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Review Article

Colonic Drug Targeting

, , &
Pages 129-149 | Received 04 Feb 1997, Accepted 14 Oct 1997, Published online: 26 Jun 2009

References

  • Adkin D. A., Davis S. S., Sparow R. A., Wilding I. R. Colonic transit of different sized tablets in healthy subjects. J. Controlled Rel 1993; 23: 147–153
  • Alwood M. C., Archer D. B., Ring S. G. Delayed release formulations. Eur. Pat. Appl. 0343993A1, 1989
  • Ashford M., Fell J. T., Attwood D., Woodhead P. J. An in vitro investigation into the suitability of pH-dependent polymer for colonic targeting. Int. J. Pharm 1992; 94: 241–245
  • Ashford M., Fell J. T., Attwood D., Sharma H., Woodhead P. J. An in vivo investigation into the suitability of pH-dependent polymers for colon targeting. Int. J. Pharm 1993a; 95: 193–199
  • Ashford M., Fell J. J., Attwood D., Sharma H. L., Woodhead P. J. An evaluation of pectin as carrier for drug targeting to the colon. J. Controlled Rel 1993b; 26: 213–220
  • Ashford M., Fell J., Attwood D., Sharma H., Woodhead P. Studies on pectin formulations for colonic drug delivery. J. Controlled Rel 1994; 30: 225–232
  • Azad Khan A. K., Piris J., Truelove S. C. An experiment to determine the active therapeutic moiety of sulphasalazine. The Lancet 1977; 2: 895–895
  • Bauer K. H., Kesselhut J. F. Novel pharmaceutical excipients for colon targeting. S. T. P. Pharma Sci 1995; 5: 54–59
  • Binder H. J., Foster E. S., Budinger M. E., Hayslett J. P. Mechanism of electroneural sodium chloride absorption in distal colon of the rat. Gastroenterology 1987; 93: 449–455
  • Binns J. S., Stevens H. N. E., Bakhshaee M., Wilson C. G. Colon targeted release using the Pulsincap delivery system. Proc. Intern. Symp. Control. Rel. Bioact. Mater 1994; 21: 260–261
  • Bown R. L., Gibson J. A., Sladen G. E., Hicks B., Dawson A. M. Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device. Gut 1974; 15: 999–1004
  • Brondsted H., Kopecek J. Hydrogels for site-specific oral drug delivery: Synthesis and characterization. Biomater-ials 1991; 12: 584–592
  • Brondsted H., Kopecek J. Hydrogels for site-specific drug delivery to the colon: In vitro and in vivo degradation. Pharm. Res 1992; 9: 1540–1545
  • Brondsted H., Hovgaard I., Simonsen I. Dextran hydrogels for colon-specific drug delivery IV. Comparative release study of hydrocortisone and prednisolone phosphate. STP Pharma Sciences 1995; 5: 65–69
  • Brown J. P., McGarraugh G. V., Parkinson T. M., Wingerd R. E., Jr., Oderndonck A. B. A polymeric drug for treatment of inflammatory bowel disease. J. Med. Chem 1983; 26: 1300–1307
  • Cann P. A., Read N. W., Brown C., Hobson N., Holdsworth. Irritable bowel syndrome: Relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 1983; 24: 405–411
  • Chan R. P., Pope D. J., Gilbert A. P., Sacra P. J., Baron J. H., Lennard-Jones J. E. Studies of two novel sulphasalazine analogs, ipsalazide and balsalazide. Dig. Dis. Sci 1983; 28: 609–615
  • Cheng C. L., Gehrke St. H., Ritschel W. A. Development of an azopolymer based colonic release capsule for delivering proteins/macromolecules. Meth. Find. Exp. Clin. Pharmacol 1994; 16: 271–278
  • Connel A. M. Motor action of the large bowel. Handbook of Physiology, C. F. Coda, W. Heidel. American Physiology Society, Washington, D. C. 1968; Vol. IV: 66–92, Sect 6
  • Cooper M. D., Perey D. Y., McKnealiky M. F., Gabrielsa A. E., Sutherland D. E. R., Good R. A. A mammalian equivalent of the avian Bursa of fabricus. Lancet 1966; 1: 1388–1391
