References
- Ayensu I, Mitchell JC, Boateng JS. (2012). Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids Surf B Biointerfaces 91:258–65.
- Ayukawa Y, Yasukawa E, Moriyama Y, et al. (2009). Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:336–42.
- Baker RW, Lonsdale HS. (1974). Controlled release of biologically active agents. New York: Plenum Press.
- Bancroft JD, Gamble M. (2008). Theory and practice of histological techniques. 6th ed. EdinburghChurchill Livingstone: Elsevier Health Sciences. p. 332--62.
- British Pharmacopoeial Commission. (2007). B.P. (British Pharmacopoeia). London: HMSO.
- Derringer G, Suich R. (1980). Simultaneous optimization of several response variables. J Quality Technol 12:214–19.
- Gu X, Fediuk DJ, Simons FER, Simons KJ. (2004). Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine. Drug Dev Ind Pharm 30:1009–17.
- Gutierrez GE, Lalka D, Garrett IR, et al. (2006). Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporos Int 17:1033–42.
- Hamman JH. (2010). Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems. Marine Drugs 8:1305–22.
- Higuchi T. (1961). Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci 50:874–5.
- Higuchi T. (1963). Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 52:1145–9.
- Hirabayashi H, Fujisaki J. (2003). Bone-specific drug delivery systems: approaches via chemical modification of bone-seeking agents. Clin Pharmacokinet 42:1319–30.
- Hughes A, Rogers MJ, Idris AI, Crockett JC. (2007). A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo. Calcif Tissue Int 81:403–13.
- Korsmeyer RW, Gurny R, Doelker E, et al. (1983). Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 15:25–35.
- Kramarenko EY, Khokhlov AR, Reineker P. (2006). Stoichiometric polyelectrolyte complexes of ionic block copolymers and oppositely charged polyions. J Chem Phys 125:194. DOI: 10.1063/1.2387173.
- Lindner WD, Lippold BC. (1995). Drug release from hydrocolloid embeddings with high or low susceptibility to hydrodynamic stress. Pharm Res 12:1781–5.
- Luisetto G, Camozzi V. (2009). Statins, fracture risk, and bone remodeling. J Endocrinol Invest 32:32–7
- Maeda T, Matsunuma A, Kawane T, Horiuchi N. (2001). Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun 280:874–7.
- McTaggart F, Buckett L, Davidson R, et al. (2001). Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy- 3-methylglutaryl coenzyme A reductase inhibitor. Am J Cardiol 87:28–32.
- Miyamoto K, Takahashi-Nishioka T, Yokogawa K, et al. (2008). Targeted drug delivery to bone: pharmacokinetic and pharmacological properties of acidic oligopeptide-tagged drugs. Curr Drug Discov Technol 5:39–48.
- Modi A, Tayade P. (2006). Enhancement of dissolution profile by solid dispersion (kneading) technique. AAPS PharmSciTech 7:E87--E92.
- Moffat AC, Osselton MD, Widdop B. (2011). Clarke’s analysis of drugs and poisons. 4th ed. London: Pharmaceutical Press. p. 2034--5.
- Monjo M, Rubert M, Ellingsen JE, Lyngstadaas SP. (2010a). Rosuvastatin promotes osteoblast differentiation and regulates SLCO1A1 transporter gene expression in MC3T3-E1 cells. Cell Physiol Biochem 26:647–56.
- Monjo M, Rubert M, Wohlfahrt JC, et al. (2010b). In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects. Acta Biomater 6:1405–12.
- Moriyama Y, Ayukawa Y, Ogino Y, et al. (2008). Topical application of statin affects bone healing around implants. Clin Oral Implants Res 19:600–5.
- Moriyama Y, Ayukawa Y, Ogino Y, et al. (2010). Local application of fluvastatin improves peri-implant bone quantity and mechanical properties: a rodent study. Acta Biomater 6:1610–18.
- Mundy G, Garrett R, Harris S, et al. (1999). Stimulation of bone formation in vitro and in rodents by statins. Science 286:1946–9.
- Mura P, Faucci MT, Bettinetti GP. (2001). The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-β-cyclodextrin. Eur J Pharm Sci 13:187–94.
- Nyan M, Miyahara T, Noritake K, et al. (2010). Molecular and tissue responses in the healing of rat calvarial defects after local application of simvastatin combined with alpha tricalcium phosphate. J Biomed Mater Res B 93:65–73.
- Nyan M, Sato D, Oda M, et al. (2007). Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect. J Pharmacol Sci 104:384–6.
- Orlu M, Cevher E, Araman A. (2006). Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm 318:103–17.
- Oxlund H, Andreassen TT. (2000). Simvastatin given orally to adult rats increases the compressive strength of vertebral bodies. J Bone Mineral Res 15:s549.
- Oxlund H, Andreassen TT. (2004). Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone 34:609–18.
- Ozeç I, Kiliç E, Gümüş C, Göze F. (2007). Effect of local simvastatin application on mandibular defects. J Craniofac Surg 18:546–50.
- Pavli M, Baumgartner S, Kos P, Kogej K. (2011). Doxazosin-carrageenan interactions: a novel approach for studying drug-polymer interactions and relation to controlled drug release. Int J Pharm 421:110–19.
- Peri D, Bogdansky S, Allababidi S, Shah JC. (1994). Development of an implantable, biodegradable, controlled drug delivery system for local antibiotic therapy. Drug Dev Ind Pharm 20:1341–52.
- Reddy KR, Mutalik S, Reddy S. (2003). Once-daily sustained-release matrix tablets of nicorandil: formulation and in vitro evaluation. AAPS PharmSciTech 4:E61.
- Shah VP, Tsong Y, Sathe P, Liu JP. (1998). In vitro dissolution profile comparison—statistics and analysis of the similarity factor, f2. Pharma Res 15:889–96.
- Shi Y, Huang G. (2009). Recent developments of biodegradable and biocompatible materials based micro/nanoparticles for delivering macromolecular therapeutics. Crit Rev Ther Drug Carrier Syst 26:29–84.
- Stojadinovic O, Lebrun E, Pastar I, et al. (2010). Statins as potential therapeutic agents for healing disorders. Expert Rev Dermatol 5:689–98.
- Sugiyama M, Kodama T, Konishi K, et al. (2000). Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem Biophys Res Commun 271:688–92.
- Tadros MI, Fahmy RH. (2014). Controlled-release triple anti-inflammatory therapy based on novel gastroretentive sponges: characterization and magnetic resonance imaging in healthy volunteers. Int J Pharm 472:27–39.
- Tanigo T, Takaoka R, Tabata Y. (2010). Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration. J Control Release 143:201–6.
- Venkatesan J, Kim SK. (2010). Chitosan composites for bone tissue engineering – an overview. Marine Drugs 8:2252–66.
- Wilkie D, Bowman B, Lyga A, et al. (2000). Cerivastatin increases cortical bone formation in OVX rats. J Bone Mineral Res 15:S549.
- Wong RWK, Rabie ABM. (2003). Statin collagen grafts used to repair defects in the parietal bone of rabbits. Br J Oral Maxillofac Surg 41:244–8.