55
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Hydralazine, but not Captopril, Decreases Free Radical Production and Apoptosis in Neurons and Thymocytes

, , , &
Pages 393-402 | Received 05 Dec 1997, Published online: 07 Jul 2009

References

  • van Zwieten P. A. New avenues in antihypertensive drug treatment. Clinical and Experimental Hyyertension 1993; 15: 1205–1220
  • Chopra M., Beswick H., Clapperton M., Dargie H. J., Smith W. E., McMurray J. Antioxidant effects of angiotensin-converting enzyme (ACE) inhibitors: free radical and oxidant scavenging are sulfhydryl dependent, but lipid peroxidation is inhibited by both sulfhydryl-and nonsulfhydryl-containing ACE inhibitors. Journal of Cardiovascular Pharmacology 1992; 19: 330–340
  • Gurney A. M., Allam M. Inhibition of calcium release from the sarcoplasmic reticulum of rabbit aorta by hydralazine. British Journal of Pharmacology 1995; 114: 238–244
  • Pi X. J., Chen X. Captopril and ramiprilat protect against free radical injury in isolated working rat hearts. Journal of Molecular and Cellular Cardiology 1989; 21: 1261–1271
  • Westlin W., Mullane K. Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals?. Circulation 1988; 77: 130–139
  • Sogaard P., Klausen I. C., Rungby J., Faergeman O., Thygesen K. Lipoprotein (a) and oxygen free radicals in survivors of acute myocardial infarction: effects of captopril. Cardiology 1996; 87: 18–22
  • Altuntas Y., Guven M., Ince E., Acbay O., Caner M., Kanigur-Sultuybek G. The in vitro effects of captopril on the levels of lipid peroxidation and glutathione of erythrocytes in type II diabetes. Journal of Basic Clinical Physiology and Pharmacology 1995; 6: 281–288
  • Weglarz L., Bartosz G. Hydralazine stimulates production of oxygen free radicals in Eagle's medium and cultured fibroblasts. Free Radical Biology arid Medicine 1991; 11: 149–155
  • Runge-Morris M., Wu N., Novak R. F. Hydrazine-mediated DNA damage: role of hemoprotein, electron transport, and organic free radicals. Toxicology and Applied Pharmacology 1994; 125: 123–132
  • de Cavanagh E. M. V., Inserra F., Ferder L., Romano L., Ercole L., Fraga C. G. Superoxide dismutase and glutathione peroxidase activities are increased by enalapril and captopril in mouse liver. FEBS Letters 1995; 361: 22–24
  • Graham J. C., Hoffman G. E., Sved A. F. c-Fos expression in brain in response to hypotension and hypertension in conscious rats. Journal of the Autonomic Nervous System 1995; 55: 92–104
  • Iwai N., Hanai K., Tooyama I., Kitamura Y., Kinoshita M. Regulation of neuronal nitric oxide synthase in rat adrenal medulla. Hypertetension 1995; 25: 431–436
  • Runge-Morris M., Feng Y., Zangar R. C., Novak R. F. Effects of hydrazine, phenelzine, and hydralazine treatment on rat hepatic and renal drug-metabolizing enzyme expression. Drug Metabolism and Disposition 1996; 24: 734–737
  • Cabell K. S., Ma L., Johnson P. Effects of antihypertensive drugs on rat tissue antioxidant enzyme activities and lipid peroxidation levels. Biochemical Pharmacology 1997; 54: 133–141
  • Maftah A., Huet O., Gallet P.-F., Ratinaud M.-H. Flow cytometry's contribution to the measurement of cell functions. Biology of the Cell 1993; 78: 85–93
  • Oyama Y., Hayashi A., Ueha T., Maekawa K. Characterization of 2′,7′-dichlorofluorescein fluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide. Brain Research 1994; 635: 113–117
  • Sarafian T. A., Bredesen D. E. Is apoptosis mediated by reactive oxygen species?. Free Radical Research 1994; 21: 1–8
  • Bustamente J., Tovar-B A., Montero G., Boveris A. Early redox changes during rat thymocyte apoptosis. Archives of Biochemistry and Biophysics 1997; 337: 121–128
