin-Lopez A., Lobato-Mendizabal E., Kuiz-Arguelles A., Nichols W. L., Katzman J. A. Acute megakaryoblastic leukaemia: a prospective study of its identification and treatment. Br. J. Haematol. 1986; 62: 55–63
   PubMed Web of Science ®Google Scholar
• Breton-Gorius J., Reyes F., Duhamel G., Majman A., Gorin N. C. Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet per-oxidase. Blood 1978; 51: 45–59
   PubMed Web of Science ®Google Scholar
• Williams D. L., Harris A., Williams K. J., Brosius M. J., Lemonds W. A direct bone marrow chromosome technique for acute lymphoblastic leukemia. Cancer Genet. Cytogenet. 1984; 13: 239–257
   PubMed Web of Science ®Google Scholar
• Testa J. R., Misawa S., Oguma N., Van Sloten K., Wiernik P. H. Chromosomal alterations in acute leukemia patients. Studies with improved culture methods. Cancer Res. 1985; 45: 430–434
   PubMed Web of Science ®Google Scholar
• ISCN. An international system for human cytogenetic nomenclature, D. G. Harnden, H. P. Klinger. Basel); also in Birth Defects: Original Articles Series, March of Dimes Birth Defects Foundation, New York 1985; Vol. 21, published in collaboration with Cytogenet Cell Genet (Karger, no. 1, 1985
   Google Scholar
• Carroll A., Civin C., Schneider N., Dahl G., Pappo A., Bowman P., Emami A., Gross S., Alvarado C., Phillips C., Krischer J., Crist W., Head D., Gresik M., Ravin-dranath Y., Weinstein H. The t(1;22)(p133) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a pediatric oncology group study. Blood 1991; 78: 748–752
   PubMed Web of Science ®Google Scholar
• Argyle J. C., Benjamin D. R., Lampkin B., Hammond D. Acute nonlymphocytic leukemias of childhood: inter-observer variability and problems in the use of the FAB classification. Cancer. 1989; 63: 295–301
   PubMed Web of Science ®Google Scholar
• Hirt A., Luethy A. R., Mueller B., Gugler E., Wagner H. P. Acute megakaryoblastic leukemia in children identified by immunological marker studies. Am. J. Pe-diat. Hematol. Oncol. 1990; 12: 27–33
   PubMedGoogle Scholar
• Windebank K. P., Tefferi A., Smithson W. A., Li C.-Y., Solberg L. A., Priest J. R., Elliott S. C., de Alarcon P. A., Weinblastt M. E., Burgert E. O., Jr. Acute megakaryocytic leukemia (M7) in children. Mayo. Clin. Proc. 1989; 64: 1339–1351
   PubMed Web of Science ®Google Scholar
• Chan W. C., Brynes R. K., Kim T. H., Verras A., Schick C., Green R. J., Ragab A. H. Acute megakaryoblastic leukemia in early childhood. Blood 1983; 62: 92–98
   PubMed Web of Science ®Google Scholar
• Cairney A. E. L., McKenna R., Arthur D. C., Nesbit M. E., Jr., Woods W. G. Acute megakaryoblastic leukemia in children. Br. J. Haematol. 1986; 63: 541–554
   PubMed Web of Science ®Google Scholar
• Sariban E., Oliver C., Corash L., Cossman J., Whang-Peng J., Jaffe E. S., Gralnich H. R., Poplack D. G. Acute megakaryoblastic leukemia in childhood. Cancer. 1984; 54: 1423–1428
   PubMed Web of Science ®Google Scholar
• Slava I., Urban C., Haas O. A., Mroisel P. M., Koller U. Acute megakaryocytic leukemia in children: clinical, immunologiC., and cytogenetic findings in two patients. Cancer., 68: 2266–2272
   PubMed Web of Science ®Google Scholar
• Jani Sait S. N., Brecher M. L., Green D. M., Sand-berg A. A. Translocation t(l;22) in congenital acute megakaryocytic leukemia. Cancer Genet. Cytogenet. 1988; 34: 277–280
   PubMed Web of Science ®Google Scholar
