Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling

References

• Angeloni C, Spencer JP, Leoncini E, Biagi PL, Hrelia S. Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress. Biochimie 2007;89:73–82.
   PubMed Web of Science ®Google Scholar
• Angeloni C, Leoncini E, Malaguti M, Angelini S, Hrelia P, Hrelia S. Role of quercetin in modulating rat cardiomyocyte gene expression profile. Am J Physiol Heart Circ Physiol 2008;294:H1233–H1243.
   PubMed Web of Science ®Google Scholar
• Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res 2005;51:117–23.
   PubMed Web of Science ®Google Scholar
• Moon SK, Cho GO, Jung SY, Gal SW, Kwon TK, Lee YC, . Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun 2003;301:1069–1078.
   PubMed Web of Science ®Google Scholar
• Kawai C. From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death. Circulation 2001;34: 199–204.
   Google Scholar
• Mitsuma W, Ito M, Kodama M, Fuse K, Okamura K, Minagawa S, . Cardioprotective effects of recombinant human erythropoietin in rats with experimental autoimmune myocarditis. Biochem Biophys Res Comm 2006;344:987–994.
   PubMed Web of Science ®Google Scholar
• Ishiyama S, Hiroe M, Nishikawa T, . Nitric oxide contributes the progression of myocardial damage in experimental autoimmune myocarditis in rats. Circulation 1997;95: 489–496.
   PubMed Web of Science ®Google Scholar
• Belch JJ, Bridges AB, Scott N, Chopra M. Oxygen free radicals and congestive heart failure. Br Heart J 1991;65: 245–248.
   PubMedGoogle Scholar
• Milenkovic M, Arsenovic-Ranin N, Stojic-Vukanic Z, Bufan B, Vucicevic D, Jancic I. Quercetin ameliorates experimental autoimmune myocarditis in rats. J Pharm Pharmacuet Sci 2010;13:311–319.
   PubMed Web of Science ®Google Scholar
• Kodama M, Matsumoto Y, Fujiwara M, Masani F, Izumi T, Shibata A. A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction. Clin Immunol Immunopathol 1990;57:250–262.
   PubMedGoogle Scholar
• Watanabe K, Nakazawa M, Fuse K, . Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation. Circulation 2001;104:1098–1100.
   PubMed Web of Science ®Google Scholar
• Thandavarayan RA, Watanabe K, Ma M, Gurusamy N, Veeraveedu PT, Konishi T, . Dominant-negative p38alpha mitogen activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. Am J Physiol Heart Circ Physiol 2009;297: H911–H919.
   PubMed Web of Science ®Google Scholar
• Thandavarayan RA, Watanabe K, Sari FR, . Modulation of doxorubicin-induced cardiac dysfunction in dominant-negative p38α mitogen-activated protein kinase mice. Free Radic Biol Med 2010;49:1422–1431.
   PubMed Web of Science ®Google Scholar
• Sukumaran V, Watanabe K, Veeraveedu PT, Thandavarayan RA, Gurusamy N, Ma M, . Beneficial effects of olmesartan, an angiotensin II receptor type 1 antagonist, in rats with dilated cardiomyopathy. Exp Biol Med (Maywood) 2010;235:1338–1346.
   PubMed Web of Science ®Google Scholar
• Arozal W, Watanabe K, Veeraveedu PT, Thandavarayan RA, Harima M, Sukumaran V, . Beneficial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats. Free Radic Res 2010;44:1369–1377.
   PubMed Web of Science ®Google Scholar
• Thandavarayan RA, Watanabe K, Ma M, Veeraveedu PT, Gurusamy N, Palaniyandi SS, . 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. Biochem Pharmacol 2008;75:1797–1806.
   PubMed Web of Science ®Google Scholar
• Kwon KB, Kim EK, Han MJ, Shin BC, Park YK, Kim KS, . Induction of apoptosis by Radix Paeoniae Alba extract through cytochrome c release and the activations of caspase-9 and caspase-3 in HL-60 cells. Biol Pharmacuet Bull 2006;29:1082–1086.
   PubMed Web of Science ®Google Scholar
• Miller FJ Jr, Gutterman DD, Rios CD, . Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 1998;82:1298–1305.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 1993;57: 715S–724S.
   PubMed Web of Science ®Google Scholar
• Park C, So HS, Shin CH, Baek SH, Moon BS, Shin SH, . Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem Pharmacol 2003;66:1287–1295.
   PubMed Web of Science ®Google Scholar
• Molina MF, Sanchez-Reus I, Iglesias I, Benedi J. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharmacuet Bull 2003;26:1398–1402.
   PubMed Web of Science ®Google Scholar
• Boots AW, Li H, Schins RP, Duffin R, Heemskerk JW, Bast A, Haenen GR. The quercetin paradox. Toxicol Appl Pharmacol 2007;222:89–96.
   PubMed Web of Science ®Google Scholar
• Kannan K, Jain SK. Oxidative stress and apoptosis. Pathophysiology 2000;7:153–163.
