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Original Article

Differential Effects of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) on the Radiation Sensitivity of Normal Versus Leukemic Bone Marrow Progenitor Cell Populations

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Pages 77-90 | Received 18 Jul 1996, Published online: 01 Jul 2009

References

  • Löwenberg B., Touw I. P. Hematopoietic growth factors and their receptors in acute leukemia. Blood 1993; 81: 281–292
  • Tavassoli M. Hematopoietic survival factors. Exp. Hematol. 1993; 21: 5111–5113
  • Testa U., Pelosi E., Gabbianelli M., Fossati C., Campisi S., Isacchi G., Pescle C. Cascade transactivation of growth factor receptors in early human hematopoiesis. Blood 1993; 81: 1442–1456
  • Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993; 81: 2844–2855
  • Kaushansky K., Karplus P. A. Hematopoietic growth factors: understanding functional diversity in structural terms. Blood 1993; 82: 3229–3240
  • Metcalf D. Hematopoietic regulators: redundancy or subtlety. Blood 1993; 82: 3515–3523
  • Neta R., Oppenheim J. J., Douches S. D. Interdependence of the radioprotective effects of human recombinant interleukin 1, tumor necrosis factor, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor. J. Immunol. 1988; 140: 108–111
  • Neta R., Vogel S. N., Sipe J. D., Wong G. G., Nordan R. P. Comparison of the in vivo effects of human recombinant IL1 and human recombinant IL6 in mice. Lymphokine Res. 1988; 7: 403–412
  • Uckun F. M., Gillis S., Souza L., Song C. W. Effects of recombinant growth factors on radiation survival of human bone marrow progenitor cells. Int. J. Radiat. Oncol. Biol. Phys. 1989; 16: 415–435
  • FitzGerald T. J., Henault B. S., Santucci M. A., Anklesaria P., Zak S., Kase K., Farber N., Pierce J. H., Ohara A., Greenberger J. S. Recombinant murine GM-CSF increases resistance of some factor-dependent hematopoietic progenitor cells to low-dose gamma irradiation. Int. J. Radiat. Oncol. Biol. Phys. 1989; 17: 323–335
  • Neta R., Vogel S. N., Plocinski J. M., Tare N. S., Benjamin W., Chizzonite R., Pilcher M. In vivo modulation with anti-interleukin-1 (IL-1) receptor (p80) antibody 35F5 of the response to IL-1. The relationship of radio-protection, colony stimulating factor, and IL-6. Blood 1990; 76: 57–62
  • Uckun F. M., Souza L., Waddick K. G., Wick M., Song C. W. In vivo radioprotective effects of recombinant granulocyte colony-stimulating factor in lethally irradiated mice. Blood 1990; 75: 638–645
  • Waddick K. G., Song C. W., Souza L., Uckun F. M. Comparative analysis of the in vivo radioprotective effects of recombinant granulocyte colony-stimulating factor (G-CSF), recombinant granulocyte-macrophage CSF, and their combination. Blood 1991; 77: 2364–2371
  • Waddick K. G., Uckun F. M. Effects of recombinant interleukin-3 and recombinant interleukin-6 on radiation survival of normal human bone marrow progenitor cells. Radiat. Oncol. Invest. 1993; 1: 34–40
  • MacVittie T. J., Monroy R. L., Patchen M. L., Souza L. M. Therapeutic use of recombinant human G-CSF (rhG-CSF) in a canine model of sublethal and lethal whole-body irradiation. Int. J. Radiat. Biol. 1990; 57: 723–736
  • Patchen M. L., MacVittie T. J., Williams J. L., Schwartz G. N., Souza L. M. Administration of interleukin-6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression. Blood 1991; 77: 472–480
  • Arnold R., Schmeiser T., Heit W., Frickhofen N., Pabst G., Heimpel H., Kubanek B. Hematopoietic reconstitution after bone marrow transplantation. Exp. Hematol. 1986; 14: 271–277
  • Barrett A. J., Adams J. A. Proliferative defect of human bone marrow after transplantation. Brit. J. Haematol. 1981; 49: 159–164
