Multinucleated variant endothelial cells (MVECs) of human aorta: Expression of tumor suppressor gene p53 and relationship to atherosclerosis and aging

References

• Bogliolo M, Fronza G., Campomenosi P., Assereto P., Izzotti A., Petrilli G. L., Abbondandolo A., De Flora S. Lack of mutations in K-ras codons 12 and 13 in human atherosclerotic lesions. Chemico-Biological Interactions 1996; 102: 55–62
   PubMed Web of Science ®Google Scholar
• Clearly M. L., Sklar J. Nucleotide sequence of at (14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci USA 1985; 82: 7439–7443
   PubMed Web of Science ®Google Scholar
• Colombel M., Symmans F., Gil S., Otoole K. M., Chopin O., Benson M., Olsson C. A., Korsmeyer S., Buttyan R. Detection of the apoptosis- suppressing oncoprotein BCL-2 in hormone-refractory human prostate cancers. Am J Pathol 1993; 143: 390–400
   PubMed Web of Science ®Google Scholar
• Cross S. M., Sauchez C. A., Morgan C. A., Schimke M. K., Ramel S., Ldzerda R. L., Raskind W. H., Reid B. J. A p53-dependent mouse spindle checkpoint. Science 1995; 267: 1353–1356
   PubMed Web of Science ®Google Scholar
• D'Agostini F., Fronza G., Campomenosi P., Izzoti, Petrilli G. L., Abbondandolo A., De Flora S. Cancer biomarkers in human atherosclerotic lesions: no evidence of p53 involvement. Cancer Epidemiology, Biomarkers & Prevention 1995; 4: 111–115
   PubMed Web of Science ®Google Scholar
• Eyfjord J. E., Thorlacius S., Steinarsdottir M, Valgardsdottir R., Ogmundsdottir H. M., Anamthawat-Jonsson K. p53 abnormalities and genomic instability in primary human breast carcinomas. Cancer Res 1995; 55: 646–651
   PubMed Web of Science ®Google Scholar
• Hartwell L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 1992; 71: 543–546
   PubMed Web of Science ®Google Scholar
• Hayashi K. PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA in PCR methods and applications. Cold Spring Harbor Laboratory Press, Cold Springer Harbor, NY 1991; 1: 34–38
   Google Scholar
• Hockenbery D. M., Zutter M., Hickey W., Nahm M., Korsmeyer S. J. BCL-2 protein is topographically restricted in tissues characterized by apoptoic cell death. Proc Natl Acad Sci USA 1991; 88: 6961–6965
   PubMed Web of Science ®Google Scholar
• Johnson R. T., Rao P. N. Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei. Nature 1970; 226: 717–722
   PubMed Web of Science ®Google Scholar
• Kern S. E., Kinzler K. W., Bruskin A., Jarosz D., Friedman P., Prives C., Vogelstein B. Identification of p53 as a sequence-specific DNA-binding protein. Science 1991; 252: 1708–1711
   PubMed Web of Science ®Google Scholar
• Kozopas K. M., Yang T., Buchan H. L., Zhou P., Craig R. W. MCL-1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL-2. Proc Natl Acad Sci USA 1993; 90: 3516–3520
   PubMed Web of Science ®Google Scholar
• Krajewski S., Tanaka S., Tokayama S., Schilder M. J., Fenton W., Reed J. C. Investigation of the subcellular distribution of the BCL-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 1993; 53: 4701–4714
   PubMed Web of Science ®Google Scholar
• Kuerbitz S. J., Plunkett B. S., Walsh W. V., Kastan M. B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 1992; 89: 7491–7495
   PubMed Web of Science ®Google Scholar
• Levine A., Momand J., Finlay C. A. The p53 tumor suppressor gene. Nature 1991; 351: 453–456
   PubMed Web of Science ®Google Scholar
• Livingston L., White A., Sprouse J., Livanos E., Jacks T., Tlsty T. D. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992; 70: 923–935
   PubMed Web of Science ®Google Scholar
