1,569
Views
13
CrossRef citations to date
0
Altmetric
Original Article

The role of protamine amount in the transfection performance of cationic SLN designed as a gene nanocarrier

, , , &
Pages 1-10 | Received 06 Apr 2011, Accepted 06 Sep 2011, Published online: 09 Nov 2011

References

  • Asasutjarit, R., Lorenzen, S.I., Sirivichayakul, S., Ruxrungtham, K., Ruktanonchai, U., Ritthidej, G.C. (2007). Effect of solid lipid nanoparticles formulation composition on their size, zeta potential and potential for in vitro pHIS-HIV-Hugag transfection. Pharm Res. 24:1098–7.
  • Braun, R.E. (2001). Packaging paternal chromosomes with protamina. Nat Genet. 28:10–12.
  • Canine, B.F., Wang, Y., Hatefi, A. (2008). Evaluation of the effect of vector architecture on DNA condensation and gene transfer efficiency. J Contr Rel. 129:117–23.
  • Del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascon, A.R., Pedraz, J.L. (2007). Solid lipid nanoparticles: Formulation factors affecting cell transfection capacity. Int J Pharm. 339: 261–8.
  • Del Pozo-Rodríguez, A., Solinís, M.A., Gascón, A.R., Pedraz, J.L.(2009). Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy. Eur J Pharm Biopharm. 71:181–9.
  • Gröne, E.F., Walli, A.K., Gröne, H.J., Miller, B., Seidel, D. (1994). The role of lipids in nephrosclerosis and glomerulosclerosis. Atherosclerosis. 107:1–13.
  • Guo, W., Huang, N., Cai, J., Xie, W., Hamilton, J.A. (2006). Fatty acid transport and metabolism in HepG2 cells. J Physiol Gastrointest Liver Physiol. 290:528–34.
  • Heydenrich, A.V., Westmeier, R., Pedersen, N., Polsen, H.S., Kristensen, H.G. (2003). Preparation and purification of cationic solid lipid nanospheres-effect on particle size, physical stability and cell toxicit. Int J Pharm. 254:355–64.
  • Huang, L., Viroonchatapan, E. (1999). Introduction. In: Huang, L., Wagner, M., ed. Nonviral vectors for gene therapy. New York: Academic Press, 39–68.
  • Huh, S.H., Do, H.J., Lim, H.Y., Kim, D.K., Choi, S.J., Song, H., Kim, N.H., Park, J.K., Chang, W.K., Chung, H.M., Kim, J.H. (2007). Optimazation of 25 KDa linear polyethylenimine for efficient gene delivery. Biologicals. 35:165–71.
  • Jain, V., Prasad, V., Jadhav, P., Mishra, P.R. (2009). Preparation and performance evaluation of saquinavir laden cationic submicron emulsions. Drug Deliv. 16:37–44.
  • Karten, B., Hayashi, H., Campenot, R.B., Vance, D.E., Vance, J.E. (2005). Neuronal models for studying lipid metabolism and transport. Methods. 36:117–28.
  • Liu, J., Guo, S., Li, Z., Liu, L., Gu, J. (2009). Synthesis and characterization of stearyl protamine and investigation of their complexes with DNA for gene delivery. Coll Surf B: Bioint. 73:36–41.
  • Mayer, G., Vogel, V., Weyermann, J., Lochmann, D., van den Broek, J.A., Tziatzios, C., Haase, W., Wouters, D., Schubert, U.S., Zimmer, A., Kreuter, J., Schubert, D. (2005). Oligonucleotide–protamine-albumin nanoparticles: Protamine sulfate causes drastic size reduction. J Contr Rel. 106:181–7.
  • Moghimi, S.M., Symonds, P., Murray, J.C., Hunter, A.C., Debska, G., Szewczyk, A. (2005). A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy. Mol Ther. 11:990–5.
  • Morille, M., Passirani, C., Vonarbourg, A., Clavreul, A., Benoit, J.P. (2008). Progress in developing cationic vectors for non viral systemic gene therapy against cancer. Biomaterials. 29:3477–96.
  • Olbrich, C., Bakowsky, U., Lehr, C.M., Muller, R.H., Kneuer, C. (2001). Cationic solid–lipid nanoparticles can efficiently bind and transfect plasmid DNA. J Contr Rel. 77:345–55.
  • Pedersen, N., Hansen, S., Heydenreich, A.V., Kristensen, H.G., Poulsen, H.S. (2006). Solid lipid nanoparticles can effectively bind DNA, streptavidin and biotinylated ligands. Eur J Pharm Biopharm. 62:155–62.
  • Pintel, D.J., Tullis, G.E. (2006). Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors. J Virol Methods. 138:85–98.
  • Rejman, J., Oberie, V., Zuhon, I.S., Hoekstra, D. (2004). Size-dependent internalization of particles via pathways of clathrin and cavoelae-mediated endocytosis. Biochem J. 377:159–69.
  • Rudolph, C., Schillinger, U., Ortiz, A., Tabatt, K., Plank, C., Müller, R.H., Rosenecker, J. (2004). Application of novel solid lipid nanoparticles (SLN)-gene vector formulations based on a dimeric HIV-1 Tat-peptide in vitro and in vivo. Pharm Res. 21:1662–9.
  • Tabatt, K., Kneuer, C., Sameti, M., Olbrich, C., Muller, R.H., Lehr, C.M., Bakowsky, U. (2004a). Transfection with different colloidal systems: comparison of solid lipid nanoparticles and liposomes. J Contr Rel. 97:321–32.
  • Tabatt, K., Sameti, M., Olbrich, C., Muller, R.H., Lehr, C.M. (2004b). Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. Eur J Pharm Biopharm. 57:155–62.
  • Tsuchiya, Y., Ishti, T., Okahata, Y., Sato, T. (2006). Characterization of Protamine as a tranfection accelerator for gene delivery. J Bioact Comp Polym. 21:519–37.
  • Van der Meer, P., Ulrich, A.M., Gonzalez-Scarano, F., Lavi, E. (2000). Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum. Exp Mol Pathol. 69:233–41.
  • Vangasseri, D.P., Han, S.J., Huang, L. (2005). Lipid-protamine-DNA-mediated antigen delivery. Curr. Drug Deliv. 2:401–6.
  • Vighi, E., Montanari, M., Ruozi, B., Tosi, G., Magli, A., Leo, E. (2010b). Nuclear localization of cationic solid lipid nanoparticles containing Protamine as transfection promoter. Eur J Pharm Biopharm. 76:384–93.
  • Vighi, E., Ruozi, B., Montanari, M., Battini, R., Leo, E. (2010a). pDNA condensation capacity and in vitro gene delivery properties of cationic solid lipid nanoparticles. Int J Pharm. 389:254–61.
  • Zink, W.E., Zheng, J., Persidsky, Y., Poluektova, L., Gendelman, H.E. (1999). The neuropathogenenesis of HIV-1 infection. FEMS Immunol Med Mic. 26:233–41.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.