High drug load, stable, manufacturable and bioavailable fenofibrate formulations in mesoporous silica: a comparison of spray drying versus solvent impregnation methods

References

• Andersson J, Rosenholm J, Areva S, Lindén M. (2004). Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices. Chem Mater 16:4160–7
   Web of Science ®Google Scholar
• Beck JS., Vartuli JC, Roth WJ, et al. (1992). A new family of mesoporous molecular sieves prepared with liquid crystal templates. J Am Chem Soc 114:10834–43
   Web of Science ®Google Scholar
• Breitenbach J. (2002). Melt extrusion: from process to drug delivery technology. Eur J Pharm Biopharm 54:107–17
   PubMed Web of Science ®Google Scholar
• Cauda V, Onida B, Platschek B, et al. (2008). Large antibiotic molecule diffusion in confined mesoporous silica with controlled morphology. J Mater Chem 18:5888–99
   Web of Science ®Google Scholar
• Charnay C, Bégu S, Tourné-Péteilh C, et al. (2004). Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property. Eur J Pharm Biopharm 57:533–40
   PubMed Web of Science ®Google Scholar
• Fitzpatrick JJ, Barringer SA, Iqbal T. (2004). Flow property measurement of food powders and sensitivity of Jenike's hopper design methodology to the measured values. J Food Eng 61:399–405
   Web of Science ®Google Scholar
• Gupta P, Bansal AK. (2005). Spray drying for generation of a ternary amorphous system of celecoxib, PVP, and meglumine. Pharm Dev Technol 10:273–81
   PubMed Web of Science ®Google Scholar
• Heikkila T, Salonen J, Tuura J, et al. (2007). Evaluation of mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 materials as API carriers for oral drug delivery. Drug Deliv 14:337–47
   PubMed Web of Science ®Google Scholar
• Horcajada P, Rámila A, Pérez-Pariente J, et al. (2004). Influence of pore size of MCM-41 matrices on drug delivery rate. Microporous Mesoporous Mater 68:105–9
   Web of Science ®Google Scholar
• Jamzad S, Fassihi R. (2006). Role of surfactant and pH on dissolution properties of fenofibrate and glipizide – a technical note. AAPS PharmSciTech 7:E17–E22
   PubMed Web of Science ®Google Scholar
• Kararli TT. (1995). Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 16:351–80
   PubMed Web of Science ®Google Scholar
• Kaushal AM, Gupta P, Bansal AK. (2004). Amorphous drug delivery systems: molecular aspects, design, and performance. Crit Rev Ther Drug Carrier Syst 21:133–93
   PubMedGoogle Scholar
• Limnell T, Heikkila T, Santos HA, et al. (2011a). Physicochemical stability of high indomethacin payload ordered mesoporous silica MCM-41 and SBA-15 microparticles. Int J Pharm 416:242–51
   PubMed Web of Science ®Google Scholar
• Limnell T, Riikonen J, Salonen J, et al. (2007). Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles. Int J Pharm 343:141–7
   PubMed Web of Science ®Google Scholar
• Limnell T, Santos HA, Makila E, et al. (2011b). Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods. J Pharm Sci 100:3294–306
   PubMed Web of Science ®Google Scholar
• Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3–26
   PubMed Web of Science ®Google Scholar
• Mellaerts R, Mols R, Jammaer JA, et al. (2008). Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica. Eur J Pharm Biopharm 69:223–30
   PubMed Web of Science ®Google Scholar
• Munoz A, Guichard JP, Reginault P. (1994). Micronised fenofibrate. Atherosclerosis 110:S45–8
   Web of Science ®Google Scholar
• Muñoz B, Rámila A, Pérez-Pariente J, et al. (2002). MCM-41 organic modification as drug delivery rate regulator. Chem Mater 15:500–3
   Web of Science ®Google Scholar
• Pan X, Julian T, Augsburger L. (2008). Increasing the dissolution rate of a low-solubility drug through a crystalline-amorphous transition: a case study with Indomethicin. Drug Dev Ind Pharm 34:221–31
   PubMed Web of Science ®Google Scholar
• Qu F, Zhu G, Huang S, et al. (2006). Controlled release of Captopril by regulating the pore size and morphology of ordered mesoporous silica. Microporous Mesoporous Mater 92:1–9
   Web of Science ®Google Scholar
• Salonen J, Laitinen L, Kaukonen AM, et al. (2005). Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs. J Control Release 108:362–74
   PubMed Web of Science ®Google Scholar
• Serajuddin AT. (1999). Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 88:1058–66
   PubMed Web of Science ®Google Scholar
• Shen SC, Ng WK, Chia L, et al. (2010). Stabilized amorphous state of ibuprofen by co-spray drying with mesoporous SBA-15 to enhance dissolution properties. J Pharm Sci 99:1997–2007
   PubMed Web of Science ®Google Scholar
• Shen SC, Ng WK, Chia L, et al. (2011). Physical state and dissolution of ibuprofen formulated by co-spray drying with mesoporous silica: effect of pore and particle size. Int J Pharm 410:188–95
   PubMed Web of Science ®Google Scholar
• Smirnova I, Mamic J, Arlt W. (2003). Adsorption of drugs on silica aerogels. Langmuir 19:8521–5
   Web of Science ®Google Scholar
• Song SW, Hidajat K, Kawi S. (2005). Functionalized SBA-15 materials as carriers for controlled drug delivery:  influence of surface properties on matrix−drug interactions. Langmuir 21:9568–75
   PubMed Web of Science ®Google Scholar
• Takeuchi H, Nagira S, Yamamoto H, Kawashima Y. (2004). Solid dispersion particles of tolbutamide prepared with fine silica particles by the spray-drying method. Powder Technology 141:187–95
   Web of Science ®Google Scholar
• Takeuchi H, Nagira S, Yamamoto H, Kawashima Y. (2005). Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray-drying method. Int J Pharm 293:155–64
   PubMed Web of Science ®Google Scholar
• Vallet-Regi M. (2006). Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering. Chemistry 12:5934–43
   PubMed Web of Science ®Google Scholar
• Vallet-Regi M, Balas F, Arcos D. (2007). Mesoporous materials for drug delivery. Angew Chem Int Ed Engl 46:7548–58
   PubMed Web of Science ®Google Scholar
• Vallet-Regi M, Rámila A, Del Real RP, Pérez-Pariente J. (2000). A new property of MCM-41: drug delivery system. Chem Mater 13:308–11
   Web of Science ®Google Scholar
• Van Speybroeck M, Barillaro V, Thi TD, et al. (2009). Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs. J Pharm Sci 98:2648–58
   PubMed Web of Science ®Google Scholar
• Van Speybroeck M, Mellaerts R, Mols R, et al. (2010). Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica. Eur J Pharm Sci 41:623–30
   PubMed Web of Science ®Google Scholar
• Watanabe T, Wakiyama N, Usui F, et al. (2001). Stability of amorphous indomethacin compounded with silica. Int J Pharm 226:81–91
   PubMed Web of Science ®Google Scholar
• Yang C, Xu X, Wang J, An Z. (2012). Use of the co-grinding method to enhance the dissolution behavior of a poorly water-soluble drug: generation of solvent-free drug-polymer solid dispersions. Chem Pharm Bull (Tokyo) 60:837–45
   PubMed Web of Science ®Google Scholar
• Zhao D, Huo Q, Feng J, et al. (1998). Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures. J Am Chem Soc 120:6024–36
   Web of Science ®Google Scholar