Association Analysis about HLA-DRB1, -DQB1 Polymorphism and Auto-Antibodies Against α₁-Adrenergic Receptors in Chinese Patients with Essential Hypertension

REFERENCES

• Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F. Autoantibodies activating human β1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation 1999;99:649–654.
   PubMed Web of Science ®Google Scholar
• Liao YH, Wei YM, Wang M, Wang ZH, Yuan HT, Cheng LX.. Autoantibodies against AT1-receptor and alpha1-adrenergic receptors in patients with hypertension. Hypertens Res 2002; 25:641–646.
   PubMed Web of Science ®Google Scholar
• Herse F, Verlohren S, Wenzel K, Pape J, Muller DN, Modrow S, Wallukat G, Luft FC, Redman CW, Dechend R. Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study. Hypertension 2009; 53:393–398.
   PubMed Web of Science ®Google Scholar
• Fu ML, Herlitz H, Schulze W, Wallukat G, Micke P, Eftekhari P, Sjögren KG, Hjalmarson A, Müller-Esterl W, Hoebeke J. Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. J Hypertension 2000; 18:945–953.
   PubMed Web of Science ®Google Scholar
• Fu ML, Herlitz H, Wallukat G, Hilme E, Hedner T, Hoebeke J, Hjalmarson A. Functional autoimmune epitope on 1-adrenergic receptors in patients with malignant hypertension. Lancet 1994;344:1660–1663.
   PubMed Web of Science ®Google Scholar
• Luther HP, Homuth V, Wallukat G. α 1-adrenergic receptor antibodies in patients with primary hypertension. Hypertension 1997; 29:678–682.
   PubMed Web of Science ®Google Scholar
• Wenzel K, Haase H, Wallukat G, Derer W, Bartel S, Homuth V, Herse F, Hubner N, Schulz H, Janczikowski M, Lindschau C, Schroeder C, Verlohren S, Morano I, Muller DN, Luft FC, Dietz R, Dechend R, Karczewski P. Potential relevance of α1-adrenergic receptor autoantibodies in refractory hypertension. PLoS One 2008;3:e3742.
   PubMed Web of Science ®Google Scholar
• Bkaily G, El-Bizri N, Bui M, Sukarieh R, Jacques D, Fu ML. Modulation of intracellular Ca2++ via L-type calcium channels in heart cells by the autoantibody directed against the second extracellular loop of the alpha1-adrenoceptors. Can J Physiol Pharmacol 2003;81: 234–246.
   PubMed Web of Science ®Google Scholar
• Fu ML, Wallukat G, Hjalmarson A, Hoebeke, J. Characterization of anti-peptide antibodies directed against an extracellular immunogenic epitope on the human a1-adrenergic receptor. Clin Exp Immunol 1994;97:146–151.
   PubMed Web of Science ®Google Scholar
• Yan L, Xu Y, Yao H, Xue W, Tian J, Ren H, Wu Y, Yang G, Ma XL, Liu H. The effects of autoantibodies against the second extracellular loop of α1-adrenoceptor on vasoconstriction. Basic Res Cardiol 2009;104:581–589.
   PubMed Web of Science ®Google Scholar
• Zhou ZH, Liao YH, Wei YM, Wei F, Wang B, Li LD, Wang M, Liu K. Cardiac remodeling after long-term stimulation by antibodies against the a1-adrenergic receptor in rats. Clin Immunol 2005;114:164–173.
   PubMed Web of Science ®Google Scholar
• Okruhlicova L, Morwinski R, Schulze W, Bartel S, Weismann P, Tribulova N, Wallukat G. Autoantibodies against G-protein-coupled receptors modulate heart mast cells. Cell Mol Immunol 2007;4:127–133.
   PubMed Web of Science ®Google Scholar
• Dzielak D. The immune system and hypertension. Hypertension 1992;19:136–144 (suppl I).
