Insulin resistance is associated with DNA damage in peripheral blood cells in non-diabetic patients with genotype 1 chronic hepatitis C

References

• De Maria N, Colantoni A, Fagiuoli S, Liu GJ, Rogers BK, Farinati F, et al. Association between reactive oxygen species and disease activity in chronic hepatitis C. Free Radic Biol Med 1996;21:291–295.
   PubMed Web of Science ®Google Scholar
• Farinati F, Cardin R, Degan P, De Maria N, Floyd RA, Van Thiel DH, Naccarato R. Oxidative DNA damage in circulating leukocytes occurs as an early event in chronic HCV infection. Free Radic Biol Med 1999;27:1284–1291.
   PubMed Web of Science ®Google Scholar
• Pal S, Polyak SJ, Bano N, Qiu WC, Carithers RL, Shuhart M, et al. Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. J Gastroenterol Hepatol 2010;25: 627–634.
   PubMed Web of Science ®Google Scholar
• Tazawa J, Maeda M, Nakagawa M, Ohbayashi H, Kusano F, Yamane M, et al. Diabetes mellitus may be associated with hepatocarcinogenesis in patients with chronic hepatitis C. Dig Dis Sci 2002;47:710–715.
   PubMed Web of Science ®Google Scholar
• Veldt BJ, Chen W, Heathcote EJ, Wedemeyer H, Reichen J, Hofmann WP, et al. Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus. Hepatology 2008;47:1856–1862.
   PubMed Web of Science ®Google Scholar
• Parise ER, Oliveira AC. [Insulin resistance in chronic hepatitis C]. Arq Gastroenterol 2007;44:178–184.
   PubMedGoogle Scholar
• Morton LM, Engels EA, Holford TR, Leaderer B, Zhang Y, Zahm SH, et al. Hepatitis C virus and risk of non-Hodgkin lymphoma: a population-based case-control study among Connecticut women. Cancer Epidemiol Biomarkers Prev 2004;13:425–430.
   PubMed Web of Science ®Google Scholar
• Nagaoka MR, Le Sueur-Maluf L, Aguiar O Jr, Castro GM, Spadari-Bratfisch RC, Ribeiro DA. Differential response related to genotoxicity in multiple organs of cirrhotic rats. Hepatol Int 2011;5:740–746.
   PubMedGoogle Scholar
• Ribeiro ML, Priolli DG, Miranda DD, Arçari DP, Pedrazzoli J Jr, Martinez CA. Analysis of oxidative DNA damage in patients with colorectal cancer. Clin Colorectal Cancer 2008;7:267–272.
   PubMedGoogle Scholar
• Bolukbas C, Bolukbas FF, Kocyigit A, Aslan M, Selek S, Bitiren M, Ulukanligil M. Relationship between levels of DNA damage in lymphocytes and histopathological severity of chronic hepatitis C and various clinical forms of hepatitis B. J Gastroenterol Hepatol 2006;21:610–616.
   PubMed Web of Science ®Google Scholar
• Grossi S, Sumberaz A, Gosmar M, Mattioli F, Testino G, Martelli A. DNA damage in peripheral blood lymphocytes of patients with cirrhosis related to alcohol abuse or to hepatitis B and C viruses. Eur J Gastroenterol Hepatol 2008;20: 22–25.
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–419.
   PubMed Web of Science ®Google Scholar
• Oliveira AC, Parise ER, Catarino RM, Lanzoni V, Leite-Mor MM, Simon KA, Junqueira VB. Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype. Free Radic Res 2009;43:1187–1194.
   PubMed Web of Science ®Google Scholar
• Salgado AL, Carvalho Ld, Oliveira AC, Santos VN, Vieira JG, Parise ER. Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals. Arq Gastroenterol 2010;47: 165–169.
   PubMedGoogle Scholar
• Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996;24:289–293.
   Google Scholar
• Gayotto LCC, Comitê SBP/SBH. Visão histórica e consenso nacional sobre a classificação das hepatites crônicas. GED Gastroenterol Endosc Dig 2000;19:137–140.
   Google Scholar
• Brunt EM. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 2001;21:3–16.
   PubMed Web of Science ®Google Scholar
• Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000;35:206–221.
   PubMed Web of Science ®Google Scholar
• Enjoji M, Kohjima M, Kotoh K, Nakamuta M. Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments. Int J Hepatol 2012;2012:264017.
