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Research Article

Spatially resolved two-photon irradiation of an intracellular singlet oxygen photosensitizer: Correlating cell response to the site of localized irradiation

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Pages 718-730 | Received 11 Mar 2013, Accepted 17 Jun 2013, Published online: 12 Jul 2013

References

  • Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. Oxford: Oxford University Press; 1999.
  • Ogilby PR. Singlet oxygen: there is indeed something new under the sun. Chem Soc Rev 2010;39:3181–3209.
  • Oleinick NL, Morris RL, Belichenko I. The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochem Photobiol Sci 2002;1:1–21.
  • Redmond RW, Kochevar IE. Spatially-resolved cellular responses to singlet oxygen. Photochem Photobiol 2006;82: 1178–1186.
  • Klotz LO, Kröncke KD, Sies H. Singlet oxygen-induced signaling effects in mammalian cells. Photochem Photobiol Sci 2003;2:88–94.
  • Davies MJ. Singlet oxygen-mediated damage to proteins and its consequences. Biochem Biophys Res Comm 2003;305: 761–770.
  • Pedersen BW, Breitenbach T, Redmond RW, Ogilby PR. Two-photon irradiation of an intracellular singlet oxygen photosensitizer: achieving localized subcellular excitation in spatially-resolved experiments. Free Radic Res 2010;44: 1383–1397.
  • Pimenta FM, Jensen RL, Holmegaard L, Esipova TV, Westberg M, Breitenbach T, Ogilby PR. Singlet-oxygen- mediated cell death using spatially-localized two-photon excitation of an extracellular sensitizer. J Phys Chem B 2012;116:10234–10246.
  • Skovsen E, Snyder JW, Ogilby PR. Two-photon singlet oxygen microscopy: the challenges of working with single cells. Photochem Photobiol 2006;82:1187–1197.
  • Silva EFF, Pedersen BW, Breitenbach T, Toftegaard R, Kuimova MK, Arnaut LG, Ogilby PR. Irradiation- and sensitizer-dependent changes in the lifetime of intracellular singlet oxygen produced in a photosenstized process. J Phys Chem B 2012;116:445–461.
  • Cló E, Snyder JW, Ogilby PR, Gothelf KV. Control and selectivity of photosensitized singlet oxygen production: challenges in complex biological systems. ChemBioChem 2007;8: 475–481.
  • Plaetzer K, Kiesslich T, Verwanger T, Krammer B. The modes of cell death induced by PDT: an overview. Med Laser Appl 2003;18:7–19.
  • Kessel D. Correlation between subcellular localization and photodynamic therapy. J Porphyrins Phthalocyanines 2004;8: 1009–1014.
  • MacDonald IJ, Morgan J, Bellnier DA, Paszkiewicz GM, Whitaker JE, Litchfield DJ, Dougherty TJ. Subcellular localization patterns and their relationship to photodynamic activity of pyropheophorbide-a derivatives. Photochem Photobiol 1999;70:789–797.
  • Usuda J, Chiu SM, Murphy ES, Lam M, Nieminen AL, Oleinick NL. Domain-dependent Photodamage to Bcl-2. J. Biol Chem 2003;278:2021–2029.
  • Rubio N, Fleury SP, Redmond RW. Spatial and temporal dynamics of in vitro photodynamic cell killing: extracellular hydrogen peroxide mediates neighboring cell death. Photochem Photobiol Sci 2009;8:457–464.
  • Spiller DG, Wood CD, Rand DA, White MRH. Measurement of single-cell dynamics. Nature 2010;465:736–745.
  • Hatz S, Lambert JDC, Ogilby PR. Measuring the lifetime of singlet oxygen in a single cell: addressing the issue of cell viability. Photochem Photobiol Sci 2007;6:1106–1116.
  • Arnbjerg J, Johnsen M, Frederiksen PK, Braslavsky SE, Ogilby PR. Two-photon photosensitized production of singlet oxygen: Optical and optoacoustic characterization of absolute two-photon absorption cross sections for standard sensitizers in different solvents. J Phys Chem A 2006;110:7375–7385.
  • Frederiksen PK, McIlroy SP, Nielsen CB, Nikolajsen L, Skovsen E, Jørgensen M, et al. Two-photon photosensitized production of singlet oxygen in water. J Am Chem Soc 2005;127:255–269.
  • Skovsen E, Snyder JW, Lambert JDC, Ogilby PR. Lifetime and diffusion of singlet oxygen in a cell. J Phys Chem B 2005;109:8570–8573.
  • Edelstein A, Amodaj N, Hoover K, Vale R, Stuurman N. Computer control of microscopes using μmanager. Curr Protoc Mol Biol 2010;92:1–17.
  • Gudgin Dickson EF, Kennedy JC, Pottier RH. Photodynamic therapy using 5-aminolevulinic acid-induced protoporphyrin IX. In: Patrice T (ed). Photodynamic therapy. Cambridge: Royal Society of Chemistry; 2003. pp. 81–103.
  • Breitenbach T, Kuimova MK, Gbur P, Hatz S, Schack NB, Pedersen BW, et al. Photosensitized production of singlet oxygen: spatially-resolved optical studies in single cells. Photochem Photobiol Sci 2009;8:442–452.
  • Wilson BC, Olivo M, Singh G. Subcellular localization of photofrin and aminolevulinic acid and photodynamic cross-resistance in vitro in radiation-induced fibrosarcoma cells sensitive or resistant to photofrin-mediated photodynamic therapy. Photochem Photobiol 1997;65:166–176.
