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Journal of Drug Targeting Volume 6, 1998 - Issue 1
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Original Article

Molecular Weight-Dependent Paracellular Transport of Fluorescent Model Compounds Induced by Palmitoylcarnitine Chloride across the Human Intestinal Epithelial Cell Line Caco-2

Anthony C. Chao ALZA Technology Institute, Biological Sciences, Alza Corporation, 950 Page Mill Road, P.O. Box 10950, Palo Alto, CA, 94303-0802, USA
,
Michele T. Taylor ALZA Technology Institute, Biological Sciences, Alza Corporation, 950 Page Mill Road, P.O. Box 10950, Palo Alto, CA, 94303-0802, USA; Department of Molecular Pharmacology, Institute of Pharmacology, Roche Bioscience, Neurobiology Unit, Palo Alto, CA, 94304-1397, USA
,
Peter E. Daddona ALZA Technology Institute, Biological Sciences, Alza Corporation, 950 Page Mill Road, P.O. Box 10950, Palo Alto, CA, 94303-0802, USA
,
Mary Broughall ALZA Technology Institute, Biological Sciences, Alza Corporation, 950 Page Mill Road, P.O. Box 10950, Palo Alto, CA, 94303-0802, USA
&
Joseph A. Fix ALZA Technology Institute, Biological Sciences, Alza Corporation, 950 Page Mill Road, P.O. Box 10950, Palo Alto, CA, 94303-0802, USA
Pages 37-43 | Received 04 Dec 1996, Accepted 23 Jan 1997, Published online: 26 Jun 2009

References

  • Anderberg E. K., Lindmark T., Artursson P. Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm. Res 1993; 10: 857–864
  • Artursson P., Magnusson C. Epithelial transport of drugs in cell culture. II: effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells. J. Pharm. Sci 1990; 79: 595–600
  • Bremer J. Camitine-metabolism and function. Physiol. Rev 1983; 63: 1420–1480
  • Chao A. C., Mochizuki H. Niflumic and flufenamic acids are potent inhibitors of chloride secretion in mammalian airway. Life Sci 1992; 51: 1453–1457
  • Fix J. A. Absorption enhancing agents for the GI system. J. Contr. Rel 1987; 6: 151–156
  • Fix J. A., Engle K., Porter P. A., Leppert P. S., Selk S. J., Gardner C. R., Alexander J. Acylcarnitines: drug absorption-enhancing agents in the gastrointestinal tract. Am. J. Physiol 1986; 251: G332–G340
  • Hidalgo I. J., Raub T. J., Borchardt R. T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989; 96: 736–749
  • Hochman J. H., Fix J. A., LeCluyse E. L. In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine. J. Pharmacol. Exp. Ther 1994; 269: 813–822
  • Hurni M. A., Noach A. B. J., Blom-Roosemalen M. C. M., de Boer A. G., Nagelkerke J. F., Breimer D. D. Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy. J. Pharmacol. Exp. Ther 1993; 267: 942–950
  • LeCluyse E. L., Appel L. E., Sutton S. C. Relationship between drug absorption enhancing activity and membrane perturbing effects of acylcarnitines. Pharm. Res 1991; 8: 84–87
  • LeCluyse E. L., Sutton T. C., Fix J. A. In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa. J. Pharmacol. Exp. Ther 1993; 265: 955–962
  • Lee V. H. L., Yamamoto A., Kompella U. B. Mucosal penetration enhancers for facilitation of peptides and protein drug absorption. Crit. Rev. Ther. Drug Carrier Syst 1991; 8: 91–192
  • Lu S., Gough A. W., Bobrowski W. F., Stewart B. H. Transport properties are not altered across Caco-2 cells with heightened TEER despite underlying physiological and ultrastructural changes. J. Pharm. Sci 1996; 85: 270–273
  • Muranishi S. Absorption enhancers. Crit. Rev. Ther. Drug Carrier Syst 1990; 7: 1–33
  • Sakai M., Noach A. B. J., Blom-Roosemalen M. C. M., de Boer A. G., Breimer D. D. Absorption enhancement of hydrophilic compounds by verapamil in Caco-2 cell monolayers. Biochem. Pharmacol 1994; 48: 1199–1210
  • Tomita M., Hayashi M., Awazu S. Absorption-enhancing mechanism of sodium caprate and decanoylcarni-tine in Caco-2 cells. J. Pharmacol. Exp. Ther 1995; 272: 739–743

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