Improving transfection efficiency of ultrapure oligochitosan/DNA polyplexes by medium acidification

References

• Alatorre-Meda M, Taboada P, Hartl F, et al. (2011). The influence of chitosan valence on the complexation and transfection of DNA: the weaker the DNA–chitosan binding the higher the transfection efficiency. Colloids Surface B Biointerfaces 82:54–62
   PubMed Web of Science ®Google Scholar
• Anchordoquy TJ, Koe G.S. (2000). Physical stability of nonviral plasmid-based therapeutics. J Pharm Sci 89:289–96
   PubMed Web of Science ®Google Scholar
• Bassnett S, Duncan G. (1985). Direct measurement of pH in the rat lens by ion-sensitive microelectrodes. Exp Eye Res 40:585–90
   PubMed Web of Science ®Google Scholar
• Borchard G. (2001). Chitosans for gene delivery. Adv Drug Deliv Rev 52:145–50
   PubMed Web of Science ®Google Scholar
• Conner SD, Schmid SL. (2003). Regulated portals of entry into the cell. Nature 422:37–44
   PubMed Web of Science ®Google Scholar
• de Martimprey H, Vauthier C, Malvy C, Couvreur P. (2009). Polymer nanocarriers for the delivery of small fragments of nucleic acids: oligonucleotides and siRNA. Eur J Pharm Biopharm 71:490–504
   PubMed Web of Science ®Google Scholar
• Duceppe N, Trabrizian M. (2010). Advances in using chitosan-based nanoparticles for in vitro and in vivo drug and gene delivery. Expert Opin Drug Deliv 7:1191–207
   PubMed Web of Science ®Google Scholar
• Gao Y, Zhang Z, Chen L, et al. (2009). Chitosan N-betainates/DNA self-assembly nanoparticles for gene delivery: in vitro uptake and transfection efficiency. Int J Pharm 371:156–62
   PubMed Web of Science ®Google Scholar
• Glover DJ, Lipps HJ, Jans DA. (2005). Towards safe, non-viral therapeutic gene expression in humans. Nat Rev Genet 6:299–310
   PubMed Web of Science ®Google Scholar
• Han HD, Mangala L.S, Lee J.W, et al. (2010). Targeted gene silencing using RGD-labeled chitosan nanoparticles. Clin Cancer Res 16:3910–22
   PubMed Web of Science ®Google Scholar
• Huang M, Khor E, Lim L. (2004). Uptake and cytotoxicity of chitosan molecules and nanoparticles: effects of molecular weight and degree of deacetylation. Pharm Res 21:344–53
   PubMed Web of Science ®Google Scholar
• Huang Z, Dong L, Chen J, et al. (2012). Low-molecular weight chitosan/vascular endothelial growth factor short hairpin RNA for the treatment of hepatocellular carcinoma. Life Sci 91:1207–15
   PubMed Web of Science ®Google Scholar
• Ishii T, Okahata Y, Sato T. (2001). Mechanism of cell transfection with plasmid/chitosan complexes. Biochimica et Biophysica Acta (BBA) – Biomembranes 1514:51–64
   PubMed Web of Science ®Google Scholar
• Kang HC, Samsonova O, Kang S, Bae YH. (2012). The effect of environmental pH on polymeric transfection efficiency. Biomaterials 33:1651–62
   PubMed Web of Science ®Google Scholar
• Kim T, Jiang H, Jere D, et al. (2007). Chemical modification of chitosan as a gene carrier in vitro and in vivo. Prog Polym Sci 32:726–53
   Web of Science ®Google Scholar
• Klausner EA, Zhang Z, Chapman RL, et al. (2010). Ultrapure chitosan oligomers as carriers for corneal gene transfer. Biomaterials 31:1814–20
   PubMed Web of Science ®Google Scholar
• Klausner EA, Zhang Z, Wong SP, et al. (2012). Corneal gene delivery: chitosan oligomer as a carrier of CpG rich, CpG free or S/MAR plasmid DNA. J Gene Med 14:100–8
   PubMed Web of Science ®Google Scholar
• Lavertu M, Méthot S, Tran-Khanh N, Buschmann MD. (2006). High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation. Biomaterials 27:4815–24
   PubMed Web of Science ®Google Scholar