  • Koopman G., Reutelingsperger C. P., Kuijten G. A., Keehnen R. M., Pals S. T., van Oers M. H. Annexin V for flow cytometric detection of phosphati-dylserine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415–7420
  • Fabisiak J. P., Kagan V. E., Ritov V. B., Johnson D. E., Lazo J. S. Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis. American Journal of Physiology 1997; 272: C675–C684
  • Haugland R. P. Handbook of Fluorescent Probes and Research Chemicals. Molecular Probes, Eugene, Oregon 1989
  • Oyama Y., Carpenter D., Chikahisa L., Okazaki E. Flow-cytometric estimation of glutamate- or kainate-induced increases in intracellular Ca2+ of brain neurons: a technical aspect. Brain Research 1996; 728: 121–124
  • Chikahisa L., Oyama Y., Okazaki E., Noda K. Fluorescent estimation of H2O2-induced changes in cell viability and cellular nonprotein thiol levels of dissociated rat thymocytes. Japanese Journal of Pharmacology 1996; 71: 299–305
  • Migliorati G., Nicoletti I., Crocicchio F., Pagliacci C., D'Adamio F., Riccardi C. Heat shock induces apoptosis in mouse thymocytes and protects them from glucocorticoid-induced cell death. Cellular Immunonology 1992; 143: 348–356
  • Reynolds I. J., Hastings T. G. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. Journal of Neuroscience 1995; 15: 3318–3327
  • Sirnonian N. A., Getz R. L., Leveque J. C., Konradi C., Coyle J. T. Kainate induces apoptosis in neurons. Neuroscience 1996; 74: 675–683
  • Jay D., Cuella A., Jay E. Superoxide dismutase activity of the captopril-iron complex. Molecular and Cellular Biochemistry 1995; 146: 45–47
  • Lapenna D., Cuccurullo F. Captopril: Does it act as a direct antioxidant by free radical scavenging in humans?. Free Radical Biology and Medicine 1995; 18: 377–378
  • Deas O., Dumont C., Mollereau B., Metivier D., Pasquier C., Bernard-Pomier G., Hirsch F., Charpentier B., Senik A. Thiol-mediated inhibition of FAS and CD2 apoptotic signaling in activated human peripheral T cells. International Immunology 1997; 9: 117–125
  • Li Z., Bing O. H. L., Long X., Robinson K. G., Lakatta E. G. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. American Journal of Physiology 1997; 272: H2313–H2319
  • Weglarz L., Drodz M., Wardas M., Goss M. Activities of antioxidant enzymes in fibroblasts cultured in vitro in the presence of hydralazine. Biomedica Biochimica Acta 1989; 48: 489–493
  • Goodwin D. C., Aust S. D., Grover T. A. Free radicals produced during the oxidation of hydrazines by hypochlorous acid. Chemical Research in Toxicology 1996; 9: 1333–1339
  • Jendryczko A., Drozdz M. Lipid peroxidation in the nuclear fraction of rat lungs induced by hydralazine. Neoplasma 1988; 35: 3740
  • Hug H., Enari M., Nagata S. No requirement of reactive oxygen intermediates in Fas-mediated apoptosis. FEBS Letters 1994; 351: 311–313
  • deBlois D., Tea B. S., Than V. D., Tremblay J., Hamet P. Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats. Hypertension 1997; 29: 340–349
  • Pandey S., Wang E. Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse. Journal of Cellular Biochemistry 1995; 58: 135–150
  • Herrera D. G., Robertson H. A. Activation of c-fos in the brain. Progress in Neurobiology 1996; 50: 85–107
  • Bolyut M. O., Bing O. H. L., Lakatta E. G. The ageing spontaneously hypertensive rat as a model of the transition from stable compensated hypertrophy to heart failure. European Heart Journal 1995; 16(suppl. N)19–30
  • Krown K. A., Page M. T., Nguyen C., Zechner D., Gutierrez V., Comstock K. L., Giembotski C. G., Quintana P. J. E., Sabbadini R. A. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Journal of Clinical Investigation 1996; 98: 2854–2865

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.