• Lowe S. W., Bodis S., McClatchey A., Remington L., Ruley E., Fisher D., Housman D., Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science 1994; 266: 807–810
   PubMed Web of Science ®Google Scholar
• Majino G., Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 1995; 146: 3–15
   PubMed Web of Science ®Google Scholar
• Matlaskewski G. L., Lamb P., Pim D., Peacock J., Crowford L., Benchimol S. Isolation and characterization of a human p53 cDNA clone; expression of the human p53 gene. EMBO J 1984; 3: 3257–3262
   PubMed Web of Science ®Google Scholar
• Oliner J. D., Pietenpol J. A., Thiagalingam S., Gyuris J., Kinzler K. W., Vogelstein B. Oncoprotein MDM-2 conceals the activation domain of tumour suppressor p53. Nature 1993; 362: 857–860
   PubMed Web of Science ®Google Scholar
• Oltvai Z. N., Millman C. L., Korsmeyer S. J. BCL-2 heterodimerizes in vivo with a conserved homolog, BAX, that accelerates programed cell death. Cell 1993; 74: 609–619
   PubMed Web of Science ®Google Scholar
• Repin V. S., Bern M. M., Coughlin C. C., Haudenshild L. W., Hoyer L. W., Antoniades H. N., Zetter B. R. Heterogeneity of endothelium in human aorta. A quantitative analysis by scanning electron microscopy. Atherosclerosis 1984; 50: 35–52
   PubMed Web of Science ®Google Scholar
• Ryan J. J., Prochownik E., Gottlieb C. A., Apel I. J., Merino G. N., Clarke M. F. c-MYC and BCL-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA 1994; 91: 5878–5882
   PubMed Web of Science ®Google Scholar
• Sambrook J., Fritsch E. F., Maniatis T. In vitro amplification of DNA by the polymerase chain reaction in molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Springer Harbor, NY 1989; 1–35
   Google Scholar
• Shaw P., Bovey R., Tardy S., Sahli R., Sordat B., Costa J. Induction of apoptosis by wild-type p53 in a human colon tumor derive cell line. Proc Natl Acad Sci USA 1992; 89: 4495–4499
   PubMed Web of Science ®Google Scholar
• Steller H. Mechanisms and genes of cellular suicide. Science 1995; 267: 1445–1449
   PubMed Web of Science ®Google Scholar
• Swanson P. E., Carroll S. B., Zhang X. F., Mackey M. A. Spontaneous premature chromosome condensation, micronuclcus formation, and non-specific cell death in heated Hila S3 cells. Am J Pathol 1995; 146: 963–971
   PubMed Web of Science ®Google Scholar
• Tashiro K., Shimokama T., Haraoka S., Tokunaga O., Watanabe T. Endothelial cell heterogeneity in experimentally-induced rabbit atherosclerosis. Demonstration of multinucleated giant endothelial cells by scanning electron microscopy and cell culture. Virchow Arch 1994; 425: 521–529
   PubMed Web of Science ®Google Scholar
• Tokunaga O., Fan J., Watanabe T. Atherosclerosis and age-related multinucleated variant endothelial cells. Am J Pathol 1989; 135: 967–976
   PubMed Web of Science ®Google Scholar
• Vaux D. L., Cory S., Adams J. M. BCL-2 gene promotes haematopoietic cell survival and cooperates with c-MYC to immortalize pre-B cells. Nature 1988; 335: 440–442
   PubMed Web of Science ®Google Scholar
• Williams G. T., Smith C. A., Spooncer E., Dexter T. M., Taylor D. R. Haemopoietic colony stimulating factor promotes cell survival by suppressing apoptosis. Nature 1990; 343: 76–79
   PubMed Web of Science ®Google Scholar
• Wiethege T., Voss B., Muller K. M. p53 accumulation in polynuclear-giant-cells. Virchows Arch 1994; 424: 357–360
   PubMed Web of Science ®Google Scholar
• Yin Y., Tainsky M. A., Bischoff F. Z., Strong L. C., Wahl G. M. Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992; 70: 937–948
   PubMed Web of Science ®Google Scholar
• Yonish-Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 1991; 352: 345–347
   PubMed Web of Science ®Google Scholar