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Original Article

Serum Proteins as Drug Carriers of Anticancer Agents: A Review

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Pages 281-299 | Received 02 May 1998, Accepted 19 Jun 1998, Published online: 02 Jul 2009

References

  • Alaupovic P. Significance of apolipoproteins for structure, function, and classification of plasma lipoproteins. Methods Enzymol 1996; 263: 32–60
  • Allen T. M., Chonn A. Large unilamellar liposomes with low uptake into the reticuloendothelial. FEBS Lett 1987; 223: 42–46
  • Anderson R. G. W., Brown M. S., Goldstein J. L. Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells. J. Cell Biol 1981; 88: 441–452
  • Andersson C., Iresjo B. M., Lundholm K. Identification of tumor sites for increased albumin degradation in sarcoma-bearing mice. J. Surg. Res 1991; 50: 156–162
  • Aulbert E. Transferrinmangelänamie bei malignen Tumorerkrankungen. Georg Thieme Verlag Stuttgart, New York 1986
  • Babson A. L., Winnick T. Protein transfer in tumor-bearing rats. Cancer Res 1954; 14: 606–611
  • Bailey S., Evans R. W., Garrat R. C., Gorinsky B., Hasnain S., Horsburgh C., Jhoti H., Lindley P. F., Mydin A., Sarra R., Watson J. L. Molecular structure of serum transferrin at 3.3 Å resolution. Biochemistry 1988; 27: 5804–5812
  • Barabas K., Sizensky J. A., Faulk W. P. Transferrin conjugates of adriamycin are cytotoxic without intercalating nuclear DNA. J. Biol. Chetn 1992; 267: 9437–9442
  • Bejaoui N., Page M., Noel C. Cytotoxicity of transferrin-daunorubicin conjugates. Anticancer Res 1991; 11: 2211–2213
  • Bergamaschi G., Cazzola M., Dezza L., Savino E., Consonni E., Lappi D. Killing of K562 cells with conjugates between human transferrin and a ribosome-inactivating protein (SO-6). Br. J. Haematol 1988; 68: 379–384
  • Beyer U., Roth T., Schumacher P., Maier G., Unold A., Frahm A. W., Fiebig H. H., Unger C., Kratz F. Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil. J. Med. Chem 1998; 41: 2701–2708
  • Bostik J., Bures L., Spundova M., Rehak L. The use of protein as a carrier of methotrexate for experimental cancer chemotherapy. IV. Therapy of murine melanona B16 by human serum albumin-methotrexate. Neoplasma 1988; 35: 343–349
  • Brock J. H. Transferrins. Metalloproteins, Part 2: Metal Proteins with Nonredox Roles, P. M. Harrison. Verlag Chemie, Weinheim 1985; 183–263
  • Bures L., Bostik J., Motycka K., Spundova M., Rehak L. The use of protein as a carrier of methotrexate for experimental cancer chemotherapy. III. Human serum albumin-methotrexate derivative, its preparation and basic testing. Neoplasma 1988; 35: 329–342
  • Bures L., Lichy A., Bostik J., Spundova M. The use of protein as a carrier of methotrexate for experimental cancer chemotherapy V. Alternative methods for preparation of serum albumin-methotrexate derivative. Neoplasma 1990; 37: 225–231
  • Butler T. P., Grantham F H., Gullino P. M. Bulk transfer of fluid in the interstitial compartment of mammary tumors. Cancer Res 1975; 35: 3034–3088
  • Cantafora A., Blotta I. Neutral lipids production, transport, utilization. Anticancer Res 1996; 16: 1441–1450
  • Cazzola M., Bergamaschi G., Dezza L., Arosio P. Manipulations of cellular iron metabolism for modulating normal and malignant cell proliferation: Achievements and prospects. Blood 1990; 75: 1903–1919
  • Chitambar C. R., Seligman P. A. Effect of different transferrin forms on transferrin-receptor expression, iron uptake, and cellular proliferation of human leukemic HL60 cells. Mechanisms responsible for the specific cytotoxicity of transferrin-gallium. J. Clin. Invest 1986; 78: 1538–1546
  • Chitambar C. R., Zivkovic Z. Uptake of gallium-67 by human leukemic cells, demonstration of transferrin receptor-dependent and transferrin-independent mechanisms. Cancer Res 1987; 47: 3929–3934