  • Li S., Champlin R., Fitchen J. H., Gale R. P. Abnormalities of myeloid progenitor cells after “successful” bone marrow transplantation. J. Clin. Invest. 1985; 75: 234–241
  • Messner N. A., Curtis J. E., Minden M. D., Tritchler D., Lockwood G., Takahashi T., Lepine J., Jamal N., Tweeddale M., Wandl U. Clonogenic hematopoietic precursors in bone marrow transplantation. Blood 1987; 70: 1425–1432
  • Ma D. D. F., Varga D. E., Biggs J. C. Haematopoietic reconstitution after allogeneic bone marrow transplantation in man: recovery of haematopoietic progenitors (CFU-Mix, BFU-E, and CFU-GM). Brit. J. Haematol 1987; 65: 5–10
  • Vellenga E., Sizoo W., Hagenbeek A., Löwenberg B. Different repopulation kinetics of erythroid (BFU-E), myeloid (CFU-GM) and T lymphocyte (TL-CFU) progenitor cells after autologous and allogeneic bone marrow transplantation. Brit. J. Haematol. 1987; 65: 137–142
  • Adams J. A., Gordon A. A., Jiang Y. Z., MacDonald D., McCarty D. M., Zuiable A., Treleaven J., Powles R. L., Barrett A. J. Thrombocytopenia after bone marrow transplantation for leukemia: changes in megakaryocyte growth and growth-promoting activity. Brit. J. Haematol. 1990; 75: 195–201
  • Henon P. R., Liang H., Beck-Wirth G., Eisenrnann J. C., Lepers M., Wunder E., Kandel G. Comparison of hematopoietic and immune recovery after autologous bone marrow transplantation. Bone Marrow Transplant. 1992; 9: 285–291
  • Domenech J., Linassier, Gihana C. E., Dayan A., Truglio D., Bout M., Petitdidier C., Delain M., Brémond J.-L., Desbois I., Lamagnère J.-P., Colombat P., Binet C. Prolonged impairment of hematopoiesis after high-dose therapy followed by autologous bone marrow transplantation. Blood. 1995; 85: 3320–3327
  • Ottman O. G., Hoelzer D., Gracien E., Ganser A., Kelly K., Reutzel R., Lipp T., Busch F. W., Schwonzen M., Heil G., Wandt H., Koch P., Kolbe K., Heyll A., Bentz M., Peters S., Diedrich H., Dethling J., Meyer P., Nowrousian M. R., Löffler B., Weiss A., Kneba M., Föoller A., Graft M., Hecht T. Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult lymphoblastic leukemia: a randomized phase III trial. Blood. 1995; 86: 444–450
  • Welte K., Reiter A., Mempel K., Pfetsch M., Schwab G., Schrappe M., Riehm H. A randomized phase-III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute leukemia. Blood. 1996; 87: 3143–3150
  • Chelstrom L. M., Finnegan D., Uckun F. M. Treatment of BCL-1 murine B-cell leukemia with recombinant cytokines: comparative analysis of the anti-leukemic potential of interleukin 1 beta (IL-1β), interleukin 2 (IL-2). interleukin 6 (IL-6), tumor necrosis factor alpha (TNFα), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and their combination. Leuk. Lymphoma. 1992; 7: 79–86
  • Waddick K. G., Finnegan D. M., Chelstrom L. M., Uckun F. M. In vivo radiosensitizing effects of recombinant interleukin 6 on radiation resistant BCL-1 B-lineage leukemia cells in acute lymphoblastic leukemia cells in a murine syngeneic bone marrow transplant model system. Leuk. Lymphoma. 1995; 19: 121–128
  • Uckun F. M., Stong R., Youle R. J., Vallera D. A. Combined ex vivo treatment with immunotoxins and mafosfamid: a novel immunotherapeutic approach for elimination of neoplastic T-cells from autologous marrow grafts. J. Immunol. 1985; 134: 3504–3515
  • Uckun F. M., Vallera D. A., Wee S. L. B-lymphocyte regulation of human hematopoiesis. J. Immunol. 1985; 135: 3817–3822
  • Uckun F. M., Chandan-Langlie M., Jaszcz W., Obuz V., Waddick K., Song C. W. Radiation damage repair capacity of primary clonogenic blasts in acute lymphoblastic leukemia. Cancer Res. 1993; 53: 1431–1436
  • Uckun F. M., Song C. W. Radiobiologic features of fresh leukemic bone marrow progenitor cells in acute lymphoblastic leukemia. Cancer Res. 1988; 48: 5788–5795
