32
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Monoclonal Antibodies in the Treatment of Human B-Cell Malignancies

&
Pages 237-249 | Received 20 Dec 1997, Published online: 01 Jul 2009

References

  • Baumler E. Paul Ehrlich: Scientist for Life. 1984
  • Pressman D., Korngold L. The in vivo localization of anti-Wagner-osteogenic sarcoma antibodies. Cancer 1953; 6: 619–623
  • Kohler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256: 495–7
  • Stein R., Belisle E., Hansen H. J., Goldenberg D. M. Epitope Specificity of the Anti-(B-Cell Lymphoma) Monoclonal Antibody, LL2. Cancer Immunol Immunother 1993; 37: 293–298
  • Nadler L. M., Stashenko P., Hardy R., Schlossman S. F. A monoclonal antibody defining a lymphoma-associ-ated antigen in man. Journal of Immunology 1980; 125: 570–7
  • Epstein A. L., Marder R. J., Winter J. N., Stathopoulos E., Chen F.-M., Parker J. W., Taylor C. R. Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human B-lymphocytes and derived tumors, with immunodi-agnostic and immunotherapeutic potential. Cancer Research 1987; 47: 830–840
  • Lucas K. G., Pollok K. E., Emanuel D. J. POST-TRANSPLANT EBV INDUCED LYMPHOPROLIF-ERATIVE DISORDERS [Review]. Leukemia & Lymphoma 1997; 25: 1–8
  • Sullivan K. M., Storb R., Buckner C D., Fefer A., Fisher L., Weiden P L., Witherspoon R. P., Appelbaum F. R., Banaji M., Hansen J., et al. Graft-versus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms. New England Journal of Medicine 1989; 320: 828–34
  • Slavin S., Strober S. Spontaneous murine B-cell leukemia. Nature 1978; 111: 624
  • Maloney D. G., Kaminski M. S., Burowski D., Haimovich J., Levy R. Monoclonal anti-idiotype antibodies against the murine B cell lymphoma 38C13: characterization and use as probes for the biology of the tumor in vivo and in vitro. Hybridoma 1986; 4: 191–209
  • Meeker T. C., Lowder J., Maloney D. G., Miller R. A., Thiele-Mans K., Warnke R., Levy R. A clinical trial of anti-idiotype therapy for B cell malignancy. Blood 1985; 65: 1349–63
  • Lowder J. N., Meeker T. C., Campbell M., Garcia C. F., Gralow J., Miller R. A., Warnke R., Levy R. Studies on B lymphoid tumors treated with monoclonal anti-idiotype antibodies: correlation with clinical responses. Blood 1987; 69: 199–210
  • Levy R., Miller R. A. Therapy of lymphoma directed at idiotypes. Journal ofthe National Cancer Institute. Monographs 1990; 61–8
  • Nadler L. M., Stashenko P., Hardy R., Kaplan W. D., Button L. N., Kufe D. W., Amman K. H., Schlossman S. F. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Research 1980; 40: 3147–54
  • Weiner G. J., Kaminski M. S. Idiotype variants emerging after anti-idiotype monoclonal antibody therapy of a murine B cell lymphoma. Journal of Immunology 1989; 142: 343–51
  • Jefferis R., Lund J., Pound J. Molecular definition of interaction sites on human IgG for Fc receptors (huFc gamma R). Molecular Immunology 1990; 27: 1237–40
  • Slavin-Chiorini D. C., Horan Hand P H., Kashmiri S. V., Calvo B., Zaremba S., Schlom J. Biologic properties of a CH2 domain-deleted recombinant immunoglobulin. International Journal of Cancer 1993; 53: 97–103
  • Lobuglio A. F., Wheeler R. H., Trang J., Haynes A., Rogers K., Harvey E. B., Sun L., Ghrayeb J., Khazaeli M. B. Mouse/human chimeric monoclonal antibody in man: kinetics and immune response. Proceedings of the National Academy of Sciences ofthe United States of America 1989; 86: 4220–4