  • Chitambar C. R., Matthaeus W. G., Antholine W. E., Graff K., O'Brien W. J. Inhibition of leukemic HL60 cell growth by transferrin-gallium, effects on ribonucleotide reductase and demonstration of drug synergy with hydroxy urea. Blood 1988; 72: 1930–1936
  • Chu B. C. R., Howell S. P. Differential toxicity of carrier-bound methotrexate toward human lymphocytes, marrow, and tumor cells. Biochem. Pharmacol 1981; 30: 2545–2552
  • Chu B. C. F., Whitely J. M. High molecular weight derivatives of methotrexate as chemotherapeutic agent. Mol. Pharmacol 1977; 13: 80–88
  • Chu B. C. F., Whitely J. M. Control of solid tumor metastasis with a high-molecular-weight derivative of methotrexate. J. Natl. Cancer Inst 1979; 62: 79–82
  • Chu B. C. F., Whitely J. M. The interaction of carrier-bound methotrexate with L1210 cells. Mol. Pharmacol 1980; 17: 382–387
  • Chun P. W., Brumbaugh E. E., Shireman R. B. Interaction of human low density lipoprotein and apolipoprotein-B with ternary lipid microemulsion. Biophys. Chem 1986; 25: 223–241
  • Colombatti M., Bisconti M., Dell'Arciprete L., Gerosa M. A., Tridente G. Sensitivity of human glioma cells to cytotoxic heteroconjugates. Int. J. Cancer 1988; 42: 441–448
  • Colombatti M., Dell'Arciprete L., Chignola R., Tridente G. Carrier protein-monensin conjugates: Enhancement of immunotoxin cytotoxicity and potential in tumor treatment. Cancer Res 1990; 50: 1385–1391
  • De Smidt P. C., van Berkel T. J. C. Prolonged serum half life of antineoplastic drugs by incorporation into the low density lipoprotein. Cancer Res 1990; 50: 7476–7482
  • Dosio F., Brusa P., Crosasso P., Arpicco S., Cartel L. Preparation, characterization, and properties in vitro and in vivo of a paclitaxel-albumin conjugate. J. Controlled Release 1997; 47: 293–304
  • Drevs J., Hofmann I., Marmé D., Unger C., Kratz F. Superior in vivo efficacy of an acid-sensitive albumin conjugate of adriamycin compared to the parent compound in murine renal cell carcinoma. Drug Del 1998, submitted
  • Duncan R., Spreafico F. Polymer conjugates. Pharmacokinetic considerations for design and development. Clin. Pharmacokinet 1994; 27: 290–306
  • Duncan R., Kopeckova-Rejmanova P., Strohalm J., Hume I. C., Lloyd J. B., Kopecek J. Anticancer agents coupled to N(2-hydroxypropyl) methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia. Br. J. Cancer 1988; 57: 147–156
  • Edwards C. L., Hayes R. L. Tumor scanning with 68Ga citrate. J. Nucl. Med 1969; 10: 103–105
  • Eley J. G., Halbert G. W., Florence A. T. Incorporation of prednimustine into low density lipoprotein: Activity against P388 cells in tissue culture. Int. J. Pharm 1990a; 65: 219–224
  • Eley J. G., Halbert G. W., Florence A. T. The incorporation of estramustine into low density lipoprotein and its activity in tissue culture. Int. J. Pharm 1990b; 63: 121
  • Elliott R. L., Elliott M. C., Head J. F. Preliminary results on 11 advanced breast cancer patients treated with cisplatin complexed to human transferrin. Breast Cancer Res. Treat 1990; 16: 169
  • Elliott R. L., Stjernholm R., Elliott M. C. Preliminary evaluation of platinum transferrin (MPTC-63) as a potential nontoxic treatment for breast cancer. Cancer Detect. Prev 1988; 12: 469–480
  • Faulk W. P., Taylor C. G., Yeh C. J., McIntyre J. A. Preliminary clinical study of transferrin-adriamycin conjugate for drug delivery to acute leukemia patients. Mol. Biother 1990; 2: 57–60
  • Filipowska D., Filipowska T., Morelowska B., Kazanowska W., Laudanski T., Lapinjoki S., Akerlund M., Breeze A. Treatment of cancer patients with a low-density lipoprotein delivery vehicle containing a cytotoxic drug. Cancer Chemother. Pharmacol 1992; 29: 396–400
  • Firestone R. A. Low-density lipoprotein as a vehicle for targeting antitumor compounds to cancer cells. Bioconjugate Chem 1994; 5: 105–113