  • Uckun F. M., Heerema N. A. Use of leukemic progenitor cell assays for a more detailed analysis of the cytogenetic changes occurring during clonal evolution in acute lymphoblastic leukemia. Leuk. Lymphoma. 1990; 2: 1–3
  • Uckun F. M., Fauci A. S., Song C. W., Mehta S. R., Heerema N. A., Gajl-Peczalska K. J., Ambrus J. L. B-cell growth factor receptor expression and B-cell growth factor response of leukemic B-cell precursors and B-lineage lymphoid progenitor cells. Blood 1987; 70: 1020–1034
  • Uckun F. M., Ledbetter J. A. Immunobiologic differences between normal and leukemic human B-cell precursors. Proc. Natl Acad. Sci. USA 1988; 85: 8603–8607
  • Uckun F. M., Kersey J. H., Vallera D. A., Ledbetter J. A., Weisdorf D., Myers D. E., Haake R., Ramsay N. K. C. Autologous bone marrow transplantation in high risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging. Blood 1990; 76: 1723–1733
  • Uckun F. M., Myers D. E., Ledbetter J. A., Swaim S. E., Gajl-Peczalska K. J., Vallera D. A. Use of colony assays and highly potent anti-T-cell immunotoxins to elucidate the immunobiological features of leukemic lymphoid progenitor cells in T-lineage acute lympoblastic leukemia. J. Immunol 1988; 140: 2103–2111
  • Uckun F. M., Mitchell J. B., Obuz V., Park C. H., Waddick K., Friedman N., Oubaha L., Min W. S., Song C. W. Radiation sensitivity of human B-lineage lymphoid precursor cells. Int. J. Radiat. Oncol. Biol. Phys. 1991; 21: 1553–1560
  • Uckun F. M., Ramsay N. K. C., Waddick K. G., Jaszcz W., Chandan-Langlie M., Obuz V., Haake R., Gajl-Peczalska K., Kersey J. H., Song C. W. In vitro and in vivo radiation resistance associated with CD3 surface antigen expression in T-lineage acute lymphoblastic leukemia. Blood 1991; 78: 2945–2955
  • Uckun F. M., Mitchell J. B., Obuz V., Chandan-Langlie M., Min W. S., Haissig S., Song C. W. Radiation and heat sensitivity of human T-lineage acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) clones displaying multiple drug resistance (MDR). Int. J. Radiat. Oncol. Biol Phys. 1992; 23: 115–125
  • Champlin R., Gale R. P. Acute lymphoblastic leukemia: recent advances in biology and therapy. Blood. 1989; 73: 2051–2066
  • Poplack D. G., Reaman G. Acute lymphoblastic leukemia in childhood. Pediatric Clinics of North America. 1988; 35: 903–932
  • Abshire T. C., Buchanan G. R., Jackson J. F., Shuster J. J., Brock B., Head D., Behm F., Crist W. M., Link M., Borowitz M., Pullen D. J. Morphologic, immunologic, and cytogenetic studies in children with acute lymphoblastic leukemia at diagnosis and relapse: a Pediatric Oncology Group study. Leukemia 1992; 6: 357–362
  • Ramsay N., LeBien T. W., Nesbit M., McGlave D., Weisdorf D., Kenyon P., Hurd D., Goldman A., Kim T., Kersey J. Autologous bone marrow transplantation for patients with acute lymphoblastic leukemia in second or subsequent remission: results of bone marrow treated with monoclonal antibodies BA-1, BA-2, and BA-3 plus complement. Blood 1985; 66: 508–513
  • Uckun F. M., Kersey J. H., Haake R., Weisdorf D., Ramsay N. K. C. Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, BA-3/CD10) plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging. Blood 1992; 79: 1094–1104
  • Barrett A. J., Horowitz M. M., Gale R. P., Biggs J. C., Camitta B. M., Dicke K. A., Gluckman E., Good R. A., Herzig R. H., Lee M. B., Marmont A. M., Masaoka T., Ramsay N. K. C., Rimm A. A., Speck B., Zwaan F. E., Bortin M. M. Marrow transplantation for acute lymphoblastic leukemia: factors affecting relapse and survival. Blood 1989; 74: 862–871
  • Woods W. G., Ramsay N. K. C., Weisdorf D. J., Haake R., Vallera D. A., Kim T. H., Lasky L., Nesbit M. E., Bostum B., Uckun F. M., Goldman A. I., Kersey J. H. Bone marrow transplantation for acute lymphoblastic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside. Lack of superiority over cyclophosphamide containing regimens. Bone Marrow Transplant 1990; 6: 9–16
