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Research Article

Preparation and evaluation of folate-modified lipid nanocapsules for quercetin delivery

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Pages 67-75 | Received 15 Jun 2013, Accepted 25 Aug 2013, Published online: 07 Oct 2013

References

  • Silva MM, Santos MR, Caroco G, et al. Structure--antioxidant activity relationships of flavonoids: a re-examination. Free Radic Res 2002;36:1219–27
  • Matsuda H, Morikawa T, Ando S, et al. Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. Bioorg Med Chem 2003;11:1995–2000
  • Boesch-saadatmandi C, Wagner AE, Wolffram S, Rimbach G. Effect of quercetin on inflammatory gene expression in mice liver in vivo – role of redox factor 1, mirna-122 and mirna-125b. Pharmacol Res 2012;65:523–30
  • Russo GL. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 2007;74:533–44
  • Radhika M, Ghoshal N, Chatterjee A. Comparison of effectiveness in antitumor activity between flavonoids and polyphenols of the methanolic extract of roots of potentilla fulgens in breast cancer cells. J Complement Integr Med 2012;9:article 24
  • Vidya priyadarsini R, Senthil murugan R, Maitreyi S, et al. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (hela) cells through p53 induction and nf-kappab inhibition. Eur J Pharmacol 2010;649:84–91
  • Kuo PC, Liu HF, Chao JI. Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. J Biol Chem 2004;279:55875–85
  • Nguyen TT, Tran E, Nguyen TH, et al. The role of activated mek-erk pathway in quercetin-induced growth inhibition and apoptosis in a549 lung cancer cells. Carcinogenesis 2004;25:647–59
  • Talirevic E, Jelena S. Quercetin in the treatment of dyslipidemia. Med Arh 2012;66:87–8
  • Boots AW, Drent M, de boer VC, et al. Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin Nutr 2011;30:506–12
  • Fasolo D, Schwingel L, Holzschuh M, et al. Validation of an isocratic lc method for determination of quercetin and methylquercetin in topical nanoemulsions. J Pharm Biomed Anal 2007;44:1174–7
  • Kumari A, Yadav SK, Pakade YB, et al. Development of biodegradable nanoparticles for delivery of quercetin. Colloids Surf B Biointerfaces 2010;80:184–92
  • Chen X, Yin OQ, Zuo Z, Chow MS. Pharmacokinetics and modeling of quercetin and metabolites. Pharm Res 2005;22:892–901
  • Justino GC, Santos MR, Canario S, et al. Plasma quercetin metabolites: structure--antioxidant activity relationships. Arch Biochem Biophys 2004;432:109–21
  • Heurtault B, Saulnier P, Pech B, et al. A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharmaceut Res 2002;19:875–80
  • Ghosh S, Dungdung SR, Chowdhury ST, et al. Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress. Free Radic Biol Med 2011;51:1893–902
  • Ramadan A, Lagarce F, Tessier-marteau A, et al. Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study. Int J Nanomed 2011;6:2941–51
  • Garcion E, Lamprecht A, Heurtault B, et al. A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats. Mol Cancer Ther 2006;5:1710–22
  • Jiang Q, Shi P, Li C, et al. (Coixan polysaccharide)-graft-polyethylenimine folate for tumor-targeted gene delivery. Macromol Biosci 2011;11:435–44
  • Yao H, Ng SS, Tucker WO, et al. The gene transfection efficiency of a folate-pei600-cyclodextrin nanopolymer. Biomaterials 2009;30:5793–803
  • Han X, Liu J, Liu M, et al. 9-nc-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro. Int J Pharm 2009;372:125–31
  • Xiang G, Wu J, Lu Y, et al. Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes. Int J Pharm 2008;356:29–36
  • Xiong S, Yu B, Wu J, et al. Preparation, therapeutic efficacy and intratumoral localization of targeted daunorubicin liposomes conjugating folate-peg-chems. Biomed Pharmacother 2011;65:2–8