  • Firestone R. A., Pisano J. M., Falck J. R., McPhaul M. M., Krieger M. Selective delivery of cytotoxic compounds to cells by the LDL pathway. J. Med. Chem 1984; 27: 1037–1043
  • Fiume L., Di Stefano G., Busi C., Mattioli A., Bonino F., Torrani-Cerenziana M., Verme G., Rapicetta M., Bertini M., Gervasi G. B. Liver targeting of antiviral nucleoside analogues through the asialoglycoprotein receptor. J. Virol. Hepat 1997; 4: 363–370
  • Friden P. M., Walus L. R., Musso G. F., Taylor M. A., Malfroy B., Starzyk R. M. Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier. Proc. Natl. Acad. Sci. USA 1991; 88: 4771–4775
  • Fritzer M., Barabas K., Szüts V., Berczi A., Szekeres T., Faulk W. P., Goldenberg H. Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells. Int. J. Cancer 1992; 52: 619–623
  • Gabizon A., Papahadjopoulous D. Liposome formulations with prolonged ciriculation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. USA 1988; 85: 6949–6953
  • Gabor F., Wollmann K., Theyer G., Haberl I., Hamilton G. In vitro antiproliferative effects of albumin-doxorubicin conjugates against Ewing's sarcoma and peripheral neuroectodermal tumor cells. Anticancer Res 1994; 14: 1943–1950
  • Gal D., MacDonald P. C., Porter J. C., Simpson E. R. Cholesterol metabolism in cancer cells in monolayer culture: III. Low-density lipoprotein metabolism. Int. J. Cancer 1981a; 28: 315–319
  • Gal D., Ottashi M., MacDonald P. C., Buschbaum H. J., Simpson E. R. Low-density lipoprotein as a potential vehicle for chemotherapeutic agents and radionucleotides in the management of gynecologic neoplasm. Am. J. Obstet. Gynecol 1981b; 139: 877–885
  • Gal D., Simpson E. R., Porter J. C., Snyder J. M. Defective internalization of low density lipoprotein in epidermoid cervical cancer cells. J. Cell Biol 1982; 92: 597–603
  • Ginsburg G. S., Walsh M. T., Small D. M., Atkinson D. Reassembled plasma low density lipoproteins. J. Biol. Chem 1984; 259: 6667–6673
  • Goldstein J. L., Brown M. S. The low-density lipoprotein pathway and its relation to artherosclerosis. Ann. Rev. Biochem 1977; 46: 897–930
  • Greenfield L., Johnson V. G., Youle R. L. Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity. Science 1987; 238: 536–539
  • Greenfield R. S., Kaneko T., Daues A., Edson M. A., Fitzgerald K. A., Olech L. J., Grattan A., Spitalny G. L., Braslawsky G. R. In vitro evaluation of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone linker. Cancer Res 1990; 50: 6600–6607
  • Gupta P. K., Hung C. T. Albumin microspheres II: Application in drug delivery. J. Microencapsulation 1989b; 6: 427–462
  • Gupta P. K., Hung C. T. Albumin microspheres I: Physiochemical characteristics. J. Microencapsulation 1989a; 6: 463–472
  • Hall W. A., Godal A., Juell S., Fodstad O. In vitro efficacy of transferrin-toxin conjugates against glioblastoma multiforme. J. Neurosurg 1992; 76: 838–844
  • Hartung G., Stehle G., Sinn H., Schrenk H. H., Heeger S., Kränzle D., Fiebig H. H., Maier-Borst W., Heene D. L., Queiβler W. Phase I-trial of a methotrexate-albumin conjugate (MTX-HSA) in cancer patients. ECCO 9, Eur. J. Cancer 1997; S249: 1129
  • He X. M., Carter D. C. Atomic structure and chemistry of human serum albumin. Nature 1992; 358: 209–215
  • Henriksson P., Ericsson S., Stege R., Ericsson M., Rudling M., Berglund R., Angelin B. Hypocholesterolemia and increased elimination of low-density lipoproteins in metastatic cancer of the prostate. Lancet 1989; II: 1178–1180
  • Ho Y. K., Smith R. G., Brown M. S., Goldstein J. L. Low density lipoprotein (LDL) receptor activity in human acute myelogenous leukemic cells. Blood 1978; 52: 1099–1114
  • Hoshino T., Misaki M., Yamamoto M., Shimizu H., Ogawa Y., Toguchi H. In vitro cytotoxicities and in vivo distribution of transferrin-platinum(II) complex. J. Pharm. Sci 1994; 84: 216–221
