pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation

References

• Amidi M, Mastrobattista E, Jiskoot W, Hennink WE. (2010). Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev 62:59–82
   PubMed Web of Science ®Google Scholar
• Anitha A, Deepa N, Chennazhi KP, et al. (2011). Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications. Carbohydr Polym 83:66–73
   Web of Science ®Google Scholar
• Arbit E, Goldberg M, Gomez-Orellana I, Majuru S. (2006). Oral heparin: status review. Thromb J 4:6. doi:10.1186/1477-9560-4-6
   PubMedGoogle Scholar
• Bagre AP, Jain K, Jain NK. (2013). Alginate coated chitosan core shell nanoparticles for oral delivery of enoxaparin: in vitro and in vivo assessment. Int J Pharm 456:31–40
   PubMed Web of Science ®Google Scholar
• Bai S, Ahsan F. (2009). Synthesis and evaluation of pegylated dendrimeric nanocarrier for pulmonary delivery of low molecular weight heparin. Pharm Res 26:539–48
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnurch A, Hornof M, Guggi D. (2004). Thiolated chitosans. Eur J Pharm Biopharm 57:9–17
   PubMed Web of Science ®Google Scholar
• Chen MC, Mi FL, Liao ZX, et al. (2013). Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. Adv Drug Deliv Rev 65:865–79
   PubMed Web of Science ®Google Scholar
• Chen MC, Wong HS, Lin KJ, et al. (2009). The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials 30:6629–37
   PubMed Web of Science ®Google Scholar
• Cushing DJ, Cooper WD, Cohen ML, et al. (2010). Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel heparin antagonist. Eur J Pharmacol 635:165–70
   PubMed Web of Science ®Google Scholar
• Fan W, Yan W, Xu Z, Ni H. (2012). Erythrocytes load of low molecular weight chitosan nanoparticles as a potential vascular drug delivery system. Colloids Surf B: Biointerf 95:258–65
   PubMed Web of Science ®Google Scholar
• Hayes PY, Ross BP, Thomas BG, Toth I. (2006). Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin. Bioorg Med Chem 14:143–52
   PubMed Web of Science ®Google Scholar
• Javot L, Lecompte T, Rabiskova M, Maincent P. (2009). Encapsulation of low molecular weight heparins: influence on the anti-Xa/anti-IIa ratio. J Contr Rel 139:8–14
   PubMed Web of Science ®Google Scholar
• Jiao Y, Ubrich N, Marchand-Arvier M, et al. (2002). In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation 105:230–5
   PubMed Web of Science ®Google Scholar
• Kast CE, Bernkop-Schnürch A. (2001). Thiolated polymers — thiomers: development and in vitro evaluation of chitosan–thioglycolic acid conjugates. Biomaterials 22:2345–52
   PubMed Web of Science ®Google Scholar
• Kokubo H, Obara S, Minemura K, Tanaka T. (1997). Development of cellulose derivatives as novel enteric coating agents soluble at pH 3.5-4.5 and higher. Chem Pharm Bull (Tokyo) 45:1350–3
   PubMed Web of Science ®Google Scholar
• Lappas LC, McKeehan W. (1967). Polymeric pharmaceutical coating materials. II. In vivo evaluation as enteric coatings. J Pharm Sci 56:1257–61
   PubMed Web of Science ®Google Scholar
• Lee YK, Kim SK, Lee DY, et al. (2006). Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys. J Control Release 111:290–8
   PubMed Web of Science ®Google Scholar
• Liu Y, Di Zang H, Kong M, et al. (2012). In vitro evaluation of mucoadhesion and permeation enhancement of polymeric amphiphilic nanoparticles. Carbohydrate Polymers 89:453–60
   PubMed Web of Science ®Google Scholar
• Makhlof A, Tozuka Y, Takeuchi H. (2011). Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur J Pharm Sci 42:445–51
   PubMed Web of Science ®Google Scholar
• Motlekar NA, Youan BB. (2006). The quest for non-invasive delivery of bioactive macromolecules: a focus on heparins. J Control Release 113:91–101
   PubMed Web of Science ®Google Scholar
• Nogueira DR, Tavano L, Mitjans M, et al. (2013). In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles. Biomaterials 34:2758–72
   PubMed Web of Science ®Google Scholar
• Oliveira SSM, Oliveira FS, Gaitani CM, Marchetti JM. (2011). Microparticles as a strategy for low-molecular-weight heparin delivery. J Pharmaceut Sci 100:1783–92
   PubMed Web of Science ®Google Scholar
• Paliwal R, Paliwal SR, Agrawal GP, Vyas SP. (2011). Biomimetic solid lipid nanoparticles for oral bioavailability enhancement of low molecular weight heparin and its lipid conjugates: in vitro and in vivo evaluation. Mol Pharm 8:1314–21
   PubMed Web of Science ®Google Scholar
• Paliwal R, Paliwal SR, Agrawal GP, Vyas SP. (2012). Chitosan nanoconstructs for improved oral delivery of low molecular weight heparin: in vitro and in vivo evaluation. Int J Pharm 422:179–84
   PubMed Web of Science ®Google Scholar
• Patel B, Gupta V, Ahsan F. (2012). PEG-PLGA based large porous particles for pulmonary delivery of a highly soluble drug, low molecular weight heparin. J Control Release 162:310–20
   PubMed Web of Science ®Google Scholar
• Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov MA. (2011). Development and in vitro evaluation of thiolated chitosan—poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system. Int J Biol Macromol 48:403–7
   PubMed Web of Science ®Google Scholar
• Wang X-Q, Zhang Q. (2012). pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. Eur J Pharmaceut Biopharmaceut 82:219–29
   PubMed Web of Science ®Google Scholar
• Watanabe E, Takahashi M, Hayashi M. (2004). A possibility to predict the absorbability of poorly water-soluble drugs in humans based on rat intestinal permeability assessed by an in vitro chamber method. Eur J Pharm Biopharm 58:659–65
   PubMed Web of Science ®Google Scholar
• Zhang N, Li J, Jiang W, et al. (2010). Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles. Int J Pharm 393:212–18
   PubMed Web of Science ®Google Scholar