Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects

References

• Jialal I, Devaraj S, Venugopal SK. Oxidative stress, inflammation, and diabetic vasculopathies: the role of alpha tocopherol therapy. Free Radic Res 2002;36:1331–1336.
   PubMed Web of Science ®Google Scholar
• Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004;27: 813–823.
   PubMed Web of Science ®Google Scholar
• Davi G, Ciabattoni G, Consoli A, Mezzetti A, Falco A, Santarone S, Pennese E, Vitacolonna E, Bucciarelli T, Costantini F, Capani F, Patrono C. In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation 1999;99:224–229.
   PubMed Web of Science ®Google Scholar
• Altomare E, Vendemiale G, Chicco D, Procacci V, Cirelli F. Increased lipid peroxidation in type 2 poorly controlled diabetic patients. Diabetes Metab 1992;18:264–271.
   Web of Science ®Google Scholar
• Hinokio Y, Suzuki S, Hirai M, Chiba M, Hirai A, Toyota T. Oxidative DNA damage in diabetes mellitus: its association with diabetic complications. Diabetologia 1999;42:995–998.
   PubMed Web of Science ®Google Scholar
• Blasiak J, Arabski M, Krupa R, Wozniak K, Zadrozny M, Kasznicki J, Zurawska M, Drzewoski J. DNA damage and repair in type 2 diabetes mellitus. Mutat Res 2004;554: 297–304.
   PubMed Web of Science ®Google Scholar
• Ceriello A, Mercuri F, Quagliaro L, Assaloni R, Motz E, Tonutti L, Taboga C. Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress. Diabetologia 2001;44: 834–838.
   PubMed Web of Science ®Google Scholar
• Bonnefont-Rousselot D, Bastard JP, Jaudon MC, Delattre J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab 2000;26:163–176.
   PubMed Web of Science ®Google Scholar
• Maxwell SR, Thomason H, Sandler D, Leguen C, Baxter MA, Thorpe GH, Jones AF, Barnett AH. Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus. Eur J Clin Invest 1997;27: 484–490.
   PubMed Web of Science ®Google Scholar
• Pickup JC, Chusney GD, Thomas SM, Burt D. Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci 2000;67:291–300.
   PubMed Web of Science ®Google Scholar
• Ford ES. Body mass index, diabetes, and C-reactive protein among U.S. adults. Diabetes Care 1999;22:1971–1977.
   PubMed Web of Science ®Google Scholar
• Helmersson J, Vessby B, Larsson A, Basu S. Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population. Circulation 2004;109:1729–1734.
   PubMed Web of Science ®Google Scholar
• Williams DE, Wareham NJ, Cox BD, Byrne CD, Hales CN, Day NE. Frequent salad vegetable consumption is associated with a reduction in the risk of diabetes mellitus. J Clin Epidemiol 1999;52:329–335.
   PubMedGoogle Scholar
• Ford ES. Vitamin supplement use and diabetes mellitus incidence among adults in the United States. Am J Epidemiol 2001;153:892–897.
   Google Scholar
• Ärnlov J, Zethelius B, Riserus U, Basu S, Berne C, Vessby B, Alfthan G, Helmersson J. Serum and dietary beta-carotene and alpha-tocopherol and incidence of type 2 diabetes mellitus in a community-based study of Swedish men: report from the Uppsala Longitudinal Study of Adult Men (ULSAM) study. Diabetologia 2009;52:97–105.
   Google Scholar
• Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004; 27:362–366.
   PubMed Web of Science ®Google Scholar
• Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, Cappuccio FP, Ceriello A, Reid ME. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 2007;147: 217–223.
   PubMed Web of Science ®Google Scholar
• Song Y, Cook NR, Albert CM, van Denburgh M, Manson JE. Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial. Am J Clin Nutr 2009;90: 429–437.
   PubMed Web of Science ®Google Scholar
• Liu S, Ajani U, Chae C, Hennekens C, Buring JE, Manson JE. Long-term beta-carotene supplementation and risk of type 2 diabetes mellitus: a randomized controlled trial. JAMA 1999;282: 1073–1075.
   PubMed Web of Science ®Google Scholar
• Liu S, Lee IM, Song Y, van Denburgh M, Cook NR, Manson JE, Buring JE. Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial. Diabetes 2006; 55:2856–2862.
   PubMed Web of Science ®Google Scholar
• Ble-Castillo JL, Carmona-Diaz E, Mendez JD, Larios-Medina FJ, Medina-Santillan R, Cleva-Villanueva G, Diaz-Zagoya JC. Effect of alpha-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics. Biomed Pharmacother 2005;59:290–295.