  • Hynds S. A., Welsh J., Stewart J. M., Jack A., Soulop M., McArdle C. S., Calmann K. C., Packard C. J., Shepherd J. Low-density lipoprotein metabolism in mice with soft tissue tumours. Biochim. Biophys. Acta 1984; 795: 589–595
  • Isaacsohn J. L., Lees A. M., Lees R. S., Strauss H. W., Barlaikovach M., Moore T. J. Adrenal imaging with technetium-99m-labelled low density lipoproteins. Metabolism 1986; 35: 364–366
  • Ishiguro K., Ho P. T., Sartorelli A. C. Characterization of the defect in a variant of HL-60 promyelocytic leukemia cells with reduced transferrin receptor expression. Somat. Cell. Mol. Genet 1992; 18: 45–63
  • Iwanik M. J., Shaw K. V., Leswith B. J., Yanovich S., Shaw J. M. Preparation and interaction of a low-density lipoprotein daunomycin complex with P 388 leukemic cells. Cancer Res 1984; 44: 1206–1215
  • Jain R. K. Transport of molecules across tumor vaculature. Cancer Metast. Rev 1987a; 6: 559–593
  • Jain R. K. Transport of molecules in the tumor interstitium: A review. Cancer Res 1987b; 47: 3039–3051
  • Jeffries W. A., Brandon M. R., Hunt S. V., Williams A. F., Gatter K. C., Mason D. Y. Transferrin receptor on endothelium of brain capillaries. Nature 1984; 312: 162–163
  • Johnson V. G., Wilson G., Greenfield L., Youle R. J. The role of the diphtheria toxin receptor in cytosol translocation. J. Biol. Chem 1988; 263: 1295–130
  • Keppler B. K., Lipponer K. -G., Stenzel B., Kratz F. New tumor-inhibiting ruthenium complexes. Metal Complexes in Cancer Chemotherapy, B. K. Keppler. Verlag Chemie, VCH, Weinheim 1993; 187–220, Verlag Chemie, VCH
  • Kerr D. J., Hynds S. A., Shepherd J., Packard C. J., Kaye S. B. Comparative cellular uptake an cytotoxicity of a complex of daunomycin-low density lipoprotein in human squamous lung tumour cell monolayers. Biochem. Pharmacol 1988; 37: 3981–3986
  • Kohgo Y., Kondo H., Kato J., Sasaki K., Tsushima N., Nishisato T., Hirayama M., Fujikawa K., Shintani N., Mogi Y. Kinetics of internalization and cytotoxicity of transferrin-neocarzinostatin conjugate in human leukemia cell line, K562. Japan. J. Cancer Res 1990; 81: 91–99
  • Kohgo Y., Niitsu Y., Nishisato T., Urushizaki Y., Kondo H., Fukushima M., Tsushima M., Urushizaki I. Transferrin receptor of tumor cells—potential tools for diagnosis and treatment of malignancies. Proteins of Iron Storage and Transport, G. Spik, J. Montreuil, R. R. Crichton, J. Mazurier. Elsevier Science Publishers, Amsterdam 1985; 155–169
  • Kornfeld S. B., Leonard J. E., Mullen M. D., Taetle R. Assessment of ligand effects in intracellular trafficking of ricin A chain using anti-ricin hybridomas. Cancer Res 1991; 51: 4316–4322
  • Kratz F. Interactions of antitumour metal complexes with serum proteins. Perspectives for anticancer drug development. A review. Metal Complexes as Antitumour Agents, B. K. Keppler. Verlag Chemie Weinhein. 1993; 392–429
  • Kratz F. Drug targeting in der antitumoralen Chemotherapie. Anti-gene und Rezeptoren als Angriffspunkte einer selektiven Chemotherapie. Pharmazie in unserer Zeit 1995; 24: 14–26
  • Kratz F., Beyer U., Coltery P., Lechenault F., Cazabat A., Schumacher P., Falken U., Linger C. Preparation, characterization, and in vitro efficacy of albumin conjugates of doxorubicin. Biol. Pharm. Bull 1998a; 21: 56–61
  • Kratz F., Beyer U., Roth T., Schütte M. T., Unold A., Fiebig H. H., Unger C. Albumin conjugates of the anticancer drug chlorambucil: Synthesis, characterization, and in vitro efficacy. Arch. Pharm. Pharm. Med. Chem 1998b; 331: 47–53
  • Kratz F., Beyer U., Roth T., Tarasova N., Collery P., Lechenault F., Cazabat A., Schumacher P., Unger C., Falken U. Transferrin conjugates of doxorubicin: Synthesis, characterization, cellular uptake, and in vitro efficacy. J. Pharm. Sci 1998c; 87: 338–346
  • Kratz F., Beyer U., Schumacher P., Krüger M., Zahn H., Roth T., Fiebig H. H., Unger C. Synthesis of new maleimide derivatives of daunorubicin and biological activity of acid labile transferrin conjugates. Bioorg. Med. Chem. Lett 1997a; 7: 617–622