  • Davis S. S. Assessment of gastrointestinal transit and drug absorption. Novel Drug Delivery and its Therapeutic Application, L. F. Prescott, S. W. Nimmo. Wiley, Chichester 1989; 89–101
  • Davis S. S., Hardy J. G., Fara J. W. Transit of pharmaceutical dosage forms through the small intestine. Gut 1986; 27: 886–892
  • Davis S. S., Hardy J. G., Newman S. P., Wilding I. R. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur. J. Nucl. Med 1992; 19: 971–986
  • Edlund C., Lidbeck A., Kager L., Nord C. E. Comparative effects of enoxacin and norfloxacin on human colonic microflora. Antimicrob. Agents Chemother 1987; 31: 1846–1848
  • Enck P., Merlin V., Erckenbrecht J. F., Wienbeck M. Stress effects on gastrointestinal transit in the rat. Gut 1989; 30: 455–459
  • Evans D. F., Pye G., Bramley R., Clark A. G., Dyson T. J., Hardcastle J. D. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 1988; 29: 1035–1041
  • Fara J. W. Colonic drug absorption and metabolism. Novel Drug Delivery and Therapeutics, L. F. Prescott, W. S. Nimmo. Wiley, Chichester 1989; 103–112
  • Fix J. A. Absorption enhancing agents for gastrointestinal system. J. Controlled Rel 1987; 6: 151–162
  • Fix J. A. Strategies for delivery peptides utilizing absorption-enhancing agents. J. Pharm. Sci 1996; 85: 1282–1285
  • Friend D. R., Chang G. W. A colon-specific drug delivery system based on drug glycosides and glycosidases of colonic bacteria. J. Med. Chem 1984; 27: 261–266
  • Friend D. R., Chang G. W. Drug glycosides: Potential prodrugs for colon-specific drug delivery. J. Med. Chem 1985; 28: 51–57
  • Friend D. R., Tozer T. N. Drug glycosides in oral colon-specific drug delivery. J. Controlled Rel 1992; 19: 109–120
  • Friend D. R. Glycoside prodrugs: novel pharmacotherapy for colonic diseases. S. T. P. Pharma Sci 1995; 5: 70–76
  • Gazzaniga A., Bussetti C., Moro L., Sangali M. E., Giordano F. Time dependent oral delivery systems for colon targeting. S. T. P. Pharma. Sci 1995; 5: 83–88
  • Gazzaniga A., Iamartino P., Maffione G., Sangalli M. E. Oral delayed release system for colonic specific delivery. Int. J. Pharm 1994; 108: 77–83
  • Ghandehari H., Kopeckova P., Kopecek J. In vitro biodegradation of pH-sensitive hydrogels containing aromatic azo bonds. Biomaterials 1997; 18: 861–872
  • Gibson S. A. W., McFarlan C., Hay S., Macfarlane G. T. Significance of microflora in proteolysis in the colon. Appl. Environm. Microbiol 1989; 55: 679–683
  • Gingell J. C., Davies M. W., Shields R. Effect of synthetic gastrin-like pentapeptide upon the intestinal transport of sodium, potassium and water. Gut 1968; 9: 111–115
  • Gleiter C. H., Antonin K. H., Bieck P., Godbillon J., Schonleber W., Malchow H. Colonoscopy in the investigation of drug absorption in healthy volunteers. Gastrointest. Endosc 1985; 31: 71–73
  • Goldstein D. A., Tan Y. K., Soldin S. J. Pharmacokinetics and absolute bioavailability of salbutamol in healthy adult volunteers. Eur. J. Clin. Pharmacol 1987; 32: 631–634
  • Gorbach S. L. Intestinal microflora. Gastroenterology 1971; 60: 1110–1129
  • Gruber P., Longer M. A., Robinson J. R. Some biological issues in oral, controlled drug delivery. Adv. Drug Del. Rev 1987; 1: 1–18
  • Haeberlin B., Friend D. R. Anatomy and physiology of the gastrointestinal tract. Oral Colon-Specific Drug Delivery, D. R. Friend. CRC Press, Boca Raton 1992; 1–43
  • Hagikara P. F., Griffin W. O. J. Physiology of the colon and the rectum. Surg. Clin. North. Am 1977; 52: 797–805
  • Harboe E., Larsen C., Johansen M., Olesen H. P. Macromolecular prodrugs XV. Colon targeted delivery bioavailability of naproxen from orally administered dex-tran-naproxen prodrugs varying in molecular size in the pig. Pharm. Res 1989; 6: 919–923
