Comparative Study on the Influence of Two 2-Chloroethylnitrosoureas with Different Carbamoylating Potential Towards Glutathione and Glutathione-Related Enzymes in Different Organs of the Rat

References

• Kehrer J. P., Klein-Szanto A. J. P. Enhanced lung damage in mice following administration of 1. 3-Bis-(2-chloroethyl)-1-nitrosourea. Cancer Research 1985; 45: 5707–5713
   PubMed Web of Science ®Google Scholar
• Eisenbrand G., Habs M. Chronic toxicity of cytostatic N-nitroso-(2-chloroethyl)-ureas after repeated intravenous application in rats. Mechanisms of toxicity and hazard evaluation, Holmstedt, et al, 1980; 273–278
   Google Scholar
• Ginsberg S. J., Comis R. L. The pulmonary toxicity of anticancer agents. Toxicity of chemotherapy. Grune and Stratton, NY 1984; 227–268
   Google Scholar
• Weiss R. B., Poster D. S., Penta J. S. The nitrosoureas and pulmonary toxicity. Cancer Treatment Review 1981; 8: 111–124
   PubMed Web of Science ®Google Scholar
• Cohen M. H., Matthews M. J. Chemotherapy-induced pulmonary toxicity in mice bearing L 1210 leukemia. Oncology (Basel) 1983; 40: 132–137
   PubMedGoogle Scholar
• Reznik-Schiiller H. M., Smith A. C., Thenot J. P., Boyd M. R. Pulmonary toxicity of the anticancer drug, bis-chloroethyl nitrosourea (BCNU) in rats. Toxicologist 1984; 4: 29
   Google Scholar
• Smith A. C., Boyd M. R. Preferential effects of l, 3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) on pulmonary glutathione reductase and glutathione glutathione disulfide ratios: possible implicating for lung toxicity. Journal of Pharmacology Experiments and Therapy 1984; 229: 658–663
   PubMed Web of Science ®Google Scholar
• Stahl W. Untersuchungen zur Reaktion von 2-Chlorethylnitrosoharnstoffen. Doctoral Thesis, Department of Food Chemistry and Environmental Toxicology, University of Kaiserslautern. 1987
   Google Scholar
• Kohn K. W. Interstrand crosslinking of DNA by 1, 3-Bis-(2-chloroethyl)-1-nitrosoureas and other 1-(2-haloethyl)-1-nitrosoureas. Cancer Research, 37: 1450–1454
   PubMedGoogle Scholar
• Eisenbrand G., Müller N., Schreiber J., Stahl W., Sterzel W., Berger M. R., Zeller W. J., Fiebig H. Drug Design: Nitrosoureas. IARC Sci. Pub. 1986; 78: 281–294
   Google Scholar
• Kann H. E. Carbamoylating activity of nitrosoureas. Nitrosoureas: current status and new developments, A. W. Prestayko, et al. Academic press, NY 1981; 95–105
   Google Scholar
• Ali-Osman F., Giblin J., Berger M., Murphy M., Rosenblum M. Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctional alkylating and carbamoylating agents. Cancer Research 1985; 45: 4185–4191
   PubMedGoogle Scholar
• Frischer H., Ahmad T. Severe generalized glutathione reductase deficiency after antitumor chemoteraphy with BCNU 1. 3-Bis-(2-chloroethyl)-1-nitrosourea. Journal of Laboratory and Clinical Medicine 1977; 89: 1080–1091
   PubMed Web of Science ®Google Scholar
• Schirmer R. H., Schöllhammer T., Eisenbrand G., Krauth-Siegel R. L. Oxidative stress as a defense mechanism against parasitic infections. Free Radical Research Communication 1987; 3: 3–12
   PubMedGoogle Scholar
• Kehrer J. P. The effect of BCNU (Carmustine) on tissue glutathione reductase activity. Toxicology Letters 1983; 17: 63–68
   PubMed Web of Science ®Google Scholar
• Babson J. R., Reed D. R. Inactivation of glutathione reductase by 2-chloroethyl-nitrosourea derived isocyanates. Biochemistry and Biophysics Research Communication 1978; 83: 754–762
   PubMedGoogle Scholar
• McConnel W. R., Kari P., Hill D. L. Reduction of glutathione levels in the liver treated with N, N'-Bis-(2-chloroethyl)-N-nitrosourea. Cancer Chemotherapy Pharmacology 1979; 2: 221–223
   PubMedGoogle Scholar
• Eisenbrand G., Fiebig H., Zeller W. J. Some new congeners of the anticancer agent 1. 3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU); synthesis of bifunctional analogues and water-soluble derivatives and preliminary evaluation of their chemotherapeutic potential. Z. Krebsforsch. 1976; 86: 279–286
   Google Scholar
• Stahl W., Krauth-Siegel R. L., Schirmer H., Eisenbrand G. A method to determine the carbamoylating potential of 1-(2-chloroethyl)-1-nitrosoureas. IARC Sci. Pub. 1987; 84: 191–193
   PubMedGoogle Scholar
• Hissin P. J., Hilf H. R. A fluorimetric method for determination of oxidized and reduced glutathione in tissues. Analgtrical Biochemistry 1976; 74: 214–226
   PubMed Web of Science ®Google Scholar
• Habig W. H., Pabst M. J., Jacoby W. B. Glutathione-S-transferases. Journal of Biological Chemistry 1974; 249: 7130–7139
   PubMed Web of Science ®Google Scholar
• Carlberg J., Mannervik B. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. Journal of Biological Chemistry 1975; 250: 5475–5480
   PubMed Web of Science ®Google Scholar
• Kramer R. A., Green K., Ahmad S., Vistica D. T. Chemosensitation of L-phenylalanine mustard by the thiol-medulating agent buthionine sulfoximine. Cancer Research 1987; 47: 1593–1597
   PubMed Web of Science ®Google Scholar
• Burton N. K., Aherne G. W. Sensitive measurement of glutathione using isocratic HPLC with fluorescence detection. Journal of Chromatography 1986; 282: 253–257
   Google Scholar
• Mohandas J., Marshall J. J., Duggin G., Horvath J. S., Tiller I. J. Low activity of glutathione related enzymes as factors in the genesis of urinary bladder cancer. Cancer Research 1984; 44: 5086–5091
   PubMed Web of Science ®Google Scholar
• Maher H. S., Weiss C., Brennan T. The effects of BCNU and CCNU on glutathione reductase and other enzymes in mouse tissue. Research and Communication in Chemical Pathology and Pharmacology 1983; 40: 355–366
   PubMedGoogle Scholar
• Crittenden D., Tranuine B. L., Haut A. Pulmonary fibrosis after prolonged therapy with 1. 3-Bis-(2-chloroethyl)-1-nitrosourea. Chest 1977; 11: 372–373
   Google Scholar
• Aronin P. A., Mahaley M. S., Rudnick S. R., Dudka L., Donohue J. F., Selker R., Moore P. Prediction of BCNU pulmonary toxicity in patients with malignant gliomas. New England Journal Medicine 1980; 4: 193–198
   Google Scholar
• Fiebig H. H., Henß H., Schuckardt C., Arnold H., Löhr G. W., Eisenbrand G. Phase I and II study of the new watersoluble nitrosourea HECNU. Journal Cancer Research and Clinical Oncology 1984; 107: 47, (Suppl)
   Google Scholar
• Berger M. R., Henne T., Bedford P. Relationship between DNA-damage and the inhibition of stem cells in the murine bone marrow after single and repeated administration of HECNU and BCNU. Journal of Cancer Research and Clinical Oncology 1985; 110: 185–190
   PubMedGoogle Scholar