  • Kratz F., Fichtner I., Beyer U., Schumacher P., Roth T., Fiebig H. H., Unger C. Antitumor activity of acid labile transferrin and albumin doxorubicin conjugates in vitro and in vivo human tumour xenograft models. Eur. J. Cancer 1997b; 33: 784
  • Kratz F., Hartmann M., Keppler B. K., Messori L. The binding properties of two antitumor ruthenium(III) complexes to apotransferrin. J. Biol. Chem 1994a; 269: 2581–2588
  • Kratz F., Keppler B. K., Hartmann M., Messori L., Berger M. R. Comparison of the antiproliferative activity of two antitumour ruthenium(III) complexes with their apotransferrin and transferrin-bound forms in a human colon cancer cell line. Metal-Based Drugs 1996; 3: 15–23
  • Kratz F., Keppler B. K., Messori L., Smith C., Baker E. N. Protein-binding properties of two antitumour Ru(III) complexes to human apotransferrin and apolactoferrin. Metal-based Drugs 1994b; 1: 169–173
  • Kratz F., Mulinacci N., Messori L., Bertini I., Keppler B. K. Kinetic, spectroscopic and LPLC studies of the interactions of antitumour ruthenium(III) complexes with serum proteins. Metal Ions in Biology and Medicine. John Libbey Limited Eurotext, John Paris 1992; Vol. 2: 69–74
  • Kratz F., Roth T., Fiebig H. H., Unger C. Superior in vivo efficacy of an acid-sensitive albumin conjugate of doxorubicin in two human xenograft models. Annual Congress of the German and Swiss Pharmaceutical Society, Zurich, Switzerland, 1997c; P55
  • Kratz F., Roth T., Fichtner I., Fiebig H. H., Unger C. Development of antitumor protein and polymer conjugates using in vitro and in vivo tumor xenograft models. Relevance of Tumor Models for Anticancer Drug Development, Contribution to Oncology, H. H. Fiebig. Karger Verlag, Basel, Switzerland 1998d, in press
  • Kratz F., Schutte M. T. Anticancer metal complexes and tumor targeting strategies. Cancer J 1998; 11: 176–181
  • Krieger M., Brown M. S., Faust J. R., Goldstein J. L. Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. J. Biol. Chem 1978; 253: 4093–4101
  • Kritchevsky S. B., Wilcosky T. C., Morris D. L., Truong K. N., Tyroler H. A. Changes in plasma lipid and lipoprotein cholesterol and weight prior to the diagnosis of cancer. Cancer Res 1991; 51: 3198–3203
  • Krüger M., Beyer U., Schumacher P., Unger C., Zahn H., Kratz F. Synthesis and stability of four maleimide derivatives of the anticancer drug doxorubicin for the preparation of chemoimmunoconjugates. Chem. Pharm. Bull 1997; 47: 399–401
  • Laurie S. M., Robbins A. R. A toxin-resistant mouse L-cell mutant defective in protein transport along the secretory pathway. J. Cell Physiol 1991; 147: 215–223
  • Lemieux P., Pagé M., Noel C. In vivo cytotoxicity and antineoplastic activity of a transferrin-daunorubicin conjugate. In Vivo 1992; 6: 621–628
  • Lombardi P., Norata G., Maggi F. M., Canti G., Franco P. O., Nicolin A., Capatano A. L. Assimilation of LDL by experimental tumours in mice. Biochim. Biophys. Acta 1989; 1003: 301–306
  • Lundberg B. Preparation of drug-low density lipoprotein complexes for delivery of antitumoral drugs via the low density lipoprotein pathway. Cancer Res 1987; 47: 4105–4108
  • Lundberg B. Assembly of prednimustine low-density lipoprotein complexes and their cytotoxic activity in tissue culture. Cancer Chemother. Pharmacol 1992; 29: 241–247
  • Lundberg B., Suominen L. Preparation of biologically active analogs of serum low density proteins. J. Lipid Res 1984; 25: 550–558
  • Maeda H., Matsumura Y. Tumoritropic and lymphotropic principles macromolecular prodrugs. Crit. Rev. Ther. Drug Carrier Sys 1989; 6: 193–210
  • Masquelier M., Vitols S., Peterson C. Low-density lipoprotein as a carrier antitumoral drugs: In vivo fate of drug-human low-density lipoprotein complexes in mice. Cancer Res 1986; 46: 3842–3847
  • Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins of the antitumor agent smancs. Cancer Res 1986; 46: 6387–6392
  • Means G. E., Feeney R. E. Chemical modification of proteins: History and application. Bioconjugate Chem 1990; 1: 2–12
  • Messori L., Kratz F. Transferrin-from inorganic biochemistry to medicine. Metal-based Drugs 1994; 1: 161–167
  • Mider G. B., Tesluk H., Morton J. J. Effects of Walker carcinoma 256 on food intake, body weight, and nitrogen metabolism of growing rats. Acta Union Int. Contra Cancrum 1948; 6: 409–420
  • Miller S. R., Tartter P. I., Papatestas A. E., Slater G., Aufses A. H., Jr. Serum cholesterol and human colon cancer. J. Natl. Cancer Inst 1981; 67: 297–300
  • Morimoto Y., Fujimoto S. Albumin microspheres as drug carriers. Crit. Rev. Then Drug Carrier Syst 1985; 2: 19–63
  • Mukherjee S., Grosh R. N., Maxfield F. R. Endocytosis. Physiol. Rev 1997; 77: 759–803
  • Mukhopadhyay A., Mukhopadhyay B., Basu S. K. Circumvention of multidrug resistance in neoplastic cells through scavenger receptor mediated drug delivery. FEBS Lett 1995; 376: 95–98
  • Neville D. M., Jr, Srinavasachar K., Stone R., Scharff J. Enhancement of immunotoxin efficacy by acid-cleavable cross-linking agents utilizing diphtheria toxin and toxin mutants. J. Biol. Chem 1989; 264: 14653–14661
  • Norata G., Canti G., Ricci L., Nicolin A., Trezzi E., Capatano A. L. In vivo assimilation of low-density lipoproteins by a fibrosarcoma tumour cell line in mice. Cancer Lett 1984; 25: 203–208
  • Ohkawa K., Hatano T., Tsukada Y., Matsuda M. Chemotherapeutic efficacy of the protein-doxorubicin conjugates on multidrug resistant rat hepatoma cell line in vitro. Br. J. Cancer 1993a; 67: 274–278
  • Ohkawa K., Hatano T., Yamada K., Joh K., Takada K., Tsukada Y., Matsuda M. Bovine serum albumin-doxorubicin conjugate overcomes multidrug resistance in a rat hepatoma. Cancer Res 1993b; 53: 4238–4242
  • O'Keefe D. O., Draper R. K. Characterization of a transferrin-diphtheria toxin conjugate. J. Biol. Chem 1985; 260: 932–937
  • O'Keefe D. O., Draper R. K. Two pathways of transferrin recycling evident in a variant of mouse LMTK-cells. Somat. Cell. Mol. Genet 1988; 14: 473–487
  • Partridge W. M. Brain drug delivery and blood-brain barrier transport. Drug Del 1996; 3: 99–115
  • Peters T., Jr. Serum albumin. Adv. Protein. Chem 1985; 37: 161–245
  • Peterson C., Vitols S., Rudling M., Blomgren H., Edsmyr F., Skoog L. Hypocholesterolemia in cancer patients may be caused by elevated LDL receptor activities in malignant cells. Med. Oncol. Tumor Pharmacother 1985; 2: 143–147
  • Porta C., Moroni M., Nastasi G., Invernizzi R., Bobbio-Pallavicini E. Hypocholesterolemia and acute myeloid leukemia (AML). Haematologica 1991; 76: 348
  • Raso V., Basala M. A highly cytotoxic human transferrin-ricin. A chain conjugate used to select receptor-modified cells. J. Biol. Chem 1984; 259: 1143–1149
  • Raso V., Lawrence J. Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain. J. Exp. Med 1984; 160: 1234–1240
  • Raso V., Watkins S. C., Slayter H., Fehrmann C. Intracellular pathway of ricin A chain cytotoxins. Ann. N. Y. Acad. Sci 1987; 507: 172–186
  • Roth T., Fiebig H. H., Eckert C., Spitzmüller B., Beyer U., Schumacher P., Unger C., Kratz F. In vitro antitumor efficacy of acid labile transferrin conjugates of doxorubicin in ten human tumor xenografts. Proc. Amer. Assoc. Cancer Res 1997; 38: 2898
  • Rybak S. M., Saxena S. K., Ackerman E. J., Youle R. J. Cytotoxic potential of ribonuclease and ribonuclease hybrid proteins. J. Biol. Chem 1991; 266: 21202–21207
  • Sands H., Jones P. L., Shah A. S., Palme D., Vessella R. L., Gallagher B. M. Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human clouser and renal cell xenografts. Cancer Res 1988; 48: 188–193
