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Journal of Drug Targeting Volume 19, 2011 - Issue 9
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Research Article

Identification of a novel peptide ligand targeting visceral adipose tissue via transdermal route by in vivo phage display

Nam Kyung LeeLaboratory of Animal Cell Biotechnology, Department of Agricultural Biotechnology, Seoul National University, Gwanak-gu, Seoul, Republic of Korea
,
Hong Shin KimLaboratory of Animal Cell Biotechnology, Department of Agricultural Biotechnology, Seoul National University, Gwanak-gu, Seoul, Republic of Korea
,
Kyung Hyun KimLaboratory of Animal Cell Biotechnology, Department of Agricultural Biotechnology, Seoul National University, Gwanak-gu, Seoul, Republic of Korea
,
Eun-Bae KimLaboratory of Animal Cell Biotechnology, Department of Agricultural Biotechnology, Seoul National University, Gwanak-gu, Seoul, Republic of Korea
,
Chong Su ChoLaboratory of Animal Cell Biotechnology, Department of Agricultural Biotechnology, Seoul National University, Gwanak-gu, Seoul, Republic of Korea
,
Sang Kee KangLaboratory of Animal Cell Biotechnology, Department of Agricultural Biotechnology, Seoul National University, Gwanak-gu, Seoul, Republic of Korea
&
Yun Jaie ChoiLaboratory of Animal Cell Biotechnology, Department of Agricultural Biotechnology, Seoul National University, Gwanak-gu, Seoul, Republic of KoreaCorrespondence[email protected] [email protected]
 show all
Pages 805-813 | Received 25 Nov 2010, Accepted 14 Mar 2011, Published online: 14 Oct 2011

References

  • Andreotti F, Rio T, Lavorgna A. (2009). Body fat and cardiovascular risk: understanding the obesity paradox. Eur Heart J, 30, 752–754.
  • Arap W, Haedicke W, Bernasconi M, Kain R, Rajotte D, Krajewski S, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E. (2002). Targeting the prostate for destruction through a vascular address. Proc Natl Acad Sci USA, 99, 1527–1531.
  • Arap W, Pasqualini R, Ruoslahti E. (1998). Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science, 279, 377–380.
  • Benson HA, Namjoshi S. (2008). Proteins and peptides: strategies for delivery to and across the skin. J Pharm Sci, 97, 3591–3610.
  • Chen Y, Shen Y, Guo X, Zhang C, Yang W, Ma M, Liu S, Zhang M, Wen LP. (2006). Transdermal protein delivery by a coadministered peptide identified via phage display. Nat Biotechnol, 24, 455–460.
  • Clapham JC, Arch JR, Tadayyon M. (2001). Anti-obesity drugs: a critical review of current therapies and future opportunities. Pharmacol Ther, 89, 81–121.
  • Després JP, Lemieux I. (2006). Abdominal obesity and metabolic syndrome. Nature, 444, 881–887.
  • Dias-Neto E, Nunes DN, Giordano RJ, Sun J, Botz GH, Yang K, Setubal JC, Pasqualini R, Arap W. (2009). Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis. PLoS ONE, 4, e8338.
  • Goldstein AL, Johnson PR. (1982). Primary culture of adipoblasts from obese and lean Zucker rat adipose tissue. Metab Clin Exp, 31, 601–607.
  • Hsiung PL, Hsiung PL, Hardy J, Friedland S, Soetikno R, Du CB, Wu AP, Sahbaie P, Crawford JM, Lowe AW, Contag CH, Wang TD. (2008). Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy. Nat Med, 14, 454–458.
  • Kang SK, Woo JH, Kim MK, Woo SS, Choi JH, Lee HG, Lee NK, Choi YJ. (2008). Identification of a peptide sequence that improves transport of macromolecules across the intestinal mucosal barrier targeting goblet cells. J Biotechnol, 135, 210–216.
  • Kim YC, Ludovice PJ, Prausnitz MR. (2007). Transdermal delivery enhanced by magainin pore-forming peptide. J Control Release, 122, 375–383.
  • Knorr F, Lademann J, Patzelt A, Sterry W, Blume-Peytavi U, Vogt A. (2009). Follicular transport route—research progress and future perspectives. Eur J Pharm Biopharm, 71, 173–180.
  • Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. (2004). Reversal of obesity by targeted ablation of adipose tissue. Nat Med, 10, 625–632.
  • Kopelman PG. (2000). Obesity as a medical problem. Nature, 404, 635–643.
  • Lee L, Buckley C, Blades MC, Panayi G, George AJ, Pitzalis C. (2002). Identification of synovium-specific homing peptides by in vivo phage display selection. Arthritis Rheum, 46, 2109–2120.
  • Prausnitz MR, Langer R. (2008). Transdermal drug delivery. Nat Biotechnol, 26, 1261–1268.
  • Prausnitz MR, Mitragotri S, Langer R. (2001). Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov, 3, 115–124.
  • Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. (1997). The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res, 25, 4876–4882.
  • Todo H, Kimura E, Yasuno H, Tokudome Y, Hashimoto F, Ikarashi Y, Sugibayashi K. (2010). Permeation pathway of macromolecules and nanospheres through skin. Biol Pharm Bull, 33, 1394–1399.
  • Wan XM, Chen YP, Xu WR, Yang WJ, Wen LP. (2009). Identification of nose-to-brain homing peptide through phage display. Peptides, 30, 343–350.

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