Lowering of elevated tissue PCO₂ in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties

References

• Bian Y, Rong Z, Ming T, Chang T. 2011. A novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant. Artif Cells Blood Substit Biotechnol. 39:127–136.
   PubMed Web of Science ®Google Scholar
• Chang EJ, Lee TH, Mun KC, Kim HC, Suh SI, Bae JH, . 2004. Effects of polyhemoglobin-antioxidant enzyme complex on ischemia-reperfusion in kidney. Transplant Proc. 36:1952–1954.
   PubMed Web of Science ®Google Scholar
• Chang TMS. 1964. Semipermeable microcapsules. Science146: 524–525.
   PubMed Web of Science ®Google Scholar
• Chang TMS. 1971. Stabilization of enzyme by microencapsulation with a concentrated protein solution or by crosslinking with glutaraldehyde. Biochem Biophys Res Com. 44:1531–1533.
   PubMed Web of Science ®Google Scholar
• Chang TMS. 2007. Monograph on Artificial cells: Biotechnology, Nanotechnology, Blood Substitutes, Regenerative Medicine, Bioencapsulation, Cell/Stem Cell Therapy. Singapore/London: World Science Publisher/Imperial College Press, p. 454 (available free online at www.artcell.mcgill.ca).
   Google Scholar
• Chang TMS. 2009. Nanobiotechnology for hemoglobin-based blood substitutes. Crit Care Clin. 25:373–382.
   PubMed Web of Science ®Google Scholar
• Chang TMS. 2012. From Artificial Red Blood Cells, Oxygen Carriers, Oxygen Therapeutics to Artificial Cells and Nanomedicine and beyond. Artif Cells Blood Immobil Substit Biotechnol. 40:197–199.
   PubMed Web of Science ®Google Scholar
• D’Agnillo D, Chang TMS. 1998. PolyHb-superoxide dismutase- catalase as a blood substitute with antioxidant properties. Nat Biotechnol. 16:667–671.
   PubMed Web of Science ®Google Scholar
• Geers C, Gros G. 2000. Carbon dioxide transport and carbonic anhydrase in blood and muscle. Physiol Rev. 80:681–715.
   PubMed Web of Science ®Google Scholar
• Jahr JS, Mackenzie C, Pearce LB, Pitman A, Greenburg AG. 2008. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopaedic surgery. J Traum. 64:1484–1497.
   PubMed Web of Science ®Google Scholar
• Kvarstein G, Mirtaheri P, Tonnessen TI. 2004. Detection of ischemia by PCO2 before adenosine triphosphate declines in skeletal muscle. Crit Care Med. 32:232–237.
   PubMedGoogle Scholar
• Liu Q, Xiu RJ. 2008. Proceedings of the XI ISBS symposium at Peking Union Medical School, Chinese Academy of Medical Sciences. Artif Cells Blood Substit Biotechnol. 36:169–293.
   Google Scholar
• Moore E, Moore FA, Fabian TC, Bernard AC, Fulda GJ, Hoyt DB, . 2009. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the multicenter trial. J Am Coll Surg. 208:1–13.
   PubMed Web of Science ®Google Scholar
• OPK Biotech LLC. 2011. Hemopure now approved in Russia [press release]. Retrieved from: http://www.investorvillage.com/smbd.asp?mb = 1666 & mid = 10711724&pt = msg.
   Google Scholar
• Powanda D, Chang TMS. 2002. Cross-linked polyhemoglobin-superoxide dismutase –catalase supplies oxygen without causing blood brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion. Artif Cells Blood Substit Immobil Biotechnol. 30:23–37.
   PubMed Web of Science ®Google Scholar
• Sims C, Seigne P, Menconi M, Monarca J, Barlow C, Pettit J, Puyana JC. 2001. Skeletal muscle acidosis correlates with the severity of blood volume loss during shock and resuscitation. J Trauma. 51:1137–1146.
   PubMed Web of Science ®Google Scholar
• Tronstad C, Pischke SE, Holhjem L, Tonnessen TI, Martinsen OG, Grimnes S. 2010. Early detection of cardiac ischemia using a conductometric PCO2 sensor: real-time drift correction and parameterization. Physiol Meas. 31:1241–1255.
   PubMed Web of Science ®Google Scholar
• Walter FB. 2010. Evaluating the role of carbonic anhydrases in the transport of HCO3–related species. Biochimica Et Biophysica Acta. 1804:410–421.
   PubMedGoogle Scholar
• Winslow R. (ed.) 2006. Blood Substitutes. San Diego: Academic Press.
   Google Scholar
• Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, . 2010. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 112:586–594.
   PubMed Web of Science ®Google Scholar
• Zapol W. 2012. Proceedings of the XIII ISBS symposium at Mass General Hospital of Harvard Medical School. Artif Cells Blood Substit Biotechnol. 40:197–238.
   PubMedGoogle Scholar