   Google Scholar
• Fu ML. Do immune system changes have a role in hypertension. J Hypertens 1995;13: 1259–1265.
   PubMed Web of Science ®Google Scholar
• Price P, Witt C, Allcock R, Sayer D, Garlepp M, Kok CC, French M, Mallal S, Christiansen F. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol Rev 1999;167:257–274.
   PubMed Web of Science ®Google Scholar
• Ogata T, Gregoire L, Goddard KAB, Skunca M, Tromp G, Lancaster WD, Parrado AR, Lu Q, Shibamura H, Sakalihasan N, Limet R, MacKean GL, Arthur C, Sueda T, Kuivaniemi H Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study. BMC Med Genet 2006;7:67–80.
   PubMed Web of Science ®Google Scholar
• Warrens A, Lechler R. HLA in Health and Disease. Elsevier: Academic Press, 1999.
   Google Scholar
• Van Eden W. Immunoregulation of autoimmune diseases. Human Immunology 2006;67:446–453.
   PubMed Web of Science ®Google Scholar
• Trowsdale J, Powis SH. The MHC: Relationship between linkage and function. Curr Opin Genet Dev 1992;2:492–497.
   PubMed Web of Science ®Google Scholar
• Janeway CA, Travers P, Walport M, Schlomchik MJ. Immunobiology, 6th ed: The Immune System in Health and Disease. New York: Garland Publishing, 2005.
   Google Scholar
• O'Hanlon TP, Rider LG, Mamyrova G, Targoff IN, Arnett FC, Reveille JD, Carrington M, Gao XJ, Oddis CV, Morel PA, Malley JD, Malley K, Shamim EA, Chanock SJ, Foster CB, Bunch T, Reed AM, Love LA, Miller FW. HLA polymorphisms in African Americans with idiopathic inflammatory myopathy. Arthritis Rheum 2006;54:3670–3681.
   PubMed Web of Science ®Google Scholar
• Liu W, Li WM, Sun NL. HLA-DQA1, -DQB1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy in Hans of Northern China. Ann Hum Genet 2005;69:382–388.
   PubMed Web of Science ®Google Scholar
• Fanning GC, Welsh KI, Bunn C, Dubois R, Black CM. HLA association in three mutually exclusive autoantibody subgrouos in UK systemic sclerosis patients. Br J Rheumatol 1998;37:201–207
   PubMedGoogle Scholar
• Gerbase-DeLima M, DeLima JJ, Persoli LB, Silva HB, Marcondes M, Bellotti G. Essential hypertension and histocompatibility antigens. A linkage study. Hypertension 1989; 14:604–609.
   PubMed Web of Science ®Google Scholar
• Patel R, Johnson J. Histocompatibility antigens in black patients with essential hypertension. Circulation 1981;64: 1042–1044.
   PubMed Web of Science ®Google Scholar
• Luque OM, Martell CN, Llorente PL, Fernández PC, Fernández-Cruz A. Severe hypertension in the Spanish population. Association with specific HLA antigens. Hypertension 1983;5:149–152.
   Web of Science ®Google Scholar
• Gerbase-DeLima M, Ladalardo MA, DeLima JJ, Silva HB, Bellotti G, Pileggi F. Essential hypertension and histocompatibility antigens. An association study. Hypertension 1992; 19:400–402.
   PubMed Web of Science ®Google Scholar
• Titkov YS, Ziskina RA, Temirov AA, Gybladze DV, Bubnova LN. HLA antigens in borderline and essential hypertension. Am J Hypertens 1993;6:885–887.
   PubMed Web of Science ®Google Scholar
• Gerbase-DeLima M, Paiva RLF, Bortolotto LA, Bernardes-Silva H, De Lima JJG. Human leukocyte antigens and malignant essential hypertension. Am J Hypertens 1998;11:729–731.