• Arico M. Acute megakaryoblastic leukemia and clonal trisomy 21 in a phenotypically normal infant (letter). Blood 1991; 77: 2542–2543
   PubMed Web of Science ®Google Scholar
• Penchansky L., Taylor S. R., Krause J. R. Three infants with acute megakaryoblastic leukemia simulating met-astatic tumor. Cancer. 1989; 64: 1366–1371
   PubMed Web of Science ®Google Scholar
• Lewis D. S., Thompson M., Hudson E., Liberman M. M., Samson D. Down's syndrome and acute megakaryoblastic leukemia: case report and review of the literature. Acta Haematol. (Basel) 1983; 70: 236–242
   PubMed Web of Science ®Google Scholar
• Nito T., Terashima K., Matsuda M., Imai Y., Yokoyama S., Hayashi T. Transient abnormal myelopoiesis followed by acute megakaryoblastic leukemia with extrame-dullary tumors: an autopsied case of Down's syndrome. Acta Pathol. Jpn. 1983; 33: 1027–1039
   PubMedGoogle Scholar
• Suarez C. R., Le Beau M. M., Silberman S., Fresco R., Rowley J. D. Acute megakaryoblastic leukemia in Down's syndrome: report of a case and review of cytogenetic findings. Med. Pediat. Oncol. 1985; 13: 225–231
   PubMedGoogle Scholar
• Zipursky A., Peeters M., Poon A. Megakaryoblastic leukemia and Down's syndrome: a review. Pediatr Hematol Oncol. 1987; 4: 211–230
   PubMed Web of Science ®Google Scholar
• Simon J. H., Tebbi C. K., Freeman A. I., Brecher M. L., Green D. M., Sandberg A. A. Acute megakaryoblastic leukemia associated with mosaic Down's syndrome. Cancer 1987; 60: 2515–2520
   PubMed Web of Science ®Google Scholar
• Wilkie A. O. M., Kitchen C., Oakhill A., Howell R. T., Berry P. J. Dicentric chromosome in the bone marrow of a child with megakaryoblastic leukemia and Down's syndrome. J. Clin. Pathol. 1988; 41: 378–380
   PubMed Web of Science ®Google Scholar
• Windenbank K. P., Tefferi A., Smithson W. A., Li C. Y., Solberg L. A., Priest J. R., Elliot S. C., de Alarcon P. A., Weinblatt M. E., Burgert E. O. Acute megakaryoblastic leukemia (M7) in children. Mayo. Clin. Proc. 1989; 64: 1339–1351
   PubMed Web of Science ®Google Scholar
• Kojima S., Matsuyama T., Sato T., Horibe K., Konishi S., Tsuchida M., Hayashi Y., Kigasawa H., Akiyama Y., Okamura J., Nakahata T., Bessho F., Eguchi M., Naka-zawa S., Ueda R. Down's syndrome and acute leukemia in children: an analysis of phenotype by use of monoclonal antibodies and electron microscopic platelet per-oxidase reaction. Blood 1990; 76: 2348–2353
   PubMed Web of Science ®Google Scholar
• Sumi S., Obayashi M., Murakami M., Ito J., Okada N., Shibata Y. Acute megakaryoblastic leukemia in Down syndrome, following thrombocytopenia with antiplate-let antibody. Tohoku J. Exp. Med. 1990; 161: 65–67
   PubMed Web of Science ®Google Scholar
• Levaltier X., Reman O., Boutard P., Mandard J. C., Troussard X., Leporrier M. Leucemie aigue megacaryoblastique: relation avec la trisomie 21. Arch. Fr. Pediat. 1991; 48: 563–566
   PubMedGoogle Scholar
• Pui C.-H., Williams D. L., Scarborough V., Jackson C. W., Price R., Murphy S. Acute megakaryoblastic leukaemia associated with intrinsic platelet dysfunction and constitutional ring 21 chromosome in a young boy. Br. J. Haematol. 1982; 50: 191–200
   PubMed Web of Science ®Google Scholar
• Phebus C. K., Berg S. L. Acute megakaryoblas-tic leukemia and Klinefelter's syndrome. Am. J. Pediat. He-matol. Oncol. 1986; 8: 260–262
   PubMedGoogle Scholar
• Dharmasena F., Catchpole M., Erber W., Mason D., Gordon-Smith E. C. Megakaryoblastic leukaemia and myelofibrosis complicating Fanconi anaemia. Scand. J. Haematol. 1986; 36: 309–313