  • Davis T., Levy R., White C. A., Maloney D. G., Link B. K., Velasquez C., Varns C., Gardner C., Grillo-Lopez A. J. Retreatments with RITUXAN (Rituximab, IDEC-C2b8) have significant efficacy, do not cause HAMA, and are a viable minimally toxic alternative in relapsed or refractory non-Hodgkin's lymphoma (NHL). Blood 1996; 90: 509a
  • Riechmann L., Clark M., Waldmann H., Winter G. Resharping human antibodies for therapy. Nature 1988; 332: 323
  • Queen C., Schneider W. P., Selick H. E., Payne P. W., Landolfi N. F., Duncan J. F., Avdalovic N. M., Levitt M., Junghans R. P., Waldmann T. A. A humanized antibody that binds to the interleukin 2 receptor. Proc. Natl.Acad. Sci. USA 1989; 86: 10029–10033
  • Fujimori K., Covell D. G., Fletcher J. E., Weinstein J. N. A modeling analysis of monoclonal antibody percola tion through tumors: a binding-site barrier. Journal of Nuclear Medicine 1990; 31: 1191–8
  • Chignola R., Pasti M., Candiani C., Franceschi A., Anselmi C., Tridente G., Colombatti M. Escape mechanisms of human leukemic cells to long-term immunotoxin treatment in an in vitro experimental model. Int J Cancer 1995; 61: 535–541
  • Hirsch R., Gress R. E., Pluznik D. H., Eckhaus M., Blue-Stone J. A. Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells. J Immunol 1989; 142: 737–43
  • Vervoordeldonk S. F., Merle P. A., Van Leeuwen E. F., Von Dem Borne A. E., Slaper-Cortenbach I. C. Preclinical studies with radiolabeled monoclonal antibodies for treatment of patients with B-cell malignancies. Cancer 1994; 73: 1006–11
  • Meeker T., Lowder J., Cleary M. L., Stewart S., Warnke R., Sklar J., Levy R. Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies. NEngl J Med 1985; 312: 1658–65
  • Baluyut A. R., Pollok K. E., Bondada S. Molecular events in B lymphocyte activation: Consequences of signals transduced through MHC class II molecules. Cellular Immunology 1993; 147: 353–366
  • Barrett T. B., Shu G. L., Draves K. E., Pezzutto A., Clark E. A. Signaling through CD19, Fc receptors or transforming growth factor-beta: each inhibits the activation of resting human B cells differently. European Journal of Immunology 1990; 20: 1053–9
  • Beckwith M., Urba W. J., Ferris D. K., Freter C. E., Kuhns D. B., Moratz C M., Longo D. L. Anti-IgM-medi-ated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosie phosphorylation. Journal of Immunology 1991; 147: 2411–2418
  • Beiske K., Clark E. A., Holte H., Ledbetter J. A., Smeland E. B., Godal T. Triggering of neoplastic B cells via surface IgM and the cell surface antigens CD20 and CDw40. Responses differ from normal blood B cells and are restricted to certain morphologic subsets. International Journal of Cancer 1988; 42: 521–8
  • Bishop G. A., Warren W. D., Berton M. T. Signaling via major histocompatibility complex class II molecules and antigen receptors enhances the B cell response to gp39/CD40 ligand. Eur J Immunol 1995; 25: 1230–1238
  • Clark E. A., Shu G. Activation of human B cell proliferation through surface Bp35 (CD20) polypeptides or immunoglobulin receptors. Journal of Immunology 1987; 138: 720–5
  • Doody G. M., Dempsey P. W., Fearon D. T. Activation of B lymphocytes: Integrating signals from CD19, CD22 and Fc gamma Rllbl. Curr Opin Immunol 1996; 8: 378–382
