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Free Radical Research Volume 26, 1997 - Issue 2
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Original Article

Synthesis and Spin Trapping Applications of 2,2-Dimethyl-d6-4-methyl-2H-imidazole-1-oxide-1-15N

Reiner F. Haseloff Institute of Molecular Pharmacology, Alfred-Kowalke-Str. 4, D-10315, Berlin, GermanyCorrespondence[email protected]
,
Igor A. Kirilylk Institute of Organic Chemistry, Novosibirsk, Russia
,
Sergey I. Dikalov Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia
,
Valery V. Khramtsov Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia
,
Darkhan I. Utepbergenov State University, Novosibirsk, Russia
,
Ingolf E. Blasig Institute of Molecular Pharmacology, Alfred-Kowalke-Str. 4, D-10315, Berlin, Germany
&
Igor A. Grigor'ev Institute of Organic Chemistry, Novosibirsk, Russia
 show all
Pages 159-168 | Received 25 Jun 1996, Accepted 29 Aug 1996, Published online: 07 Jul 2009

References

  • Janzen E. G., Blackburn B. J. Detection and identification of short-lived free radicals by an electron spin resonance trapping technique. Journal of the American Chemical Society 1968; 90: 5909–5910
  • Finkelstein E., Rosen G. M., Rauckman E. J. Production of hydroxyl radical by decomposition of superoxide spin-trapped adducts. Molecular Pharmacology 1982; 21: 262–265
  • Hanna P. M., Chamulitrat W., Mason R. P. When are metal ion-dependent hydroxyl and alkoxyl radical adducts of 5,5-dimethyl-1-pyrroline N-oxide artifacts?. Archives of Biochemistry and Bioplysics 1992; 296: 460–644
  • Makino K., Hagiwara, Hagi A., Nishi M., Murakami A. Cautionary note for DMPO spin trapping in the presence of iron ion. Biochemical and Biophysical Research Communications 1990; 172: 1073–1080
  • Janzen E. G., Zhang Y. K., Haire D. L. New 2-substituted pyrroline-N-oxides: an EPR solvent study of the radical spin adducts. Mognetic Resonance in Chemistry 1994; 32: 711–720
  • Janzen E. G., Kotake Y., Hinton R. D. Stabilities of hydroxyl radical spin adducts of PBN-type spin traps. Free Radical Biology and Medicine 1992; 12: 169–173
  • Frejaville C., Karoui H., Tuccio B., le Moigne F., Culcasi M., Pietri S., Lauricella R., Tordo P. 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: a new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen-centered radicals. Journal of Medicinal Chemistry 1995; 38: 258–265
  • Dikalov S. I., Kirilyuk I. A., Grigor'ev I. A., Volodarskii L. B. The 2H-imidazole-N-oxides as spin traps (in russian), Izvestiya Akademii Nauk Seriya Khimicheskaya 1992; 1064–1068
  • Klauschenz E., Haseloff R. F., Volodarskii L. B., Blasig I. E. Spin trapping using 2,2-dimethyl-2H-imidazole-1-oxides. Free Radical Research 1994; 20: 103–111
  • Halpern H. J., Pou S., Peric M., Yu C., Barth E., Rosen G. M. Detection and imaging of oxygen-centered free radicals with low-frequency electron paramagnetic resonance and signal-enhancing deuterium-containing spin traps. Journal of the American Chemical Society 1993; 115: 218–223
  • Keana J. F. W., Lex L., Mann J. S., May J. M., Park J. H., Pou S., Prabhu V. S., Rosen G. M., Sweetman B. J., Wu Y. Novel nitroxides for spin-labeling, -trapping, and magnetic-resonance-imaging applications. Pure and Applied Chemistry 1990; 62: 201–205
  • Barasch D., Krishna M. C., Russo A., Katzhendler J., Samuni A. Novel DMPO-Derived 13C-Labeled Spin Traps Yield Identifiable Stable Nitroxides. Journal of the American Chemical Society 1994; 116: 7319–7324
  • Zhang Y. K., Janzen E. G. An EPR and MS investigation of hexa-substituted pyrrolidine-1-oxyl aminoxyl stable radicals. Unexpectedly large gamma-hydrogen splittings. Zeitschrift für Naturforschung 1995; 50 b: 1531–1536
  • Haire D. L., Janzen E. C. Enhanced diagnostic EPR and ENDOR spectroscopy of radical spin adducts of deuterated α-phenyl N-tert-butyl nitrone. Magnetic Resonance in Chemistry 1994; 32: 151–157
  • Reinke L. A., Kotake Y., McCay P. B., Janzen E. G. Spin-trapping studies of hepatic free radicals formed following the acute administration of ethanol to rats: in vivo detection of 1-hydroxyethyl radicals with PBN. Free Radical Biology and Medicine 1991; 11: 31–39
  • Buehler C. A., Pearson D. E. Survey of Organic Syntheses. Wiley Interscience, NY-L-Sydney-Toronto 1970
  • Haire D. L., Kotake Y., Janzen E. G. An EPR/ENDOR study of aminoxyls (nitroxides) capable of intramolecular bonding: hydroxyalkyl radical spin adducts of nitrones. Canandian Journal of Chemistry-Revue Canadienne de Chimie 1988; 66: 1901–1911
  • Krishna C. M., Kondo T., Riesz P. Sonochemistry of alcohol-water mixtures. Spin-trapping evidence for thermal decomposition and isotope-exchange reactions. Journal of Physical Chemistry 1989; 93: 5166–5172
  • Khramtsov V. V., Weiner L. M., Eremenko S. I., Belchenko O. I., Schastnev P. V., Grigor'ev I. A., Reznikov V. A. Proton exchange in stable nitroxide radicals of imidazoline and imidazolidine series. Journal of Magnetic Resonance 1985; 61: 397–408
  • Skubnevskaya G. I., Dultseva G. G., Schukin G. I., Volodarsky L. B. Influence of pH on EPR spectra of spin adducts of a new spin trap, 1,2,2,5,5-pentamethyl-3-imidazoline-3-oxide. Izvestiya Akademii Nauk Seriya Khimicheskaya 1987; 312–317

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