  • Hardy J. G. Colonic transit and drug delivery. Drug Delivery to the Gastrointestinal Tract, J. G. Hardy, S. S. Davis, C. G. Wilson. Ellis Horwood, Chichester 1989; 75–81
  • Hardy J. G., Healy J. N. C., Reynolds J. R. Evaluation of an enteric coated delayed release 5-aminosalicylic acid tablet in patients with inflammatory bowel disease. Alimentary Pharmacol. Therap 1987; 1: 273–280
  • Hardy J. G., Davis S. S., Khosla R., Robertson C. S. Gastrointestinal transit of small tablets in patients with ulcerative colitis. Int. J. Pharm 1988; 48: 79–82
  • Hardy J. G., Wilson C. G., Wood E. Drug delivery to the proximal colon. J. Pharm. Pharmacol 1985; 37: 874–877
  • Hawker P. C., Mashier K. E., Turnberg L. A. Mechanism of transport of sodium chloride and potassium in the human colon. Gastroenterology 1978; 74: 1241–1247
  • Hill M. J., Drasar B. S. The normal colonic bacterial flora. Gut 1975; 16: 318–323
  • Hirayama F., Minami K., Uekama K. In vitro evaluation of biphenyl acetic acid-β-cyclodextrin conjugates as colon targeting prodrugs: drug release behaviour in rat biological media. J. Pharm. Pharmacol 1996; 48: 27–31
  • Hirsch S., Binder V., Kolter K., Kesselhut J. F., Bauer K. H. Lauroyldextran as a coating material for site-specific drug delivery to the colon: in vitro dissolution of coated tablets. Proc. Int. Symp. Control. Rel. Bioact. Mater 1997; 24: 379–380
  • Hovgaard L., Bronsted H. Dextran hydrogels for colon-specific drug delivery. J. Controlled Rel 1995; 36: 159–166
  • Ikesue K., Kopeckova P., Kopecek J. Degradation of proteins by enzymes of the gastrointestinal tract. Proc. Intern. Symp. Control. Rel. Bioact. Mater 1991; 18: 580–581
  • Jay M., Beihn R. M., Digenis G. A., Deland F. H., Caldwell L., Mlodozeniec A. R. Disposition of radiolabeled suppositories in humans. J. Pharm. Pharmacol 1985; 37: 266–268
  • Kalala W., Kinget R., Van den Mooter G., Samyn C. Colonic drug targeting: in vitro release of ibuprofen from capsules coated with poly(ether-ester) azo polymers. Int. J. Pharm 1996; 139: 187–195
  • Khosla R., Davis S. S. Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects. Int. J. Pharm 1989; 52: 1–10
  • Kim J. S., Oberle R. L., Krummel D. A., Dressman J. B., Fleisher D. Absorption of ACE inhibitors from small intestine and colon. J. Pharm. Sci 1994; 83: 1350–1356
  • Kimura Y., Makita Y., Kumagai T., Yamane H., Kitao T., Sasatani H., Kim S. I. Degradation of azo containing polyurethane by the action of intestinal microflora. Polymer 1992; 33: 5294–5299
  • Kopecek J., Kopeckova P., Brondsted H., Rathi R., Rihova B., Yeh P. Y., Ikesue K. Polymers for colon-specific drug delivery. J. Controlled Rel 1992; 19: 121–130
  • Kopeckova P., Kopecek J. Release of 5-aminosalicylic acid from bioadhesive N-(2-hydroxypropyl)metha-crylamide copolymers by azoreductases in vitro. Makromol. Chem 1990; 191: 2037–2045
  • Kopeckova P., Rathi R., Takada S., Rihova B., Berenson M. M., Kopecek J. Bioadhesive N-(2-hydroxy-propyl)methacrylamide copolymers for colon-specific drug delivery. J. Controlled Rel 1994; 28: 211–222
  • Langguth P., Breves G., Stokli A., Merkle H. P., Wolffram S. Colonic absorption and bioavailability of the pentapeptide metkephamid in the rat. Pharm. Res 1994; 11: 1640–1645
  • Lee V. H. L. Changing needs in drug delivery in the era of peptide and protein drugs. Peptide and Protein Drug Delivery, V. H. L. Lee. Marcel Dekker, New York 1991; 1–56