  • Ledbetter J. A., Shu G., Gallagher M., Clark E. A. Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40). Journal of Immunology 1987; 138: 788–94
  • Tedder T. F., Forsgren A., Boyd A. W., Nadler L. M., Schlossman S. F. Antibodies reactive with the Bl molecule inhibit cell cycle progression but not activation of human B lymphocytes. European Journal of Immunology 1986; 16: 881–7
  • Brown S. L., Miller R. A., Levy R. Antiidiotype antibody therapy of B-cell lymphoma. Semin Oncol 1989; 16: 199–210
  • Miller R. A., Maloney D. G., Warnke R., Levy R. Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. New England Journal of Medicine 1982; 306: 517–22
  • Vlasveld L. T., Hekman A., Vythdreese F. A., Melief C. J.M., Sein J. J., Voordouw A. C., Dellemijn T. A.M., Rankin E. M. Treatment of low-grade non-Hodgkin's lymphoma with continuous infusion of low dose recombinant interleukin-2 in combination with the B-cell-specific monoclonal antibody CLB-CD19. Cancer Immunol Immunother 1995; 40: 37–47
  • Press O. W., Appelbaum E., Ledbetter J. A., Martin P. J., Zariing J., Kidd P., Thomas E. D. Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas. Blood 1987; 69: 584–91
  • Scheinberg D. A., Straus D. J., Yeh S. D., Divgi C., Garin-Chesa P., Graham M., Pentlow K., Coit D., Oettgen H. F., Old L. J. A phase I toxicity, pharmacology, and dosimetry trial of monoclonal antibody OKB7 in patients with non-Hodgkin's lymphoma: effects of tumor burden and antigen expression. Journal of Clinical Oncology 1990; 8: 792–803
  • Canon P C, Schwartz M. A., Co M. S., Queen C., Finn R. D., Graham M. C., Divgi C. R., Larson S. M., Scheinberg D. A. Murine and Humanized Constructs of Monoclonal Antibody M195 (Anti-Cd33) for the Therapy of Acute Myelogenous Leukemia. Cancer 1994; 73: 1049–1056
  • Haga Y., Sivinski C. L., Woo D., Tempero M. A. Dose-related comparison of antibody-dependent cellular cytotoxicity with chimeric and native murine monoclonal antibody 17–1A. Improved cytolysis of pancreatic cancer cells with chimeric 17–1A. International Journal of Pancre-atology 1994; IS: 43–50
  • Meredith R. F., Khazaeli M. B., Grizzle W. E., Orr R. A., Plott G., Urist M. M., Liu X., Russell C D., Wheeler R. H., Schlom J., et al. Direct localization comparison of murine and chimeric B72.3 antibodies in patients with colon cancer. Human Antibodies & Hybridomas 1993; 4: 190–7
  • Weiden P. L., Breitz H. B., Seiler C. A., Bjorn M. J., Ratliff B. A., Mallett R., Beaumier P L., Appelbaum J. W., Fritzberg A. R., Salk D. Rhenium-186–1 abeled chimeric antibody NR-LU-13: pharmacokinetics, biodistribution and immunogenicity relative to murine analog NR-LU-10. Journal of Nuclear Medicine 1993; 34: 2111–9
  • Dyer M. J. Chimeric antibodies for the treatment of hematologic malignancy. (72 Refs). Cancer Treatment & Research 1993; 68: 161–80
  • Shitara K., Kuwana Y., Nakamura K., Tokutake Y., Ohta S., Miyaji H., Hasegawa M., Hanai N. A mouse/human chimeric anti-(ganglioside GD3) antibody with enhanced antitumor activities. Cancer Immunology, Immunotherapy 1993; 36: 373–80
  • Dyer M. J., Hale G., Marcus R., Waldman R. Remission induction in patients with lymphoid malignancies using unconjugated Campath-1 monoclonal antibodies. Leukemia and Lymphoma 1990; 2: 179–193
