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Drug Delivery Volume 2, 1995 - Issue 1
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Research Article

Red blood cells as a delivery system for AZT

Mauro Magnani Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
,
Marco Giovine Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
,
Alessandra Fraternale Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
,
Gianluca Damonte Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
,
Luigia Rossi Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
,
Sonia Scarfì Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
,
Umberto Benatti Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
&
Antonio Deflora Institute of Biochemistry “G. Fornaini,” University of Urbino and Institute of Biochemistry, University of Genoa, Italy
 show all
Pages 57-61 | Received 08 Apr 1994, Published online: 27 Sep 2008

References

  • Hirsch M. S., D'Aquila R. T. Therapy for human immunodeficiency virus infection. N. Engl. J. Med. 1993; 328: 1686–4695
  • Zimmerman T. P., Mahony W. B., Prus K. L. 3′Azido-3′-deoxythymidine an unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion. J. Biol. Chem. 1987; 262: 5748–5754
  • Furman P. A., Fyfe J. A., St. Clair M. H., Weinhold K., Rideout J. L., Freeman G. A., Nusinoff-Lehrman S., Bolognesi D. P., Broder S., Mitsuya H., Barry D. W. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus re-verse transcriptase. Proc. Natl. Acad. Sci. USA 1986; 83: 8333–8337
  • Yarchoan R., Mitsuya H., Myers C. E., Broder S. Clinical pharmacology of 3′-azido-2′,3′-dideoxythymidine (zidovudine) and related dideoxynucleosides. N. Engl. J. Med. 1983; 321: 726–738
  • Gogu S. R., Aggarwal S. K., Raugan S. R. S., Agrawal K. C. A pro-drug of zidovudine with enhanced efficacy against human immunodeficiency virus. Biochim. Biophys. Res. Commun. 1983; 160: 656–661
  • Aggarwal S. K., Gogu S. R., Raugan S. R. S., Agrawal K. C. Synthesis and biological evaluation of pro-drugs of zidovudine. J. Med. Chem. 1990; 33: 1505–1510
  • De Flora A., Benatti U., Tonetti M., Gasparini A., Giovine M., Damonte G. L., Sdraffa A. Engineered erythrocytes as carriers and bioreactors for biomedical applications. “Proceedings of the 6th European Congress of Biotechnology”, L. Alberghina, L. Frontali, P. Semi. Elsevier, Amsterdam 1994; 73–85
  • Magnani M., Rossi L., Bianchi M., Cucchiarini L., Stocchi V. Reversed phase liquid chromatographic determination of 2′,3′-dideoxycytidine in human blood samples. J. Chromatogr. 1989; 491: 215–220
  • Magnani M., Rossi L., Brandi G., Schiavano G. F., Montroni M., Piedimonte G. Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: In vitro and in vivo studies. Proc. Natl. Acad. Set. USA 1992; 89: 6477–6481
  • Paglia D. E., Valentine W. N., Brockway R. A. Identification of thymidine nucleotidase and deoxyribonucleotidase activities among normal isozymes of 5′-nucleotidase in human erythrocytes. Proc. Natl. Acad. Sci. USA 1984; 81: 588–592
  • De Flora A., Zocchi E., Guida L., Polvani C., Benatti U. Conversion of encapsulated 5-fluoro-2′-deoxyuridine 5′-monophosphate to the antineoplastic drug 5-fluoro-2′-deoxyuridine in human erythrocytes. Proc. Natl. Acad. Sci. USA 1988; 85: 3145–3149
  • Magnani M., Bianchi M., Rossi L., Stocchi V. Human red blood cells as bioreactors for the release of 2′,3′-dideoxycytidine, an inhibitor of HIV infectivity. Biochem. Biophys. Res. Commun. 1985; 164: 446–452
  • Fridland A., Connelly M. C., Ashmun R. Relation-ship of deoxynucleotide changes to inhibition of DNA synthesis induced by antiretroviral agent 3′-azido-3′-deoxythymidime and release of its monophosphate by human lymphoid cells (CCRFCEM). Mol. Pharmacol. 1990; 37: 665–670
  • Arner E. S., Valentin A., Erikson S. Thymidine and 3′-azido-3′-2-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages: A study of both anabolic and catabolic pathways. J. Biol. Chem. 1992; 267: 10968–10975
  • Solimano F., Bischi G. I., Bianchi M., Rossi L., Magnani M. A nonlinear three-compartment medel for the administration of 2′,3′-dideoxycytidine by using red blood cells as bioreactors. Bull. Math. Biol. 1990; 52: 785–796

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