Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells

References

• Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004;109:III27–III32.
   PubMed Web of Science ®Google Scholar
• Shinohara M, Thornalley PJ, Giardino I, Beisswenger P, Thorpe SR, Onorato J, Brownlee M. Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest 1998;101:1142–1147.
   PubMed Web of Science ®Google Scholar
• Yavuz A, Tetta C, Ersoy FF, D'intini V, Ratanarat R, De Cal M, Bonello M, Bordoni V, Salvatori G, Andrikos E, Yakupoglu G, Levin NW, Ronco C. Uremic toxins: a new focus on an old subject. Semin Dial 2005;18:203–211.
   PubMed Web of Science ®Google Scholar
• Han Y, Randell E, Vasdev S, Gill V, Gadag V, Newhook LA, Grant M, Hagerty D. Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with type I diabetes. Mol Cell Biochem 2007;305:123–131.
   PubMed Web of Science ®Google Scholar
• Miyata T, Horie K, Ueda Y, Fujita Y, Izuhara Y, Hirano H, Uchida K, Saito A, Strihou van Ypersele de C, Kurokawa K. Advanced glycation and lipidoxidation of the peritoneal membrane: respective roles of serum and peritoneal fluid reactive carbonyl compounds. Kidney Int 2000;58:425–435.
   PubMed Web of Science ®Google Scholar
• Beisswenger PJ, Drummond KS, Nelson RG, Howell SK, Szwergold BS, Mauer M. Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. Diabetes 2005;54:3274–3281.
   PubMed Web of Science ®Google Scholar
• Rabbani N, Sebekova K, Sebekova K Jr, Heidland A, Thornalley PJ. Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function. Kidney Int 2007;72:1113–1121.
   PubMed Web of Science ®Google Scholar
• Staniszewska MM, Nagaraj RH. Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses. Mol Cell Biochem 2006;288:29–36.
   PubMed Web of Science ®Google Scholar
• Nakayama M, Sakai A, Numata M, Hosoya T. Hyper-vascular change and formation of advanced glycation endproducts in the peritoneum caused by methylglyoxal and the effect of an anti-oxidant, sodium sulfite. Am J Nephrol 2003;23:390–394.
   PubMed Web of Science ®Google Scholar
• Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Ahmed N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M. Methlyglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription. Cell 2006;124:275–286.
   PubMedGoogle Scholar
• Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Rabbani N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M. High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem 2007;282:31038–31045.
   PubMed Web of Science ®Google Scholar
• Cantero AV, Portero-Otín M, Ayala V, Auge N, Sanson M, Elbaz M, Thiers JC, Pamplona R, Salvayre R, Nègre-Salvayre A. Methyglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis. FASEB J 2007;21:3096–3106.
   PubMed Web of Science ®Google Scholar
• Wang X, Desai K, Chang T, Wu L. Vascular methylglyoxal metabolism and the development of hypertension. J Hypertension 2005;23:1565–1573.
   PubMed Web of Science ®Google Scholar
• Wang X, Chang t, Jiang B, Desai K, Wu L. attenuation of hypertension development by aminoguanidine in spontaneously hypehtensivi rats: role of methylglyoxal. Am J Hypertens 2007;20:629–636.
   PubMed Web of Science ®Google Scholar
• Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813–820.
   PubMed Web of Science ®Google Scholar
• Cai H, Harrison DG. Endothelial dysfunction in cardiovascular disease. The role of oxidant stress. Circ Res 2000;87:840–844.
   PubMed Web of Science ®Google Scholar
• Johansen JS, Harris AK, Rychly DJ, Erqul A. Oxidative stress and the use of antioxidants in diabetes. Cardiovasc Diabetol 2005;4:5–15.
   PubMed Web of Science ®Google Scholar
• Nakayama M, Saito K, Sato E, Nakayama K, Terawaki H, Ito S, Kohno M. Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide. Redox Rep 2007;12:125–133.
   PubMed Web of Science ®Google Scholar
• Ward RA. McLeish KR. Methylglyoxal: a stimulus to neutrophil oxygen radical production in chronic renal failure? Nephrol Dial Transplant 2004;19:1702–1707.
   PubMed Web of Science ®Google Scholar
• Leoncini G, Poggi M. Effects of methylglyoxal on platelete hydrogen peroxide accumulation, aggregation and release reaction. Cell Biochem Funct 1996;14:89–95.
   PubMed Web of Science ®Google Scholar
• Chang T, Wang R, Wu L. Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells. Free Radic Biol Med 2005;38:286–293.
   PubMed Web of Science ®Google Scholar
• Ho HY, Cheng ML, Lu FJ, Chou YH, Stern A, Liang CM, Chiu DT. Enhanced oxidative stress and accelerated cellular senescence on glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med 2000;29:156–169.
   PubMed Web of Science ®Google Scholar
• Seki S, Flavahan NA, Smedira NG, Murray PA. Superoxide anion scavenger restore NO-mediated pulmonary vasodilation after lung transplantation. Am J Physiol 1999;276:H42–H46.
   Google Scholar
• Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 1999;27:612–616.
   PubMed Web of Science ®Google Scholar
• Ghosh M, Wang HD, McNeill JR. Tiron exerts effects unrelated to its role as a scavenger of superoxide anion: effects on calcium binding and vascular responses. Can J Physiol Pharmacol 2002;80:755–760.
