Particulate Endothelial Nitric Oxide Synthase: Requirement and Content of Tetrahydrobiopterin, FAD, and FMN

References

• Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976; 72: 248–254
   PubMed Web of Science ®Google Scholar
• Bredt D., Snyder S. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proceedings of National Academy of Sciences USA 1990; 87: 682–685
   PubMed Web of Science ®Google Scholar
• Bredt D. S., Hwang P. M., Glatt C. E., Lowenstein C, Reed R. R., Snyder S. H. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (London) 1991; 351: 714–718
   PubMed Web of Science ®Google Scholar
• Förstermann U., Mülsch A., Böhme E., Busse R. Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries. Circulation Research 1986; 58: 531–538
   PubMed Web of Science ®Google Scholar
• Förstermann U., Schmidt H. H. H. W., Pollock J. S., Sheng H., Mitchell J. A., Warner T. D., Nakane M., Murad F. Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochemical Pharmacology 1991; 42: 1849–1857
   PubMed Web of Science ®Google Scholar
• Fukushima T., Nixon J. C. Analysis of reduced forms of biopterin in biological tissues and fluids. Analytical Biochemistry 1980; 102: 176–188
   PubMed Web of Science ®Google Scholar
• Furchgott R. F., Zawadzki J. V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (London) 1980; 288: 373–376
   PubMed Web of Science ®Google Scholar
• Hevel J. M., Marietta M. A. Macrophage nitric oxide synthase: Relationship between enzyme-bound tetrahydro-biopterin and synthase activity. Biochemistry 1992; 31: 7160–7165
   PubMed Web of Science ®Google Scholar
• Hevel J. M., White K. A., Marietta M. A. Purification of the inducible murine macrophage nitric oxide synthase. Journal of Biological Chemistry 1991; 266: 22789–22791
   PubMed Web of Science ®Google Scholar
• Hiki K., Hattori R., Kawai C., Yui Y. Purification of insoluble nitric oxide synthase from rat cerebellum. Journal of Biochemistry 1992; 111: 556–558
   PubMed Web of Science ®Google Scholar
• Ignarro L. J., Harbison R. G., Wood K. S., Kadowitz P. J. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: Stimulation by acetylcholine, bradykinin and arachidonic acid. Journal of Pharmacology and Experimental Therapeutics 1986; 237: 893–900
   PubMed Web of Science ®Google Scholar
• Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 1970; 227: 680–685
   PubMed Web of Science ®Google Scholar
• Lamas S., Marsden P., Li G. K., Tempst P., Michel T. Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme isoform. Proceedings of National Academy Sciences USA 1992; 89: 6348–6352
   PubMed Web of Science ®Google Scholar
• Light D. R., Walsh C., Marietta M. A. Analytical and preparative high-performance liquid chromatography separation of flavin and flavin analog coenzymes. Analytical Biochemistry 1980; 109: 87–93
   PubMed Web of Science ®Google Scholar
• Lyons C. R., Orloff G. J., Cunningham J. M. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. Journal of Biological Chemistry 1992; 267: 6370–6374
   PubMed Web of Science ®Google Scholar
• Mayer B., John M., Böhme E. Purification of a Ca2+ /calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin. FEBS Letters 1990; 277: 215–219
   PubMed Web of Science ®Google Scholar
• Mayer B., John M., Heinzer B., Werner E. R., Wachter H., Schultz G., Böhme E. Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase. FEBS Letters 1991; 288: 187–191
   PubMedGoogle Scholar
• Myers P. R., Minor R. L., Jr., Guerra R., Jr., Bates J. N., Harrison D. G. Vasorelaxant properties of the endothelium-derived relaxing factor more, closely resemble S-nitrosocysteine than nitric oxide. Nature (London) 1990; 345: 161–163
   PubMed Web of Science ®Google Scholar
• Nishida K., Harrison D. G., Navas J. P., Fisher A. A., Dockery S. P., Uematsu M., Nerem R. M., Alexander R. W., Murphy T. J. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. Journal of Clinical Investigation 1992; 90: 2092–2096
   PubMed Web of Science ®Google Scholar
• Palmer R. M. J., Ferrige A. G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (London) 1987; 327: 524–526
   PubMed Web of Science ®Google Scholar
• Palmer R. M. J., Ashton D. S., Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature (London) 1988; 333: 646–666
   Google Scholar
• Pollock J. S., Förstermann U., Mitchell J. A., Warner T. D., Schmidt H. H. H. W., Nakane M., Murad F. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proceedings of National Academy of Sciences USA 1991; 88: 10480–10484
   PubMed Web of Science ®Google Scholar
• Rapoport R. M., Murad F. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circulation Research 1983; 52: 352–357
   PubMed Web of Science ®Google Scholar
• Schmidt H. H. H. W., Nau H., Wittfoht W., Gerlach J., Prescher K. E., Klein M. M., Niroomand F., Böhme E. Arginine is a physiological precursor of endothelium-derived nitric oxide. European Journal of Pharmacology 1988; 154: 213–216
   PubMed Web of Science ®Google Scholar
• Schmidt H. H. H. W., Pollock J. S., Nakane M., Gorsky L. D., Förstermann U., Murad F. Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proceedings of National Academy of Sciences USA 1991; 88: 365–369
   PubMed Web of Science ®Google Scholar
• Schmidt H. H. H. W., Smith R. M., Nakane M., Murad F. Ca2+/calmodulin-dependent NO synthase type I: A biopteroflavoprotein with Ca2+/calmodulin-independent diaphorase and reductase activities. Biochemistry 1992; 31: 3242–3249
   Google Scholar
• Sessa WC., Harrison J. K., Barber C. M., Zeng D., Durieux M. E., D'Angelo D. D., Lynch K. R., Peach M. J. Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. Journal of Biological Chemistry, 267: 15274–15276
   PubMed Web of Science ®Google Scholar
• Stuehr D. J., Cho H. J., Kwon N. S., Nathan C. F. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: An FAD- and FMN- containing flavoprotein. Proceedings of National Academy Sciences USA 1991; 88: 7773–7777
   PubMed Web of Science ®Google Scholar
• Wemer E. R., Fuchs D., Hausen A., Reibnegger G., Wachter H. Simultaneous determination of neopterin and creatinine in serum with solid-phase extraction and online elution liquid chromatography. Clinical Chemistry 1987; 33: 2028–2033
   PubMed Web of Science ®Google Scholar
• Xie Q-W., Cho H. J., Calaycay J., Mumford R. A., Swiderek K. M., Lee T. D., Ding A., Troso T., Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 1992; 256: 225–228
   PubMed Web of Science ®Google Scholar