  • Prentice H. G., Burnett A. K., Simonsson B., Brenner M. K., Gottlieb D. J., Totterman T., Gilmore M., Heslop H., Reittie J. E., Bianchi A., Grob J., Hann I. M. ABMT versus chemotherapy in high risk acute lymphoblastic leukemia. Autologous bone marrow transplantation. Proceedings of the 4th International Symposium, Texas. K. A. Dicke, G. Spitzer, S. Jagannath, M. J. Eringer-Hodzesleds. 1989; 139
  • Kersey J. H., Weisdorf D., Nesbit M. E., LeBien T. W., Woods W. G., McGlave P. B., Kim T., Vallera D. A., Goldman A. I., Bostrom B. Comparison of autologous and allogeneic bone marrow transplantation for treatment of high-risk refractory acute lymphoblastic leukemia. N. Engl. J. Med. 1987; 317: 361–467
  • Dopfer R., Henze G., Bender-Gotze C., Ebell W., Ehninger G., Friedrich W., Gadner H., Klingebiel T., Peters C., Riehm H., Suttorp M., Schmitz N., Siegert W., Stollman-Gibbels B., Hartmann R., Niethammer D. Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission after intensive primary and relapse therapy according to the BFM-and CoALL-Protocols: results of the German cooperative study. Blood 1991; 78: 2780–2784
  • Dicke K. A., Spitzer G. F. Clinical studies of autografting in acute lymphoblastic leukemia. Clin. Hematol. 1986; 15: 86
  • Doney K., Buckner C. D., Kopecky K. J., Sanders J. E., Appelbaum F. R., Clift R., Sullivan K., Witherspoon R., Storb R., Thomas E. D. Marrow transplantation for patients with acute lymphoblastic leukemia in first marrow remission. Bone Marrow Transplant 1987; 2: 355
  • Coccia P. F., Strandjord S. E., Warkentin P. I., Cheung N. V., Gordon E. M., Novak L. J., Shina D. C., Herzig R. H. High dose cytosine arabinoside and fractionated total body irradiation: an improved preparative regimen for bone marrow transplantation of children with acute lymphoblastic leukemia in remission. Blood 1988; 71: 888
  • Uckun F. M., Kersey J. H., Vallera D. A., Ledbetter J. A., Weisdorf D., Myers D. E., Haake R., Ramsay N. K. C. Autologous bone marrow transplantation in high risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging. Blood 1990; 76: 1723–1733
  • Uckun F. M., Kersey J. H., Haake R., Weisdorf D., Nesbit M. E., Ramsay N. K. C. Pretransplant leukemic cell burden as a predictor of relapse after autologous bone marrow transplantation for high risk remission acute lymphoblastic leukemia. N. Engl. J. Med. 1993; 329: 1296–1301
  • Dicke K. A. Summary report on marrow purging symposium. New strategies in bone marrow transplantation, R. P. Gale, R. E. Champlin. Wiley-Liss, New York 1991; 185–191
  • Santos G. W., Kaiser H. In vitro chemotherapy as a prelude to autologous marrow transplantation in hematologic malignancy. Minimal residual disease in acute leukemia, B. Löwenberg, A. Hagenbeek. A. Martinus Nijhoff Publishers, Boston, NY 1984; 165–170
  • Uckun F. M., Kim T. H., Ramsay N. C., Min W. S., Song C. W. Radiobiological heterogeneity of leukemic lymphocyte precursors from acute lymphoblastic leukemia patients. Int. J. Radiat. Biol. 1989; 56: 611–615
  • Uckun F. M., Jaszcz W., Chandan-Langlie M., Waddick K. G., Gajl-Peczalska K., Song C. W. Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia. J. Clin. Invest. 1993; 91: 1044–1051
  • Uckun F. M., Aeppli D., Song C. W. Radiation resistance of primary clonogenic blasts from children with acute lymphoblastic leukemia. Int. J. Radiat. Oncol Biol. Phys. 1993; 27: 899–906
  • Uckun F. M., Song C. W. Lack of CD24 antigen expression in B-lineage acute lymphoblastic leukemia is associated with intrinsic radiation resistance of primary clonogenic blasts. Blood 1993; 81: 1323–1332
  • Uckun F. M., Song C. W., Nesbit M., Kersey J. H., Ramsay N. K. C. Immunophenotype predicts radiation resistance in T-lineage acute lymphoblastic leukemia and T-lineage non-Hodgkin's lymphoma. Int. J. Radiat. Oncol. Biol. Phys. 1992; 24: 705–712