  • Ji Z, Yang G, Vasovic V, Cunderlikova B, Suo Z, Nesland JM, Peng Q. Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines. J Photochem Photobiol B Biology 2006;84:213–220.
  • Goyan RL, Cramb DT. Near-infrared two-photon excitation of protoporphyrin IX: photodynamics and photoproduct generation. Photochem Photobiol 2000;72:821–827.
  • Williamson R, Boardman S, Eaton G, Graham T, Parramore K. Advancing maths for AQA: statistics 2. Oxford: Heinemann Educational Publishers; 2005.
  • van Emden HF. Statistics for terrified biologists. Oxford: Blackwell; 2008. p. 59
  • Redmond RW, Gamlin JN. A compilation of singlet oxygen yields from biologically relevant molecules. Photochem Photobiol 1999;70:391–475.
  • Cox GS, Bobillier C, Whitten DG. Photooxidation and singlet oxygen sensitization by protoporphyrin IX and its photooxidation products. Photochem Photobiol 1982;36:401–407.
  • Karrer S, Bäumler W, Abels C, Hohenleutner U, Landthaler M, Szeimies RM. Long-pulse dye laser for photodynamic therapy: investgations in vitro and in vivo. Lasers Surg Med 1999;25:51–59.
  • Buchczyk DP, Klotz LO, Lang K, Fritsch C, Sies H. High efficiency of 5-aminolevulinate-photodynamic treatment. Carcinogenesis 2001;22:879–883.
  • Li B, Jarvi MT, Moriyama EH, Wilson BC. Correlation between cell viability and cumulative singlet oxygen luminescence from protoporphyrin IX in varying subcellular localizations. Proc SPIE 2007;6427:642707.
  • Cox GS, Krieg M, Whitten DG. Self-sensitized photooxidation of protoporphyrin IX derivatives in aqueous surfactant solutions: product and mechanistic studies. J Am Chem Soc 1982;104:6930–6937.
  • Rello S, Stockert JC, Moreno V, Gámez A, Pacheco M, Juarranz A, et al. Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments. Apoptosis 2005;10:201–208.
  • Häcker G. The morphology of apoptosis. Cell Tissue Res 2000;301:5–17.
  • Pedersen BW, Sinks LE, Breitenbach T, Schack NB, Vinogradov SA, Ogilby PR. Single cell responses to spatially-controlled photosensitized production of extracellular singlet oxygen. Photochem Photobiol 2011;87:1077–1091.
  • Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012;8:445–544.
  • Johnson LV, Walsh ML, Chen LB. Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acad Sci USA 1980;77:990–994.
  • Heggeness MH, Simon M, Singer SJ. Association of mitochondria with microtubules in cultured cells. Proc Natl Acad Sci USA 1978;75:3863–3866.
  • Huang S, Heikal AA, Webb WW. Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. Biophys J 2002;82:2811–2825.
  • Baier J, Maisch T, Maier M, Engel E, Landthaler M, Bäumler W. Singlet oxygen generation by UVA light exposure of endogenous photosensitizers. Biophys J 2006;91:1452–1459.
  • Görner H. Oxygen uptake after electron transfer from amines, amino acids and ascorbic acid to triplet flavins in air-saturated aqueous solution. J Photochem Photobiol B Biol 2007;87: 73–80.
  • Lyamzaev KG, Nepryakhina OK, Saprunova VB, Bakeeva LE, Pletjushkina OY, Chernyak BV, Skulachev VP. Novel mechanism of elimination of malfunctionaing mitochondria (mitoptosis): formation of mitoptotic bodies and extrusion of mitochondrial material from the cell. Biochim Biophys Acta Bioenergetics 2008;1777:817–825.
  • Pelloux S, Robillard J, Ferrera R, Bilbaut A, Ojeda C, Saks V, et al. Non-beating HL-1 cells for confocal microscopy: application to mitochondrial functions during cardiac preconditioning. Prog Biophys Mol Biol 2006;90:270–298.
  • Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell. New York: Garland Science; 2002.
  • Hatz S, Poulsen L, Ogilby PR. Time-resolved singlet oxygen phosphorescence measurements from photosensitized experiments in single cells: effects of oxygen diffusion and oxygen concentration. Photochem Photobiol 2008;84:1284–1290.
  • Snyder JW, Skovsen E, Lambert JDC, Poulsen L, Ogilby PR. Optical detection of singlet oxygen from single cells. Phys Chem Chem Phys 2006;8:4280–4293.
  • Dysart JS, Patterson MS. Photobleaching kinetics, photoproduct formation, and dose extimation during ALA induced PpIX PDT of MLL cells under well oxygenated and hypoxic conditions. Photochem Photobiol Sci 2006;5:73–81.
  • König K, Wyss-Desserich MT, Tadir Y, Haller U, Tromberg B, Berns MW, Wyss P. Modifications of protoporphyrin IX fluorescence during ALA-based photodynamic therapy of endometriosis. Med Laser Appl 2006;21:291–297.
  • Lozovaya GI, Masinovsky Z, Sivash AA. Protoporphyrin IX as a possible ancient photosensitizer: spectral and photochemical studies. Orig Life Evol Biosph 1990;20:321–330.
  • Blazquez-Castro A, Carrasco E, Calvo MI, Jaen P, Stockert JC, Juarranz A, et al. Protoporphyrin IX-dependent photodynamic production of endogenous ROS stimulates cell proliferation. Eur J Cell Biol 2012;91:216–223.

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