  • Schilling U., Friedrich A., Sinn H., Schrenk H. H., Clorius J. H., Maier-Borst W. Design of compounds having enhanced tumour uptake, using serum albumin as a carrier-Part 2. Nucl. Med. Biol 1990; 19: 685–695, Int. J. Rod. Appl. Instrum. B:
  • Schüler J., Fiebig H. H., Sausville E. A., Burger A. M. (1997) Characterization of vascular permeability in human tumor xenografts-identification of suitable tumor models to evaluate polymer conjugates. Int. Symposium “Relevance of Tumor Models for Anticancer Drug Development”. 10, 1997. Tumor Biology Center, Freiburg, FRG, 15–17, P6
  • Seymour L. W. Passive tumor targeting of soluble macromolecules and drug conjugates. Crit. Rev. Ther. Drug Carrier Sys 1992; 9: 135–187
  • Seymour L. W., Miyamoto Y., Maeda H., Brereton M., Strohalm J., Ulbrich K., Duncan R. Influence of molecular weight on passive tumour accumulation of a soluble macromolecular carrier. Eur. J. Cancer 1995; 31A: 766–770
  • Sinn H., Schrenk H. H., Friedrich A., Schilling U., Maier-Borst W. Design of compounds having an enhanced tumour uptake, using serum albumin as a carrier. Nucl. Med. Biol 1990; 17: 819–827, Int. J. Rad. Appl. Instrum. B, Part 1
  • Smith C. A., Sutherland-Smith A. J., Keppler B. K., Kratz F., Baker E. N. Binding of ruthenium(III) anti-tumor drugs to human lactoferrin by high resolution X-ray crystallographic structure analysis. J. Bioinorg. Chem 1996; 1: 424–431
  • Som P., Oster Z. H., Matsui K., Guglelmi G., Persson B. R. R., Pellettieri M. L., Srivastava S. C., Richards P., Atkins H. L., Brill A. B. Ru-97-transferrin uptake in tumor and abscess. Eur. J. Nucl. Med 1983; 8: 491–494
  • Srivastava S. C., Richards P., Meinken G. E., Larson S. M., Grunbaum Z. Tumor uptake of radioruthenium compounds. Radiopharmaceuticals: Structure-Activity Relationship, R. Spencer. Grune and Stratton, New York 1981; 207–223
  • Stehle G., Sinn H., Wunder A., Schrenk H. H., Schütt S., Heene D. L., Maier-Borst W. The loading rate determines tumor targeting of methotrexate-albumin conjugates in rats. Anti-Cancer Drugs 1997a; 8: 677–685
  • Stehle G., Sinn H., Wunder A., Schrenk H. H., Stewart J. C. M., Hartung G., Maier-Borst W., Heene D. L. Plasma protein (albumin) catabolism by the tumor itself-implications for tumor metabolism and the genesis of cachexia. Crit. Rev. Oncol. Hematol 1997; 26: 77–100
  • Stehle G., Wunder A., Sinn H., Schrenk H. H., Schütt S., Frei E., Hartung G., Maier-Borst W., Heene D. L. Pharmacokinetics of methotrexate-albumin conjugates in tumor bearing rats. Anti-Cancer Drugs 1997b; 8: 835–844
  • Stjernholm R. L. Platinum bound to transferrin for use in the treatment of breast tumors. US patent 4590001 A 20, 1986, May 1986
  • Stjernholm R., Warner F. W., Robinson J. W., Ezekiel E., Katayama N. Binding of platinum to human transferrin. Bioinorg. Chem 1978; 9: 277–280
  • Subr V., Strohalm J., Ulbrich K., Duncan R. Polymers containing enzymatically degradable bonds. XII. Release of daunomycin and adriamycin from poly[N-(2-hydroxypropyl)methacrylamide] copolymers. J. Controlled Release 1992; 18: 123–132
  • Sun I. L., Sun E. E., Crane F. L., Morre D. J., Faulk W. P. Inhibition of transplasma membrane electron transport by transferrin-adriamycin conjugates. Biochim. Biophys. Acta 1992; 1105: 84–88
  • Sutherland R., Delia D., Schneider C., Newmann R., Kemshead J., Greaves M. Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proc. Natl. Acad. Sci. USA 1980; 78: 4515–4519
  • Takakura Y., Fujita T., Hashida M., Sezaki H. Disposition and tumor localization of mitomycin C dextran conjugates in mice. Pharm. Res 1987; 4: 293–300
  • Takakura Y., Fujita T., Hashida M., Sezaki H. Disposition characteristics of macromolecules in tumor-bearing mice. Pharm. Res 1990; 7: 339–346
  • Takakura Y., Hashida M. Macromolecular drug carrier systems in cancer chemotherapy: Macromolecular prodrugs. Crit. Rev Oncol. Hematol 1994; 18: 207–231
  • Tanaka T., Kaneo Y., Iguchi S. Properties of mitomycin C-protein conjugates in vitro and in vivo. Bioconjugate Chem 1991; 2: 261–269
