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Review Article

Microneedles for drug delivery: trends and progress

&
Pages 2338-2354 | Received 19 Sep 2014, Accepted 06 Nov 2014, Published online: 23 Dec 2014

References

  • Aggarwal G, Garg A, Dhawan S. (2009). Transdermal drug delivery: evolving technologies and expanding opportunities. Indian J Pharm Educ Res 43:251–9
  • Ahmad Z, Stride E, Edirisinghe M. (2009). Novel preparation of transdermal drug-delivery patches and functional wound healing materials. J Drug Target 17:724–9
  • Ainslie KM, Desai TA. (2008). Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing. Lab Chip 8:1864–78
  • Akiyoshi B. Biocompatible microneedle, manufacture thereof, and sheet having the microneedle. Kitakyushu-shi Patent JP 2011083387, 18 April 2012
  • Al-Saidan SM. (2004). Transdermal self-permeation enhancement of ibuprofen. J Control Release 100:199–209
  • Arora A, Prausnitz MR, Mitragotri S. (2008). Micro-scale devices for transdermal drug delivery. Int J Pharm 364:227–36
  • Backovic A, Wolfram D, Del-Frari B, et al. (2007). Simultaneous analysis of multiple serum protiens adhering to the surface of medical grade polydimethylsiloxane elastomers. J Immunol Methods 328:118–27
  • Banga AK. (2009). Microporation applications for enhancing drug delivery. Expert Opin Drug Deliv 6:343–54
  • Bariya SH, Gohel MC, Mehta TA, Sharma OP. (2011). Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol 64:11–29
  • Bariya SH, Gohel MC, Mehta TA, Sharma OP. (2012). Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol 64:11–29
  • Bediz B, Korkmaz E, Khilwani R, et al. (2013). Dissolvable microneedle arrays for intradermal delivery of biologics: fabrication and application. Pharm Res 31:117–35
  • Behin SR, Punitha IS, Saju F. (2013). Development of matrix dispersion transdermal therapeutic system containing glipizide. Der Pharmacia Lettre 5:278–86
  • Benson HA. (2005). Transdermal drug delivery: penetration enhancement techniques. Current drug delivery 2:23–33
  • Benson HAE, Namjoshi S. (2008). Proteins and peptides: strategies for delivery to and across the skin. J Pharm Sci 97:3591–610
  • Bohling A, Bielfeldt S, Himmelmann A, et al. (2013). Comparison of the stratum corneum thickness measured in vivo with confocal Raman spectroscopy and confocal reflectance microscopy. Skin Res Technol 20:50–7
  • Boettcher B, Stahlhofer KJ, Mattle V, et al. (2013). Ultrasonographic assessment of skin thickness in patients with PCOS – a case-control study. Gynecol Endocrinol 29:380–3
  • Bronger C. (2014). Insulin pen needles and adherance. Aus J Pharm 95:68–71
  • Cai Y, Xu M, Yuan M, et al. (2014). Developments in human growth hormone preparations: sustained-release, prolonged half-life, novel injection devices, and alternative delivery routes. Int J Nanomed 9:3527–38
  • Cantor AS, Stockholm AJ. Transdermal adhesive patch assembly with removable microneedle array and method of using same. St Paul Patent WO 2013096026, 27 June 2013
  • Chandrasekhar S, Iyer LK, Panchal JP, et al. (2013). Microarrays and microneedle arrays for delivery of peptides, proteins, vaccines and other applications. Exp Opin Drug Deliv 10:1155–70
  • Chen X, Zhang W. Method and apparatus for delivery of bioactive molecules to cells. Hong Kong Patent US 20130171722, 4 July 2013
  • Cheung K, Han T, Das DB. (2014). Effect of force of microneedle insertion on the permeability of insulin in skin. J Diabetes Sci Technol 8:444–52
  • Choi HJ, Bondy BJ, Yoo DG, et al. (2013). Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles. J Control Release 166:159–71
  • Chowdhury DFH. Microneedle transdermal delivery device. Loughborough Patent US 2010042050, 18 February 2010
  • Chu LY, Choi S-O, Prausnitz MR. (2010). Fabrication of dissolving polymer microneedles for controlled. J Pharm Sci 99:4228–38
  • Chu LY, Prausnitz MR. (2011). Separable arrowhead microneedles. J Control Release 149:242–9