  • Dyer M. J., Hale G., Hayhoe F. G., Waldmann H. Effects Of Campath-1 Antibodies In Vivo In Patients With Lymphoid Malignancies: Influence Of Antibody Isotype. Blood 1989; 73: 1431–9
  • Xia M. Q., Hale G., Waldmann H. Efficient complement mediated-lysis of cells containing the Campath-1 H (CDw52) antigen. Molecular Immunology 1993; 30
  • Osterborg A., Dyer M. J., Bunjes D., Pangalis G. A., Bastion Y., Catovsky D., Mellstedt H. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAM-PATH-1H Treatment in Chronic Lymphocytic Leukemia. Journal of Clinical Oncology 1997; 15: 1567–74
  • Osterborg A., Fassas A. S., Anagnostopoulos A., Dyer M. J., Catovsky D., Mellstedt H. Humanized CD52 monoclonal antibody Campath-1 H as first-line treatment in chronic lymphocytic leukaemia. British Journal of Haema-tology 1996; 93: 151–3
  • Tang S. C., Hewitt K., Berinstein N. L. Objective clinical responses in patients with recurrent low grade lymphoma treated with CAMPATH-1 H monoclonal antibody (Meeting abstract). Proc Annu Meet Am Soc Clin Oncol 1995; 14: A1255
  • De Nully Brown P., Hansen M. M., Nissen N. I. [Campath-1H-a monoclonal antibody for treatment of non-Hodgkin's and chronic lymphatic leukemia]. Ugeskrifi forLaeger 1997; 159: 4389–93
  • Bowen A. L., Zomas A., Emmett E., Matutes E., Dyer M. J., Catovsky D. Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-pro-lymphocytic leukaemia. British Journal of Haematology 1997; 96: 617–9
  • Reff M. E., Carner K., Chambers K. S., Chinn P. C., Leonard J. E., Raab R., Newman R. A., Hanna N., Anderson D. R. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 1994; 83: 435–45
  • Maloney D. G., Liles T. M., Czerwinski D. K., Waldichuk C., Rosenberg J., Grillo-Lopez A., Levy R. Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. Blood 1994; 84: 2457–66
  • Maloney D. G., Grillolopez A. J., White C. A., Bodkin D., Schilder R. J., Neidhart J. A., Janakiraman N., Foon K. A., Liles T. M., Dallaire B. K., Wey K., Royston I., Davis T., Levy R. Idec-C2b8 (Rituximab) Anti-Cd20 Monoclonal Antibody Therapy Patients With Relapsed Low-Grade Non-Hodgkins Lymphoma. Blood 1997; 90: 2188–2195
  • Maloney D. G., Grillo-Lopez A. J., Bodkin D. J., White C. A., Liles T. M., Royston I., Varns C., Rosenberg J., Levy R. Idec-C2b8 - Results Of a Phase I Multiple-Dose Trial In Patients With Relapsed Non-Hodgkins Lymphoma. Journal of Clinical Oncology 1997; 15: 3266–3274
  • McLaughlin P., Grillo-Lopez A. J., Czuczman M., Link B. K., Levy R., Dillman R. O., Ho A., Bennett J. M., Heyman M. R., Schilder R. J., Cabanillas R., Rogers J., Dallaire B. K. Preliminary Report on a Phase III Pivotal Trial of the Anti-CD20 Antibody IDEC-C2B8 in Patients with Relapsed Low Grade or Follicular Lymphoma. Proceedings American Society of Clinical Oncology 1996; 15: 417
  • Demidem A., Lam T., Alas S., Hariharan K., Hanna N., Bonavida B. Chimeric Anti-Cd20 (Idec-C2b8) Monoclonal Antibody Sensitizes Cell Lymphoma Cell Line to Cell Killing By Cytotoxic Drugs. Cancer Biotherapy & Radiopharmaceuticals 1997; 12: 177–186
  • Czuczman M., Grillo-Lopez A. J., Saleh M., Gordon L., Jonas C., Varns C. Phase II clinical trial of IDEC-C2B8/CHOP combination therapy in low-grade lymphoma: preliminary results (Meeting abstract). Proc Annu Meet Am Soc Clin Oncol 1995; 14: A1261
