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Research Article

Thermosensitive PEG–PCL–PEG (PECE) hydrogel as an in situ gelling system for ocular drug delivery of diclofenac sodium

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Pages 63-68 | Received 09 Feb 2014, Accepted 09 Mar 2014, Published online: 24 Apr 2014

References

  • Anumolu SS, Singh Y, Gao D, et al. (2009). Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response. J Control Release 137:152–9
  • Asasutjarit R, Thanasanchokpibull S, Fuongfuchat A, Veeranondha S. (2011). Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels. Int J Pharm 411:128–35
  • Baba K, Tanaka Y, Kubota A, et al. (2011). A method for enhancing the ocular penetration of eye drops using nanoparticles of hydrolysable dye. J Control Release 153:278–87
  • Bauer M, Lautenschlaeger C, Kempe K, et al. (2012). Poly(2-ethyl-2-oxazoline) as alternative for the stealth polymer poly(ethylene glycol): comparison of in vitro cytotoxicity and hemocompatibility. Macromol Biosci 12:986–98
  • Casolaro M, Casolaro I, Lamponi S. (2012). Stimuli-responsive hydrogels for controlled pilocarpine ocular delivery. Eur J Pharm Biopharm 80:553–61
  • Chen X, Li X, Zhou Y, et al. (2011). Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization, and in vivo evaluation. J Biomat Sci Polym E 27:391–402
  • Diebold Y, Jarrín M, Sáez V, et al. (2007). Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP). Biomaterials 28:1553–64
  • Gan L, Wang J, Jiang M, et al. (2012). Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discov Today 18:290–7
  • Gong C, Shi S, Dong P, et al. (2009a). Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. Int J Pharm 365:89–99
  • Gong C, Shi S, Wu L, et al. (2009b). Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: sol–gel–sol transition and drug delivery behavior. Acta Biomater 5:3358–70
  • Gratieri T, Gelfuso GM, de Freitas O, et al. (2011). Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel. Eur J Pharm Biopharm 79:320–7
  • Gupta H, Aqil M, Khar RK, et al. (2011). Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery. J Drug Target 19:409–17
  • Holden CA, Tyagi P, Thakur A, et al. (2012). Polyamidoamine dendrimer hydrogel for enhanced delivery of antiglaucoma drugs. Nanomed Nanotechnol 8:776–83
  • Kronek J, Kroneková Z, Lustoň J, et al. (2011). In vitro bio-immunological and cytotoxicity studies of poly (2-oxazolines). J Mate Sci Mater Med 22:1725–34
  • Li X, Zhang Z, Li J, et al. (2012). Diclofenac/biodegradable polymer micelles for ocular applications. Nanoscale 4:4667–73
  • Li X, Li L, Zhang Z, Chen H. (2013a). An overview on pharmacokinetics, disposition, and safety of nanoparticles in ocular applications. Curr Drug Metab 14:857–62
  • Li X, Zhang Z, Chen H. (2013b). Development and evaluation of fast forming nano-composite hydrogel for ocular delivery of diclofenac. Int J Pharm 448:96–100
  • Perret R, Skoulios A. (1972). Crystallization of trisequenced poly (ɛ-caprolactone)/poly (oxyethylene)/poly (ɛ-caprolactone) copolymers. I. Copolymers with sequences of very different lengths. Makromol Chem 162:147–62
  • Seyfoddin A, Shaw J, Al-Kassas R. (2010). Solid lipid nanoparticles for ocular drug delivery. Drug Deliv 17:467–89
  • Shirasaki Y. (2008). Molecular design for enhancement of ocular penetration. J Pharm Sci 97:2462–96
  • Stella B, Arpicco S, Rocco F, et al. (2012). Nonpolymeric nanoassemblies for ocular administration of acyclovir: pharmacokinetic evaluation in rabbits. Eur J Pharm Biopharm 80:39–45
  • Sultana Y, Jain R, Aqil M, Ali A. (2006). Review of ocular drug delivery. Curr Drug Deliv 3:207–17
  • Urtti A. (2006). Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliver Rev 58:1131–5

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