21
Views
3
CrossRef citations to date
0
Altmetric
Original Article

Vasoactive Effects and Placental Transfer of Nifedipine, Celiprolol, and Magnesium Sulfate in the Placenta Perfused in Vitro

, , &
Pages 93-102 | Published online: 07 Jul 2009

References

  • Henry P. Comparative pharmacology of calcium antagonists: nifedipine, verapamil, and diltiazem. Am J Cardiol 1980; 46: 1047–58
  • Ahokas R A, Sibai B M, Mabie W C, Anderson G D. Nifedipine does not adversely affect uteroplacental flow in the hypertensive term-pregnant rat. Am J Obstet Gynecol 1988; 159: 1440–5
  • Pirhonen J P, Erkkola R U, Ekblad U U, Nyman L. Single dose of nifedipine in normotensive pregnancy: nifedipine concentrations, hemodynamic responses, and uterine and fetal flow velocity waveform. Obstet Gynecol 1990; 76: 807–11
  • Lurie S, Fenakel K, Friedman A. Effect of nifedipine on fetal heart rate in the treatment of severe pregnancy-induced hypertension. Am J Perinatal 1990; 7: 285–6
  • Malminiemi K. Association between serum lipids, glucose tolerance, and insulin sensitivity during 12 months of celiprolol treatment. Cardiovasc Drugs Ther 1995; 9: 295–304
  • Milne R J, Buckley M MT. Celiprolol–-an updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in cardiovascular disease. Drugs 1991; 41: 941–69
  • Hinderling P H, Schmidlin O, Seydel J. Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man. J Pharmacokin Biopharm 1984; 12: 263–87
  • Schneider H, Proegler M. Placental transfer of beta-adrenergic antagonists studied in an in vitro perfusion system of human placental tissue. Am J Obstet Gynecol 1988; 159: 42–7
  • Wendtlandt W, Pittner H. Toxicological evaluation of celiprolol a cardioselective β-adrenergic blocking agent. Arzn Forsch 1983; 33: 41–50
  • Pittner H, Takacs F, Fellier H. Pharmacokinetic and toxicokinetic investigations with the cardioselective β-adrenergic blocking agent celiprolol in rats dogs and rabbits. Arzn Forsch 1983; 33: 33–41
  • Milne R J, Buckley M-T. Celiprolol. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in cardiovascular disease. Drugs 1991; 41(6)941–69
  • Kofahl B, Henke D, Hettenbach A, Mutschler E. Studies on placental transfer of celiprolol. Eur J Clin Pharmacol 1993; 44: 381–2
  • The Eclampsia Trial Collabourative Group. Which anticonvulsant for women with eclampsia? Evidence from the Collabourative Eclampsia Trial. Lancet 1995; 345: 1455–63
  • Peaceman A M, Meyer B A, Thorp J A. The effect of magnesium sulfate tocolysis on the fetal biophysical profile. Am J Obstet Gynecol 1989; 161: 771–4
  • Nelson K B, Grether J K. Can magnesium sulphate reduce the risk of cerebral palsy in very low birthweight infants. Pediatrics 1995; 95: 263–9
  • Hauth J C, Goldenberg R L, Nelson K G, Dubard M B, Peralta M A, Gaudier F L. Reduction of cerebral palsy with maternal MgS04 treatment in newborns weighing 500–1000 g. Am J Obstet Gynecol 1995; 173: 578–84
  • Cotton D B, Gonik B, Dorman K F. Cardiovascular alterations in severe pregnancy induced hypertension: acute effects of intravenous magnesium sulphate. Am J Obstet Gynecol 1984; 148: 162–5
  • Schneider H, Panigel M, Dancis J. Transfer across the perfused human placenta of antipyrine sodium and leucine. Am J Obstet Gynecol 1972; 114: 822–8
  • Bach P R. Determination of nifedipine in serum or plasma by reversed-phase liquid chromatography. Clin Chem 1983; 29(7)1344–8
  • Buskin J N, Upton R A, Sörgel F, Williams R L. Specific and sensitive assay of celiprolol in blood plasma and urine using high-performance liquid chromatography. J Chromatogr 1982; 230: 454–60
  • Brodie B B, Axelrod J, Soberman R, Levy B B. An estimation of antipyrine in biological materials. J Biol Chem 1949; 179: 25–9
  • Thiagarajah S, Harbert G M, Bourgeois F J. Magnesium sulfate and ritodrine hydrochloride: systemic and uterine hemodynamic effects. Am J Obstet Gynecol 1985; 153: 666–74
  • Petersen O, Skajaa K, Svane D, Gregersen H, Forman A. The effects of dihydralazine, labetalol and magnesium sulphate on isolated, perfused human placental cotyledon. Br J Obstet Gynaecol 1994; 101: 871–8
  • Belfort M, Saade G, Moise K. The effect of magnesium sulfate on maternal and fetal blood flow in pregnancy-induced hypertension. Acta Obstet Gynaecol Scand 1993; 72: 526–30
  • Fried G, Liu Y-A. Effects of endothelin calcium channel blockade and EDRF inhibition on the contractility of human uteroplacental arteries. Acta Physiol Scand 1994; 151: 477–84
  • Chesley L C, Tepper I. Plasma levels of magnesium attained in magnesium sulphate therapy for pre-eclampsia and eclampsia. Surg Clin North Am April, 1957; 353–67
  • Lubbe W F. Hypertension in pregnancy. Pathophysiology and management. Drugs 1984; 28: 170–88
  • Hubel C, Roberts J, Taylor R, Musci T, Rogers G, McLaughlin M. Lipid peroxidation in pregnancy: new perspectives on preeclampsia. Am J Obstet Gynecol 1989; 161: 1025–34
  • Poranen A-K, Ekblad U, Uotila P, Ahotupa M. Lipid peroxidation and antioxidants in normal and pre-eclamptic pregnancies. Placenta 1996; 17: 401–5
  • Mehta J L, Lopez L M, Chen L, Cox O E. Alterations in nitric oxide synthase activity, superoxide anion generation, and platelet aggregation in systemic hypertension, and effects of celiprolol. Am J Cardiol 1994; 74: 901–5
  • Haught W H, Yang B C, Lawson D L, Mehta J L. Slow channel calcium blockers attenuate reoxygenation-mediated vascular contraction but augment anoxia-mediated vascular contraction. J Cardiovasc Pharmacol 1992; 19: 701–8
  • Ding Y-A, Han C-L, Chon T C, Lai W-Y, Shiao M-F. Effects of the calcium antagonist isradipine on 24-hour ambulatory blood pressure, platelet aggregaion, and neutrophil oxygen free radical in hypertension. J Cardiovasc Pharmacol 1992; 19: S32–7, Suppl 3
  • Panigel M. Placental perfusion experiments. Am J Obstet Gynecol 1962; 84: 1664–83
  • Kuhn D C, Crawford M A, Gordon G B, Stuart M J. Aspects of in vitro placental perfusion: effects of hyperoxia and phenol red. Placenta 1988; 9: 201–3

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.