   PubMed Web of Science ®Google Scholar
• Fields HA, Davis CL, Bradley DW, Mayanrd JE. Experimental conditions affecting the sensitivity of enzyme-linked immunosorbent assay (ELISA) for detection of hepatitis B surface antigen (HBsAg). Bull World Health Organ 1983;61:135–142.
   PubMed Web of Science ®Google Scholar
• Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific prmers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantion. Tissue Antigens 1992;39:225–235.
   PubMed Web of Science ®Google Scholar
• Bunce M, O'Neill CM, Barnardo MCNM, Krausa P, Browning MJ, Morris PJ, Welsh KI. Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilising sequence-specific primers (PCR-SSP). Tissue Antigens 1995;46:355–367.
   PubMed Web of Science ®Google Scholar
• Olerup O, Aldener A, Fogdell A. HLA-DQB1 and DQA1 typing by PCR amplifications with sequence specific primers (PCR-SSP). Tissue Antigens 1993;41:119–134.
   PubMed Web of Science ®Google Scholar
• Bland JM, Altman DG. Multiple significance tests: the Bonferroni method. BMJ 1995;310: 170.
   PubMed Web of Science ®Google Scholar
• Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphic loci. Cell Res 2005;15:97–98.
   PubMed Web of Science ®Google Scholar
• John DR, Abul KA. Paths to understanding the genetic basis of autoimmune disease. Nature 2005;435:584–589.
   PubMed Web of Science ®Google Scholar
• Pearce SH, Merriman TR. Genetic progress towards the molecular basis of autoimmunity. Trends Mol Med 2006;12: 90–98.
   PubMed Web of Science ®Google Scholar
• Ferrari I, Levin MJ, Wallukat G, Elies R, Lebesgue D, Chiale P, Elizari M, Rosenbaum M, Hoebeke J. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1-adrenergic receptor. J Exp Med 1995;182:59–65.
   PubMed Web of Science ®Google Scholar
• Stepan H, Wallukat G, Schultheiss HP, Faber R, Walther T. Is parvovirus B19 the cause for autoimmunity against the angiotensin II type receptor?? J Reprod Immunol 2007;73: 130–134.
   PubMed Web of Science ®Google Scholar
• LaMarca B, Wallukat G, Llinas M, Herse F, Dechend R, Granger JP. Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats. Hypertension 2008;52:1168–1172.
   PubMed Web of Science ®Google Scholar
• Andersson EC, Hansen BE, Jacobsen H, Madsen LS, Andersen CB, Engberg J, Rothbard JB, Sönderstrup-McDevitt G, Malmström V, Holmdahl R, Svejgaard A, Fugger L. Definition of MHC and T cell receptor contacts in the HLA-DR4 restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc Natl Acad Sci USA 1998;95:7574–7569.
   PubMed Web of Science ®Google Scholar
• Fugger L, Rothbard JB, McDevitt GS. Specificity of an HLADRB1**0401-restricted T cell response to type II collagen. Eur J Immunol 1996;26:923–933.
   Web of Science ®Google Scholar
• Jun KR, Choi SE, Cha CH, Oh HB, Heo YS, Ahn HY, Lee KJ. Meta-analysis of the association between HLA-DRB1 allele and rheumatoid arthritis susceptibility in Asian populations. J Korean Med Sci 2007;22:973–980.
   PubMed Web of Science ®Google Scholar
• Lin L, Chen Y, Xiao Z, Huang S, Yang Z. The association of HLA-DRB1 alleles with rheumatoid arthritis in the Chinese Shantou population: a follow-up study. Biochem Cell Biol 2007;85:227–238.
   PubMed Web of Science ®Google Scholar
• Kilpatrick DC, Liston WA, Gibson F, Livingstone J. Association between susceptibility to preeclampsia within families and HLA DR4. Lancet 1989;2:1063–1065.