   PubMedGoogle Scholar
• Pan C, Giraldo GS, Prentice H, Wu JY. Taurine protection of PC12 cells against endoplasmic reticulum stress induced by oxidative stress. J Biomed Sci 2010;17S1:17S17.
   Web of Science ®Google Scholar
• Lai E, Teodoro T, Volchuk A. Endoplasmic reticulum stress: signaling the unfolded protein response. Physiology 2007;22:193–201.
   PubMed Web of Science ®Google Scholar
• Shimazaki H, Watanabe K, Veeraveedu PT, Harima M, Thandavarayan RA, Arozal W, . The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis. Free Radic Res 2010;44:1082–1090.
   PubMed Web of Science ®Google Scholar
• Yamauchi M, Tsuruma K, Imai S, Nakanishi T, Umigai N, Shimazawa M, Hara H. Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. Eur J Pharmacol 2011;650: 110–119.
   PubMed Web of Science ®Google Scholar
• Natsume Y, Ito S, Satsu H, Shimizu M. Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells. Toxicology 2009;258:164–175.
   PubMed Web of Science ®Google Scholar
• Mao W, Fukuoka S, Iwai C, Liu J, Sharma VK, Sheu SS, . Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. Am J Physiol Heart Circ Physiol 2007;293:H1636–H1645.
   PubMed Web of Science ®Google Scholar
• Okada K, Minamino T, Tsukamoto Y, Liao Y, Tsukamoto O, Takashima S, . Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Circulation 2004;110:705–712.
   PubMed Web of Science ®Google Scholar
• Border WA, Noble NA. Transforming growth factorβ in tissue fibrosis. N Engl J Med 1994;331:1286–1292.
   PubMed Web of Science ®Google Scholar
• Szalay G, Sauter M, Haberland M, . Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Circ Res 2009;104:851–859.
   PubMed Web of Science ®Google Scholar
• Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, . Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 1993;92:398–403.
   PubMed Web of Science ®Google Scholar
• Sun CK, Chang LT, Sheu JJ, Chiang CH, Lee FY, Wu CJ, . Bone marrow-derived mononuclear cell therapy alleviates left ventricular remodeling and improves heart function in rat-dilated cardiomyopathy. Crit Care Med 2009;37: 1197–1205.
   PubMed Web of Science ®Google Scholar
• Lekli I, Szabo G, Juhasz B, Das S, Das M, Varga E, . Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin. Am J Physiol Heart Circ Physiol 2008;294:H859–H866.
   PubMed Web of Science ®Google Scholar
• Bulhak AA, Sjoquist PO, Xu CB, Edvinsson L, Pernow J. Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1. Basic Res Cardiol 2006;101:244–252.
   PubMed Web of Science ®Google Scholar
• Clerk A, Sugden PH. The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs). FEBS Lett 1998;426:93–96.
   PubMed Web of Science ®Google Scholar
• James KY. Cardiac Hypertrophy: a risk factor for QT-Prolongation and cardiac sudden death. Toxicol Pathol 2006; 34:58–66.
   PubMed Web of Science ®Google Scholar
• Kyaw M, Yoshizumi M, Tsuchiya K, . Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases, Acta Pharmacol Sin 2004;25:977–985.
   PubMed Web of Science ®Google Scholar
• Lean MEJ, Noroozi M, Kelly I, Burns J, Talwar D, Sattar N, Crozie A. Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes 1999;48:176–181.
   PubMed Web of Science ®Google Scholar
• Shahbaz AU, Kamalov G, Zhao W, Zhao T, Johnson PL, Sun Y, . Mitochondria-targeted cardioprotection in aldosteronism. J Cardiovasc Pharmacol 2011;57:37–43.
   PubMed Web of Science ®Google Scholar
• Shen J, Lee W, Gu Y, Tong Y, Fung PC, Tong L. Ginkgo biloba extract (EGb761) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes. Chin Med 2011;6:8.
   PubMed Web of Science ®Google Scholar
• Tosaki A, Pali T, Droy-Lefaix MT. Effects of ginkgo biloba extract and preconditioning on the diabetic rat myocardium. Diabetologia 1996;39:1255–1262.
   PubMed Web of Science ®Google Scholar
• Kahraman A, Erkasap N, Serteser M, Koken T. Protective effect of quercetin on renal ischemia/reperfusion injury in rats. J Nephrol 2003;16:219–224.
   PubMed Web of Science ®Google Scholar
• Pei TX, Xu CQ, Li B, Zhang ZR, Gao XX, Yu J, . Protective effect of quercetin against adriamycin-induced cardiotoxicity and its mechanism in mice. ao Xue Xue Bao 2007; 42:1029–1033.
   PubMedGoogle Scholar
• Park C, So HS, Shin CH, Baek SH, Moon BS, Shin SH, . Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem Pharmacol 2003;66:1287–1295.
   PubMed Web of Science ®Google Scholar