  • Lee V. H. L., Doddo-Kashi S., Grasss G. M., Rubas W. Oral route of peptide and protein drug delivery. Peptide and Protein Drug Delivery, V. H. L. Lee. Marcel Dekker, New York 1991; 691–738
  • Lee V. H. L. Oral route of peptide and protein drug delivery. BioPHARM 1992; 5: 39–50
  • Lehmann K. Magensaftresistente und retardierende Arzneimittelüberzuge aus wässrigen Acrylharzdispersionen. Acta Pharm. Techn 1975; 21: 255–260
  • Lehmann K. O. R., Dreher K. D. Methacrylate-galactomannan coating for colon-specific drug delivery. Proceed. Intern. Symp. Control. Rel. Bioact. Mater 1991; 18: 331–332
  • Leopold C. S., Friend D. R. Poly (L-aspartic acid) as drug carrier for colon-specific drug delivery. An in vitro assesment. Proc. Intern. Symp. Control. Rel. Bioact. Mater 1994; 21: 258–259
  • Lindsey J. T., Smith J. W., McCluggage S. G. J., Nicholas R. L. Effects of commonly used bowel preparations on the large bowel mucosa-associated and luminal microflora in the rat model. Dis. Col. Rectum 1990; 33: 554–560
  • Macfarlane G. T., Cummings J. H., Allison C. Protein degradation by human intestinal bacteria. J. Gen. Biol 1986; 132: 1647–1656
  • Macfarlane G. T., Allison C., Gibson S. A. W., Cummings J. H. Contribution of the microflora to proteolysis in the human large intestine. J. Appl. Bacteriol 1988; 64: 37–46
  • Macfarlane G. T., Hay S., Gibson G. R. Influence of mucin on glycosidase, protease and arylamidase activities of human gut bacteria grown in a 3-stage continuous culture system. J. Appl. Bacteriol 1989; 66: 407–417
  • Macfarlane G. T., Gibson G. R., Beatty J. H., Cummings J. H. Estimation of short chain fatty acid production from protein by human intestinal bacteria based on branched-chain fatty acid measurements. FEMS Microbiol. Ecol 1992; 101: 81–88
  • Mackay M., Tomlinson E. Colonic delivery of therapeutic peptides and proteins. Colonic Absorption and Metabolism, P. R. Biek. Marcel Dekker, New York 1993; 159–176
  • Macleod A. D., Tozer T. N. Kinetic perspectives in colonic drug delivery. Oral Colon-Specific Drug Delivery, DR. Friend. CRC Press, Boca Raton 1992; 85–114
  • Macleod A. D., Tolentino L., Tozer T. N. Glucocorticoid dextran conjugates as potential prodrugs for colon-specific delivery: Steady state pharmacokinetics in the rats. Biopharm. Drug Disp 1994; 15: 151–161
  • MacNeil M. E., Stevens H. N. E. Patent WO. 90/09168, 1990
  • Madara J. L., Dharmsathaphorn K. Occluding junction structure-function relationships in cultured epithelial monolayer. J. Cell Biol 1985; 101: 2124–2133
  • Malagelada J. R., Robertson J. S., Brown M. L., Remington M., Duenes J. A., Thomforde G. M., Carryer P. W. Intestinal transit of solid and liquid components of a meal in health. Gastroenterology 1984; 87: 1255–1263
  • Meldrum S. J., Watson B. W., Riddle H. C., Bown R. L., Sladen G. E. pH profile of gut as measured by radiotelemetry capsule. Br. Med. J 1972; 2: 104–106
  • Meschan I. Small intestine, colon and biliary tract. An Atlas of Basic Anatomy to Radiology, I. Meschan. W. B. Saunders Co., Philadelphia 1975; 843–925
  • Milojevic S., Newton J. M., Cummings J. H., Gibson G. R., Botham R. L., Ring S. G., Stockham M., Allwood M. C. Amylose as a coating for drug delivery to the colon: preparation and in vitro evaluation using 5-aminosalicylic acid pellets. J. Controlled Rel 1996; 38: 75–84
  • Misiewics J. J. Colonic motility. Gut 1975; 16: 311–314
  • Molly K., Vande Woestyne M., Verstraete W. Development of a 5-step multi chamber reactor as a simulation of the human intestinal microbial ecosystem. Appl. Microbiol. Biotechnol 1993; 39: 254–258