  • Cork University Patent (2011). A microneedle device and method for the fabrication thereof. EP 2289843 (https://doi.org/http://www.google.com/patents/EP2289843A1?cl=en)
  • Cua AB, Wilhelm KP, Maibach HI. (1990). Elastic properties of human skin: relation to age, sex, and anatomical region. Arch Dermatol Res 282:283–8
  • Daugimont L, Baron N, Vandermeulen G, et al. (2010). Hollow microneedle arrays for intradermal drug delivery and DNA electroporation. J Memb Biol 236:117–25
  • Davis SP, Landis BJ, Adams ZH, et al. (2004). Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. J Biomech 37:1155–63
  • Davis SP, Martanto W, Allen MG, Prausnitz MR. (2005). Hollow metal microneedles for insulin delivery to diabetic rats. Trans Biomed Eng 52:909–15
  • Desale RS, Wagh KS, Akarte AM, et al. (2012). Microneedle technology for advanced drug delivery: a review. Int J PharmTech Res 4:181–9
  • Dhamech DL, Rajendra VB, Rathi VB, et al. (2010). Physical approaches to penetration enhancement. Int J Health Res 3:57–70
  • Donnelly RF, Mooney K, Caffarel-Salvador E, et al. (2014). Microneedle-mediated minimally invasive patient monitoring. Ther Drug Monit 36:10–17
  • Donnelly RF, Woolfson AD. (2014). Patient safety and beyond: what should we expect from microneedle arrays in the transdermal delivery arena? Therapeutic Deliv 5:653–62
  • Eckhoff PA, Hyde RA, Ishikawa MY, et al. Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject. Bellevue Patent US 20110118560, US 20110118656, US 20110117150, US 20110118652, US 20110118696, US 20110118653, US 20110118697, US 20110118698, US 20110118652, US 20110118656, 19 May 2011
  • El-Laboudi A, Oliver NS, Cass A, Johnston D. (2013). Use of microneedle array devices for continuous glucose monitoring: a review. Diabetes Technol Ther 15:101–15
  • Edens C, Collins ML, Ayers J, et al. (2013). Measles vaccination using a microneedle patch. Vaccine 31:3403–9
  • Escobar-Chávez JJ., Bonilla-Martínez D, Villegas-González MA, et al. (2011). Microneedles: a valuable physical enhancer to increase transdermal drug delivery. J Clin Pharmacol 51:964–77
  • Ezan E. (2013). Pharmacokinetic studies of protein drugs: past, present and future. Adv Drug Deliv Rev 65:1065–73
  • Fang JY, Liu PF, Huang CM. (2008). Decreasing systemic toxicity via transdermal delivery of anticancer drugs. Curr Drug Metab 9:592–7
  • Fazil M, Ali A, Baboota S, et al. (2013). Exploring drug delivery systems for treating osteoporosis. Exp Opin Drug Deliv 10:1123–36
  • Gill HS, Kang S-M, Quan F-S, Compans RW. (2014). Cutaneous immunization: an evolving paradigm in influenza vaccines. Exp Opin Drug Deliv 11:615–27
  • Gratieri T, Alberti I, Lapteva M, Kalia YN. (2013). Next generation intra- and transdermal therapeutic systems: using non- and minimally-invasive technologies to increase drug delivery into and across the skin. Eur J Pharm Sci 50:609–22
  • Garland MJ, Caffarel-Salvador E, Migalska K, et al. (2012). Dissolving polymeric microneedle arrays for electrically assisted transdermal. J Control Release 159:52–9
  • Garland MJ, Migalska K, Mazlelaa T, et al. (2011). Microneedle arrays as medical devices for enhanced transdermal drug delivery. Exp Rev Med Devices 8:459–82
  • Giri Nandagopal MS, Antony R, Rangabhashiyam S, Sreekumar N. (2014). Overview of microneedle system: a third generation transdermal drug delivery approach. Microsystem Technol 20:1249–72
  • Gittard SD, Ovsianikov A, Chichkov BN, et al. (2010). Two-photon polymerization of microneedles for transdermal drug delivery. Expert Opin Drug Deliv 7:513–33
  • Gonzalez BA, Burton SA, Hu J, et al. Hollow microneedle arrays. St Paul Patent WO 2011014514, 3 February 2011
  • Gray H. (2005). Gray’s anatomy, 39th ed. Spain: Elsevier
  • Gray H. (2008). Gray’s anatomy. 40th ed. Spain: Elsevier Limited
  • Griss P, Stemme G. (2003). Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer. IEEE J Microelectromech Syst 12:296–301
  • Gupta J, Felner EI, Prausnitz MR. (2009). Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles. Diabetes Technol Ther 11:329–37
