312
Views
28
CrossRef citations to date
0
Altmetric
Research Article

Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells

, , , , , , & show all
Pages 1019-1028 | Received 08 Jan 2012, Accepted 05 Mar 2012, Published online: 23 Apr 2012

References

  • Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem 2001;49:3106–3112.
  • Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000;130(8S Suppl):2073S–2085S.
  • Day AJ, Mellon F, Barron D, Sarrazin G, Morgan MR, Williamson G. Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res 2001;35:941–952.
  • Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, . Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med 2011;51:1329–1336.
  • de Boer VC, Dihal AA, van der Woude H, Arts IC, Wolffram S, Alink GM, . Tissue distribution of quercetin in rats and pigs. J Nutr 2005;135:1718–1725.
  • Youdim KA, Shukitt-Hale B, Joseph JA. Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 2004;37:1683–1693.
  • Youdim KA, Spencer JP, Schroeter H, Rice-Evans C. Dietary flavonoids as potential neuroprotectants. Biol Chem 2002; 383:503–519.
  • Yoshino S, Hara A, Sakakibara H, Kawabata K, Tokumura A, Ishisaka A, . Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria. Nutrition 2011; 27:847–852.
  • Lotharius J, Brundin P. Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci 2002; 3:932–942.
  • Zhang J, Perry G, Smith MA, Robertson D, Olson SJ, Graham DG, . Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol 1999;154:1423–1429.
  • Sechi G, Deledda MG, Bua G, Satta WM, Deiana GA, Pes GM, . Reduced intravenous glutathione in the treatment of early Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 1996; 20:1159–1170.
  • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, . Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001;65:135–172.
  • Miyama A, Saito Y, Yamanaka K, Hayashi K, Hamakubo T and Noguchi N. Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS One 2011;6:e27883.
  • Angeles DC, Gan BH, Onstead L, Zhao Y, Lim KL, Dachsel J, . Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. Hum Mutat 2011;32:1390–1397.
  • Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996; 47(6 Suppl 3): S161–S170.
  • Shirai M, Kawai Y, Yamanishi R, Kinoshita T, Chuman H, Terao J. Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells. Free Radic Res 2006;40:1047–1053.
  • Moon JH, Tsushida T, Nakahara K, Terao J. Identification of quercetin 3-O-beta-d-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 2001;30:1274–1285.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248–254.
  • Cohen G, Heikkila RE. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J Biol Chem 1974;249:2447–2452.
  • Yamazaki M, Chiba K. Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells. Eur J Pharmacol 2008;581:255–261.
  • Saito Y, Nishio K, Ogawa Y, Kinumi T, Yoshida Y, Masuo Y, . Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: Involvement of hydrogen peroxide-dependent and -independent action. Free Radic Biol Med 2007;42:675–685.
  • Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, . p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. J Neurosci Res 2005;79:849–860.
  • Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585:325–337.
  • Metodiewa D, Jaiswal AK, Cenas N, Dickancaite E, Segura-Aguilar J. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 1999;26: 107–116.
  • Ossola B, Kaarainen TM, Raasmaja A, Mannisto PT. Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Toxicology 2008;250:1–8.
  • Bieger J, Cermak R, Blank R, de Boer VC, Hollman PC, Kamphues J, . Tissue distribution of quercetin in pigs after long-term dietary supplementation. J Nutr 2008;138: 1417–1420.
  • Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, . ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005;8:752–758.
  • Fetler L, Amigorena S. Neuroscience. Brain under surveillance: the microglia patrol. Science 2005;309:392–393.
  • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38:1285–1291.
  • Liu J, Hong Z, Ding J, Zhang J, Chen S. Predominant release of lysosomal enzymes by newborn rat microglia after LPS treatment revealed by proteomic studies. J Proteome Res 2008;7:2033–2049.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.