  • Tanaka T., Kaneo Y., Miyashita M. Synthesis of transferrin-mitomycin C conjugate as a receptor-mediated drug targeting system. Biol. Pharm. Bull 1996; 19: 114–111
  • Tanaka T., Kaneo Y., Shiramoto S., Iguchi S. The disposition of serum proteins as drug carriers in mice bearing sarcoma 180. Biol. Pharm. Bull 1993; 16: 1270–1275
  • Testa U., Pelosi E., Peschle C. The transferrin receptor. Crit. Rev. Oncogenesis 1993; 4: 241–276
  • Trouet A., Masquelier M., Baurain R., Campeneere D. D.-D. A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolaseed, as required for a lysosomotropic drug carrier conjugate: In vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 1982; 79: 626–629
  • Trowbridge I. S. Transferrin receptor as a potential therapeutic agent. Prog. Allergy 1988; 45: 121–146
  • Trowbridge I. S., Omary M. B. Human cell surface glycoprotein related to the cell proliferation is the receptor for transferrin. Proc. Natl. Sci. USA 1981; 78: 3039–3043
  • Urushizaki I. Targeting effect of transferrin-neocarzinostatin conjugate by receptor-mediated endocytosis. Nippon Rinsho-Japan. J. Clin. Med 1989; 47: 1423–1431
  • Versluis A. J., van Geel P. J., Oppelaar H., van Berkel T. J. C., Bijsterbosch M. K. Receptor-mediated uptake of low-density lipoprotein by B16 melanoma cells in vitro and in vivo in mice. Br. J. Cancer 1996; 74: 525–532
  • Vitols S. Uptake of low-density lipoprotein by malignant cells-possible therapeutic applications. Cancer Cells 1991; 3: 488–495
  • Vitols S., Gahrton G., Öst Å., Peterson C. Elevated low density lipoprotein receptor activity in leukemic cells with monocytic differentiation. Blood 1984; 63: 1186–1193
  • Vitols S., Söderberg-Reid K., Masquelier M., Sjöström B., Peterson C. Low density lipoprotein for delivery of a water-insoluble alkylating agent to malignant cells. In vitro and in vivo studies of a drug-lipoprotein complex. Br. J. Cancer 1990; 62: 724–729
  • Wagner E., Curiel D., Cotten M. Delivery of drugs, proteins and genes into cells using transferrin as ligand for receptor-mediated endocytosis. Adv. Drug Del. Rev 1994; 14: 113–135
  • Walsh M. T., Ginsburg G. S., Small D. M., Atkinson D. Apo B-lecithin-cholesterol ester complexes: Reassembly of low density lipoprotein. Arteriosclerosis 1982; 2: 445a
  • Ward S. G., Taylor R. C. Anti-tumor activity of the main-group metallic elements: Aluminium, gallium, thallium, germanium, lead, antimony and bismuth. Metal-based Antitumor Drugs, M. F. Gielen. Freund Publishing House Ltd., London 1988, Chapter 1
  • Warner F. W., Demanuelle M., Stjernholm R., Cohn I., Baddley W. H. Response to transferrin bound iron to treatment of rat lymphosarcoma with cisdichlorodiammine-platinum(II). J. Clin. Hematol. Oncol 1977; 7: 180–189
  • White S., Taetle R., Seligman P. A., Rutherford M., Trowbridge I. S. Combinations of anti-transferrin receptor monoclonal antibodies inhibit human tumor cell growth in vitro and in vivo: Evidence for synergistic antiproliferative effects. Cancer Res 1991; 50: 6295–6301
  • Wunder A., Stehle G., Sinn H., Schrenk H. H., Hoff-Biederbeck D., Bader F., Friedrich E. A., Peschke P., Maier-Borst W., Heene D. L. Enhanced albumin uptake by rat tumors. Int. J. Oncol 1997; 11: 497–507
  • Yeh C. J., Faulk W. P. Killing of human tumor cells in culture with adriamycin conjugates of human transferrin. Clin. Immunol. Immunopath 1984; 32: 1–11
  • Yuan F., Deilian M., Fukumura D., Leuning M., Berk D. A., Torchilin V. P., Jain R. K. Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size. Cancer Res 1995; 55: 3752–3756
  • Zyada L. E., Hassan H. T., Rees J. K. H., Ragab M. H. The relation between hypocholesterolemia and degree of maturation of in acute myeloid leukemia. Hematol. Oncol 1990; 8: 65–69

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