243
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment

, , , , , , , , , , , & show all
Pages 956-967 | Received 26 Jul 2013, Accepted 16 Aug 2013, Published online: 16 Sep 2013

References

  • Hudson D, Margaritis A. Biopolymer nanoparticle production for controlled release of biopharmaceuticals. Crit Rev Biotechnol 2013. [Epub ahead of print]. doi: 10.3109/07388551.2012.743503
  • Gu FX, Karnik R, Wang AZ, et al. Targeted nanoparticles for cancer therapy. Nano Today 2007;2:14–21
  • Chandna P, Khandare JJ, Ber E, et al. Multifunctional tumor-targeted polymer--peptide--drug delivery system for treatment of primary and metastatic cancers. Pharm Res 2010;27:2296–306
  • Sandoval MA, Sloat BR, Lansakara PD, et al. EGFR-targeted stearoyl gemcitabine nanoparticles show enhanced anti-tumor activity. J Control Release 2012;157:287–96
  • Ljubimova JY, Fujita M, Ljubimov AV, et al. Poly(malic acid) nanoconjugates containing various antibodies and oligonucleotides for multitargeting drug delivery. Nanomedicine 2008;3:247–65
  • Ruiz F, Alvarez G, Ramos M, et al. Cyclosporin A targets involved in protection against glutamate excitotoxicity. Eur J Pharmacol 2000;404:29–39
  • Kumar DM, Perez E, Cai ZY, et al. Role of nonfeminizingestrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity. Free Radic Biol Med 2005;38:1152–63
  • Zhang Y, Bhavnani BR. Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neurosci 2006;7:49–71
  • Gupta N, Yücel YH. Glaucoma as a neurodegenerative disease. Curr Opin Ophthalmol 2007;18:110–14
  • Kishore BK, Lambricht P, Laurent G, et al. Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly-l-aspartic, poly-l-glutamic and poly-d-glutamic acids. J Pharmacol Exp Ther 1990;255:875–85
  • Kishore BK, Maldague P, Tulkens PM, Courtoy PJ. Poly-d-glutamic acid induces an acute lysosomal thesaurismosis of proximal tubules and a marked proliferation of interstitium in rat kidney. Lab Invest 1996;74:1013–23
  • Schneerson R, Kubler-Kielb J, Liu TY, et al. Poly(γ-d-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine. Proc Natl Acad Sci USA 2003;100:8945–50
  • Hudson SP, Padera PF, Langer R, Kohane DS. The biocompatibility of mesoporous silicates. Biomaterials 2008;29:4045–55
  • Liu T, Li L, Teng X, et al. Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice. Biomaterials 2011;32:1657–68
  • Fujita M, Lee BS, Khazenzon NM, et al. Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(β-l-malic acid). J Control Release 2007;122:356–63
  • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002;7:2–8
  • Ljubimova JY, Fujita M, Khazenzon NM, et al. Association between laminin-8 and glial tumor grade, recurrence, and patient survival. Cancer 2004;101:604–12
  • Fujita M, Khazenzon NM, Bose S, et al. Overexpression of β1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases. Breast Cancer Res 2005;7:R411–21
  • Ljubimova JY, Lakhter AJ, Loksh A, et al. Overexpression of α4 chain-containing laminins in human glial tumors identified by gene microarray analysis. Cancer Res 2001;61:5601–10
  • Ding H, Inoue S, Ljubimov AV, et al. Inhibition of brain tumor growth by intravenous poly(β-l-malic acid) nanobioconjugate with pH-dependent drug release. Proc Natl Acad Sci USA 2010;107:18143–8
  • Pal SK, Childs BH, Pegram M. Triple negative breast cancer: unmet medical needs. Breast Cancer Res Treat 2011;125:627–36
  • Esposito CL, Passaro D, Longobardo I, et al. A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death. PLoS One 2011;6:e24071
  • Agrawal A, Gutteridge E, Gee JM, et al. Overview of tyrosine kinase inhibitors in clinical breast cancer. Endocr Relat Cancer 2005;12:S135–44
  • Huang S, Armstrong EA, Benavente S, et al. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res 2004;64:5355–62
  • Widakowich C, de Castro G Jr, de Azambuja E, et al. Side effects of approved molecular targeted therapies in solid cancers. Oncologist 2007;12:1443–55
  • Inoue S, Ding H, Portilla-Arias J, et al. Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res 2011;71:1454–64
  • Inoue S, Patil R, Portilla-Arias J, et al. Nanobiopolymer for direct targeting and inhibition of EGFR expression in triple negative breast cancer. PLoS One 2012;7:e31070