  • Guy RH. (1996). Current status and future prospects of trandermal drug delivery. Pharm Res 13:1765–9
  • Han T., Das DB. (2013). Permeability enhancement for transdermal delivery of large molecule using low-frequency sonophoresis combined with microneedles. J Pharm Sci 102:3614–22
  • Hashmi S, Ling P, Hashmi G, et al. (1995). Genetic transformation of nematodes using arrays of micromechanical piercing structures. Biotechniques 19:766–70
  • Henry S, McAllister DV, Allen MG, Prausnitz MR. (1998). Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 87:922–5
  • Herwadkar A, Banga AK. (2012). Peptide and protein transdermal drug delivery. Drug Discov Today Technol 9:147–54
  • Hilt JZ, Peppas NA. (2005). Microfabricated drug delivery devices. Int J Pharm 206:15–23
  • Honda K, Motoi M, Takada K. Method for producing stamper for microneedle. Kyoto Patent CA 2696810, JP 2011078618, WO 2011043086, AU 2010201434, KR 2011067009, EP 2343102 A1, 10 February 2011
  • Hong X, Wei L, Wu F, et al. (2013). Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine. Drug Des Dev Ther 7:945–52
  • Huizhen Z, Huibin W, WZhang X, Eizheng J. Degradable polymer-based microneedle patch and its preparation method. Beijing Patent CN 102000020, 6 April 2011
  • Ita KB. (2014). Transdermal drug delivery: progress and challenges. J Drug Deliv Sci Technol 24:245–50
  • Indermun S, Luttge R, Choonara YE, et al. (2014). Current advances in the fabrication of microneedles for transdermal delivery. J Control Release 185:130–8
  • Ito Y, Hagiwara E, Saeki A, et al. (2006). Feasibility of microneedles for percutaneous absorption of insulin. Eur J Pharm Sci 29:82–8
  • Jain A, Jain P, Kurmi J, et al. (2014). Novel strategies for effective transdermal drug delivery: a review. Crit Rev Ther Drug Carrier Syst 31:219–72
  • Jain D, Jain V, Singh R. (2011). Novel antigen delivery technologies: a review. Drug Deliv Transl Res 1:103–12
  • Kalluri H, Banga AK. (2011). Transdermal delivery of proteins. Am Ass Pharm Sci 12:431–41
  • Kamboj S, Jhawat V, Saini V, Bala S. (2013). Recent advances in permeation enhancement techniques for transdermal drug delivery systems: a review. Curr Drug Ther 8:181–8
  • Karande PK, Jain A, Mitragotri S. (2006). Relationships between skin’s electrical impedance and permeability in the presence of chemical enhancers. J Control Release 110:307–13
  • Katsumi H, Quan YS, Kamiyam F, et al. (2014). Development of a novel transdermal delivery system of peptide and protein drugs using microneedle arrays. Yakugaku Zasshi 134:63–7
  • Khan H, Mehta P, Msallam H, et al. (2014). Smart microneedle coatings for controlled delivery and biomedical analysis. J Drug Target 22:790–5
  • Khanna P, Strom JA, Bhansali S. (2008). Microneedle-based automated therapy for diabetes mellitus. J Diabetes Sci Technol 2:1122–9
  • Kobayashi K, Hamamoto H. Applicator device of pinholder type microneedle. Kagawa Patent WO 2011016230, 10 February 2011
  • Kis EE, Winter G., Myschik J. (2012). Devices for intradermal vaccination. Vaccine 30:523–38
  • Kochhar JS, Zou S, Chan SY, Kang L. (2012). Protein encapsulation in polymeric microneedles by photolithography. Int J Nanomed 7:3143–54
  • Kommareddy S, Baudner BC, Bonificio A, et al. (2013). Influenza subunit vaccine coated microneedle patches elicit comparable immune responses to intramuscular injection in guinea pigs. Vaccine 31:3435–41
  • Krapp KM, Longe JL. (1998). How products are made. Detroit: Gale Research
  • Koutsonanos DG, Compans RW, Skountzou L. (2013). Targeting the skin for microneedle delivery of influenza vaccine. Adv Exp Med Biol 785:121–32
  • Langkjær L, Brange J, Grodsky GM, Guy RH. (1998). Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment. J Control Release 51:47–56
  • Lanke SS, Strom JG, Banga AK. (2009). Enhancement of transdermal delivery of heparin by various physical and chemical enhancement techniques. Crit Rev Ther Drug Carrier Syst 26:581–606