  • Moore W. E. C., Holdeman L. V. Discussion of current bacteriologic investigations of the relationship between intestinal flora, diet and colon cancer. Cancer Res 1975; 35: 3418–3420
  • Mrsny R. J. The colon as a site for drug delivery. J. Controlled Rel 1992; 22: 15–34
  • Munjeri O., Collet J. H., Fell J. T. Hydrogel beads based on amidated pectins for colon-specific drug delivery: the role of chitosan in modifying drug release. J. Controlled Rel 1997; 46: 273–278
  • Murakami M., Yoshikawa H., Takada K., Muranishi S. Effect of oleic acid vesicles on intestinal absorption of carboxyfluorescein in rats. Pharm. Res 1986; 3: 35–40
  • Muranishi S. Potentials and limitations of absorption enhancers. Proceed. Int. FIP Sat. Symp.. 1987; L18
  • Muranishi S. Absorption enhancers. Crit. Rev. Ther. Drug Car. Sys 1990; 7: 1–33
  • Muranishi S., Muranishi N., Sezaki K. Improvement of absolute bioavailability of normally poorly absorbed drug: Inducement of intestinal absorption of streptomycin and gentamycin by lipid–bile salt mixed micelles in rat and rabbit. Int. J. Pharm 1979; 2: 101–109
  • Niibuchi J. J., Aramaki Y., Tchusiya S. Binding of antibiotics to rat intestinal mucin. Int. J. Pharm 1986; 30: 181–187
  • Niwa K., Takaya T., Morimoto T., Takada K. Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs. J. Drug Target 1995; 3: 83–89
  • Nord C. E., Heimdahl A. Impact of orally administered antimicrobial agents on human oropharyngeal and colonic microflora. J. Antimicrob. Chemother 1986; 18(Suppl. C)159–164
  • Ovesen L., Bendsten F., Tage-Jensen K., Pedersen N. T., Gram B. R., Rune S. J. Intraluminal pH in the stomach, duodenum and proximal jejenum in normal subjects and patients with exocrine pancreatic insufficiency. Gastroenterology 1986; 90: 258–262
  • Peeters R. Studie over de ontwikkeling van een colon-specifieke artsenijvorm. Doctoral Thesis, K. U. Leuven. 1990
  • Peeters R., Kinget R. Film-forming polymers for colonic drug delivery. I. Synthesis and physical and chemical properties of methyl derivatives of Eudragit S. Int. J. Pharm 1993; 94: 125–134
  • Phillips S. F. Gastrointestinal physiology and its relevance to targeted drug delivery. Current Status on Targeted Drug Delivery to the Gastrointestinal Tract. Capsugel Symposia Series, 1993; 8–18
  • Pozzi F., Furlani P., Gazzaniga A., Davis S. S., Wilding I. R. The TIME-CLOCK® system: a new oral dosage form for fast and complete release of drug after a predetermined lag time. J. Controlled Rel 1994; 31: 99–108
  • Rahman A., Barrowman J. A., Rahimtula A. The influence of bile on the bioavailability of polynuclear aromatic hydrocarbons from rat intestines. Can. J. Physiol. Pharmacol 1986; 64: 1214–1218
  • Rihova B., Rathi R. C., Kopeckova P., Kopecek J. In vitro bioadhesion of carbohydrate-containing N-(2-hydro-xypropyl)methacrylamide copolymers to the GI tract of guinea pigs. Int. J. Pharm 1992; 87: 105–116
  • Roslyn J. J., Zinner M. Y. Surgical anatomy and operative procedures. Textbook of Surgery, D. L. Sabiston. W. B. Saunders Co., Philadelphia 1991; 899–901
  • Rowland I. R. Factors affecting metabolic activity of the intestinal microflora. Drug Metabol. Rev 1988; 19: 243–261
  • Rubinstein A. Microbially controlled drug delivery to the colon. Biopharm. Drug Dispos 1990; 11: 465–475
  • Rubinstein A., Gliko-Kabir I. Synthesis and swelling-dependent enzymatic degradation of borax-modified guar gum for colonic delivery purposes. S. T. P. Pharma Sci 1995; 5: 41–46
  • Rubinstein A., Nakar D., Sintov A. Colonic drug delivery enhanced release of indomethacin from cross-linked chondroitin matrix in rat caecal contents. Pharm. Res 1992a; 9: 276–278
