Development of in situ gel for nasal delivery: design, optimization, in vitro and in vivo evaluation

References

• Badgujar SD, Sontakke MA, Narute DR. (2010). Formulation and evaluation of sumatriptan succinate nasal in-situ gel using fulvic acid as novel permeation enhancer. Int J Pharm Res Develop 2:1–8
   PubMedGoogle Scholar
• Bajaj IB, Survase SA, Saudagar PS. (2007). Gellan gum: fermentative production, downstream processing and applications. gellan gum – review. Food Technol Biotechnol 45:341–54
   Web of Science ®Google Scholar
• Brahmankar DM, Jaiswal SB. (2002). Biopharmaceutics and pharmacokinetics. A Treatise. 1st Edition. Delhi: Vallabh Prakashan, 1–74
   Google Scholar
• Basu S, Bandyopadhyay A. (2010). Development and characterization of mucoadhesive in- situ nasal gel of midazolam prepared with Ficus carica mucilage. Eur J Pharma Sci 11:1223–31
   Google Scholar
• Dey S, Mahanti B. (2011). Nasal drug delivery: an approach of drug delivery through nasal route. Der Pharmacia Sinica 2:94–106
   Google Scholar
• Dhuria SV, Hanson LR, Frey WH. (2010). Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99:1654–73
   PubMed Web of Science ®Google Scholar
• Elshafeey AH, Bendas ER, Osama HM. (2009). Intranasal microemulsion of sildenafil citrate: in-vitro evaluation and in-vivo pharmacokinetic study in rabbits. AAPS Pharm SciTech 10:361–7
   PubMed Web of Science ®Google Scholar
• Gaikwad V. (2010). Formulation and evaluation of in-situ gel of metoprolol tartrate for nasal delivery. J Pharm Res 3:788–93
   Google Scholar
• Gowda DV, Tanuja D, Khan MS. (2011). Formulation and evaluation of in situ gel of diltiazem hydrochloride for nasal delivery. Der Pharmacia Letter 3:371–81
   Google Scholar
• Gupta H, Sharma A. (2009). Ion activated bioadhesive in-situ gel of clindamycin for vaginal application. Int J Drug Delivery 1:32–40
   Google Scholar
• Pio HM, Balakrishnan P, Cho HJ. (2010). Preparation and evaluation of fexofenadine microemulsion for intranasal delivery. Int J Pharm 395:309–16
   PubMedGoogle Scholar
• Jadhav KR. (2007). Nasal drug delivery system-factors affecting and applications. Current Drug Therapy 2:27–38
   Google Scholar
• Jaya Raj Kumar K, Jayachandran E, Srinivas GM. (2010). Formulation and evaluation of pH–induced povidone iodine in-situ gel for oralthrush. J Pharm Sci & Res 2:294–301
   Google Scholar
• Jess C, Rhodes CT. (1990). Drug stability principles and practices. 3rd edition. Delhi, India: CBS Publisher, 252–5
   Google Scholar
• Kumbhar AB, Galgatte UC, Warkad S, Santhakumari B. (2013). Development and validation of a sensitive bioanalytical method for the determination of sumatriptan in rat plasma by UPLC-MS. Int J Pharm Pharm Sci 5:78–82
   Google Scholar
• Kushwaha KS, Keshari R, Rai AK. (2011). Advances in nasal trans-mucosal drug delivery. J Appl Pharm Sci 1:21–8
   Google Scholar
• Gibaldi M, Perrier D. (1982). Pharmacokinetics. New York: Marcel Dekker
   Google Scholar
• Majithiya RJ, Ghosh PK, Umrethia ML. (2006). Thermoreversible mucoadhesive gel for nasal delivery of sumatriptan. AAPS Pharm Sci Tech 7:1–7
   PubMed Web of Science ®Google Scholar
• Mahajan H, Shaikh H, Gattani S, Nerkar P. (2009). In situ gelling system based on thiolated gellan gum as a new carrier for nasaladministration of dimenhydrinate. Int J Pharm Sci Nanotechnol 2:544–9
   Web of Science ®Google Scholar
• More HN, Hajare AA. (2008). Practical physical pharmacy. 1st edn. India: Career Publications, 236–8
   Google Scholar
• Morris ER, Nishinari K, Rinaudo M. (2012). Gelation of gellan – A review. Food Hydrocolloids 28:373–411
   Web of Science ®Google Scholar
• Nisha GS, Maithi P, Charyulu RN. (2012). Formulation and development of nasal in-situ gels of triptans for anti migraine activity. Int J Pharm Biomedical sci 3:861–4
   Google Scholar
• Nirmal HB, Bakliwal SR, Pawar SP. (2010). In-situ gel: new trends in controlled and sustained drug delivery system. Int J Pharm 2:1398–408
   Google Scholar
• Noha MZ, Gehanne AA, Nahed DM. (2007). Enhance bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in-situ gel with modulated rheological and mucociliary transport properties. Eur J pharm sci 32:296–307
   PubMed Web of Science ®Google Scholar
• Pavia DL, Gary ML, George SK. (2007). Spectroscopy. Indian edition. Delhi, India: Cengage Learning, 26–107
   Google Scholar
• Pires A, Fortuna A, Alves G, Falcao A. (2009). Intranasal drug delivery: how, why and what for? J Pharm Pharm Sci 12:288–311
   PubMed Web of Science ®Google Scholar
• Ryan R, Elkind A, Baker CC. (1997). Sumatriptan nasal spray for the acute treatment of migraine: results of two clinical studies. Neurology 49:1225–30
   PubMed Web of Science ®Google Scholar
• Skoog DA, Holler FJ, Crouch SR. (2007). Instrumental analysis. Indian edition. Delhi, India: Cengage Learning, 477–8
   Google Scholar
• Shastri DH, Prajapati ST, Patel LD. (2010). Thermoreversible mucoadhesive ophthalmic in-situ hydrogel: design and optimization using a combination of polymers. Acta Pharm 60:349–60
   PubMed Web of Science ®Google Scholar
• Shinde JV, Mali KK. (2008). In-situ mucoadhesive nasal gels of metoclopramide hydrochloride: preformulation and formulation studies. J Pharm Res 1:88–96
   Google Scholar
• Singh AK, Singh A, Satheesh Madhav NV. (2012). Nasal cavity: a promising transmucosal platform for drug delivery and research approaches from nasal to brain targeting. J Drug Delivery Ther 2:22–33
   Google Scholar
• Ugwoke MI, Agu RU. (2005). Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv Drug Dev Rev 57:1640–65
   PubMed Web of Science ®Google Scholar
• Uttarwar S. (2012). Formulation and development of in-situ gelling system for nasal administration for an antiemetic drug ondansetron hydrochloride by using pluronics 127P and pluronics 68. Int J Res Pharm Biomed Sci 3:1103–18
   Google Scholar
• Vyas TK, Babbar AK, Sharma RK. (2005). Preliminary brain-targeting on intranasal mucoadhesive microemulsion of sumatriptan. AAPS Pharm Sci Tech 7:E1–9
   Google Scholar
• Zaki NM, Awad GA, Mortuda ND. (2007). Enhanced bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in-situ gel with modulated rheological and mucociliary transport properties. Eur J Pharm Sci 32:296–300
   PubMed Web of Science ®Google Scholar