   PubMed Web of Science ®Google Scholar
• Sharma A, Kharb S, Chugh SN, Kakkar R, Singh GP. Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients. Metabolism 2000;49:160–162.
   PubMed Web of Science ®Google Scholar
• Sardas S, Yilmaz M, Oztok U, Cakir N, Karakaya AE. Assessment of DNA strand breakage by comet assay in diabetic patients and the role of antioxidant supplementation. Mutat Res 2001;490:123–129.
   PubMed Web of Science ®Google Scholar
• Devaraj S, Jialal I. Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Free Radic Biol Med 2000;29:790–792.
   PubMed Web of Science ®Google Scholar
• Darko D, Dornhorst A, Kelly FJ, Ritter JM, Chowienczyk PJ. Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes. Clin Sci (Lond) 2002;103:339–344.
   PubMed Web of Science ®Google Scholar
• Bartlett HE, Eperjesi F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt 2008; 28:503–523.
   PubMed Web of Science ®Google Scholar
• Neuzil J, Thomas SR, Stocker R. Requirement for, promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation. Free Radic Biol Med 1997;22:57–71.
   PubMed Web of Science ®Google Scholar
• Greenwald P, Anderson D, Nelson SA, Taylor PR. Clinical trials of vitamin and mineral supplements for cancer prevention. Am J Clin Nutr 2007;85:314S–317S.
   PubMed Web of Science ®Google Scholar
• Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003;78:517S–520S.
   PubMed Web of Science ®Google Scholar
• Johansson C, Rytter E, Nygren J, Vessby B, Basu S, Möller L. Down-regulation of oxidative DNA lesions in human mononuclear cells after antioxidant supplementation correlates to increase of gamma-tocopherol. Int J Vitam Nutr Res 2008; 78:183–194.
   PubMed Web of Science ®Google Scholar
• Åsgård R, Rytter E, Basu S, Abramsson-Zetterberg L, Möller L, Vessby B. High intake of fruit and vegetables is related to low oxidative stress and inflammation in a group of patients with type 2 diabetes. Scan J Food Nutr 2007;51:149–158.
   Google Scholar
• Becker W, Lennernäs M, Gustafsson I-B, Haraldsdottír J, Nydahl M, Vessby B, Ytterfors A. Precoded food records compared with weighed food records measuring dietary habits in a population of Swedish adults. Scand J Nutrition 1998;42: 145–149.
   Google Scholar
• Becker W, Pearson M. Food habits and nutrient intake in Sweden 1997–98 Swedish: kostvanor och näringsintag i Sverige. Metod- och resultatanalys. Livsmedelsverket, Uppsala, Sweden: Swedish National Food Administration; 2002.
   Google Scholar
• Becker W. The populations food habits and nutrient intake in Sweden 1989 Swedish: befolkningens kostvanor och näringsintag i Sverige 1989. Metod och resultatanalys. Statens Livsmedelsverk, Uppsala, Sweden: Swedish National Food Administration; 2004.
   Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502.
   PubMed Web of Science ®Google Scholar
• Öhrvall M, Tengblad S, Vessby B. Lower tocopherol serum levels in subjects with abdominal adiposity. J Intern Med 1993; 234:53–60.
   PubMed Web of Science ®Google Scholar
• Thurnham DI, Davies JA, Crump BJ, Situnayake RD, Davis M. The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status. Ann Clin Biochem 1986;23:514–520.
   PubMed Web of Science ®Google Scholar
• Deutch MJ, Weeks CE. Microfluorometric assay for vitamin C. J Assoc Offic Anal Chem 1965;48;1248–1256.
   Google Scholar
• Vuilleumier JP, Keck E. Fluorometric assay of vitamin C in biological materials using a centrifugal analyser with fluorescence attachment. J Micronutr Anal 1989;5:25–34.
   Google Scholar
• Basu S. Radioimmunoassay of 8-iso-prostaglandin F2alpha: an index for oxidative injury via free radical catalysed lipid peroxidation. Prostaglandins Leukot Essent Fatty Acids 1998; 58:319–325.
   PubMed Web of Science ®Google Scholar
• Ohrvall M, Tengblad S, Ekstrand B, Siegbahn A, Vessby B. Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. Atherosclerosis 1994;108:103–110.
   PubMed Web of Science ®Google Scholar
• Hofer T, Möller L. Optimization of the workup procedure for the analysis of 8-oxo-7,8-dihydro-2´-deoxyguanosine with electrochemical detection. Chem Res Toxicol 2002;15:426–432.
   PubMed Web of Science ®Google Scholar
• Nagy E, Johansson C, Zeisig M, Möller L. Oxidative stress and DNA damage caused by the urban air pollutant 3-NBA and its isomer 2-NBA in human lung cells analyzed with three independent methods. J Chromatogr B Analyt Technol Biomed Life Sci 2005;827:94–103.