  • Herpst J. M., Klein J. L., Leichner P. K., Quadri S. M., Vriesendorp H. M. Survival of patients with resistant Hodgkin's disease after polyclonal yttrium 90-labeled antiferritin treatment. Journal of Clinical Oncology 1995; 13: 2394–400
  • Corcoran M. C., Eary J., Bernstein I., Press O. W. Radioimmunotherapy strategies for non-Hodgkin's lymphomas. Annals of Oncology 1997; 8: 133–8
  • Wilder R. B., Denardo G. L., Denardo S. J. Radioimmunotherapy: recent results and future directions. Journal of Clinical Oncology 1996; 14: 1383–400
  • Appelbaum F. R. Radiolabeled Monoclonal Antibodies in the Treatment of Non-Hodgkin's Lymphoma. Hematology - Oncology Clinics of North America 1991; 5: 1013–1025
  • Knox S. J., Levy R., Miller R. A., Uhland W., Schiele J., Ruehl W., Finston R., Day L. P., Goris M. L. Determinants of the antitumor effect of radiolabeled monoclonal antibodies. Cancer Res 1990; 50: 4935–40
  • Mattes M. J., Griffiths G. L., Diril H., Goldenberg D. M., Ong G. L., Shih L. B. Processing of Anti-body-Radioisotope Conjugates After Binding to the Surface of Tumor Cells. Cancer 1994; 73: 787–793
  • Buchsbaum D. J., Wahl R. L., Glenn S. D., Normolle D. P., Kaminski M. S. Improved Delivery of Radiolabeled Anti-B1 Monoclonal Antibody to Raji Lymphoma Xenografts by Predosing with Unlabeled Anti-B1 Monoclonal Antibody. Cancer Res 1992; 52: 637–642
  • Press O. W., Eary J. F., Appelbaum F. R., Martin P. J., Badger C. C., Nelp W. B., Glenn S., Butchko G., Fisher D., Porter B., et al. Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support [see comments]. New England Journal of Medicine 1993; 329: 1219–24
  • Press O. W., Eary J. F., Appelbaum F. R., Martin P. J., Nelp W. B., Glenn S., Fisher D. R., Porter B., Matthews D. C., Gooley T., et al. Phase II trial of 131I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas. Lancet 1995; 346: 336–40
  • Kaminski M. S., Fig L. M., Zasadny K. R., Koral K. F., Delrosario R. B., Francis I. R., Hanson C. A., Normolle D. P., Mudgett E., Liu C. P., Moon S., Scott P., Miller R. A., Wahl R. L. Imaging, dosimetry, and radioimmunotherapy with iodine 131-labeled anti-CD37 antibody in B-cell lymphoma. Journal of Clinical Oncology 1992; 10: 1696–1711
  • Kaminski M. S., Zasadny K. R., Francis I. R., Fenner M. C., Ross C. W., Milik A. W., Estes J., Tuck M., Regan D., Fisher S., Glenn S. D., Wahl R. L. Iodine - 131-anti-B1 radioimmunotherapy for B-cell lymphoma. Journal of Clinical Oncology 1996; 17: 1974–1981
  • Lewis J. P., Denardo G. L., Denardo S. J. Radioimmunotherapy of lymphoma: a UC Davis experience. Hybridoma 1995; 14: 115–20
  • Goldenberg D. M., Horowitz J. A., Sharkey R. M., Hall T. C., Murthy S., Goldenberg H., Lee R. E., Stein R., Siegel J. A., Izon D. O., et al. Targeting, dosimetry, and radioimmunotherapy of B-cell lymphomas with iodine-131-labeled LL2 monoclonal antibody [see comments]. Journal of Clinical Oncology 1991; 9: 548–64
  • Knox S. J., Goris M. L., Trisler K., Negrin R., Davis T., Liles T.-M., Grillo-Lopez A., Chinn P., Varns C., Shou-Cheng N., Fowler S., Nimisha D., Becker M., Marquez C., Levy R. Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma. Clinical Cancer Research 1996; 2: 457–470
  • White C. A., Halpern S. E., Parker B. A., Miller R. A., Hupf H. B., Shawler D. L., Collins H. A., Royston I. Radioimmunotherapy of relapsed B-cell lymphoma with Yttrium anti-idiotype monoclonal antibodies. Blood 1996; 87: 3640–3649