• Layman J, Ramirez S, Green M, Long T. (2009). Influence of polycation molecular weight on poly(2-dimethylaminoethyl methacrylate)-mediated DNA delivery in vitro. Biomacromolecules 10:1244–52
   PubMed Web of Science ®Google Scholar
• Lee DW, Powers K, Baney R. (2004). Physicochemical properties and blood compatibility of acylated chitosan nanoparticles. Carbohydr Polym 58:371–7
   Web of Science ®Google Scholar
• Lu B, Wang C, Wu D, et al. (2009). Chitosan based oligoamine polymers: synthesis, characterization, and gene delivery. J Control Release 137:54–62
   PubMed Web of Science ®Google Scholar
• Mao S, Sun W, Kissel T. (2010). Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 62:12–27
   PubMed Web of Science ®Google Scholar
• Mumper RJ, Wang J, Claspell JM, Rolland AP. (1995). Novel polymeric condensing carriers for gene delivery. Proc Intl Symp Control Rel Bioact Mater 22:178–9
   Google Scholar
• Nimesh S, Thibault M, Lavertu M, Thibault M. (2010). Enhanced gene delivery mediated by low molecular weight chitosan/DNA complexes: effect of pH and serum. Mol Biotechnol 46:182–96
   PubMed Web of Science ®Google Scholar
• Noh SM, Park MO, Shim G, et al. (2010). Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA. J Control Release 145:159–64
   PubMed Web of Science ®Google Scholar
• Panyam J, Labhasetwar V. (2003). Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55:329–47
   PubMed Web of Science ®Google Scholar
• Puras, G, Zarate, J, Aceves, M, et al. (2013a). Low molecular weight oligochitosans for non-viral retinal gene therapy. Eur J Pharm Biopharm 83:131--40
   Google Scholar
• Puras G, Zarate J, Díaz-Tahoces A, et al. (2013b). Oligochitosan polyplexes as carriers for retinal gene delivery. Eur J Pharm Sci 48:323–31
   PubMed Web of Science ®Google Scholar
• Salva E, Kabasakal L, Eren F, et al. (2010). Chitosan/short hairpin RNA complexes for vascular endothelial growth factor suppression invasive breast carcinoma. Oligonucleotides 20:183–90
   PubMed Web of Science ®Google Scholar
• Sato T, Ishii T, Okahata Y. (2001). In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency. Biomaterials 22:2075–80
   PubMed Web of Science ®Google Scholar
• Strand S, Danielsen S, Christensen B, Vårum K. (2005). Influence of chitosan structure on the formation and stability of DNA–chitosan polyelectrolyte complexes. Biomacromolecules 6:3357–66
   PubMed Web of Science ®Google Scholar
• Strand SP, Lelu S, Reitan NK, et al. (2010). Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking. Biomaterials 31:975–87
   PubMed Web of Science ®Google Scholar
• Tannock IF, Rotin D. (1989). Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res 49:4373–84
   PubMed Web of Science ®Google Scholar
• Tripathi SK, Goyal R, Kumar P, Gupta KC. (2012). Linear polyethylenimine-graft-chitosan copolymers as efficient DNA/siRNA delivery vectors in vitro and in vivo. Nanomed Nanotechnol Biol Med 8:337–45
   PubMed Web of Science ®Google Scholar
• Wang CK, Chan LW, Johnson RN, et al. (2011). The transduction of Coxsackie and Adenovirus Receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirus. Biomaterials 32:9536–45
   PubMed Web of Science ®Google Scholar
• Yue Z, Wei W, Lv P, et al. (2011). Surface charge affects cellular uptake and intracellular trafficking of chitosan-based nanoparticles. Biomacromolecules 12:2440–6
   PubMed Web of Science ®Google Scholar
• Zhao X, Yu S, Wu F, et al. (2006). Transfection of primary chondrocytes using chitosan-pEGFP nanoparticles. J Control Release 112:223–8
   PubMed Web of Science ®Google Scholar