Generation of Probucol Radicals and Their Reduction by Ascorbate and Dihydrolipoic Acid in Human Low Density Lipoproteins

References

• Parthasarathy S., Printz D. J., Boyd D., Joy L., Steinberg D. Macrophage oxidation of low density lipoprotein generates a form reg = cognized by the scavenger receptor. Arteriosclerosis 1986; 6: 505–510
   PubMedGoogle Scholar
• Steinberg D., Parthasarathy S., Carew T. F., Khoo J. C., Witztum J. L. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. New England Journal of Medicine 1989; 329: 915–925
   Google Scholar
• Goldstein J. L., Ho Y. K., Basu S. K., Brown M. S. Binding site on macrophages that mediates the uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proceedings of the National Academy of Sciences USA 1979; 76: 333–337
   PubMed Web of Science ®Google Scholar
• Steinbrecher U. P., Zhang H., Lougheed M. Role of oxidatively modified LDL in atherosclerosis. Free Radical Biology and Medicine 1990; 9: 155–168
   PubMed Web of Science ®Google Scholar
• Quehenberger O., Koller E., Jurgens G., Esterbauer H. Investigation of lipid peroxidation in human low density lipoprotein. Free Radical Research Communications 1987; 3: 233–242
   PubMedGoogle Scholar
• Breugnot C., Maziere C., Salmon S., Auclair M., Santus R., Morliere P., Lenaers A., Maziere J. C. Phenothiazines inhibit copper and endothelial cell-induced peroxidation of low density lipoprotein – a comparative study with probucol, butylated hydroxytoluene and vitamin E. Biochemical Pharmacology 1990; 40: 1975–1980
   PubMed Web of Science ®Google Scholar
• Morel D. W., Chisolm G. M. Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity. Journal of Lipid Research 1989; 30: 1827–1834
   PubMed Web of Science ®Google Scholar
• Esterbauer H., Dieber-Rothenderm M., Striegl G., Waeg G. Role of vitamin E in preventing the oxidation of low-density lipoprotein. American Journal of Clinical Nutrition 1991; 53: S314–S321
   PubMed Web of Science ®Google Scholar
• Jessup W., Rankin S. M., de Whalley C. V., Hoult R. S., Scott J., Leake D. S. α-Tocopherol consumption during low density-lipoprotein oxidation. Biochemical Journal 1990; 265: 399–405
   PubMed Web of Science ®Google Scholar
• Snipping G., Rothneder M., Strieg G., Esterbauer H. Antioxidants and resistance against oxidation of porcine LDL subfractions. Journal of Lipid Research 1990; 31: 1965–1972
   PubMed Web of Science ®Google Scholar
• Bjorkhem J., Henriksson-Freyschuss A., Breuer O., Diczfalusy U., Berglund L., Henriksson P. The antioxidant butylated hydroxytoluene protects against atherosclerosis. A rteriosclerosis and Thrombosis 1991; 11: 15–22
   PubMed Web of Science ®Google Scholar
• Jessup W., Dean R. T., de Whalley C. V., Rankin S. M., Leak D. S. The role of oxidative modification and antioxidants in LDL metabolism and atherosclerosis. Advances in Experimental Medicine and Biology 1990; 264: 139–142
   PubMedGoogle Scholar
• Buckley M. M., Goa K. L., Price A. H., Brogden R. N. Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia. Drugs 1989; 37: 761–800
   PubMed Web of Science ®Google Scholar
• P. Zimetbaum, H. Eder and W. Frishman (1990) Probucol: pharmacology and clinical application. Journal of Clinical Pharmacology, 30, 3–9.
   PubMed Web of Science ®Google Scholar
• R.L. Barnhart, S.J. Busch and R.L. Jackson (1989) Concentration-dependent antioxidant acivity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation. Journal of Lipid Research, 30, 1703–1710.
   PubMed Web of Science ®Google Scholar
• S.J. Mao, M.T. Yates, A.E. Rechtin, R.L. Jackson and W.A. Van Sickle (1991) Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits. Journal of Medicinal Chemistry, 34, 298–302.
   PubMed Web of Science ®Google Scholar
• O.I. Aruoma, P.J. Evans, H. Kaur, L. Sutclifie and B. Halliwell (1990) An evaluation of the antioxidant and potential pro-oxidant properties of food additives and of Trolox C, vitamin E and probucol. Free Radical Research Communications, 10, 143–157.
   PubMed Web of Science ®Google Scholar
• H. Minakami, A. Sotomatsu, C. Ohma and M. Makano (1989) Antioxidant activity of probucol. Short Communication. Arzneimittel-Forschung, 39, 1090–1091.
   PubMed Web of Science ®Google Scholar
• V.E. Kagan, E.A. Serbinova and L. Packer (1990) Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochemical and Biophysical Research Communications, 169, 851–857.
   PubMed Web of Science ®Google Scholar
• V.E. Kagan, E.A. Serbinova and L. Packer (1990) Recycling and antioxidant activity of tocopherol homologues of differing hydrocarbon chain length in liver microsomes. Archives of Biochemistry and Biophysics, 282, 221–225.
   PubMed Web of Science ®Google Scholar
• V.E. Kagan, E.A. Serbinova, T. Forte, G. Scita and L. Packer (1991) Recycling of vitamin E in human low density lipoproteins: interplay between water- and lipid-soluble antioxidants. Free Radical Biology and Medicine, submitted.
   Google Scholar
• U.P. Steinbrecher (1987) Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. Journal of Biological Chemistry, 262, 3603–3608.
   PubMed Web of Science ®Google Scholar
• K. Kawai-Kobayashi and A. Yoshida (1986) Effect of dietary ascorbic acid and vitamin E on metabolic changes in rats and guinea pigs exposed to PCB. Journal of Nutrition, 116, 98–106.
   PubMed Web of Science ®Google Scholar
• H. Esterbauer, G. Jurgens, O. Quechenberger and E. Koller (1987) Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. Journal of Lipid Research, 28, 495–509.
   PubMed Web of Science ®Google Scholar
• G.W. Burton, A. Joyce and K.U. Ingold (1983) Is vitamin E the only lipid-soluble chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Archives of Biochemistry and Biophysics, 221, 281–290.
   PubMed Web of Science ®Google Scholar
• I. Jialal and S.M. Grundy (1991) Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification. Journal of Clinical Investigations, 87, 597–601.
   PubMed Web of Science ®Google Scholar
• W. Plenert and W. Heine (1986) Normal Values. Karger, Basel, p.84.
   Google Scholar
• R.L. Searls and D.R. Sanadi (1960) a-Ketoglutaric dehydrogenase. 8. Isolation and some properties of a flavoprotein component. Journal of Biological Chemistry, 235, 2485–2491.
   PubMed Web of Science ®Google Scholar