  • Frankel A. E., Fitzgerald D., Siegall C., Press O. W. Advances in immunotoxin biology and therapy: A summary of the Fourth International Symposium on Immunotoxins. Cancer Res 1996; 56: 926–932
  • Ghetie V., Vitetta E. Immunotoxins in the therapy of cancer: From bench to clinic. Pharmacol Ther 1994; 63: 209–234
  • Grossbard M. L., Nadler L. M. Immunotoxin Therapy of Lymphoid Neoplasms. Semin Hematol 1994; 31: 88–97
  • Vitetta E. S., Stone M., Amlot P., Fay J., May R., Till M., Newman J., Clark P., Collins R., Cunningham D., Ghetie V., Uhr J. W., Thorpe P. E. Phase-I Immunotoxin Trial in Patients with B-Cell Lymphoma. Cancer Research 1991; 51: 4052–4058
  • Amlot P. J., Stone M. J., Cunningham S. D., Fay J., Collins N. R., May R., McCarthy M., Richardson J., Ghetie V., Ramilo O., Thorpe P. E., Uhr J. W., Vitetta E. S. A phase 1 study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy. Blood 1993; 82: 2624–2633
  • Sausville E. A., Headlee D., Stetler-Stevenson M., Jaffe E. S., Solomon D., Figg W. D., Herdt J., Kopp W. C., Rager H., Steinberg S. M., et al. Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study. Blood. 1995; 85: 3457–65
  • Stone M. J., Sausville E. A., Fay J. W., Headlee D., Collins R. H., Figg W. D., Stetler-Stevenson M., Jain V., Jaffe E. S., Solomon D., Lush R. M., Senderowicz A., Ghetie V., Schlindler J., Uhr J. W., Vitetta E. S. A phase I study of bolus versus continuous infusion of the anti-CD 19 immunotoxin, Ig-HD37-dgA in patients with B-cell lymphoma. Blood 1996; 88: 118–1197
  • Grossbard M. L., Freedman A. S., Ritz J., Coral R., Goldmacher V. S., Eliseo L., Spector N., Dear K., Lambert J. M., Blat-Tler W. A., Taylor J. A., Nadler L. M. Serotherapy of B-Cell Neoplasms with Anti-B4-Blocked Ricin - A Phase-I Trial of Daily Bolus Infusion. Blood 1992; 79: 576–585
  • Grossbard M. L., Lambert J. M., Goldmacher V. S., Spector N. L., Kinsella J., Eliseo L., Coral R., Taylor J. A., Blattler W. A., Epstein C. L., Nadler L. M. Anti-B4-Blocked Ricin - A Phase-I Trial of 7-Day Continuous Infusion in Patients with B-Cell Neoplasms. J Clin Oncol 1993; 11: 726–737
  • Grossbard M. L., Gribben J. G., Freedman A. S., Lambert J. M., Kinsella J., Rabinowe S. N., Eliseo L., Taylor J. A., Blattler W. A., Epstein C. L., Nadler L. M. Adjuvant Immunotoxin Therapy with Anti-B4-Blocked Ricin After Autologous Bone Marrow Transplantation for Patients with B-Cell Non-Hodgkin's Lymphoma. Blood 1993; 81: 2263–2271
  • Grossbard M. L., O'Day S., Gribben J. G., Kolesar C., Freedman A. S., Rabinowe S. N., Neuberg D., Esseltine D. L., Epstein C. L., Nadler L. M. A Phase II study of anti-B4-blocked ricin (anti-B4-bR) therapy following autologous bone marrow transplantation (ABMT) for B-cell non-Hodgkin's lymphoma (B-NHL) (Meeting abstract). Proc Annu Meet Am Soc Clin Oncol 1994; 13: A951
  • Vuist W. M.J., Levy R., Maloney D. G. lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein. Blood 1994; 83: 899–906
  • Vitetta E. S., Tucker T. R, Racila E., Huang Y. W., Marches R., Lane N., Scheuermann R. H., Street N. E., Watanabe T., Uhr J. W. Tumor dormancy and cell signaling. V. Regrowth of the BCL1 tumor after dormancy is established. Blood 1997; 89: 4425–36

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.