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Research Article

Formulation of intranasal mucoadhesive temperature-mediated in situ gel containing ropinirole and evaluation of brain targeting efficiency in rats

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Pages 223-234 | Received 21 Jul 2009, Accepted 27 Sep 2009, Published online: 23 Dec 2009

References

  • Abd ElHady SS, Mortada ND, Awad GAS, Zaki NM, Taha RA. (2003). Development of in situ gelling and mucoadhesive mebeverine hydrochloride solution for rectal administration. Saudi Pharm J, 11: 159–171.
  • Ahuja A, Khar RK, Ali J. (1997). Mucoadhesive drug delivery system. Drug Dev Ind Pharm, 23: 489–515.
  • Artursson P, Lindmark T, Davis SS, Illum L. (1994). Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res, 11: 1358–1361.
  • Babbar AK, Singh AK, Goel HC, Chauhan UP, Sharma RK. (2000). Evaluation of (99m)Tc-labeled photosan-3, a hematoporphyrin derivative, as a potential radiopharmaceutical for tumor scintigraphy. Nucl Med Biol, 27: 587–592.
  • Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R. (2004). Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharm Biopharm, 57: 19–34.
  • Borchard G, Luessen HL, deBoer AG, Verhoef JC, Lehr CM, Junginger HE. (1996). The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J Control Release, 39: 131–138.
  • Callens C, Pringels E, Remon JP. (2003). Influence of multiple nasal administrations of bioadhesive powders on the insulin bioavailability. Int J Pharm, 250: 415–422.
  • Callens C, Remon JP. (2000). Evaluation of starch-maltodextrin-Carbopol 974 P mixtures for the nasal delivery of insulin in rabbits. J Control Release, 66: 215–220.
  • Charlton ST, Davis SS, Illum L. (2007a). Evaluation of bioadhesive polymers as delivery systems for nose to brain delivery: in vitro characterisation studies. J Control Release, 118: 225–234.
  • Charlton ST, Davis SS, Illum L. (2007b). Nasal administration of an angiotensin antagonist in the rat model: effect of bioadhesive formulations on the distribution of drugs to the systemic and central nervous systems. Int J Pharm, 338: 94–103.
  • Charlton ST, Whetstone J, Fayinka ST, Read KD, Illum L, Davis SS. (2008). Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model. Pharm Res, 25: 1531–1543. 10.1007/s11095-008-9550-2.
  • Chenite A, Buschmann M, Wang D, Chaput C, Kandani N. (2001). Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions. Carbohydrate Polym, 46: 39–47.
  • Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, Leroux JC, Atkinson BL, Binette F, Selmani A. (2000). Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials, 21: 2155–2161.
  • Deli MA. (2009). Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. Biochim Biophys Acta, 1788: 892–910. 10.1016/j.bbamem.2008.09.016.
  • Dodane V, Amin Khan M, Merwin JR. (1999). Effect of chitosan on epithelial permeability and structure. Int J Pharm, 182: 21–32.
  • Galichet LY. (2004). Clarke’s Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Post Mortem Material, 3rd ed. (pp. 1542–1543 ). Royal Pharmaceutical Society of Great Britain, UK: Pharmaceutical Press.
  • Graff CL, Pollack GM. (2005). Nasal drug administration: potential for targeted central nervous system delivery. J Pharm Sci, 94: 1187–1195. 10.1002/jps.20318.
  • Hinchcliffe M, Illum L. (1999). Intranasal insulin delivery and therapy. Adv Drug Deliv Rev, 35: 199–234.
  • Hussain A, Hirai S, Bawarshi R. (1980). Nasal absorption of propranolol from different dosage forms by rats and dogs. J Pharm Sci, 69: 1411–1413.
  • Illum L, Jorgensen H, Bisgaard H, Krogsgaard O, Rossing N. (1987). Bioadhesive microspheres as a potential nasal drug delivery system. Int J Pharm, 39: 189–199.
  • Illum L. (2000). Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci, 11: 1–18.
  • Illum L. (2004). Is nose-to-brain transport of drugs in man a reality? J Pharm Pharmacol, 56: 3–17. 10.1211/0022357022539.