  • Deschavanne P. J., Mailaise E. P. The relevance of α/β ratios determined in vitro for human cell lines to the understanding of in vivo values. Int. J. Radiat. Biol. 1989; 56: 539–542
  • Fertil B., Mailaise E. P. Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 11 published curves. Int. J. Radiat. Oncol. Biol. Phys. 1985; 11: 1699–1707
  • Mailaise E. P., Fertil B., Deschavanne P. J., Chavaudra N., Brock W. A. Initial slope of radiation survival curves is characteristic of the origin of primary and established cultures of human tumor cells and fibroblasts. Radiat. Res. 1987; 111: 319–333
  • Rofstad E. K., Wahl A., Brustad T. Radiation sensitivity in vitro of cells isolated from human tumor surgical specimens. Cancer Res. 1987; 47: 106–110
  • Steel G. G., Courtenay V. D. The radiobiology of human tumor cells. The biological basis of radiotherapy, W. Steel, M. Adams, J. H. Peckham. Elsevier Science Publishers B.V., Amsterdam 1983; 123–137
  • Weichselbaum R. R., Nove J., Little J. B. X-ray sensitivity of human tumor cells in vitro. Int. J. Radiat. Oncol. Biol. Phys. 1980; 6: 437–440
  • Weichselbaum R. R., Rotmensch J., Ahmed-Swan S., Beckett M. A. Radiobiological characterization of 53 human tumor cell lines. Int. J. Radiat. Biol 1989; 56: 553–560
  • Weichselbaum R. R., Dahlberg W., Little J. B. Inherently radioresistant cells. Proc. Natl. Acad. Sci. USA 1985; 82: 4732–4735
  • Yoshida T., Nakamura S., Ohtake S., Okafuji K., Kobayashi K., Kondo K., Kanno M., Matano S., Matsuda T., Kanai M., Sugimoto R., Ogawa M., Takaku F. Effect of granulocyte colony-stimulating factor on neutropenia due to chemotherapy for non-Hodgkin's lymphoma. Cancer 1990; 66: 1904–1909
  • Pettengell R., Gurney H., Radford J. A., Deakin D. P., James R., Wilkinson P. M., Kane K., Bentley J., Crowther D. Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: a randomized controlled trial. Blood 1992; 80: 1430–1436
  • Ohno R., Tomonaga M., Kobayashi T., Kanamura A., Shirakawa S., Masaoka T., Omine M., Oh H., Nomura T., Sakai Y., Hirano M., Yokomaku S., Nakayama S., Yoshida Y., Miura A. B., Morishima Y., Dohy H., Niho Y., Hamajima N., Takaku F. Effects of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia. N. Engl. J. Med. 1990; 323: 871–877
  • Sheridan W. P., Morstyn G., Wolf M., Dodds A., Lusk J., Maher D., Layton J. E., Green M. D., Souza L., Fox R. M. Granulocyte colony-stimulating factor and neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation. Lancet 1989; 2: 891–895
  • Schriber J. R., Negrin R. S., Chao N. J., Long G. D., Horning S. J., Blume K. G. The efficacy of granulocyte colony-stimulating factor following autologous bone marrow transplantation for non-Hodgkin's lymphoma with monoclonal antibody purged bone marrow. Leukemia. 1993; 7: 1491–1495
  • Taylor K. M., Jagannath S., Spitzer G., Spinolo J. A., Tucker S. L., Fogel B., Cabanillas F. F., Hagemeister F. B., Souza L. M. Recombinant human granulocyte colony-stimulating factor hastens recovery after high-dose chemotherapy and autologous bone marrow transplantation in Hodgkin's disease. J. Clin. Oncol. 1990; 7: 1791–1799
  • Kaczmarski R. S., Mufti G. J. The cytokine receptor superfamily. Blood Reviews. 1991; 5: 193–203
  • Matsuda T., Yakahashi-Tezuka M., Fukuda T., Okuyama Y., Fujitana Y., Tsukada S., Mano H., Hirai H., Witte O. N., Hirano T. Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines. Blood. 1995; 85: 627–633
  • Nishimura C., Watanabe A., Gouda H., Shimada I., Arata Y. Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy. Biochemistry 1996; 35: 273–281
  • Bruce A. G., Hoggatt I. H., Rose T. M. Oncostatin M is a differentiation factor for myeloid leukemia cells. J. Immunol 1992; 149: 1271–1275