  • Popplewell L, Koo T, Leclerc X, et al. Gene correction of a Duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in. Hum Gene Ther 2013;24:692–701
  • Moulton HM. In vivo delivery of morpholino oligos by cell-penetrating peptides. Curr Pharm Des 2013;19:2963–9
  • Li C. Poly(l-glutamic acid) anticancer drug conjugates. Adv Drug Deliv Rev 2002;54:695–713
  • Lee BS, Fujita M, Khazenzon NM, et al. Polycefin, a new prototype of a multifunctional nanoconjugate based on poly(β-l-malic acid) for drug delivery. Bioconjug Chem 2006;17:317–26
  • Ljubimova JY, Fujita M, Khazenzon NM, et al. Nanoconjugate based on polymalic acid for tumor targeting. Chem Biol Interact 2008;171:195–203
  • Nag A, Mitra G, Ghosh PC. A colorimetric assay for estimation of polyethylene glycol and polyethylene glycolated protein using ammonium ferrothiocyanate. Anal Biochem 1996;237:224–31
  • Mullen DG, Desai AM, Waddell JN, et al. The implications of stochastic synthesis for the conjugation of functional groups to nanoparticles. Bioconjug Chem 2008;19:1748–52
  • Dobrovolskaia MA, Neun BW, Clogston JD, et al. Ambiguities in applying traditional Limulus amebocyte lysate tests to quantify endotoxin in nanoparticle formulations. Nanomedicine 2010;5:555–62
  • Aida Y, Pabst MJ. Removal of endotoxin from protein solutions by phase separation using Triton X-114. J Immunol Methods 1990;132:191–5
  • Assay Cascade Protocols, Frederick National Lab, Nanotechnology Characterization Laboratory. Available from: http://ncl.cancer.gov/working_assay-cascade.asp [last accessed 14 Aug 2013]
  • Ding H, Portilla-Arias J, Patil R, et al. Polymalic acid peptide copolymers: design and optimization for endosomolytic drug delivery. Biomaterials 2011;32:5269–78
  • Lorenz MR, Holzapfel V, Musyanovych A, et al. Uptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cells. Biomaterials 2006;27:2820–8
  • Wilhelm C, Billotey C, Roger J, et al. Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. Biomaterials 2003;24:1001–11
  • Ding H, Portilla-Arias J, Patil R, et al. Distinct mechanisms of membrane permeation induced by two polymalic acid copolymers. Biomaterials 2013;34:217–25
  • Edick MJ, Tesfay L, Lamb LE, et al. Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death. Mol Biol Cell 2007;18:2481–90
  • Yu X, Miyamoto S, Mekada E. Integrin α2β1-dependent EGFR receptor activation at cell--cell contact sites. J Cell Sci 2000;113:2139–47
  • Elgue G, Sanchez J, Egberg N, et al. Effect of surface-immobilized heparin on the activation of adsorbed factor XII. Artif Organs 1993;17:721–6
  • Fujita M, Khazenzon NM, Ljubimov AV, et al. Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis. Angiogenesis 2006;9:183–91
  • Kallergi G, Agelaki S, Kalykaki A, et al. Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients. Breast Cancer Res 2008;10:R80
  • Liu D, He J, Yuan Z, et al. EGFR expression correlates with decreased disease-free survival in triple-negative breast cancer: a retrospective analysis based on a tissue microarray. Med Oncol 2012;29:401–5
  • Mainelis G, Seshadri S, Garbuzenko OB, et al. Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice. J Aerosol Med Pulm Drug Deliv 2013. [Epub ahead of print] PMID: 23530772
  • Zhang M, Garbuzenko OB, Reuhl KR, et al. Two-in-one: combined targeted chemo and gene therapy for tumor suppression and prevention of metastases. Nanomedicine 2012;7:185–97
  • Hiroi N, Funahashi A, Kitano H. Comparative studies of suppression of malignant cancer cell phenotype by antisense oligo DNA and small interfering RNA. Cancer Gene Ther 2006;13:7–12
  • Kinali M, Arechavala-Gomeza V, Feng L, et al. Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study. Lancet Neurol 2009;8:918–28
  • Craft BS, Hortobagyi GN, Moulder SL. Adjuvant biologic therapy for breast cancer. Cancer J 2007;13:156–61
  • Ding H, Helguera G, Rodríguez JA, et al. Polymalic acid nanobioconjugate for simultaneous immunostimulation and inhibition of tumor growth in HER2/neu-positive breast cancer. J Control Release 2013. [Epub ahead of print] PMID: 23770212

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.