  • Jansson B, Hägerström H, Fransén N, Edsman K, Björk E. (2005). The influence of gellan gum on the transfer of fluorescein dextran across rat nasal epithelium in vivo. Eur J Pharm Biopharm, 59: 557–564. 10.1016/j.ejpb.2004.10.001.
  • Jha SK, Dougall P, Behari M, Ahuja GK. (1998). Interictal brain 99m Tc-HMPAO SPECT study in chronic epilepsy. J Assoc Physicians India, 46: 438–441.
  • Khan SA, Patil KS, Yeole PG. (2008). Intranasal mucoadhesive buspirone formulation: in vitro characterization and nasal clearance studies. Pharmazie, 63: 348–351.
  • Kumar M, Misra A, Babbar AK, Mishra AK, Mishra P, Pathak K. (2008). Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm, 358: 285–291. 10.1016/j.ijpharm.2008.03.029.
  • Mao S, Chen J, Wei Z, Liu H, Bi D. (2004). Intranasal administration of melatonin starch microspheres. Int J Pharm, 272: 37–43.
  • Merkus FW, Verhoef JC, Marttin E, Romeijn SG, van der Kuy PH, Hermens WA, Schipper NG. (1999). Cyclodextrins in nasal drug delivery. Adv Drug Deliv Rev, 36: 41–57.
  • Mitra R, Pezron I, Chu WA, Mitra AK. (2000). Lipid emulsions as vehicles for enhanced nasal delivery of insulin. Int J Pharm, 205: 127–134.
  • Mortazavi S, Smart JD. (1994). An in vitro method for assessing the duration of mucoadhesion. J Control Release, 31: 207–221.
  • Reddy L, Sharma R, Chuttani K, Mishra A, Murthy R. (2004). Etoposide-incorporated tripalmitin nanoparticles with different surface charge: formulation, characterization, radiolabeling, and biodistribution Studies. AAPS J, 6(3): article 23.
  • Reger MA, Watson GS, Frey WH II, Baker LD, Cholerton B, Keeling ML, Belongia DA, Fishel MA, Plymate SR, Schellenberg GD, Cherrier MM, Craft S. (2006). Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging, 27: 451–458. 10.1016/j.neurobiolaging.2005.03.016.
  • Smith JM, Dornish M, Wood EJ. (2005). Involvement of protein kinase C in chitosan glutamate-mediated tight junction disruption. Biomaterials, 26: 3269–3276. 10.1016/j.biomaterials.2004.06.020.
  • Soane RJ, Frier M, Perkins AC, Jones NS, Davis SS, Illum L. (1999). Evaluation of the clearance characteristics of bioadhesive systems in humans. Int J Pharm, 178: 55–65.
  • Thorne RG, Hanson LR, Ross TM, Tung D, Frey WH II. (2008). Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience, 152: 785–797. 10.1016/j.neuroscience.2008.01.013.
  • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH II (2004). Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience, 127: 481–496. 10.1016/j.neuroscience.2004.05.029.
  • Vyas TK, Babbar AK, Sharma RK, Singh S, Misra A. (2006). Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. J Pharm Sci, 95: 570–580. 10.1002/jps.20480.
  • Wadell C, Björk E, Camber O. (1999). Nasal drug delivery–evaluation of an in vitro model using porcine nasal mucosa. Eur J Pharm Sci, 7: 197–206.
  • Wadell C, Björk E, Camber O. (2003). Permeability of porcine nasal mucosa correlated with human nasal absorption. Eur J Pharm Sci, 18: 47–53.
  • Wang D, Gao Y, Yun L. (2006). Study on brain targeting of raltitrexed following intranasal administration in rats. Cancer Chemother Pharmacol, 57: 97–104. 10.1007/s00280-005-0018-3.
  • Wang Q, Chen G, Zeng S. (2007). Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v. Int J Pharm, 341: 20–25. 10.1016/j.ijpharm.2007.03.041.
  • Wu J, Su ZG, Ma GH. (2006). A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate. Int J Pharm, 315: 1–11. 10.1016/j.ijpharm.2006.01.045.
  • Wu J, Wei W, Wang LY, Su ZG, Ma GH. (2007). A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system. Biomaterials, 28: 2220–2232. 10.1016/j.biomaterials.2006.12.024.
  • Yong CS, Choi JS, Quan QZ, Rhee JD, Kim CK, Lim SJ, Kim KM, Oh PS, Choi HG. (2001). Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium. Int J Pharm, 226: 195–205.
  • Zhang Q, Jiang X, Jiang W, Lu W, Su L, Shi Z. (2004). Preparation of nimodipine-loaded microemulsion for intranasal administration. Int J Pharm, 275: 85–96.

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