   PubMedGoogle Scholar
• Petta S, Cammà C, Di Marco V, Alessi N, Cabibi D, Caldarella R, et al. Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection. Am J Gastroenterol 2008;103:1136–1144.
   PubMed Web of Science ®Google Scholar
• Ijaz B, Ahmad W, Javed FT, Gull S, Sarwar MT, Kausar H, et al. Association of laboratory parameters with viral factors in patients with hepatitis C. Virol J 2011;8:361.
   PubMed Web of Science ®Google Scholar
• Cardin R, Saccoccio G, Masutti F, Bellentani S, Farinati F, Tiribelli C. DNA oxidative damage in leukocytes correlates with the severity of HCV-related liver disease: validation in an open population study. J Hepatol 2001;34:587–592.
   PubMed Web of Science ®Google Scholar
• Horoz M, Bolukbas C, Bolukbas FF, Kocyigit A, Aslan M, Koylu AO, et al. Assessment of peripheral DNA damage by alkaline comet assay in maintenance hemodialysis subjects with hepatitis C infection. Mutat Res 2006;596:137–142.
   PubMedGoogle Scholar
• Reshetnyak VI, Sharafanova TI, Ilchenko LU, Golovanova EV, Poroshenko GG. Peripheral blood lymphocytes DNA in patients with chronic liver diseases. World J Gastroenterol 2001;7:235–237.
   PubMed Web of Science ®Google Scholar
• Song F, Jia W, Yao Y, Hu Y, Lei L, Lin J, et al. Oxidative stress, antioxidant status and DNA damage in patients with impaired glucose regulation and newly diagnosed Type 2 diabetes. Clin Sci (Lond) 2007;112:599–606.
   PubMed Web of Science ®Google Scholar
• Jahan S, Ashfaq UA, Qasim M, Khaliq S, Saleem MJ, Afzal N. Hepatitis C virus to hepatocellular carcinoma. Infect Agent Cancer 2012;7:2.
   PubMed Web of Science ®Google Scholar
• Jain N, Naseem I, Ahmad J. Evaluation of DNA damage and metabolic syndrome parameters in diabetic rabbits supplemented with antioxidants. Fundam Clin Pharmacol 2009;23: 197–205.
   PubMed Web of Science ®Google Scholar
• Zengi A, Ercan G, Caglayan O, Tamsel S, Karadeniz M, Simsir I, et al. Increased oxidative DNA damage in lean normoglycemic offspring of type 2 diabetic patients. Exp Clin Endocrinol Diabetes 2011;119:467–471.
   PubMed Web of Science ®Google Scholar
• Bloch-Damti A, Bashan N. Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal 2005;7:1553–1567.
   PubMed Web of Science ®Google Scholar
• Stump CS, Clark SE, Sowers JR. Oxidative stress in insulin-resistant conditions: cardiovascular implications. Treat Endocrinol 2005;4:343–351.
   PubMedGoogle Scholar
• Trevisan M, Browne R, Ram M, Muti P, Freudenheim J, Carosella AM, Armstrong D. Correlates of markers of oxidative status in the general population. Am J Epidemiol 2001;154:348–356.
   PubMed Web of Science ®Google Scholar
• Wang X, Gu C, He W, Ye X, Chen H, Zhang X, Hai C. Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress. Biochimie 2012;94:1705–1717.
   PubMedGoogle Scholar
• Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes (Lond) 2006;30:400–418.
   PubMed Web of Science ®Google Scholar
• Clement S, Pascarella S, Negro F. Hepatitis C virus infection: molecular pathways to steatosis, insulin resistance and oxidative stress. Viruses 2009;1:126–143.
   PubMedGoogle Scholar
• Mitsuyoshi H, Itoh Y, Sumida Y, Minami M, Yasui K, Nakashima T, Okanoue T. Evidence of oxidative stress as a cofactor in the development of insulin resistance in patients with chronic hepatitis C. Hepatol Res 2008;38:348–353.
   PubMed Web of Science ®Google Scholar
• Lai MS, Hsieh MS, Chiu YH, Chen TH. Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection. Hepatology 2006;43:1295–1302.
   PubMed Web of Science ®Google Scholar
• Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005;54:533–539.
   PubMed Web of Science ®Google Scholar
• Tsukiyama-Kohara K, Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus. Int J Mol Sci 2012;13:15271–15278.
   PubMedGoogle Scholar