  • Scopes J., Daly S., Atkinson R., Ball S. E., Fordon-Smith E. C., Gibson F. M. Aplastic anemia: evidence for dysfunctional bone marrow progenitor cells and the corrective effect of granulocyte colony-stimulating factor in vitro. Blood. 1996; 87: 3179–3185
  • Fukushima N., Nishina H., Koishhara Y., Ohkawa H. Enhanced hematopoiesis in vivo and in vitro by splenic stromal cells derived from the mouse with recombinant granulocyte colony-stimulating factor. Blood. 1992; 80: 1914–1922
  • Ikebuchi K., Clark S. C., Ihle J. N., Souza L. M., Ogawa M. Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hematopoietic progenitors. Proc. Natl. Acad. Sci. USA. 1988; 85: 3445–3449
  • Leary A. G., Ikebuchi K., Hirai Y., Wong G. G., Yang Y. C., Clark S. C., Ogawa M. Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha. Blood 1988; 71: 1759–1763
  • Tsuji K., Zsebo K. M., Ogawa M. Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit. Blood 1991; 78: 1223–1229
  • Tohda S., Minden M. D. Modulation of growth factor receptors on acute myeloblastic leukemia cells by retinoic acid. Jap. J. Cancer Res. 1994; 85: 378–383
  • Gianni M., Terao M., Zanotta S., Barbui T., Ramaldi A., Garattini E. Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells. Blood. 1994; 83: 1909–1921
  • Dubois C., Schlageter M. H., De Gentile A., Guidez F., Balitrand N., Toubert M. E., Krawice I., Fenaux P., Castaigne S., Najean Y. Hematopoietic growth factor expression and ATRA sensitivity in acute promyelocytic blast cells. Blood. 1994; 83: 3264–3270
  • Touw I., Donath J., Pouwels K., Van Buitenen, Schipper C. P., Santini V., Hagemeijer A., Löwenberg B., Delwel R. Acute myeloid leukemias with chromosomal abnormalities involving the 21q22 region identified by their in vitro responsiveness to interleukin-5. Leukemia. 1991; 5: 687–692
  • Eto T., Akashi K., Harada M., Shibuya T., Takamatsu Y., Teshima T., Niho Y. Biological characteristics of CD7 positive acute myelogenous leukaemia. Brit. J. Haematol. 1992; 82: 508–514
  • Uckun F. M. Regulation of human B-cell ontogeny. Blood. 1990; 76: 1908–1923
  • Shimizu S., Hirano T., Yoshioka R., Sugai S., Matsuda T., Yaga T., Kishimoto T. Interleukin-6 (B-cell stimulatory factor 2)-dependent growth of a Lennert's lymphoma-derived T-cell line (KT-3). Blood. 1988; 72: 1826–1828
  • Taga T., Kawanishi Y., Hardy R. R., Hirano T., Kishimoto T. Receptors for B cell stimulatory factor 2. Quatitation, specificity, distribution, and regulation of their expression. J. Exp. Med. 1987; 166: 967–981
  • Drach D., Estrov Z., Zhao S., Drach J., Cork A., Collins D., Kantajarian H., Andreeff M. Granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, PIXY-321, stem cell factor, interleukin-3. and interleukin-7: receptor-binding and effects on clonogenic proliferation in acute lymphoblastic leukemia. Leak. Lymphoma. 1994; 16: 79–88
  • Kita K., Nishii K., Ohishi K., Morita N., Takakura N., Kawakami K., Miwa H., Shirakawa S. Frequent gene expression of granulocyte colony-stimulating factor (G-CSF) receptor in CD7+ surface CD3- acute lymphoblastic leukaemia. Leukemia. 1993; 7: 1184–1190
  • Park L. S., Waldron P. E., Friend D., Sassenfeld H. M., Price V., Anderson D., Cosman D., Andrews R. G., Bernstein I. D., Urdal D. L. Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. Blood 1989; 74: 56–65
  • Inukai T., Sugita K., Iijima K., Tezuka T., Goi K., Kojika S., Shiraishi K., Kagami K., Nakazawa S. Expression of granulocyte colony-stimulating factor receptor on CD10-positive human B-cell precursors. Brit. J. Haematol. 1995; 89: 623–626
  • Meckenstock G., Heyll A., Schneider E. M., Hildebrandt B., Runde V., Aul C., Bertram C. R., Ludwig W. D., Scheider W. Acute leukemia coexpressing myeloid, B-, and T-lineage associated markers: multiparameter analysis of criteria defining lineage commitment and maturational stage in a case of undifferentiated leukemia. Leukemia. 1995; 9: 260–264