  • Lawrence G. (2002). The hypodermic syringe. Lancet 359:1074
  • Lee JW, Han MR, Park JH. (2013). Polymer microneedles for transdermal drug delivery. J Drug Target 21:211–23
  • Lee K, Jung H. (2012). Drawing lithography for microneedles: a review of fundamentals and biomedical applications. Biomaterials 33:7309–26
  • Lee K, Lee CY, Jung H. (2011). Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. Biomaterials 32:3134e3140
  • Lee Y, Hwang K. (2002). Skin thickness of Korean adults. Surg Radiol Anat 24:183–9
  • Li H, Yu Y, Faraji DS, et al. (2013). Novel engineered systems for oral, mucosal and transdermal drug delivery. J Drug Target 21:611–29
  • Li M, Liu Y, Wang C, et al. Inactivated vaccine for immunoprophylaxis of bovine mastitis caused by Escherichia coli and its preparation method. Raleigh Patent CN 101991846, 30 March 2011
  • Li N, Peng L-H, Chen X, et al. (2011b). Transcutaneous vaccines: novel advances in technology and delivery for overcoming the barriers. Vaccine 29:6179–90
  • Lim CY. The plastic microneedle strip. Singapore Patent WO 2013066262, 10 May 2013
  • Liebl H, Kloth LC. (2012). Skin cell proliferation stimulated by microneedles. J Am Coll Clin Wound Spec 4:2–6
  • Ling MH, Chen MC. (2013). Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats. Acta Biomater 9:8952–61
  • Magnenat-Thalmann N, Kalra P, Lévêque JL, et al. (2002). A computational skin model: fold and wrinkle formation. IEEE Trans Inf Technol Biomed 6:317–23
  • Mansoor I, Liu Y, Häfeli UO, Stoeber B. (2013). Arrays of hollow out-of-plane microneedles made by metal electrodeposition onto solvent cast conductive polymer structures. J Micromech Microeng 23:1–10
  • Martin CJ, Allender CJ, Brian KR, et al. (2012). Low temperature fabrication of Biodegradable sugar glass microneedles for transdermal drug delivery applications. J Control Release 158:93–101
  • Martanto W, Davis SP, Holiday NR, et al. (2004). Transdermal delivery of insulin using microneedles in vivo. Pharm Res 21:947–52
  • Margetts L, Sawyer R. (2007). Transdermal drug delivery: principles and opioid therapy. Cont Educ Anaesth Crit Care Pain 7:171–6
  • McAllister HS, Allen DV, Allen MG, Prausnitz MR. (1998). Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 87:922–5
  • Milewski M, Brogden NK, Stinchcomb AL. (2010). Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin. Expert Opin Drug Deliv 7:617–29
  • Milewski M, Mitra A. (2012). Recent developments in microneedle technology for transdermal drug delivery & vaccination. Drug Dev Deliv 12:30–5
  • Mitragotri S. (2012). Mechanical disruption of skin barrier for vaccine delivery. Drug Deliv Syst 27:202–12
  • Mitragotri S. (2013). Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers. Adv Drug Deliv Rev 65:100–3
  • Mitragotri S, Kost J. (2004). Low-frequency sonophoresis: a review. Adv Drug Deliv Rev 56:589–601
  • Moga BJ, Chase KB, Smith GD. DD device. Madison Patent WO 2011084951, US 20110172645, 14 July 2011
  • Nalesniak M, Iwaniak K, Kasperek R, Poleszak E. (2013). A review of TTS-development, types and preparations. Curr Issues Pharm Med Sci 26:88–93
  • Nalwa HS. (2014). A special issue on reviews in nanomedicine, drug delivery and vaccine development. J Biomed Nanotechnol 10:1635–40
  • Natayan RJ. (2014). Transdermal delivery of insulin via microneedles. J Biomed Nanotechnol 10:2244–60
  • Nava-Arzaluz MG, Calderón-Lojero L, Quintanar-Guerrero D, et al. (2012). Microneedles as transdermal delivery systems: combination with other enhancing strategies. Curr Drug Deliv 9:57–73
  • Nayak A, Das DB. (2013). Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine. Biotechnol Lett 35:1351–63
  • Nayak A, Das DB, Vladisavljevic GV. (2014). Microneedle assisted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel. Pharm Res 31:1170–84
  • Nayak A, Babla H, Han T, Das DB. (in press). Lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel delivery by combined microneedle and ultrasound. Drug Deliv. DOI: 10.3109/10717544.2014.935985. [Epub ahead of print]