   PubMed Web of Science ®Google Scholar
• Odani H, Shinzato T, Matsumoto Y, Usami J, Maeda K. Increase in three α,β-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction. Biochem Biophys Res Commun 1999;256:89–93.
   PubMed Web of Science ®Google Scholar
• Hipkiss AR. Dietary restriction, glycolysis, hormesis and ageing. Biogerontlogy 2007;8:221–224.
   PubMed Web of Science ®Google Scholar
• Schoneich C. Protein modification in aging: an update. Exp Gerontol 2006;41:807–812.
   PubMed Web of Science ®Google Scholar
• Fujioka K, Shibamoto T. Determination of toxic carbonyl compounds in cigarette smoke. Environ Toxicol 2006;21:47–54.
   PubMed Web of Science ®Google Scholar
• Golej J, Hoeger H, Radner W, Unfried G, Lubec G. Oral administration of methylglyoxal leads to kidney collagen accumulation in the mouse. Life Sci 1998;63:801–807.
   PubMed Web of Science ®Google Scholar
• Davidson SM, Duchen MR. Endothelial mitochondria: contributing to vascular function and disease. Circ Res 2007;100:1128–1141.
   PubMed Web of Science ®Google Scholar
• Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404:787–890.
   PubMed Web of Science ®Google Scholar
• Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Radic Biol Med 2003;35:1491–1499.
   PubMed Web of Science ®Google Scholar
• Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF. Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol 2005;289:420–430.
   PubMed Web of Science ®Google Scholar
• Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001;88:e14–e22.
   PubMed Web of Science ®Google Scholar
• Shangari N, Chan TS, Popovic M, O'Brien PJ. Glyoxal markedly compromises hepatocyte resistance to hydrogen peroxide. Biochem Pharmacol 2006;71:1610–1618.
   PubMed Web of Science ®Google Scholar
• Huie RE, Padmaja S. The reaction of NO with superoxide. Free Radic Res Commun 1993;18:195–199.
   PubMed Web of Science ®Google Scholar
• Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 2002;109:817–826.
   PubMed Web of Science ®Google Scholar
• Cai H. NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease. Circ Res 2005;96:818–822.
   PubMed Web of Science ®Google Scholar
• Sorescu D, Weiss D, Lassègue B, Clempus RE, Szöcs K, Sorescu GP, Valppu L, Quinn MT, Lambeth JD, Vega JD, Taylor WR, Griendling KK. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 2002;105:1429–1435.
   PubMed Web of Science ®Google Scholar
• Ho C, Lee PH, Huang WJ, Hsu YC, Lin CL, Wang JY. Methylglyoxal-induced fibronectin gene expression through Ras-mediated NADPH oxidase activation in renal mesangial cells. Nephrology 2007;12:348–356.
   PubMed Web of Science ®Google Scholar
• Touyz RM. Apocynin, NADPH oxidase, and vascular sells. A complex matter. Hypertension 2008;51:172–174.
   PubMed Web of Science ®Google Scholar
• Heumuller S, Wind S, Barbosa-Sicard E, Schmidt HHHW, Busse R, Schroder K, Brandes RP. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008;51:211–217.
   PubMed Web of Science ®Google Scholar
• Frederick LM, von Loehneysen K, Dinauer MC, Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 2006;18:69–82.
   PubMed Web of Science ®Google Scholar
• Thornalley PJ. Modification of the glyoxalase system in human red blood cells by glucose in vitro. Biochem J 1988;254:751–755.
   PubMed Web of Science ®Google Scholar
• Akhand AA, Hossain K, Mitsui H, Kato M, Miyata T, Inagi R, Du J, Takeda K, Kawamoto Y, Suzuki H, Kurokawa K, Nakashima I. Glyoxal and methylglyoxal trigger distinct signals for MAP family kinases and caspase activation in human endothelial cells. Free Radic Biol Med 2001;31:20–30.
   PubMed Web of Science ®Google Scholar
• Shimokawa H, Morikawa K. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans. J Mol Cell Cardiol 2005;29:725–732.
   Google Scholar
• Li W, Ota K, Nakamura J, Naruse K, Nakashima E, Oiso Y, Hamda Y. Antiglycation effect of gliclazide on in vitro AGE formation from glucose and methylglyoxal. Exp Biol Med 2008;233:176–179.
   Web of Science ®Google Scholar
• Li Y, Cohenford MA, Dutta U, Dain JA. The structural modification of DNA nucleosides by nonenzymatic glycation: an in vitro study based on the reactions of glyoxal and methylglyoxal with 2'-deoxyguanosine. Anal Bioanal Chem 2008;390:679–688.
   PubMed Web of Science ®Google Scholar
• Nohara Y, Usui T, Kinoshita T, Watanabe M. Generation of superoxide anions during the reaction of guanidino compounds with methylglyoxal. Chem Pharm Bull 2002;50:179–184.
   PubMed Web of Science ®Google Scholar
• Quagliaro L, Piconi L, Assaloni R, Da Ros R, Szabó C, Ceriello A. Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC. Nutr Metab Cardiovasc Dis 2007;17:257–267.
   PubMed Web of Science ®Google Scholar