   PubMed Web of Science ®Google Scholar
• Gedik CM, Collins A. Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J 2005;19:82–84.
   PubMed Web of Science ®Google Scholar
• Abramsson-Zetterberg L, Zetterberg G, Bergqvist M, Grawe J. Human cytogenetic biomonitoring using flow-cytometric analysis of micronuclei in transferrin-positive immature peripheral blood reticulocytes. Environ Mol Mutagen 2000;36:22–31.
   PubMed Web of Science ®Google Scholar
• Basu S. Radioimmunoassay of 15-keto-13,14-dihydro- prostaglandin F2alpha: an index for inflammation via cyclooxygenase catalysed lipid peroxidation. Prostaglandins Leukot Essent Fatty Acids 1998;58:347–352.
   PubMed Web of Science ®Google Scholar
• Becker W, Hagman U. More fruit and vegetables is beneficial for health Swedish: mer frukt och grönt bra för hälsan. Vår Föda 1999;51:24–28.
   Google Scholar
• Wu JH, Ward NC, Indrawan AP, Almeida CA, Hodgson JM, Proudfoot JM, Puddey IB, Croft KD. Effects of alpha- tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes. Clin Chem 2007;53:511–519.
   PubMed Web of Science ®Google Scholar
• Ward NC, Wu JH, Clarke MW, Puddey IB, Burke V, Croft KD, Hodgson JM. The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. J Hypertens 2007;25: 227–234.
   PubMed Web of Science ®Google Scholar
• Upritchard JE, Sutherland WH, Mann JI. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000;23:733–738.
   PubMed Web of Science ®Google Scholar
• Armstrong AM, Chestnutt JE, Gormley MJ, Young IS. The effect of dietary treatment on lipid peroxidation and antioxidant status in newly diagnosed noninsulin dependent diabetes. Free Radic Biol Med 1996;21:719–726.
   PubMed Web of Science ®Google Scholar
• Lean ME, Noroozi M, Kelly I, Burns J, Talwar D, Sattar N, Crozier A. Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes 1999;48: 176–181.
   PubMed Web of Science ®Google Scholar
• Rytter E, Vessby B, Åsgård R, Johansson C, Sjödin A, Abramsson-Zetterberg L, Möller L, Basu S. Glycaemic status in relation to oxidative stress and inflammation in well-controlled type 2 diabetes subjects. Br J Nutr 2009;101:1423–1426.
   Google Scholar
• Tomasch R, Wagner KH, Elmadfa I. Antioxidative power of plant oils in humans: the influence of alpha- and gamma-tocopherol. Ann Nutr Metab 2001;45:110–115.
   PubMed Web of Science ®Google Scholar
• Hofer T, Karlsson HL, Möller L. DNA oxidative damage and strand breaks in young healthy individuals: a gender difference and the role of life style factors. Free Radic Res 2006;40: 707–714.
   PubMed Web of Science ®Google Scholar
• Slatter DA, Bolton CH, Bailey AJ. The importance of lipid-derived malondialdehyde in diabetes mellitus. Diabetologia 2000;43:550–557.
   PubMed Web of Science ®Google Scholar
• Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327–334.
   PubMed Web of Science ®Google Scholar
• Polidori MC, Mecocci P, Stahl W, Parente B, Cecchetti R, Cherubini A, Cao P, Sies H, Senin U. Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes. Diabetes Metab Res Rev 2000;16:15–19.
   PubMed Web of Science ®Google Scholar
• Polidori MC, Stahl W, Eichler O, Niestroj I, Sies H. Profiles of antioxidants in human plasma. Free Radic Biol Med 2001;30: 456–462.
   PubMed Web of Science ®Google Scholar
• Al-Delaimy WK, van Kappel AL, Ferrari P, Slimani N, Steghens JP, Bingham S, Johansson I, Wallstrom P, Overvad K, Tjonneland A, Key TJ, Welch AA, Bueno-de-Mesquita HB, Peeters PH, Boeing H, Linseisen J, Clavel-Chapelon F, Guibout C, Navarro C, Quiros JR, Palli D, Celentano E, Trichopoulou A, Benetou V, Kaaks R, Riboli E. Plasma levels of six carotenoids in nine European countries: report from the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr 2004;7:713–722.
   PubMed Web of Science ®Google Scholar
• Ylonen K, Alfthan G, Groop L, Saloranta C, Aro A, Virtanen SM. Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study. Am J Clin Nutr 2003;77:1434–1441.
   PubMed Web of Science ®Google Scholar