  • Nordquist L, Roxhed N, Griss P, Stemm G. (2007). Novel microneedle patches for active insulin delivery are efficient in maintaining glycaemic control: an initial comparison with subcutaneous administration. Pharm Res 24:1381–8
  • Norman JJ, Arya JM, McClain MA, et al. (2014). Microneedle patches: usability and acceptability for self-vaccination against influenza. Vaccine 32:1856–62
  • Olatunji O, Igwe CC, Ahmed AS, et al. (2014). Microneedles from fish scale biopolymer. Appl Polym Sci 131:1–10
  • Osborne JL, Sanchez IC, Paul DR. (2013). An asymptotic analysis of drug delivery from transdermal patches. J Memb Sci 442:27–30
  • Pankratz A. (1983). Forecasting with Univariate Box–Jenkins Models: concepts and cases. New York: John Wiley & Sons. ISBN: 978-0-471-09023-6
  • Park JH, Allen MG, Prausnitz MR. (2005). Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Release 104:51–66
  • Petrofsky JS, Prowse M, Lohman E. (2008). The influence of ageing and diabetes on skin and subcutaneous fat thickness in different regions of the body. J Appl Res 8:55–61
  • Pierre MBR, Rossetti FC. (2014). Microneedle-based drug delivery systems for transdermal route. Curr Drug Targets 15:281–91
  • Prausnitz MR. (2004). Microneedles for transdermal drug delivery. Adv Drug Deliv Rev 56:581–7
  • Prausnitz MR, Langer R. (2008). Transdermal drug delivery. Nat Biotechnol 26:1261–8
  • Prausnitz MR, Mikszta JA, Cormier M, Andrianov AK. (2009). Microneedle-based vaccines. Curr Top Microbiol Immunol 333:369–93
  • Prausnitz MR, Mitragoti S, Langer R. (2004). Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 3:115–24
  • Ravi S, Sharma PK, Bansal M. (2011). A review: transdermal drug delivery of nicotine. Int J Drug Dev Res 3:1–8
  • Rizwan M, Aqil M, Talegaonkar S, et al. (2009). Enhanced transdermal drug delivery techniques: an extensive review of patents. Recent Pat Drug Deliv Formul 3:105–24
  • Rose JE, Jarvik ME, Rose KD. (1984). Transdermal administration of nicotine. Drug Alcohol Depend 13:209–13
  • Roxhed N, Gasser TC, Griss P, et al. (2007). Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J Microelectromech Syst 16:1429–40
  • Sachdeva V, Banga AK. (2011). Microneedles and their applications. Recent Pat Drug Deliv Formul 5:95–132
  • Saacs E, Cobbledick T. A microneedle roller. Borehamwood Patent GB2472778A, 23 February 2011
  • Seidenari S, Pagnoni A, Di Nardo A, Giannetti A. (1994). Echographic evaluation with image analysis of normal skin: variations according to age and sex. Skin Pharmacol 7:201–9
  • Shah UU, Roberts M, Gul MO, et al. (2011). Needle-free and microneedle drug delivery in children: a case for disease-modifying antirheumatic drugs (DMARDs). Int J Pharm 416:1–11
  • Shikida M. (2012). Fabrication of microneedles by MEMS technologies. Drug Deliv Syst 27:176–83
  • Sinha VR, Kaur MP. (2000). Permeation enhancers for transdermal drug delivery. Drug Dev Ind Pharm 26:1131–40
  • Singh N, Kalluri H, Herwadkar A, et al. (2012). Transcending the skin barrier to deliver peptides and proteins using active technologies. Crit Rev Ther Drug Carrier Syst 29:265–98
  • Singh ND, Banga AK. (2013). Controlled delivery of ropinirole hydrochloride through skin using modulated iontophoresis and microneedles. J Drug Target 21:354–66
  • Singh TR, Dunne NJ, Cunningham E, Donnelly RF. (2011). Review of patents on micro needle applicators. Recent Pat Drug Deliv Formul 5:11–23
  • Singh TR, Garland MJ, Cassidy CM, et al. (2010). Microporation techniques for enhanced delivery of therapeutic agents. Recent Pat Drug Deliv Formul 4:1–17
  • Smalls LK, Wickett RR, Visscher MO. (2006). Effect of dermal thickness, tissue composition, and body site on skin biomechanical properties. Skin Res Technol 12:43–9
  • Stinchcomb AL, Banks SL, Golinski MJ, et al. Cannabidiol prodrugs in topical and transdermal administration with microneedles. Lexington Patent WO 2011026144, S 20110052694, 3 March 2011
