27
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Statistical Modelling of the Formulation Variables in Non-Viral Gene Delivery Systems

, , , &
Pages 169-184 | Received 23 Aug 2000, Published online: 08 Apr 2010

References

  • Anchordoquy T. J., Carpenter J. F., Kroll D. J. Maintenance of transfection rates and physical characterization of lipid/DNA complexes after freeze-drying and rehydration. Arch. Biochem. Biophys 1997; 348: 199–206
  • Bermejo-Barrera P., Muniz-Naveiro O., Moreda-Pineiro A., Bermejo-Barrera A. Experimental designs in the optimisation of ultrasonic bath-acid-leaching procedures for the determination of trace elements in human hair samples by atomic absorption spectrometry. Forensic Sci. Int 2000; 107: 105–120
  • Birchall J. C., Kellaway I. W., Mills S. N. Physico-chemical characterisation of cationic lipid:plasmid DNA gene delivery complexes. Int. J. Pharm 1999; 183: 195–207
  • Birchall J. C., Kellaway I. W., Gumbleton M. Physical stability and in-vitro gene expression efficiency of nebulised lipid-peptide-DNA complexes. Int. J. Pharm 2000; 197: 221–231
  • Brachet A., Christen P., Gauvrit J., Longeray R., Lanteri P., Veuthey J. Experimental design in supercritical fluid extraction of cocaine from cocoa leaves. J. Biochem. Biophys. Methods 2000; 43: 353–366
  • Branchu S., Forbes R. T., York P., Nyqvist H. A central composite design to investigate the thermal stabilization of lysozyme. Pharm. Res 1999; 16: 702–708
  • Crook K., McLachlan G., Stevenson B. J., Porteus D. J. Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation. Gene Ther 1996; 3: 834–839
  • Farhood H., Serbina N., Huang L. The role of dioloeylphosphatidyletyhanolamine in cationic liposome mediated gene transfer. Biochim. Biophys. Acta 1994; 1189: 195–203
  • Gao X., Huang L. Potentiation of liposome-mediated gene delivery by polycations. Biochem 1996; 35: 1027–1036
  • Gohel M. C., Amin A. F. Formulation design and optimization of modified-release microspheres of diclofenac sodium. Drug Dev. Ind. Pharm 1999; 25: 247–51
  • Li S., Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther 1997; 4: 891–900
  • Li S., Rizzo M. A., Bhattacharya S., Huang L. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery. Gene Ther 1998; 5: 930–937
  • Mahato R. I., Takakura Y., Hashida M. Development of targeted delivery systems for nucleic acid drugs. J. Drug Targeting 1997; 4: 337–357
  • McLachlan G., Davidson D. J., Stevenson B. J., Dickinson P., Davidson-Smith H., Dorin J. R., Porteus D. J. Evaluation in vitro and in vivo of cationic liposome-expression construct complexes for cystic fibrosis gene therapy. Gene Ther 1995; 2: 614–622
  • Rolland A. P. From genes to gene medicines: Recent advances in nonviral gene delivery. Crit. Rev. Ther. Drug Carrier Syst 1998; 15: 143–198
  • Rotthauser B., Kraus G., Schmidt P. C. Optimization of an effervescent tablet formulation containing spray dried L-leucine and polyethylene glycol 6000 as lubricants using a central composite design. Eur. J. Pharm. Biopharm 1998; 46: 85–94
  • Seddon J., Templer R. Liquid crystals and the living cell. New Scientist May, 1991; 44–49
  • Sorgi F. L., Bhattacharya S., Huang L. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther 1997; 4: 961–968
  • Tate S. S., Urade R., Micanovic R., Gerber L., Volenfriend S. Secreted alkaline phosphatase: an internal standard for expression of injected mRNA's into the Xenopus oocyte. FASEB J 1990; 4: 227–231
  • Tomlinson E., Rolland A. P. Controllable gene therapy. Pharmaceutics of non-viral gene delivery systems. J. Controlled Release 1996; 39: 357–372
  • Zabner K., Fasbender A. J., Moninger T., Poellinger K. A., Welsh M. J. Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem 1995; 270: 18997–19007
  • Zuidam N. J., Barenholz Y. Characterization of DNA-lipid complexes commonly used for gene delivery. Int. J. Pharm 1999; 183: 43–46

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.