  • Ferrari F, Bertoni M, Bonferoni CM, et al. Dissolution enhancement of an insoluble drug by physical mixture with a superdisintegrant: optimization with a simplex lattice design. Pharm Dev Technol 1996;1:159–64
  • Gao Y, Wang Y, Ma Y, et al. Formulation optimization and in situ absorption in rat intestinal tract of quercetin-loaded microemulsion. Colloids Surf B Biointerfaces 2009;71:306–14
  • Feng C, Wang T, Tang R, et al. Preparation, therapeutic efficacy and intratumoral localization of targeted daunorubicin liposomes conjugating folate-peg-chems cells. Pediatr Surg Int 2011;26:1185–91
  • Li H, Lu Y, Piao L, et al. Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid. Int J Pharm 2010;402:57–63
  • Manojlovic V, Winkler K, Bunjes V, et al. Membrane interactions of ternary phospholipid/cholesterol bilayers and encapsulation efficiencies of a rip ii protein. Colloids Surf B Biointerfaces 2008;64:284–96
  • Singh B, Mehta G, Kumar R, et al. Design, development and optimization of nimesulide-loaded liposomal systems for topical application. Curr Drug Deliv 2005;2:143–53
  • Sorensen EN, Weisman G, Vidaver GA. A sephadex column procedure for measuring uptake and loss of low molecular weight solutes from small, lipid-rich vesicles. Anal Biochem 1977;82:376–84
  • Zhao L, Shi Y, Zou S, et al. Formulation and in vitro evaluation of quercetin loaded polymeric micelles composed of pluronic p123 and d-a-tocopheryl polyethylene glycol succinate. J Biomed Nanotechnol 2011;7:358–65
  • Li H, Zhao X, Ma Y, et al. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Rel 2009;133:238–44
  • Duo J, Ying GG, Wang GW, Zhang L. Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid. Mol Med Report 2010;5:1453–6
  • Van der woude H, Gliszczynska-swiglo A, Struijs K, et al. Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 2003;200:41–7
  • Huang LQ, Zhang W, Yang Y, Tao L. Effects and its mechanism of quercetin on cervical cancer hela cells. Zhonghua Fu Chan Ke Za Zhi 2009;44:436–9
  • Hu K, Li J, Shen Y, et al. Lactoferrin-conjugated peg-pla nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J Contr Rel 2009;134:55–61
  • Allard E, Passirani C, Garcion E, et al. Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas. J Contr Rel 2008;130:146–53
  • Tian QE, Li HD, Yan M, et al. Astragalus polysaccharides can regulate cytokine and p-glycoprotein expression in h22 tumor-bearing mice. World J Gastroenterol 2012;18:7079–86
  • Yuan ZP, Chen IJ, Fan L, et al. Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin Cancer Res 2006;12:3193–9
  • Huynh NT, Passirani C, Saulnier P, Benoit JP. Lipid nanocapsules: a new platform for nanomedicine. Int J Pharm 2009;379:201–9
  • Ghosh D, Ghosh S, Sarkar S, et al. Quercetin in vesicular delivery systems: evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model. Chem Biol Interact 2010;186:61–71
  • Zhang L, Zhu W, Yang C, et al. A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting. Int J Nanomed 2012;7:151–62
  • Zhu W, Yu A, Wang W, et al. Formulation design of microemulsion for dermal delivery of penciclovir. Int J Pharm 2008;360:184–90
  • Lamprecht A, Saumet JL, Roux J, Benoit JP. Lipid nanocarriers as drug delivery system for ibuprofen in pain treatment. Int J Pharm 2004;278:407–14
  • Abdel-mottaleb MM, Neumann D, Lamprecht A. In vitro drug release mechanism from lipid nanocapsules (lnc). Int J Pharm 2010;390:208–13
  • Khaled KA, El-sayed YM, Al-hadiya BM. Disposition of the flavonoid quercetin in rats after single intravenous and oral doses. Drug Dev Ind Pharm 2003;29:397–403
  • Xu Y, Jin X, Ping Q, et al. A novel lipoprotein-mimic nanocarrier composed of the modified protein and lipid for tumor cell targeting delivery. J Control Rel 2010;146:299–308
  • Wang R, Hu X, Wu S, et al. Biological characterization of folate-decorated biodegradable polymer--platinum(ii) complex micelles. Mol Pharm 2012;9:3200–8

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