  • Subedi RK, Oh SY, Chun M-K, Choi H-K. (2010). Recent advances in transdermal drug delivery. Arch Pharm Res 33:339–51
  • Sugimura H, Suzuki G, Ueno M, et al. Microneedle and method of manufacturing microneedle. Tokyo Patent US 20130030374 A1, 31 January 2013
  • Sullivan SP, Murthy N, Prausnitz MR. (2008). Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Adv Mater 20:933–8
  • Swain S, Beg S, Singh A, et al. (2011). Advanced techniques for penetration enhancement in transdermal drug delivery system. Curr Drug Deliv 8:456–73
  • Tanner T, Marks R. (2008). Delivering drugs by the transdermal route: review and comment. Skin Res Technol 14:249–60
  • Taylor MJ, Sahota TS. (2013). New technologies in insulin delivery. Pract Diabetes 30:21–6
  • Torrisi BM, Zarnitsyn V, Prausnitz MR, et al. (2013). Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A. J Control Release 165:146–52
  • Trommer H, Neubert RH. (2006). Overcoming the stratum corneum: the modulation of skin penetration. A review. Skin Pharmacol Physiol 19:106–21
  • Tsioris K, Raja WK, Pritchard EM, et al. (2012). Fabrication of silk microneedles for controlled-release drug delivery. Adv Functional Mater 22:330–5
  • Tuan-Mahmood TM, McCrudden MC, Torrisi BM, et al. (2013). Microneedles for intradermal and transdermal drug delivery. Eur J Pharm Sci 50:623–37
  • Ukawala Ravikumar D, Vasava J. (2012). Physical enhancement techniques for transdermal delivery system: a review. Int J Pharm Technol 4:2174–200
  • van der Maaden K, Trietsch SJ, Kraan H, et al. (2014). Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats. Pharm Res 31:1845–54
  • Wang X, Chen X, Yu Z, Wang L. (2006). A novel fabrication approach for microneedles using silicon micromaching technology. 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems; Zhuhai
  • Wei-Ze L, Mei-Rong H, Jian-Ping Z, et al. (2010). Super-short solid silicon microneedles for transdermal drug delivery applications. Int J Pharm 389:122–9
  • Wolff HM. (2014). Future of transdermal drug delivery systems (TDDS). Am Pharm Rev 17. https://doi.org/http://www.americanpharmaceuticalreview.com/Featured-Articles/163672-Future-of-Transdermal-Drug-Delivery-Systems-TDDS/
  • Wu F, Yang S, Yuan W, Jin T. (2012). Challenges and strategies in developing microneedle patches for transdermal delivery of protein and peptide therapeutics. Curr Pharm Biotechnol 13:1292–8
  • Yadav JD, Vaidya KA, Kulkarni PR, Raut R. (2011). Microneedles: promising technique for transdermal drug delivery. Int J Pharma Bio Sci 2:684–708
  • Yamashita A, Hirai Y, Tojo K. (1996). Effect of ultrasound on rate of drug absorption through skin. J Chem Eng Japan 29:812–16
  • Yang Y, Kalluri H, Banga AK. (2011). Effects of chemical and physical enhancement techniques on transdermal delivery of cyanocobalamin (vitamin B12) in vitro. Pharmaceutics 3:474–84
  • Yue R, Wang Y. Metal microneedle array, transdermal patch, micro needle roller and micro needle electrode array. Beijing Patent CN 103263727, 28 August 2013
  • Zahn JD, Hsieh YC, Yang M. (2005). Components of an integrated microfluidic device for continuous glucose monitoring with responsive insulin delivery. Diabetes Technol Ther 7:536–45
  • Zhang D, Das DB, Rielly CD. (2014a). Potential of microneedle-assisted micro-particle delivery by gene guns: a review. Chem Eng Sci. DOI: 10.1016/j.ces.2014.06.031 [Epub ahead of print]
  • Zhang D, Das DB, Rielly CD. (2014b). Microneedle assisted micro-particle delivery by gene guns: mathematical model formulation and experimental verification. Drug Deliv. DOI: 10.3109/10717544.2013.864345 [Epub ahead of print]
  • Zhang J, Zhu Q, Zhang L. (2013). Research advances in applications of microneedles in transdermal drug delivery. Pharma Care Res 13:326–31
  • Zhang L, Wu Z. Riamcinolone acetonide biodegradable maltose microneedle array for treating scar and its preparation method. Shanghai Patent CN 103181887, 3 July 2013

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