   PubMed Web of Science ®Google Scholar
• Limas C, Limas CJ, Boudoulas H, Bair R, Graber H, Sparks L, Wooley CF. Anti-beta-receptor antibodies in familial cardiomyopathy: correlation with HLA-DR and HLA-DQ gene polymorphisms. Am Heart J 1994;127:382–386.
   PubMed Web of Science ®Google Scholar
• Takakuwa K, Honda K, Ishii K, Hataya I, Yasuda M, Tanaka K. Studies on the HLA-DRB1 genotypes in Japanese women with severe preeclampsia positive and negative for cardiolipin antibody using a polymerase chain reaction-restriction fragment length polymorphism method. Hum Reprod 1999;14: 2980–2986.
   PubMedGoogle Scholar
• Limas CJ, Limas C. HLA-DR antigen linkage of anti-beta receptor antibodies in idiopathic dilated and ischaemic cardiomyopathy. Br Heart J 1992;67:402–405.
   PubMedGoogle Scholar
• Ou D, Mitchell LA, Tingle AJ. HLA-DR restrictive supertypes dominate promiscuous T cell recognition: association of multiple HLA-DR molecules with susceptibility to autoimmune diseases. J Rheumatol 1997;24:253–261.
   PubMed Web of Science ®Google Scholar
• Cornelia MW, Jörg JG. Association of MHC and rheumatoid arthritis: HLA polymorphisms in phenotypic variants of rheumatoid arthritis. Arthritis Res 2000;2:212–216.
   PubMedGoogle Scholar
• Jones EY, Fugger L, Strominger JL, Siebold C. MHC class II proteins and disease: A structural perspective. Nat Rev Immunol 2006;6:271–282.
   PubMed Web of Science ®Google Scholar
• Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 2002;53:79–91.
   PubMed Web of Science ®Google Scholar
• Jeffrey DW, Jonathan K P. Haplotype blocks and linkage disequilibrium in the human genome. Nature Reviews Genetics 2003;4:587–597.
   PubMed Web of Science ®Google Scholar
• Petrone A, Giorgi G, Mesturino CA, Capizzi M, Cascino I, Nistico L, Osborn J, Mario UD, Buzzetti R.. Association of DRB1**04-DQB1**0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population. THYROID 2001;11:171–175.
   PubMed Web of Science ®Google Scholar
• Hermann R. Turpeinen H, Laine AP, Veijola R, Knip M, Simell O, Sipilä I, Akerblom HK, Ilonen J. HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families. Tissue Antigens 2003;62:162–169.
   PubMed Web of Science ®Google Scholar
• Yongsoo P, George S. Eisenbarth Genetic susceptibility factors of Type 1 diabetes in Asians. Diabetes Metab Res Rev 2001;17:2–11.
   PubMed Web of Science ®Google Scholar
• Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P. Type 1 Diabetes Genetics Consortium, Type 1 Diabetes Genetics Consortium HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008;57:1084–1092.
   PubMed Web of Science ®Google Scholar
• Zanelli E, Huizinga TW, Guerne PA, Vischer TL, Tiercy JM, Verduyn W, Schreuder GM, Breedveld FC, de Vries RR. An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition. Immunogenetics 1998;48: 394–401.
   PubMed Web of Science ®Google Scholar
• Laivoranta-Nyman S, Mottonen T, Hermann R, Tuokko J, Luukkainen R, Hakala M, Hannonen P, Korpela M, Yli-Kerttula U, Toivanen A, Ilonen J. HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis. Ann Rheum Dis 2004;63:1406–1412.
   PubMed Web of Science ®Google Scholar
• Schork NJ. Genetically complex cardiovascular traits: origins, problems, and potential solutions. Hypertension 1997;29:145–149.
   PubMed Web of Science ®Google Scholar
• Vidan-Jeras B, Gregoric A, Jurca B, Jeras M, Bohinjec M. Possible influence of genes located on chromosome 6 within or near to the major histocompatibility complex on development of essential hypertension. Eur J Physiol 2000;439:60–62 (suppl).
   Google Scholar