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Original Article

The role of hypoxia related angiogenesis in uterine smooth muscle tumors

, , , , &
Pages 102-110 | Accepted 09 May 2014, Published online: 16 Sep 2014

References

  • Anderson P, Kedersha N (2009)RNA granules: post- transcriptional and epigenetic modulators of gene expression. Nat. Rev. Mol. Cell Biol. 10: 430–436.
  • Aprelikova O, Wood M, Tackett S, Chandramouli GV, Barrett JC (2006)Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res. 66: 5641–5647.
  • Bhadada SV, Goyal BR, Patel MM (2011)Angiogenic targets for potential disorders. Fund. Clin. Pharmacol. 25: 29–47.
  • Bodner-Adler B, Nather A, Bodner K, Czerwenka K, Kimberger O, Leodolter S, Mayerhofer K (2006)Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study. Gynecol. Oncol. 103: 186–189.
  • Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo HM, Abeloff MD, Simons JW, van Diest PJ, van der Wall E (2001)Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J. Natl. Cancer Inst. 93: 309–314.
  • Brown JM, Wilson WR (2004)Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer 4: 437–447.
  • Campbell SC, Volpert OV, Ivanovich M, Bouck NP (1998)Molecular mediators of angiogenesis in bladder cancer. Cancer Res. 58: 1298–1304.
  • Cardenas-Navia LI, Mace D, Richardson RA, Wilson DF, Shan S, Dewhirst MW (2008)The pervasive presence of fluctuating oxygenation in tumors. Cancer Res. 68: 5812–5819.
  • Clemens MJ (2004)Targets and mechanisms for the regulation of translation in malignant transformation. Oncogene 23: 3180–3188.
  • Connolly E, Braunstein S, Formenti S, Schneider RJ (2006)Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol. Cell. Biol. 26: 3955–3965.
  • Dewhirst MW (2007)Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res. 67: 854–855.
  • Di Lieto A, De Falco M, Pollio F, Mansueto G, Salvatore G, Somma P, Ciociola F, De Rosa G, Staibano S (2005)Clinical response, vascular change, and angiogenesis in gonadotropin-releasing hormone analogue-treated women with uterine myomas. J. Soc. Gynecol. Invest. 12: 123–128.
  • Folkman J (1986)How is blood vessel growth regulated in normal and neoplastic tissue? Cancer Res. 46: 467–473.
  • Folkman J (2006)Angiogenesis. Ann. Rev. Med. 57: 1–18.
  • Fujioka S, Sclabas GM, Schmidt C, Niu J, Frederick WA, Dong QG, Abbruzzese JL, Evans DB, Baker C, Chiao PJ (2003)Inhibition of constitutive NF-ĸB activity by IĸBαM suppresses tumorigenesis. Oncogene 22: 1365–1370.
  • Gardner LB, Corn PG (2008)Hypoxic regulation of mRNA expression. Cell Cycle 7: 1916–1924.
  • Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, Gatter KC, Harris AL (2001)Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br. J. Cancer 85: 881–890.
  • Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, Anderson P (2004)Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol. Biol. Cell 15: 5383–5398.
  • Good DJ, Polverini PJ, Rastinejad F, Le Beau MM, Lemons RS, Frazier WA, Bouck NP (1990)A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. USA 87: 6624–6628.
  • Goonewardene TI, Sowter HM, Harris AL (2002)Hypoxia-induced pathways in breast cancer. Microsc. Res. Tech. 59: 41–48.
  • Gottschald OR, Malec V, Krasteva G, Hasan D, Kamlah F, Herold S, Rose F, Seeger W, Hanze J (2010)TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway. J. Mol. Cell Biol. 2: 345–356.
  • Han Y, Zhou Y, Zheng S (2002)Study on the expression of vascular endothelial growth factor in patients with adenomyosis of the uterus. Zhong. Fu Chan Ke Za Zhi. 37: 539–541.
  • Hong T, Shimada Y, Uchida S, Itami A, Li Z, Ding Y, Kaganoi J, Komoto I, Sakurai T, Imamura M (2001)Expression of angiogenic factors and apoptotic factors in leiomyosarcoma and leiomyoma. Int. J. Mol. Med. 8: 141–148.
  • Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ (2000)Blockade of nuclear factor-ĸB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res. 60: 5334–5339.
  • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F (2004)Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350: 2335–2342.
  • Jin K, Li W, Nagayama T, He X, Sinor AD, Chang J, Mao X, Graham SH, Simon RP, Greenberg DA (2000)Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. J. Neurosci. Res. 59: 767–774.
  • Jud MC, Czerwinski MJ, Wood MP, Young RA, Gallo CM, Bickel JS, Petty EL, Mason JM, Little BA, Padilla PA, Schisa JA (2008)Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway. Dev. Biol. 318: 38–51.
  • Kazerounian S, Yee KO, Lawler J (2008)Thrombospondins in cancer. Cell Mol. Life Sci. 65: 700–712.
  • Kedersha N, Anderson P (2007)Mammalian stress granules and processing bodies. Methods Enzymol. 431: 61–81.
  • Kedersha N, Tisdale S, Hickman T, Anderson P (2008)Real-time and quantitative imaging of mammalian stress granules and processing bodies. Methods Enzymol. 448: 521–552.
  • Kedersha N, Ivanov P, Anderson P (2013)Stress granules and cell signaling: more than just a passing phase. Trends Biochem. Sci. 38: 494–506.