   PubMedGoogle Scholar
• Bullorsky E. O., Shanley C. M., Stemmelin G., Venditti J., Lajous J. R. Acute megakaryoblastic leukemia with massive myelofibrosis: complete remission and reversal of marrow fibrosis with allogeneic bone marrow transplantation as the only treatment. Bone Marrow Transplant 1990; 6: 449–452
   PubMed Web of Science ®Google Scholar
• Breton-Gorius J., Bizet M., Reyer F., Duput E., Mear C., Vannier J.-P., Tron P. Myelofibrosis and acute megakaryoblastic leukemia in a child: topographic relationship between fibroblasts and megakaryocytes with an α-granule defect. Leuk. Res. 1982; 8: 97–110
   Web of Science ®Google Scholar
• Hanada T., Nakazawa M., Sakuma H., Takahashi M., Kondo I., Takita H. Megakaryoblastic transformation of chronic myelogenous leukaemia in a child. Scand. J. Haematol. 1984; 33: 476–481
   PubMedGoogle Scholar
• Robison L. L., Nesbit M. E., Sather H. N., Level C., Shahidi N., Kennedy A., Hammond D. Down syndrome and acute leukemia in children: a 10-year retrospective survey from Childrens Cancer Study Group. J. Pediat. 1984; 105: 235–242
   PubMed Web of Science ®Google Scholar
• Kalwinsky D. K., Raimondi S. C., Bunin N. J., Fair-clough D., Pui C.-H., Relling M. V., Ribeiro R., Rivera G. K. Clinical and biological characteristics of acute lymphocytic leukemia in children with Down syndrome. Am. J. Med. Genet. 1990; 7: 267–271
   Google Scholar
• Rosner F., Lee S. L. Down's syndrome and acute leukemia: myeloblastic or lymphoblastic? Report of forty-three cases and review of the literature. Am. J. Med. 1972; 53: 203–218
   PubMed Web of Science ®Google Scholar
• Ragab A. H., Abdel-Mageed A., Shuster J. J., Frankel L. S., Pullen J., van Eys J., Sullivan M. P., Boyett J., Bo-rowitz M., Crist W. M. Clinical characteristics and treatment outcome of children with acute lymphocytic leukemia and Down's syndrome. Cancer 1991; 67: 1057–1063
   PubMed Web of Science ®Google Scholar
• Levitt G. A., Stiller C. A., Chessells J. M. Prognosis of Down's syndrome with acute leukaemia. Arch. Dis. Child 1990; 64: 212–216
   Google Scholar
• Raimondi S. C., Pui C.-H., Head D., Behm F., Privitera E., Roberson P. K., Rivera K. R., Williams D. Trisomy 21 as the sole acquired chromosomal abnormality in children with acute lymphoblastic leukemia. Leukemia 1992; 3: 171–175
   Google Scholar
• Raimondi S. C., Kalwinsky D. K., Hayashi Y., Behm F. G., Mirro J., Jr., Williams D. L. Cytogenetics of Childhood Acute Nonlymphocytic Leukemia. Cancer Genet. Cytogenet. 1989; 40: 13–27
   PubMed Web of Science ®Google Scholar
• Cuneo A., Mecucci C., Kerim S., Vandenberghe E., Dal Cin P., Van Orshoven A., Rodhain J., Bosly A., Mi-chaux J.-L., Martiat P., Boogaerts M., Carli M. G., Cas-toldi G., van den Berghe H. Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients. Blood 1989; 74: 1781–1790
   PubMed Web of Science ®Google Scholar
• Ohyashiki K., Ohyashiki J. H., Hojo H., Ohtaka M., Toy-ama K., Sugita K., Nakazawa S., Sugiura K., Nakazawa K., Nagasawa T., Enomoto Y., Watanabe T. Cytogenetic findings in adult acute leukemia and myelopro-liferative disorders with an involvement of megakaryocyte lineage. Cancer 1990; 65: 940–948
   PubMed Web of Science ®Google Scholar
• Robison L. Down Syndrome and leukemia. Leukemia 1992; 6: 5–7
   PubMed Web of Science ®Google Scholar