  • Rubinstein A., Nakar D., Sintov A. Chondroitin sulfate: a potential biodegradable carrier for colon-specific drug delivery. Int. J. Pharm 1992b; 84: 141–150
  • Rubinstein A., Radai R., Ezna M., Pathnack S. In vitro evaluation of calcium pectate: A potential colon-specific drug delivery carrier. Pharm. Res 1993; 10: 258–263
  • Rubinstein A., Radai R. In vitro and in vivo analysis of colon specificity of calcium pectinate formulations. Eur. J. Pharm. Biopharm 1995; 41: 291–295
  • Saffran M., Kumar G. S., Savariar C., Burnham J. C., Williams S., Neckers D. C. A new approach to the oral administration of insulin and other peptide drugs. Science 1986; 233: 1081–1084
  • Saffran M., Kumar G. S., Neckers D. G., Williams F., Field J. B., Jones R. H., Panepinto L. New approaches to the oral administration of peptide drugs. Pharm. Week Sci. Ed 1988; 10: 43–44
  • Saffran M., Field J. B., Pena J., Jones R. H., Okuda Y. Oral insulin in diabetic dogs. J. Endocrinol 1991; 131: 267–278
  • Sakai K., Kutsuna T. M., Nishino T., Fujihara Y., Yata N. Contribution of calcium ion sequestration by polyoxyethylated nonionic surfactants to the enhanced colonic absorption of p-aminobenzoic acid. J. Pharm. Sci 1986; 75: 387–390
  • Samuel P. G., Sypol G. M., Meilman E., Mosbach E. H., Chafizadeh M. Absorption of bile acids from large bowel in man. J. Clin. Invest 1968; 42: 2070–2078
  • Samyn C., Kalala W., Van den Mooter G., Kinget R. Synthesis and in vitro biodegradation of poly(ether-ester) azo polymers designed for colon targeting. Int. J. Pharm 1995; 121: 211–216
  • Sarlikiotis A. W., Bauer K. H. Synthese und unterschung von polyurethanen mit galactomannan-segmenten als hilfsstoffe zur freizetzung von peptid-arzneistoffen im dickdarm. Pharm. Ind 1992; 54: 873–886
  • Schacht E., Gevaert A., Kenawy E. R., Molly K., Verstraete W., Adriaensens P., Carleer R., Gelan R. Polymers for colon specific drug delivery. J. Controlled Rel 1996; 39: 327–338
  • Scheline R. R. Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol. Rev 1973; 25: 451–523
  • Shanta K. L., Ravishandran P., Rao K. P. Azo polymeric hydrogels for colon targeted drug delivery. Biomaterials 1995; 16: 1313–1318
  • Simon G. L., Gorbach S. L. The human intestinal microflora. Dig. Dis. Sc 1986; 31: 147S–162S
  • Simonsen L., Hovgaard L., Mortensen P. B., Brondsted H. Dextran hydrogels for colon-specific drug delivery. V. Degradation in human intestinal incubation models. Eur. J. Pharm. Sci 1995; 3: 329–337
  • Spitael J., Kinget R. Solubilité et vitesse de dissolution de différents polymères entériques. Lab. Pharm 1977a; 25: 847–849
  • Spitael J., Kinget R. Factors affecting the dissolution rate of enteric coatings. Pharm. Ind 1977b; 39: 502–505
  • Spitael J., Kinget R. Solubility and dissolution rate of enteric polymers. Acta Pharm. Technol 1979; 25(Suppl 7)163–168
  • Spitael J., Kinget R., Naessens K. Dissolution rate of cellulose acetate pthalate and the Bronsted catalysis law. Pharm. Ind 1980; 42: 846–849
  • Stella V. Pro-drugs: an overview and definition. Pro-drugs as Novel Drug Delivery Systems, T. Higuchi, V. Stella. ACS, Washington, D. C 1975; 1–115
  • Taniguchi K., Muranishi S., Sezaki H. Enhanced intestinal permeability to macromolecules. II. Improvement of the large intestinal absorption of heparin by lipid-surfactant mixed micelles in rat. Int. J. Pharm 1980; 4: 219–228
  • Thomas P., Richard A., Rogers L., Evans B. K., Dew M. J., Rhodes J. Absorption of delayed-release prednisolone in ulcerative colitis and Crohn's disease. J. Pharm. Pharmacol 1985; 37: 757–758