  • Kiriakidis S, Andreakos E, Monaco C, Foxwell B, Feldmann M, Paleolog E (2003)VEGF expression in human macrophages is NF-ĸB-dependent: studies using adenoviruses expressing the endogenous NF-ĸB inhibitor IĸBα and a kinase-defective form of the IĸB kinase 2. J. Cell Sci. 116: 665–674.
  • Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG (2006)Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 25: 1114–1125.
  • Koumenis C, Wouters BG (2006)‘’Translating’’ tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways. Mol. Cancer Res. 4: 423–436.
  • Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG (2002)Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol. Cell Biol. 22: 7405–7416.
  • Liekens S, De Clercq E, Neyts J (2001)Angiogenesis: regulators and clinical applications. Biochem. Pharmacol. 61: 253–270.
  • Lou JJ, Chua YL, Chew EH, Gao J, Bushell M, Hagen T (2010)Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents. PLoS One 5: e10522.
  • Lu X, Kang Y (2010)Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin. Cancer Res. 16: 5928–5935.
  • Magagnin MG, van den Beucken T, Sergeant K, Lambin P, Koritzinsky M, Devreese B, Wouters BG (2008)The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency. Proteomics 8: 1019–1028.
  • Masuda K, Abdelmohsen K, Gorospe M (2009)RNA-binding proteins implicated in the hypoxic response. J. Cell. Mol. Med. 3: 2759–2769.
  • Mazan-Mamczarz K, Lal A, Martindale JL, Kawai T, Gorospe M (2006). Translational repression by RNA-binding protein TIAR. Mol. Cell Biol. 26: 2716–2727.
  • Messmer-Blust A, An X, Li J (2009)Hypoxia-regulated angiogenic inhibitors. Trends Cardiovasc. Med. 19: 252–256.
  • Mirochnik Y, Kwiatek A, Volpert OV (2008)Thrombospondin and apoptosis: molecular mechanisms and use for design of complementation treatments. Curr. Drug Targets 9: 851–862.
  • Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC (2004)Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 64: 1765–1772.
  • Mizukami Y, Kohgo Y, Chung DC (2007)Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clin. Cancer Res. 13: 5670–5674.
  • Moeller BJ, Dewhirst MW (2004)Raising the bar: how HIF-1 helps determine tumor radiosensitivity. Cell Cycle 3: 1107–1110.
  • Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999)Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 3: 9–22.
  • Papadakis AI, Paraskeva E, Peidis P, Muaddi H, Li S, Raptis L, Pantopoulos K, Simos G, Koromilas AE (2010)eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF- 1{alpha}. Cancer Res. 70: 7820–7829.
  • Robboy SJ, Bentley RC, Butnor K, Anderson MC (2000)Pathology and pathophysiology of uterine smooth muscle tumors. Environ. Health Perspec. 108: 779–784.
  • Rosca EV, Koskimaki JE, Rivera CG, Pandey NB, Tamiz AP, Popel AS (2011)Anti-angiogenic peptides for cancer therapeutics. Curr. Pharm. Biotechnol. 12: 1101–1116.
  • Ryan HE, Lo J, Johnson RS (1998)HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17: 3005–3015.
  • Sanci M, Dikis C, Inan S, Turkoz E, Dicle N, Ispahi C (2011)Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma. Acta Histochem. 113: 317–325.
  • Semenza GL (2000)HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88: 1474–1480.
  • Semenza GL (2002)HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8: 62–67.
  • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A (1996)Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 71: 32529–32537.
  • Shi YH, Fang WG (2004)Hypoxia-inducible factor-1 in tumour angiogenesis. World J. Gastroenterol. 10: 1082–1087.
  • Solomon LA, Schimp VL, Ali-Fehmi R, Diamond MP, Munkarah AR (2005)Clinical update of smooth muscle tumors of the uterus. J. Min. Invas. Gynecol. 12: 401–408.
  • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL (2000)The expression and distribution of the hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157: 411–421.
  • Tsai SJ, Lin SJ, Cheng YM, Chen HM, Wing LYC (2005)Expression and functional analysis of pituitary tumor transforming growth factor-1 in uterine leiomyomas. J. Clin. Endocrinol. Metab. 90: 3715–3723.
  • van den Beucken T, Koritzinsky M, Wouters BG (2006)Translational control of gene expression during hypoxia. Cancer Biol. Ther. 5: 749–755.
  • Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M, Nagasue N (2004)Prognostic impact of hypoxia-inducible factors 1-alpha and 2-alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin. Cancer Res. 10: 8554–8560.
  • Zabrenetzky V, Harris CC, Steeg PS, Roberts DD (1994)Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Int. J. Cancer 59: 191–195.
  • Zhang J, Cao J, Weng Q, Wu R, Yan Y, Jing H, Zhu H, He Q, Yang B (2010)Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway. PLoS One 5: e13910.
  • Zhang YW, Su Y, Volpert OV, Vande Woude GF (2003)Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc. Natl. Acad. Sci. USA 100: 12718–12723.
  • Zhu K, Chan W, Heymach J, Wilkinson M, McConkey DJ (2009)Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression. Cancer Res. 69: 1836–1843.

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