  • Higashigawa M., Komada Y., Washio N., Kuwabara H., Hori H., Ido M., Sakurai M. Recombinant human granulocyte colony-stimulating factor enhanced cytotoxocity of Ara-C in Ara-C-resistant leukemia cells from a patient with biphenotypic leukemia in cell kinetic quiescence. Leukemia Res. 1992; 16: 1049–1054
  • Shimoda K., Okamura S., Harada N., Ikematsu W., Kondo S., Kawasaki C., Tanaka T., Etou T., Akashi K., Okamura T. Granulocyte colony-stimulating factor receptors on human acute leukemia: biphenotypic leukemia cells possess granulocyte colony-stimulating factor receptors. Cancer Res. 1992; 52: 3052–3055
  • Tamura M., Hattori K., Ono M., Hata S., Hayata I., Asano S., Bessho M., Kunitake H. Effects of recombinant granulocyte colony-stimulating factor (rG-CSF) on murine myeloid leukemia: stimulation of proliferation of leukemic cells in vitro and inhibition of development of leukemia in vivo. Leukemia 1989; 3: 853–858
  • Baer M. R., Bernstein S. H., Brunette V. L., Heinonen K., Mrózek K., Swann V. L., Minderman H., Block A. M. W., Pixley L. A., Christiansen N. P., Fay J. W., Barcos M., Rustum Y., Herzig G. P., Bloomfield C. D. Biological effects of recombinant human granulocyte colony-stimulating factor in patients with untreated acute myeloid leukemia. Blood 1996; 87: 1484–1494
  • Ohno R., Naoe T., Kanamaru A., Yoshida M., Hiraoka A., Kobayashi T., Ueda T., Minami S., Morishima Y., Saito Y., Furusawa S., Imai K., Takemoto Y., Miura Y., Teshima H., Hamajima N. Kohseisho Leukemia Study Group: a double blind controlled study of granulocyte colony-stimulating factor started two days before induction chemotherapy in refractory acute myeloid leukemia. Blood 1994; 83: 2086–2092
  • Estey E., Thall P., Andreeff M., Beran M., Kantajarian H., O'Brien S., Escudier S., Robertson L. E., Roller C., Kornblau S., Pierce S., Freireich E. J., Dreisseroth A., Keiting M. Use of granulocyte colony-stimulating factor before, during, and after fludarabine plus cytarabine induction therapy of newly diagnosed acute myelogenous leukemia or myelodysplastic syndromes: comparison with fludarabine plus cytarabine without granulocyte colony-stimulating factor. J. Clin. Oncol. 1994; 12: 671–678
  • Lotem J., Sachs L. Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor β1 and cancer chemotherapy compounds in myeloid leukaemia cells. Blood 1992; 80: 1750–1757
  • Yonish-Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukemia cells that is inhibited by interleukin-6. Nature 1991; 352: 345–347
  • Crawford J., Ozer H., Stoller R., Johnson D., Lyman G., Tabbara I., Kris ML, Grous J., Picozzi V., Rausch G., Smith R., Gradishar W., Yahanda A., Vincent ML, Stewart M., Glaspy J. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N. Engl. J. Med. 1991; 325: 164–170
  • Bronchud M. H., Scarffe J. H., Thatcher N., De Crowther A. L., Souza L. M., Alton N. K., Testa N. G., Dexter T. M. Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small-cell lung cancer. Brit. J. Cancer 1987; 56: 809–813
  • Kotake T., Miki T., Akaza H., Kubota Y., Mishio Y., Matsumura Y., Ota K., Ogawa N. Effects of recombinant granulocyte colony-stimulating factor (rG-CSF) on chemotherapy-induced neutropenia in patients with urogenital cancer. Cancer Chemother. Pharmacol. 1991; 27: 253–257
  • Neidhart J., Mangalik A., Kohler W., Stidley C., Saiki J., Duncan P., Souza L., Downing M. Granulocyte colony-stimulating factor stimulates recovery of granulocytes in patients receiving dose-intensive chemotherapy without bone marrow transplantation. J. Clin. Oncol. 1989; 7: 1685–1692

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