  • Tomita M., Shiga M., Hayashi M., Awazu S. Enhancement of colonic drug absorption by paracellular permeation route. Pharm. Res 1988; 5: 431–435
  • Touitou E., Rubinstein A. Targeted enteral delivery of insulin to rats. Int. J. Pharm 1986; 30: 95–99
  • Ueda S., Ibuki R., Kawamuza A., Murata S., Takahashi T., Kimuza S., Hata T. Development of a novel drug delivery system, Time-Controlled-Explosion System (TES). J. Drug Targeting 1994; 2: 133–140
  • Ueda T., Yamaoka T., Miyamoto M., Kimura Y., Sasatani H., Kim S. I. Bacterial reduction of azo compounds as a model reaction for the degradation of azo-containing polyurethane by the action of intestinal flora. Bull. Chem. Soc. Jpn 1996; 69: 1139–1142
  • Vandelli M. A., Leo E., Forni F., Bernabei M. T. In vitro evaluation of a potential colonic delivery system that releases drug after a controllable lag-time. Eur. J. Pharm. Biopharm 1996; 43: 148–151
  • Van den Mooter G., Offringa M., Kalala W., Samyn C., Kinget R. Synthesis and evaluation of new linear azo-polymers for colonic targeting. S. T. P. Pharma Sci 1995; 5: 36–40
  • Van den Mooter G., Samyn C., Kinget R. Azo polymers for colon-specific drug delivery. Int. J. Pharm 1992; 87: 37–46
  • Van den Mooter G., Samyn C., Kinget R. Azo polymers for colon-specific drug delivery. Part II: Influence of the type of azo polymer on the degradation by intestinal microflora. Int. J. Pharm 1993; 97: 133–139
  • Van den Mooter G., Samyn C., Kinget R. The relationship between swelling properties and enzymatic degradation of azo polymers designed for colon-specific drug delivery. Pharm. Res 1994; 11: 1737–1741
  • Van den Mooter G., Samyn C., Kinget R. In vivo evaluation of a colon-specific drug delivery system: An absorption study of theophylline from capsules coated with azo polymers in rats. Pharm. Res 1995; 12: 244–247
  • Van Hozegard R. A. Pharmacokinetics of olsalazine and its metabolites. Scand. J. Gastroenterol 1988; 148(23 Suppl.)17–20
  • Vervoort L., Kinget R. In vitro degradation by colonic bacteria of inulin HP incorporated in Eudragit films. Int. J. Pharm 1996; 129: 185–190
  • Wakerly Z., Fell J. T., Attwood D., Parkins D. Pectin/ethylcellulose film coating formulations for colonic drug delivery. Pharm. Res 1996; 13: 1210–1212
  • Wilding I. R., Davis S. S., Stevens H. N. E., Bakhshaee M., Sparrow R. A., Brennan J. Gastrointestinal transit and systemic absorption of captopril from a pulsed release formulation. Pharm. Res 1992; 9: 654–657
  • Willoughby C. P., Cowan R. E., Gould S. R., Machell R. J., Stewart J. B. Double-blind comparison of olsalazine and sulphasalazine in active ulcerative colitis. Scand. J. Gastroenterol 1988; 23(Suppl. 148)40–44
  • Wilson C. G., Washington N. Physiological Pharmaceutics, Biological Barriers to Drug Absorption. Ellis Hor-wood Ltd., ChichesterUK 1989
  • Wood E., Wilson C. G., Hardy J. G. The spreading of foam and solution enemas. Int. J. Pharm 1985; 25: 191–197
  • Yeh P. Y., Kopeckova P., Kopecek J. Biodegradable and pH-sensitive hydrogels: synthesis by crosslinking of N,N-dimethylacrylamide copolymer precursors. J. Polymer Sci. Part A Polymer Chem 1994; 32: 1627–1637
  • Yeh P. Y., Berenson M. M., Samowitz W. S., Kopeckova P., Kopecek J. Site-specific drug delivery and penetration enhancement in the gastrointestinal tract. J. Controlled Rel 1995; 36: 109–124
  • Zeitoun P., Brisard P. Im colon zelfallende tabletten und ihre herstellung, Patent Rousel-Uclaf, Patentschrift DE. 3046559 C2, 1988

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